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Guanine nucleotide-binding protein G(T) subunit gamma-T1 O75747 UniProt Endoplasmic Reticulum CPD-8587 BioCyc true P28482 UniProt direct_interaction true true Dual specificity mitogen-activated protein kinase kinase 1 Calcium IP3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 NF-kappa-B inhibitor alpha Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(i) subunit alpha-1 P04049 UniProt Protein-tyrosine kinase 2-beta PIP2 PI3K 1.0 Focal adhesion kinase 1 Guanine nucleotide-binding protein G(q) subunit alpha P63096 UniProt P61073 UniProt GTPase HRas Cytoplasm SMP0064625 SMPDB DG_PKC_Calcium Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-1 1.0 PLCG1, GNAQ true NF-kappa-B inhibitor alpha PW065635 PathWhiz Adapter molecule crk CXCR4 Signaling Pathway ERK1, ERK2 true 1.0 GO:0005783 GENE ONTOLOGY Guanine nucleotide-binding protein G(T) subunit gamma-T1 C-X-C chemokine receptor type 4 P56945 UniProt P01112 UniProt O4P Phosphate 94.95342 P19838 UniProt Dual specificity mitogen-activated protein kinase kinase 1 Focal adhesion kinase 1 Guanine nucleotide-binding protein G(q) subunit alpha Mitogen-activated protein kinase 3 1.0 Breast cancer anti-estrogen resistance protein 1 Paxillin PKC Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 PIP2 266 ChemSpider P46108 UniProt Paxillin 1.0 Breast cancer anti-estrogen resistance protein 1 Mitogen-activated protein kinase 1 C-X-C chemokine receptor type 4 9606 TAXONOMY Q14289 UniProt FAK, PYK2, CRK, PAXILLIN true Mitogen-activated protein kinase 1 Interaction775 C-X-C chemokine receptor type 4 activates Gαi P62873 UniProt Interaction774 Stromal cell-derived factor 1 activates C-X-C chemokine receptor type 4 Interaction777 C-X-C chemokine receptor type 4 activates GNB1, GNGT1 C00076 KEGG Compound Interaction779 RAF proto-oncogene serine/threonine-protein kinase activates Dual specificity mitogen-activated protein kinase kinase 1 Interaction778 GNB1, GNGT1 activates GTPase HRas P49023 UniProt Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma DG CA%2b2 BioCyc SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY Ca Calcium 39.96259 PIP2 PIP2_PLCG1, GNAQ (Homo sapiens) Cell Membrane C00009 KEGG Compound P48061 UniProt Interaction780 Dual specificity mitogen-activated protein kinase kinase 1 activates ERK1, ERK2 14265-44-2 CAS Breast cancer anti-estrogen resistance protein 1 Interaction782 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma activates FAK, PYK2, CRK, PAXILLIN Interaction781 Gαi activates Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Interaction784 GNB1, GNGT1 activates Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma Stromal cell-derived factor 1 Interaction783 FAK, PYK2, CRK, PAXILLIN activates Breast cancer anti-estrogen resistance protein 1 Transport283 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Protein-tyrosine kinase 2-beta HMDB0001429 HMDB Interaction786 PI3K activates NFKB Interaction785 GNB1, GNGT1 activates PI3K Interaction788 PIP2 activates DG Nuclear factor NF-kappa-B p105 subunit Interaction787 C-X-C chemokine receptor type 4 activates PIP2 + PLCG1, GNAQ (Homo sapiens) 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase P63211 UniProt CHEBI:18367 ChEBI Interaction789 DG activates DG + PKC + Calcium 1032 ChemSpider Phosphate 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 HMDB0000464 HMDB P25963 UniProt DG P50148 UniProt Nuclear factor NF-kappa-B p105 subunit Guanine nucleotide-binding protein G(q) subunit alpha P19174 UniProt Interaction791 Calcium activates DG + PKC + Calcium Interaction790 PIP2 + PLCG1, GNAQ (Homo sapiens) activates IP3 C-X-C chemokine receptor type 4 PLCG1, GNAQ PIP2_PLCG1, GNAQ (Homo sapiens) PI3K Q05397 UniProt PKC 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 GNB1, GNGT1 Adapter molecule crk Q02750 UniProt 1.0 14127-61-8 CAS SMILES [Ca++] 1.0 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Calcium 1061 PubChem-compound Stromal cell-derived factor 1 GTPase HRas Calcium Interaction568 GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase GTPase HRas 1.0 P27361 UniProt NFKB GNB1, GNGT1 RAF proto-oncogene serine/threonine-protein kinase IP3 Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 1.0 Stromal cell-derived factor 1 C-X-C chemokine receptor type 4 Guanine nucleotide- binding protein G(i) subunit alpha-1 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide- binding protein G(T) subunit gamma-T1 GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 3 Mitogen- activated protein kinase 1 Phosphatidylinositol- 4-phosphate 3-kinase C2 domain- containing subunit gamma Protein- tyrosine kinase 2-beta Focal adhesion kinase 1 Paxillin Adapter molecule crk Breast cancer anti-estrogen resistance protein 1 Nuclear factor NF-kappa-B p105 subunit NF-kappa-B inhibitor alpha 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Guanine nucleotide- binding protein G(q) subunit alpha Ca + Ca + P i P i P i Ca + PI3K DG IP3 PIP2 DG PKC Pertussis Toxin Cell Migration HIV gp120 Extracellular Lymphocyte Cytoplasm
