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B-cell linker protein Q06187 UniProt 937 ChemSpider B-cell receptor Protein kinase C alpha type Proto-oncogene vav P63000 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Nuclear factor of activated T-cells, cytoplasmic 4 direct_interaction Nuclear factor of activated T-cells, cytoplasmic 3 Dual specificity mitogen-activated protein kinase kinase 1 SMILES O P40259 UniProt P43405 UniProt 1.0 GRB2/SOS complex SMP0069871 SMPDB P04049 UniProt Tyrosine-protein kinase BTK P19419 UniProt Mitogen-activated protein kinase kinase kinase 1 Interaction902 B-cell antigen receptor complex-associated protein (Homo sapiens) + B-cell receptor + Phosphate activates Tyrosine-protein kinase Lyn B-cell antigen receptor complex-associated protein SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC Interaction905 Tyrosine-protein kinase Lyn activates Tyrosine-protein kinase SYK with Phosphate Interaction907 Tyrosine-protein kinase Lyn activates B-cell linker protein with Phosphate Water Q14934 UniProt Q96D31 UniProt P29353 UniProt Protein kinase C alpha type Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Transcription factor AP-1 P01100 UniProt 1.0 CHEBI:16595 ChEBI Interaction919 Tyrosine-protein kinase SYK with Phosphate activates B-cell linker protein with Phosphate B-cell receptor Calmodulin-1 85166-31-0 CAS Calmodulin-2 Calmodulin-3 Q12968 UniProt SMILES CCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC\C=C\CCCCCCCC Nuclear factor of activated T-cells P01112 UniProt O4P Phosphate 94.95342 Interaction922 Tyrosine-protein kinase SYK with Phosphate activates Proto-oncogene vav with Phosphate Interaction924 SHC-transforming protein 1 with phosphorylation activates GRB2/SOS complex Interaction923 Tyrosine-protein kinase SYK with Phosphate activates SHC-transforming protein 1 with phosphorylation Interaction926 Tyrosine-protein kinase SYK with Phosphate activates Tyrosine-protein kinase BTK with Phosphate Interaction925 GRB2/SOS complex activates GTPase HRas with GTP Interaction928 Diacylglycerol activates Protein kinase C complex Interaction807 Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate Interaction927 Tyrosine-protein kinase SYK with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate 266 ChemSpider Interaction929 Calcium activates Protein kinase C complex Proto-oncogene c-Fos Q8WV28 UniProt P17252 UniProt Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Tyrosine-protein kinase SYK Interaction931 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase with Phosphate Interaction930 Protein kinase C complex activates ETS domain-containing protein Elk-1 Interaction933 Mitogen-activated protein kinase 3 with Phosphate activates FOS,JUN Complex Interaction932 RAF proto-oncogene serine/threonine-protein kinase with Phosphate activates Active Dual specificity mitogen-activated protein kinase kinase 1 Growth factor receptor-bound protein 2 Interaction935 Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium Interaction934 Proto-oncogene vav with Phosphate activates Ras-related C3 botulinum toxin substrate 1 Proto-oncogene c-Fos Interaction937 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 14 with Magnesium Interaction936 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 8 without Magnesium Interaction938 Mitogen-activated protein kinase 14 with Magnesium activates FOS,JUN Complex SMILES [O-]P([O-])([O-])=O 6026790 PubChem-compound Inositol 1,4,5-trisphosphate inositol_1,4,5-trisphosphate BioCyc C00009 KEGG Compound Calmodulin(123) HMDB0001429 HMDB C00001 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider Mitogen-activated protein kinase 8 Q07889 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider HMDB0000464 HMDB Interaction706 Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex P15498 UniProt Growth factor receptor-bound protein 2 24742074 PubChem-compound Phosphatidylinositol 4,5-bisphosphate Nuclear factor of activated T-cells, cytoplasmic 3 GTPase HRas Son of sevenless homolog 1 P19174 UniProt Nuclear factor of activated T-cells (Homo sapiens)_Phosphate Nuclear factor of activated T-cells, cytoplasmic 4 Tyrosine-protein kinase SYK Son of sevenless homolog 1 Interaction832 Calcium activates Calmodulin(123) Diacylglycerol Interaction833 Calmodulin(123) activates protein