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Pathway Description
Lectin-Induced Complement Pathway
Homo sapiens
Protein Pathway
Created: 2018-07-30
Last Updated: 2019-08-16
The lectin-induced complement pathway, also known as the MBL pathway, is a complement activation pathway that is triggered by mannose-binding lectin binding to sugars found on carbohydrates found on pathogens. Unlike other complement pathways, this pathways components do not bind directly to the antibodies attached to the pathogen. The bacteria that MBL binds to include listeria, salmonella, and HIV-1.
References
Lectin-Induced Complement Pathway References
https://cgap.nci.nih.gov/Pathways/BioCarta/h_lectinPathway
https://www.qiagen.com/kr/shop/genes-and-pathways/pathway-details?pwid=269
http://pathwaymaps.com/maps/665
Takada F, Takayama Y, Hatsuse H, Kawakami M: A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochem Biophys Res Commun. 1993 Oct 29;196(2):1003-9. doi: 10.1006/bbrc.1993.2349.
Pubmed: 8240317
Sato T, Endo Y, Matsushita M, Fujita T: Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. Int Immunol. 1994 Apr;6(4):665-9. doi: 10.1093/intimm/6.4.665.
Pubmed: 8018603
Endo Y, Sato T, Matsushita M, Fujita T: Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: comparison with complement C1r and C1s genes. Int Immunol. 1996 Sep;8(9):1355-8. doi: 10.1093/intimm/8.9.1355.
Pubmed: 8921412
Lozano F, Suarez B, Munoz A, Jensenius JC, Mensa J, Vives J, Horcajada JP: Novel MASP2 variants detected among North African and Sub-Saharan individuals. Tissue Antigens. 2005 Aug;66(2):131-5. doi: 10.1111/j.1399-0039.2005.00436.x.
Pubmed: 16029433
Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC: A second serine protease associated with mannan-binding lectin that activates complement. Nature. 1997 Apr 3;386(6624):506-10. doi: 10.1038/386506a0.
Pubmed: 9087411
Takahashi M, Endo Y, Fujita T, Matsushita M: A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway. Int Immunol. 1999 May;11(5):859-63. doi: 10.1093/intimm/11.5.859.
Pubmed: 10330290
Ezekowitz RA, Day LE, Herman GA: A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins. J Exp Med. 1988 Mar 1;167(3):1034-46. doi: 10.1084/jem.167.3.1034.
Pubmed: 2450948
Sastry K, Herman GA, Day L, Deignan E, Bruns G, Morton CC, Ezekowitz RA: The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. J Exp Med. 1989 Oct 1;170(4):1175-89. doi: 10.1084/jem.170.4.1175.
Pubmed: 2477486
Taylor ME, Brickell PM, Craig RK, Summerfield JA: Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein. Biochem J. 1989 Sep 15;262(3):763-71. doi: 10.1042/bj2620763.
Pubmed: 2590164
Ulgiati D, Townend DC, Christiansen FT, Dawkins RL, Abraham LJ: Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype. Immunogenetics. 1996;43(4):250-2.
Pubmed: 8575831
Martinez-Quiles N, Paz-Artal E, Moreno-Pelayo MA, Longas J, Ferre-Lopez S, Rosal M, Arnaiz-Villena A: C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination. J Immunol. 1998 Oct 1;161(7):3438-43.
Pubmed: 9759862
Lopez-Goyanes A, Moreno MA, Ferre S, Paz-Artal E: C4d DNA sequence of complement C4B93 and recombination mechanisms for its generation. Tissue Antigens. 2004 Mar;63(3):260-2. doi: 10.1111/j.0001-2815.2004.00147.x.
Pubmed: 14989716
Yu CY: The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene. J Immunol. 1991 Feb 1;146(3):1057-66.
Pubmed: 1988494
Sargent CA, Anderson MJ, Hsieh SL, Kendall E, Gomez-Escobar N, Campbell RD: Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex. Hum Mol Genet. 1994 Mar;3(3):481-8. doi: 10.1093/hmg/3.3.481.
Pubmed: 8012361
Bentley DR: Primary structure of human complement component C2. Homology to two unrelated protein families. Biochem J. 1986 Oct 15;239(2):339-45. doi: 10.1042/bj2390339.
Pubmed: 2949737
Horiuchi T, Macon KJ, Kidd VJ, Volanakis JE: cDNA cloning and expression of human complement component C2. J Immunol. 1989 Mar 15;142(6):2105-11.
Pubmed: 2493504
Ishii Y, Zhu ZB, Macon KJ, Volanakis JE: Structure of the human C2 gene. J Immunol. 1993 Jul 1;151(1):170-4.
Pubmed: 8326124
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