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Peptidoglycan recognition protein 1 Monocyte differentiation antigen CD14 Toll-like receptor 2 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 TNF receptor- associated factor 6 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen- activated protein kinase kinase kinase 1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator Nuclear factor NF-kappa-B p105 subunit Transcription factor p65 NF-kappa-B inhibitor alpha NF-kappa-B inhibitor alpha Monocyte differentiation antigen CD14 Toll-like receptor 4 Lymphocyte antigen 96 Toll- interacting protein Interferon- induced, double-stranded RNA-activated protein kinase Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 Toll/interleukin- 1 receptor domain- containing adapter protein Mitogen- activated protein kinase kinase kinase 7 TGF-beta- activated kinase 1 and MAP3K7-binding protein 2 TGF-beta- activated kinase 1 and MAP3K7-binding protein 1 Mitogen- activated protein kinase 14 Dual specificity mitogen- activated protein kinase kinase 3 Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 4 Mitogen- activated protein kinase kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 4 Mitogen- activated protein kinase 14 Mitogen- activated protein kinase 8 Proto-oncogene c-Fos Transcription factor AP-1 ETS domain- containing protein Elk-1 Peroxisome proliferator- activated receptor alpha Nuclear factor NF-kappa-B p105 subunit Toll-like receptor 9 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 Toll-like receptor 3 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 Toll-like receptor 7 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 Nuclear factor NF-kappa-B p105 subunit Mitogen- activated protein kinase 8 Pi Pi Pi Pro-inflammatory cytokines (IL12, IL1, TNF-a) oxidized EPA oxidized EPA Lipoproteins (BLP, PGN, LAM, Mannans) Lipopolysaccharides (LPS) Apoptosis of host cells Influence adaptive immune system T cells Cell-mediated immunity Direct antimicrobial response speculated CpG DNA Poly (I:c) Imiquimod, R848 Extracellular Cytoplasm of Monocytes/Macrophages, Dendritic cells, Intestinal Epithelial & Endothelial cells
Nucleus PGLYRP1 CD14 TLR2 MYD88 IRAK1 TRAF6 ECSIT MAP3K1 CHUK IKBKB IKBKG NFKB1 RELA NFKBIA NFKBIA CD14 TLR4 LY96 TOLLIP EIF2AK2 MYD88 IRAK1 TIRAP MAP3K7 TAB2 TAB1 MAPK14 MAP2K3 MAP2K6 MAP2K4 MAP3K1 MAP2K4 MAPK14 MAPK8 FOS JUN ELK1 PPARA NFKB1 TLR9 MYD88 IRAK1 TLR3 MYD88 IRAK1 TLR7 MYD88 IRAK1 NFKB1 MAPK8 Phosphate Phosphate Phosphate
PGLYRP1 CD14 TLR2 MYD88 IRAK1 TRAF6 ECSIT MAP3K1 CHUK IKBKB IKBKG NFKB1 RELA NFKBIA NFKBIA CD14 TLR4 LY96 TOLLIP EIF2AK2 MYD88 IRAK1 TIRAP MAP3K7 TAB2 TAB1 MAPK14 MAP2K3 MAP2K6 MAP2K4 MAP3K1 MAP2K4 MAPK14 MAPK8 FOS JUN ELK1 PPARA NFKB1 TLR9 MYD88 IRAK1 TLR3 MYD88 IRAK1 TLR7 MYD88 IRAK1 NFKB1 MAPK8 Pi Pi Pi Pro-inflammatory cytokines (IL12, IL1, TNF-a) oxidized EPA oxidized EPA Lipoproteins (BLP, PGN, LAM, Mannans) Lipopolysaccharides (LPS) Apoptosis of host cells Influence adaptive immune system T cells Cell-mediated immunity Direct antimicrobial response speculated CpG DNA Poly (I:c) Imiquimod, R848 Extracellular Cytoplasm of Monocytes/Macrophages, Dendritic cells, Intestinal Epithelial & Endothelial cells
Nucleus PGLYRP1 CD14 TLR2 MYD88 IRAK1 TRAF6 ECSIT MAP3K1 CHUK IKBKB IKBKG NFKB1 RELA NFKBIA NFKBIA CD14 TLR4 LY96 TOLLIP EIF2AK2 MYD88 IRAK1 TIRAP MAP3K7 TAB2 TAB1 MAPK14 MAP2K3 MAP2K6 MAP2K4 MAP3K1 MAP2K4 MAPK14 MAPK8 FOS JUN ELK1 PPARA NFKB1 TLR9 MYD88 IRAK1 TLR3 MYD88 IRAK1 TLR7 MYD88 IRAK1 NFKB1 MAPK8 Pi Pi Pi