phosphatase 3 Interaction836 protein phosphatase 3 activates Nuclear factor of activated T-cells (Homo sapiens) + Phosphate Extracellular Space Calmodulin-1 Q02750 UniProt B-cell linker protein 1.0 14127-61-8 CAS SMILES [Ca++] protein phosphatase 3 1.0 GTPase HRas Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Calcium P0DP23 UniProt C47H80O19P3 Phosphatidylinositol 4,5-bisphosphate 1041.4507 Tyrosine-protein kinase BTK P0DP24 UniProt P11912 UniProt P0DP25 UniProt P27361 UniProt RAF proto-oncogene serine/threonine-protein kinase Calcium release-activated calcium channel protein 1 C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI Nuclear factor of activated T-cells, cytoplasmic 2 Protein kinase C beta type 1.0 Nuclear factor of activated T-cells, cytoplasmic 1 1.0 CPD-8587 BioCyc C01245 KEGG Compound 1.0 Calcium P07948 UniProt 1.0 TransportCatalysis996 ACTIVATION Calmodulin-3 P05771 UniProt P05412 UniProt C37H70O5 Diacylglycerol 594.52234 FOS,JUN Complex O95644 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Calmodulin-2 Tyrosine-protein kinase Lyn Cytoplasm Ras-related C3 botulinum toxin substrate 1 Homo sapiens 7732-18-5 CAS ETS domain-containing protein Elk-1 B-cell antigen receptor complex-associated protein alpha chain 1.0 Reaction115852 false Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT 439456 PubChem-compound Reaction115976 false Nuclear factor of activated T-cells (Homo sapiens) + Phosphate → Nuclear factor of activated T-cells + Phosphate LEFT_TO_RIGHT 1.0 Dual specificity mitogen-activated protein kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 Mitogen-activated protein kinase 3 Tyrosine-protein kinase Lyn Calcium release-activated calcium channel protein 1 HMDB0001498 HMDB GTPase HRas Reaction122705 false 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate + Water → Phosphatidylinositol 4,5-bisphosphate LEFT_TO_RIGHT 9606 TAXONOMY 962 PubChem-compound Q13233 UniProt Protein kinase C complex P48454 UniProt ETS domain-containing protein Elk-1 C00076 KEGG Compound SHC-transforming protein 1 P62993 UniProt Q08209 UniProt CA%2b2 BioCyc P45983 UniProt P16298 UniProt BCR Signaling Pathway Ca Calcium 39.96259 PW070885 PathWhiz HMDB0002111 HMDB CHEBI:15377 ChEBI B-cell antigen receptor complex-associated protein beta chain B-cell antigen receptor complex-associated protein (Homo sapiens)_B-cell receptor_Phosphate B-cell antigen receptor complex-associated protein alpha chain 14265-44-2 CAS 271 PubChem-compound Interaction669 GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate RAF proto-oncogene serine/threonine-protein kinase Phosphate Protein kinase C beta type 1.0 Reaction115846 false Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol LEFT_TO_RIGHT B-cell antigen receptor complex-associated protein beta chain Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 H2O Water 18.010565 1061 PubChem-compound Mitogen-activated protein kinase 8 Transcription factor AP-1 GTPase HRas SHC-transforming protein 1 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Transport3328 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Calcium release-activated calcium channel protein 1 Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Mitogen-activated protein kinase 3 1.0 Q13469 UniProt Tyrosine- protein kinase Lyn Tyrosine- protein kinase SYK B-cell linker protein B-cell linker protein GTPase HRas GTPase HRas Proto-oncogene vav SHC- transforming protein 1 Son of sevenless homolog 1 Growth factor receptor-bound protein 2 Tyrosine- protein kinase BTK 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Protein kinase C alpha type Protein kinase C beta type Calmodulin-3 Calmodulin-2 Calmodulin-1 Serine/threonine- protein phosphatase 2B catalytic subunit alpha isoform Serine/threonine- protein phosphatase 2B catalytic subunit beta isoform Serine/threonine- protein phosphatase 2B catalytic subunit gamma isoform ETS domain- containing protein Elk-1 RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 3 Transcription factor AP-1 Proto-oncogene c-Fos Ras-related C3 botulinum toxin substrate 1 Mitogen- activated protein kinase kinase kinase 1 Mitogen- activated protein kinase 8 Calcium release- activated calcium channel protein 1 Calcium release- activated calcium channel protein 1 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 