Guanine nucleotide-binding protein G(T) subunit gamma-T1 O75747 UniProt Endoplasmic Reticulum CPD-8587 BioCyc true P28482 UniProt direct_interaction true true Dual specificity mitogen-activated protein kinase kinase 1 Calcium IP3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 NF-kappa-B inhibitor alpha Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(i) subunit alpha-1 P04049 UniProt Protein-tyrosine kinase 2-beta PIP2 PI3K 1.0 Focal adhesion kinase 1 Guanine nucleotide-binding protein G(q) subunit alpha P63096 UniProt P61073 UniProt GTPase HRas Cytoplasm SMP0064625 SMPDB DG_PKC_Calcium Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-1 1.0 PLCG1, GNAQ true NF-kappa-B inhibitor alpha PW065635 PathWhiz Adapter molecule crk CXCR4 Signaling Pathway ERK1, ERK2 true 1.0 GO:0005783 GENE ONTOLOGY Guanine nucleotide-binding protein G(T) subunit gamma-T1 C-X-C chemokine receptor type 4 P56945 UniProt P01112 UniProt O4P Phosphate 94.95342 P19838 UniProt Dual specificity mitogen-activated protein kinase kinase 1 Focal adhesion kinase 1 Guanine nucleotide-binding protein G(q) subunit alpha Mitogen-activated protein kinase 3 1.0 Breast cancer anti-estrogen resistance protein 1 Paxillin PKC Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 PIP2 266 ChemSpider P46108 UniProt Paxillin 1.0 Breast cancer anti-estrogen resistance protein 1 Mitogen-activated protein kinase 1 C-X-C chemokine receptor type 4 9606 TAXONOMY Q14289 UniProt FAK, PYK2, CRK, PAXILLIN true Mitogen-activated protein kinase 1 Interaction775 C-X-C chemokine receptor type 4 activates Gαi P62873 UniProt Interaction774 Stromal cell-derived factor 1 activates C-X-C chemokine receptor type 4 Interaction777 C-X-C chemokine receptor type 4 activates GNB1, GNGT1 C00076 KEGG Compound Interaction779 RAF proto-oncogene serine/threonine-protein kinase activates Dual specificity mitogen-activated protein kinase kinase 1 Interaction778 GNB1, GNGT1 activates GTPase HRas P49023 UniProt Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma DG CA%2b2 BioCyc SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY Ca Calcium 39.96259 PIP2 PIP2_PLCG1, GNAQ (Homo sapiens) Cell Membrane C00009 KEGG Compound P48061 UniProt Interaction780 Dual specificity mitogen-activated protein kinase kinase 1 activates ERK1, ERK2 14265-44-2 CAS Breast cancer anti-estrogen resistance protein 1 Interaction782 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma activates FAK, PYK2, CRK, PAXILLIN Interaction781 Gαi activates Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Interaction784 GNB1, GNGT1 activates Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma Stromal cell-derived factor 1 Interaction783 FAK, PYK2, CRK, PAXILLIN activates Breast cancer anti-estrogen resistance protein 1 Transport283 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Protein-tyrosine kinase 2-beta HMDB0001429 HMDB Interaction786 PI3K activates NFKB Interaction785 GNB1, GNGT1 activates PI3K Interaction788 PIP2 activates DG Nuclear factor NF-kappa-B p105 subunit Interaction787 C-X-C chemokine receptor type 4 activates PIP2 + PLCG1, GNAQ (Homo sapiens) 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase P63211 UniProt CHEBI:18367 ChEBI Interaction789 DG activates DG + PKC + Calcium 1032 ChemSpider Phosphate 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 HMDB0000464 HMDB P25963 UniProt DG P50148 UniProt Nuclear factor NF-kappa-B p105 subunit Guanine nucleotide-binding protein G(q) subunit alpha P19174 UniProt Interaction791 Calcium activates DG + PKC + Calcium Interaction790 PIP2 + PLCG1, GNAQ (Homo sapiens) activates IP3 C-X-C chemokine receptor type 4 PLCG1, GNAQ PIP2_PLCG1, GNAQ (Homo sapiens) PI3K Q05397 UniProt PKC 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 GNB1, GNGT1 Adapter molecule crk Q02750 UniProt 1.0 14127-61-8 CAS SMILES [Ca++] 1.0 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Calcium 1061 PubChem-compound Stromal cell-derived factor 1 GTPase HRas Calcium Interaction568 GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase GTPase HRas 1.0 P27361 UniProt NFKB GNB1, GNGT1 RAF proto-oncogene serine/threonine-protein kinase IP3 Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 1.0 CXCL12 CXCR4 GNAI1 GNB1 GNGT1 HRAS RAF1 MAP2K1 MAPK3 MAPK1 PIK3C2G PTK2B PTK2 PXN CRK BCAR1 NFKB1 NFKBIA PLCG1 GNAQ Calcium Calcium Phosphate Phosphate Phosphate Calcium PI3K DG IP3 PIP2 DG PKC