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PW070692 PathWhiz 1.0 3702 TAXONOMY 1.0 Tyrosine-protein kinase JAK2 Signal transducer and activator of transcription 5A C00035 KEGG Compound direct_interaction 1.0 Dual specificity mitogen-activated protein kinase kinase 1 Growth factor receptor-bound protein 2 (Homo sapiens)_SHC-transforming protein 1 (Homo sapiens)_Son of sevenless homolog 1 (Homo sapiens) Erythropoietin EPO Signaling Pathway 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mitogen-activated protein kinase 8 Transcription factor AP-1 (Homo sapiens)_Proto-oncogene c-Fos (Homo sapiens) Tyrosine-protein phosphatase non-receptor type 6 1.0 P04049 UniProt P05412 UniProt C00044 KEGG Compound P19419 UniProt 1.0 1.0 Cytoplasm Erythropoietin (Homo sapiens)_Erythropoietin receptor (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens)_Tyrosine-protein kinase JAK2 (Homo sapiens)_Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) Signal transducer and activator of transcription 5A P29353 UniProt P01100 UniProt Homo sapiens Interaction875 Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) activates STAT5A homodimer complex P29350 UniProt ETS domain-containing protein Elk-1 Interaction879 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 activates Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) Guanosine diphosphate O60674 UniProt Erythropoietin P01588 UniProt Guanosine triphosphate 1.0 Interaction883 Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) activates SHC-transforming protein 1 P01112 UniProt Interaction882 STAT5A homodimer complex activates Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) 1.0 Interaction885 Growth factor receptor-bound protein 2 (Homo sapiens) + SHC-transforming protein 1 (Homo sapiens) + Son of sevenless homolog 1 (Homo sapiens) activates Guanosine diphosphate Interaction884 SHC-transforming protein 1 activates Growth factor receptor-bound protein 2 (Homo sapiens) + SHC-transforming protein 1 (Homo sapiens) + Son of sevenless homolog 1 (Homo sapiens) Dual specificity mitogen-activated protein kinase kinase 1 8977 PubChem-compound Interaction886 Guanosine triphosphate activates Guanosine diphosphate 6830 PubChem-compound Interaction888 GTPase HRas with GTP activates GTPase HRas with GDP Mitogen-activated protein kinase 3 C10H15N5O11P2 Guanosine diphosphate 443.02432 Erythropoietin 1.0 Proto-oncogene c-Fos Erythropoietin receptor Erythropoietin receptor 9606 TAXONOMY Signal transducer and activator of transcription 5A C10H16N5O14P3 Guanosine triphosphate 522.99066 Transport3837 false STAT5A homodimer complex (?) Transport: Homo sapiens, Cell to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT SHC-transforming protein 1 P62993 UniProt Interaction779 RAF proto-oncogene serine/threonine-protein kinase activates Dual specificity mitogen-activated protein kinase kinase 1 8630 ChemSpider Growth factor receptor-bound protein 2 Proto-oncogene c-Fos Interaction939 Mitogen-activated protein kinase 8 activates Transcription factor AP-1 (Homo sapiens) + Proto-oncogene c-Fos (Homo sapiens) P45983 UniProt GO:0005886 GENE ONTOLOGY 1.0 SMP0069678 SMPDB Cell Membrane 1.0 ETS domain-containing protein Elk-1 Erythropoietin receptor 6569 ChemSpider Tyrosine-protein kinase JAK2 Interaction423 Mitogen-activated protein kinase 3 activates ETS domain-containing protein Elk-1 CHEBI:17552 ChEBI SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 RAF proto-oncogene serine/threonine-protein kinase GTP BioCyc Signal transducer and activator of transcription 5A 1.0 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Q07889 UniProt GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Growth factor receptor-bound protein 2 GO:0005634 GENE ONTOLOGY 1.0 HMDB0001273 HMDB P19174 UniProt Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 6 Son of sevenless homolog 1 1.0 1.0 Interaction676 Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 Transcription factor AP-1 Mitogen-activated protein kinase 3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 HMDB0001201 HMDB Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 6 Q02750 UniProt 86-01-1 CAS Nucleus 1.0 Erythropoietin (Homo sapiens)_Erythropoietin receptor (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens)_Tyrosine-protein kinase JAK2 (Homo sapiens)_Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) GTPase HRas CHEBI:15996 ChEBI Interaction201 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase Mitogen-activated protein kinase 8 Signal transducer and activator of transcription 5A Transcription factor AP-1 SHC-transforming protein 1 GTPase HRas P27361 UniProt P19235 UniProt RAF proto-oncogene serine/threonine-protein kinase 1.0 Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY 146-91-8 CAS BiologicalState253 Arabidopsis thaliana P42229 UniProt Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5A Tyrosine- protein kinase JAK2 Tyrosine- protein phosphatase non-receptor type 6 Transcription factor AP-1 Casein kinase II subunit alpha Signal transducer and activator of transcription 5A 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Signal transducer and activator of transcription 5A SHC- transforming protein 1 GTPase HRas GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 3 ETS domain- containing protein Elk-1 Mitogen- activated protein kinase 8 Signal transducer and activator of transcription 5A Erythropoietin Erythropoietin receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Tyrosine- protein kinase JAK2 Tyrosine- protein phosphatase non-receptor type 6 Growth factor receptor-bound protein 2 SHC- transforming protein 1 Son of sevenless homolog 1 Transcription factor AP-1 Proto-oncogene c-Fos GDP GTP P i P i GTP GDP Zinc Magnesium Calcium Calcium Nucleus Cytoplasm Extracellular