4 Nuclear factor of activated T-cells, cytoplasmic 3 B-cell antigen receptor complex- associated protein alpha chain B-cell antigen receptor complex- associated protein beta chain Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 4 Nuclear factor of activated T-cells, cytoplasmic 3 Diacylglycerol Ca + Ca + H 2 O Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate P i Ca + Phosphate Phosphate Phosphate Guanosine triphosphate Guanosine diphosphate Phosphate ion Phosphate Phosphate Phosphate Phosphate Calcium Phosphate Phosphate Phosphate P i P i B-cell receptor B cell ontogeny; autoimmunity; energy; immune response; Ig Production; GC formation endoplasmic reticulum Nucleus Cytoplasm Extracellular
B-cell linker protein Q06187 UniProt 937 ChemSpider B-cell receptor Protein kinase C alpha type Proto-oncogene vav P63000 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Nuclear factor of activated T-cells, cytoplasmic 4 direct_interaction Nuclear factor of activated T-cells, cytoplasmic 3 Dual specificity mitogen-activated protein kinase kinase 1 SMILES O P40259 UniProt P43405 UniProt 1.0 GRB2/SOS complex SMP0069871 SMPDB P04049 UniProt Tyrosine-protein kinase BTK P19419 UniProt Mitogen-activated protein kinase kinase kinase 1 Interaction902 B-cell antigen receptor complex-associated protein (Homo sapiens) + B-cell receptor + Phosphate activates Tyrosine-protein kinase Lyn B-cell antigen receptor complex-associated protein SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC Interaction905 Tyrosine-protein kinase Lyn activates Tyrosine-protein kinase SYK with Phosphate Interaction907 Tyrosine-protein kinase Lyn activates B-cell linker protein with Phosphate Water Q14934 UniProt Q96D31 UniProt P29353 UniProt Protein kinase C alpha type Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Transcription factor AP-1 P01100 UniProt 1.0 CHEBI:16595 ChEBI Interaction919 Tyrosine-protein kinase SYK with Phosphate activates B-cell linker protein with Phosphate B-cell receptor Calmodulin-1 85166-31-0 CAS Calmodulin-2 Calmodulin-3 Q12968 UniProt SMILES CCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC\C=C\CCCCCCCC Nuclear factor of activated T-cells P01112 UniProt O4P Phosphate 94.95342 Interaction922 Tyrosine-protein kinase SYK with Phosphate activates Proto-oncogene vav with Phosphate Interaction924 SHC-transforming protein 1 with phosphorylation activates GRB2/SOS complex Interaction923 Tyrosine-protein kinase SYK with Phosphate activates SHC-transforming protein 1 with phosphorylation Interaction926 Tyrosine-protein kinase SYK with Phosphate activates Tyrosine-protein kinase BTK with Phosphate Interaction925 GRB2/SOS complex activates GTPase HRas with GTP Interaction928 Diacylglycerol activates Protein kinase C complex Interaction807 Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate Interaction927 Tyrosine-protein kinase SYK with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate 266 ChemSpider Interaction929 Calcium activates Protein kinase C complex Proto-oncogene c-Fos Q8WV28 UniProt P17252 UniProt Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Tyrosine-protein kinase SYK Interaction931 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase with Phosphate Interaction930 Protein kinase C complex activates ETS domain-containing protein Elk-1 Interaction933 Mitogen-activated protein kinase 3 with Phosphate activates FOS,JUN Complex Interaction932 RAF proto-oncogene serine/threonine-protein kinase with Phosphate activates Active Dual specificity mitogen-activated protein kinase kinase 1 Growth factor receptor-bound protein 2 Interaction935 Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium Interaction934 Proto-oncogene vav with Phosphate activates Ras-related C3 botulinum toxin substrate 1 Proto-oncogene c-Fos Interaction937 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 14 with Magnesium Interaction936 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 8 without Magnesium Interaction938 Mitogen-activated protein kinase 14 with Magnesium activates FOS,JUN Complex SMILES [O-]P([O-])([O-])=O 6026790 PubChem-compound Inositol 1,4,5-trisphosphate inositol_1,4,5-trisphosphate BioCyc C00009 KEGG Compound Calmodulin(123) HMDB0001429 HMDB C00001 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider Mitogen-activated protein kinase 