Tyrosine-
protein kinase
Lck
Tyrosine-
protein kinase
ZAP-70
Tyrosine-
protein kinase
Fyn
Proto-oncogene
vav
Linker for
activation of
T-cells family
member 1
SHC-
transforming
protein 1
Growth factor
receptor-bound
protein 2
Son of
sevenless
homolog 1
RAS guanyl-
releasing
protein 1
GTPase HRas
RAF
proto-oncogene
serine/threonine-
protein kinase
Dual
specificity
mitogen-
activated
protein kinase
kinase 1
Mitogen-
activated
protein kinase
3
Tyrosine-
protein
phosphatase
non-receptor
type 7
Phosphatidylinositol-
4,5-
bisphosphate
3-kinase
catalytic
subunit alpha
isoform
Phosphatidylinositol
3-kinase
regulatory
subunit alpha
Phosphatidylinositol-
4,5-
bisphosphate
3-kinase
catalytic
subunit gamma
isoform
Ras-related C3
botulinum toxin
substrate 1
Mitogen-
activated
protein kinase
kinase kinase 1
Dual
specificity
mitogen-
activated
protein kinase
kinase 4
Mitogen-
activated
protein kinase
8
Transcription
factor AP-1
Proto-oncogene
c-Fos
ETS domain-
containing
protein Elk-1
1-
phosphatidylinositol
4,5-
bisphosphate
phosphodiesterase
gamma-1
Polyubiquitin-C
Transcription
factor p65
Nuclear factor
NF-kappa-B p105
subunit
NF-kappa-B
inhibitor alpha
Calmodulin-3
Calmodulin-2
Calmodulin-1
Serine/threonine-
protein
phosphatase 2B
catalytic
subunit alpha
isoform
Serine/threonine-
protein
phosphatase 2B
catalytic
subunit beta
isoform
Serine/threonine-
protein
phosphatase 2B
catalytic
subunit gamma
isoform
Nuclear factor
NF-kappa-B p105
subunit
Transcription
factor p65
NF-kappa-B
inhibitor alpha
Nuclear factor
of activated
T-cells,
cytoplasmic 1
Nuclear factor
of activated
T-cells,
cytoplasmic 2
Nuclear factor
of activated
T-cells,
cytoplasmic 4
Nuclear factor
of activated
T-cells,
cytoplasmic 3
T cell receptor
alpha constant
T cell receptor
beta constant 1
T-cell surface
glycoprotein
CD3 zeta chain
T-cell surface
glycoprotein
CD3 gamma chain
T-cell surface
glycoprotein
CD3 delta chain
T-cell surface
glycoprotein
CD3 epsilon
chain
Protein kinase
C alpha type
Protein kinase
C beta type
Nuclear factor
of activated
T-cells,
cytoplasmic 1
Nuclear factor
of activated
T-cells,
cytoplasmic 2
Nuclear factor
of activated
T-cells,
cytoplasmic 4
Nuclear factor
of activated
T-cells,
cytoplasmic 3
Diacylglycerol
Ca+
Tacrolimus
Cyclosporin A
H2O
Phosphatidylinositol
4,5-
bisphosphate
Inositol 1,4,5-
trisphosphate
Pi
Phosphate
Phosphate
Phosphate
Guanosine
triphosphate
Phosphate
Phosphate
Phosphate
Calcium
Phosphate
Ca+
Pi
Antigen
IP3 triggers the release of
Ca2+ from the ER
Transcription factors
increase gene expression by
interacting with their
regulatory sequences
Cytoplasm
Extracellular Space
Nucleus
Endoplasimc Reticulum