PW070692 PathWhiz 1.0 3702 TAXONOMY 1.0 Tyrosine-protein kinase JAK2 Signal transducer and activator of transcription 5A C00035 KEGG Compound direct_interaction 1.0 Dual specificity mitogen-activated protein kinase kinase 1 Growth factor receptor-bound protein 2 (Homo sapiens)_SHC-transforming protein 1 (Homo sapiens)_Son of sevenless homolog 1 (Homo sapiens) Erythropoietin EPO Signaling Pathway 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mitogen-activated protein kinase 8 Transcription factor AP-1 (Homo sapiens)_Proto-oncogene c-Fos (Homo sapiens) Tyrosine-protein phosphatase non-receptor type 6 1.0 P04049 UniProt P05412 UniProt C00044 KEGG Compound P19419 UniProt 1.0 1.0 Cytoplasm Erythropoietin (Homo sapiens)_Erythropoietin receptor (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens)_Tyrosine-protein kinase JAK2 (Homo sapiens)_Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) Signal transducer and activator of transcription 5A P29353 UniProt P01100 UniProt Homo sapiens Interaction875 Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) activates STAT5A homodimer complex P29350 UniProt ETS domain-containing protein Elk-1 Interaction879 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 activates Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) Guanosine diphosphate O60674 UniProt Erythropoietin P01588 UniProt Guanosine triphosphate 1.0 Interaction883 Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) activates SHC-transforming protein 1 P01112 UniProt Interaction882 STAT5A homodimer complex activates Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) 1.0 Interaction885 Growth factor receptor-bound protein 2 (Homo sapiens) + SHC-transforming protein 1 (Homo sapiens) + Son of sevenless homolog 1 (Homo sapiens) activates Guanosine diphosphate Interaction884 SHC-transforming protein 1 activates Growth factor receptor-bound protein 2 (Homo sapiens) + SHC-transforming protein 1 (Homo sapiens) + Son of sevenless homolog 1 (Homo sapiens) Dual specificity mitogen-activated protein kinase kinase 1 8977 PubChem-compound Interaction886 Guanosine triphosphate activates Guanosine diphosphate 6830 PubChem-compound Interaction888 GTPase HRas with GTP activates GTPase HRas with GDP Mitogen-activated protein kinase 3 C10H15N5O11P2 Guanosine diphosphate 443.02432 Erythropoietin 1.0 Proto-oncogene c-Fos Erythropoietin receptor Erythropoietin receptor 9606 TAXONOMY Signal transducer and activator of transcription 5A C10H16N5O14P3 Guanosine triphosphate 522.99066 Transport3837 false STAT5A homodimer complex (?) Transport: Homo sapiens, Cell to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT SHC-transforming protein 1 P62993 UniProt Interaction779 RAF proto-oncogene serine/threonine-protein kinase activates Dual specificity mitogen-activated protein kinase kinase 1 8630 ChemSpider Growth factor receptor-bound protein 2 Proto-oncogene c-Fos Interaction939 Mitogen-activated protein kinase 8 activates Transcription factor AP-1 (Homo sapiens) + Proto-oncogene c-Fos (Homo sapiens) P45983 UniProt GO:0005886 GENE ONTOLOGY 1.0 SMP0069678 SMPDB Cell Membrane 1.0 ETS domain-containing protein Elk-1 Erythropoietin receptor 6569 ChemSpider Tyrosine-protein kinase JAK2 Interaction423 Mitogen-activated protein kinase 3 activates ETS domain-containing protein Elk-1 CHEBI:17552 ChEBI SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 RAF proto-oncogene serine/threonine-protein kinase GTP BioCyc Signal transducer and activator of transcription 5A 1.0 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Q07889 UniProt GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Growth factor receptor-bound protein 2 GO:0005634 GENE ONTOLOGY 1.0 HMDB0001273 HMDB P19174 UniProt Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 6 Son of sevenless homolog 1 1.0 1.0 Interaction676 Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 Transcription factor AP-1 Mitogen-activated protein kinase 3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 HMDB0001201 HMDB Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 6 Q02750 UniProt 86-01-1 CAS Nucleus 1.0 Erythropoietin (Homo sapiens)_Erythropoietin receptor (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens)_Tyrosine-protein kinase JAK2 (Homo sapiens)_Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) GTPase HRas CHEBI:15996 ChEBI Interaction201 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase Mitogen-activated protein kinase 8 Signal transducer and activator of transcription 5A Transcription factor AP-1 SHC-transforming protein 1 GTPase HRas P27361 UniProt P19235 UniProt RAF proto-oncogene serine/threonine-protein kinase 1.0 Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY 146-91-8 CAS BiologicalState253 Arabidopsis thaliana P42229 UniProt Nucleus STAT5A STAT5A JAK2 PTPN6 JUN CSNK2A1 STAT5A PLCG1 STAT5A Unknown HRAS HRAS RAF1 MAP2K1 MAPK3 ELK1 MAPK8 STAT5A EPO EPOR PLCG1 JAK2 PTPN6 GRB2 Unknown SOS1 JUN FOS Guanosine diphosphate Guanosine triphosphate Phosphate Phosphate Guanosine triphosphate Guanosine diphosphate