8 Q07889 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider HMDB0000464 HMDB Interaction706 Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex P15498 UniProt Growth factor receptor-bound protein 2 24742074 PubChem-compound Phosphatidylinositol 4,5-bisphosphate Nuclear factor of activated T-cells, cytoplasmic 3 GTPase HRas Son of sevenless homolog 1 P19174 UniProt Nuclear factor of activated T-cells (Homo sapiens)_Phosphate Nuclear factor of activated T-cells, cytoplasmic 4 Tyrosine-protein kinase SYK Son of sevenless homolog 1 Interaction832 Calcium activates Calmodulin(123) Diacylglycerol Interaction833 Calmodulin(123) activates protein phosphatase 3 Interaction836 protein phosphatase 3 activates Nuclear factor of activated T-cells (Homo sapiens) + Phosphate Extracellular Space Calmodulin-1 Q02750 UniProt B-cell linker protein 1.0 14127-61-8 CAS SMILES [Ca++] protein phosphatase 3 1.0 GTPase HRas Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Calcium P0DP23 UniProt C47H80O19P3 Phosphatidylinositol 4,5-bisphosphate 1041.4507 Tyrosine-protein kinase BTK P0DP24 UniProt P11912 UniProt P0DP25 UniProt P27361 UniProt RAF proto-oncogene serine/threonine-protein kinase Calcium release-activated calcium channel protein 1 C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI Nuclear factor of activated T-cells, cytoplasmic 2 Protein kinase C beta type 1.0 Nuclear factor of activated T-cells, cytoplasmic 1 1.0 CPD-8587 BioCyc C01245 KEGG Compound 1.0 Calcium P07948 UniProt 1.0 TransportCatalysis996 ACTIVATION Calmodulin-3 P05771 UniProt P05412 UniProt C37H70O5 Diacylglycerol 594.52234 FOS,JUN Complex O95644 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Calmodulin-2 Tyrosine-protein kinase Lyn Cytoplasm Ras-related C3 botulinum toxin substrate 1 Homo sapiens 7732-18-5 CAS ETS domain-containing protein Elk-1 B-cell antigen receptor complex-associated protein alpha chain 1.0 Reaction115852 false Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT 439456 PubChem-compound Reaction115976 false Nuclear factor of activated T-cells (Homo sapiens) + Phosphate → Nuclear factor of activated T-cells + Phosphate LEFT_TO_RIGHT 1.0 Dual specificity mitogen-activated protein kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 Mitogen-activated protein kinase 3 Tyrosine-protein kinase Lyn Calcium release-activated calcium channel protein 1 HMDB0001498 HMDB GTPase HRas Reaction122705 false 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate + Water → Phosphatidylinositol 4,5-bisphosphate LEFT_TO_RIGHT 9606 TAXONOMY 962 PubChem-compound Q13233 UniProt Protein kinase C complex P48454 UniProt ETS domain-containing protein Elk-1 C00076 KEGG Compound SHC-transforming protein 1 P62993 UniProt Q08209 UniProt CA%2b2 BioCyc P45983 UniProt P16298 UniProt BCR Signaling Pathway Ca Calcium 39.96259 PW070885 PathWhiz HMDB0002111 HMDB CHEBI:15377 ChEBI B-cell antigen receptor complex-associated protein beta chain B-cell antigen receptor complex-associated protein (Homo sapiens)_B-cell receptor_Phosphate B-cell antigen receptor complex-associated protein alpha chain 14265-44-2 CAS 271 PubChem-compound Interaction669 GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate RAF proto-oncogene serine/threonine-protein kinase Phosphate Protein kinase C beta type 1.0 Reaction115846 false Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol LEFT_TO_RIGHT B-cell antigen receptor complex-associated protein beta chain Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 H2O Water 18.010565 1061 PubChem-compound Mitogen-activated protein kinase 8 Transcription factor AP-1 GTPase HRas SHC-transforming protein 1 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Transport3328 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Calcium release-activated calcium channel protein 1 Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Mitogen-activated protein kinase 3 1.0 Q13469 UniProt Nucleus Unknown SYK BLNK BLNK HRAS Unknown VAV1 Unknown SOS1 GRB2 BTK PLCG1 PRKCA PRKCB CALM3 CALM2 CALM1 PPP3CA PPP3CB PPP3CC ELK1 RAF1 MAP2K1 MAPK3 JUN FOS RAC1 MAP3K1 MAPK8 ORAI1 ORAI1 NFATC1 NFATC2 NFATC4 NFATC3 CD79A CD79B NFATC1 NFATC2 NFATC4 NFATC3 Diacylglycerol Calcium Calcium Water Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate Phosphate Calcium Phosphate Phosphate B-cell receptor