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Sodium/potassium- transporting ATPase subunit gamma ATPase, (Na+)/K+ transporting, beta 4 polypeptide K+ K+ Ca+ Sodium/potassium- transporting ATPase subunit beta-3 Beta-1 adrenergic receptor Guanine nucleotide- binding protein G(s) subunit alpha isoforms short cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit Voltage- dependent T-type calcium channel subunit alpha-1G Potassium voltage-gated channel subfamily E member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 ATPase Na+/K+ transporting family member beta 4 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Calcium uniporter protein, mitochondrial Cytochrome b-c1 complex subunit 10 Sodium/hydrogen exchanger 1 Sodium/calcium exchanger 1 Sodium/calcium exchanger 1 Tropomyosin alpha-1 chain Tropomyosin beta chain Beta-1 adrenergic receptor cAMP-dependent protein kinase type I-alpha regulatory subunit Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 Muscarinic acetylcholine receptor M2 Cardiac phospholamban Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-2 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Sodium/calcium exchanger 1 cAMP-dependent protein kinase catalytic subunit alpha Sodium/potassium- transporting ATPase subunit beta-1 Inward rectifier potassium channel 2 cAMP Amiodarone Ca+ Ca+ K+ K+ Ca+ Ca+ Ca+ Ca+ Ca+ Ca+ H+ H+ Na+ Na+ H+ H+ Ca+ Ca+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Na+ Na+ Ca+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca+ Ca+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ ATP H2O Ca+ ADP Pi Ca+ Ca+ Adenylyl cyclase Troponin Troponin G-protein signalling cascade G-protein signalling cascade Muscle Contraction Potassium voltage-gated channel subfamily H member 2 G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase Voltage- dependent T-type calcium channel subunit alpha-1H Calcium enters the cells by voltage gated channels and causes the transport of calcium out of the sarcoplasmic reticulum to increase intracellular calcium levels Muscle Contraction Muscle Relaxation Affected Organs Symptom Relief Vascular resistance decreases Regulates Heart Rate Amiodarone inhibits the contraction of the heart to prolong contractions to decrease irregular heart rhythms and decrease vascular resistance Cytoplasm Mitochondria Calcium is also pumped out of the cell by sodium/calcium exchanger for relaxation Cardiac Muscle Skeletal Muscle Striated Muscle Cell Nucleus Mitochondrion Myofibril Sarcoplasmic Reticulum Myofibril Sarcolema Sarcoplasmic Reticulum Calcium binding to troponin displaces tropomyosin from the myosin binding sites on the actin filaments Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together. Many actin filaments pulled together at the same time leads to muscle contraction. Actin Filament Myosin Filament T-Tubule Depolarization Mitochondrion Single Sarcomere Functioning Unit
Mitochondria Chloroplast Chloroplast Mitochondria FXYD2 Unknown Potassium Potassium Calcium ATP1B3 ADRB1 GNAS PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2B PRKAR2A CACNA1G KCNE2 ALG10B CACNA1C CACNA2D2 CACNB1 RYR2 ATP1B4 ATP2A2 MCU UQCR11 SLC9A1 SLC8A1 SLC8A1 TPM1 TPM2 ADRB1 PRKAR1A CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 KCNJ4 KCND3 KCNIP2 Unknown Unknown KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 Unknown KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 PRKACA ATP1B1 KCNJ2 cAMP Amiodarone Calcium Calcium Potassium Potassium Calcium Calcium Calcium Calcium Calcium Calcium Hydrogen Hydrogen Sodium Sodium Hydrogen Ion Hydrogen Ion Calcium Calcium Sodium Sodium Potassium Potassium Sodium Sodium Calcium Calcium Sodium Sodium Calcium Sodium Sodium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Calcium Calcium Sodium Sodium Sodium Sodium Potassium Potassium Sodium Sodium Calcium Calcium Calcium Calcium Calcium Sodium Sodium Adenosine triphosphate Water Calcium Adenosine diphosphate Phosphate Calcium Calcium Adenylyl cyclase Troponin Troponin G-protein signalling cascade G-protein signalling cascade Muscle Contraction KCNH2 KCNJ3 KCNJ5 KCNH2 ALG10B CACNA1H Created with Snap
FXYD2 K+ K+ Ca+ ATP1B3 ADRB1 GNAS PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2B PRKAR2A CACNA1G KCNE2 ALG10B CACNA1C CACNA2D2 CACNB1 RYR2 ATP1B4 ATP2A2 MCU UQCR11 SLC9A1 SLC8A1 SLC8A1 TPM1 TPM2 ADRB1 PRKAR1A CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 KCNJ4 KCND3 KCNIP2 KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 PRKACA ATP1B1 KCNJ2 cAMP Amiod Ca+ Ca+ K+ K+ Ca+ Ca+ Ca+ Ca+ Ca+ Ca+ H+ H+ Na+ Na+ H+ H+ Ca+ Ca+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Na+ Na+ Ca+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca+ Ca+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ ATP H2O Ca+ ADP Pi Ca+ Ca+ AC Troponi Troponi G-p s c G-p s c Mus Con KCNH2 KCNJ3 KCNJ5 KCNH2 ALG10B CACNA1H Calcium enters the cells by voltage gated channels and causes the transport of calcium out of the sarcoplasmic reticulum to increase intracellular calcium levels Muscle Contraction Muscle Relaxation Affected Organs Symptom Relief Vascular resistance decreases Regulates Heart Rate Amiodarone inhibits the contraction of the heart to prolong contractions to decrease irregular heart rhythms and decrease vascular resistance Cytoplasm Mitochondria Calcium is also pumped out of the cell by sodium/calcium exchanger for relaxation Cardiac Muscle Skeletal Muscle Striated Muscle Cell Nucleus Mitochondrion Myofibril Sarcoplasmic Reticulum Myofibril Sarcolema Sarcoplasmic Reticulum Calcium binding to troponin displaces tropomyosin from the myosin binding sites on the actin filaments Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together. Many actin filaments pulled together at the same time leads to muscle contraction. Actin Filament Myosin Filament T-Tubule Depolarization Mitochondrion Single Sarcomere Functioning Unit
Mitochondria Chloroplast Chloroplast Mitochondria FXYD2 K+ K+ Ca2+ ATP1B3 ADRB1 GNAS PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2B PRKAR2A CACNA1G KCNE2 ALG10B CACNA1C CACNA2D2 CACNB1 RYR2 ATP1B4 ATP2A2 MCU UQCR11 SLC9A1 SLC8A1 SLC8A1 TPM1 TPM2 ADRB1 PRKAR1A CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 KCNJ4 KCND3 KCNIP2 KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 PRKACA ATP1B1 KCNJ2 cAMP Amiod Ca2+ Ca2+ K+ K+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ H2 H2 Na+ Na+ H+ H+ Ca2+ Ca2+ Na+ Na+ K+ K+ Na+ Na+ Ca2+ Ca2+ Na+ Na+ Ca2+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca2+ Ca2+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Na+ Na+ ATP H2O Ca2+ ADP Pi Ca2+ Ca2+ AC Troponi Troponi G-p s c G-p s c Mus Con KCNH2 KCNJ3 KCNJ5 KCNH2 ALG10B CACNA1H Created with Snap