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DIACYLGLYCEROL BioCyc Q9BXA5 UniProt Interaction973 Succinate receptor 1 activates Phospholipase C, beta 1 C01243 KEGG Compound 127983 ChemSpider Interaction975 Calcium activates Mitogen-activated protein kinase 11 Interaction974 Inositol 1,3,4-trisphosphate activates Calcium 5280360 PubChem-compound Interaction977 Nitric-oxide synthase, endothelial activates Nitric oxide Interaction976 Calcium activates Nitric-oxide synthase, endothelial C20H32O5 Prostaglandin E2 352.22498 Interaction979 Protein kinase C activates ERK1, ERK2 P28482 UniProt Interaction978 DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) activates Protein kinase C HMDB0000254 HMDB direct_interaction 3.1.4.11 false 3.1.4.11 PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) → DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) + Inositol 1,3,4-trisphosphate LEFT_TO_RIGHT SMILES OC(=O)CCC(O)=O Nitric-oxide synthase, endothelial Calcium Inhibitor of nuclear factor kappa-B kinase DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) Nitric oxide CHEBI:77096 ChEBI SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC 1.0 53480273 PubChem-compound HMDB0001220 HMDB Inhibitor of nuclear factor kappa-B kinase subunit beta Interaction980 ERK1, ERK2 activates COX1 homodimer complex Interaction982 Protein kinase C activates Inhibitor of nuclear factor kappa-B kinase Interaction981 COX1 homodimer complex activates Prostaglandin E2 1.0 C00165 KEGG Compound Interaction983 Mitogen-activated protein kinase 11 activates Cyclic AMP-responsive element-binding protein 1 ReactionCatalysis133147 ACTIVATION 1.0 C00042 KEGG Compound 1078 ChemSpider NITRIC-OXIDE BioCyc Q9Y6K9 UniProt 1.0 HMDB0003378 HMDB Cytoplasm P29474 UniProt SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Nitric oxide synthase, endothelial Mitogen-activated protein kinase 11 Homo sapiens Succinate receptor 1 INOSITOL-1-3-4-TRIPHOSPHATE BioCyc 439455 PubChem-compound PW085652 PathWhiz Q9NQ66 UniProt C6H15O15P3 Inositol 1,3,4-trisphosphate 419.96237 Succinate Signaling During Inflammation ERK1, ERK2 Protein kinase C alpha type HMDB0010082 HMDB Succinate receptor 1 C00626 KEGG Compound CHEBI:16480 ChEBI C00584 KEGG Compound P19838 UniProt Nuclear factor NF-kappa-B p105 subunit Prostaglandin G/H synthase 1 Inhibitor of nuclear factor kappa-B kinase subunit beta NO Nitric oxide 29.997988 Mitogen-activated protein kinase 3 CHEBI:15551 ChEBI 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 363-24-6 CAS C47H85O19P3 PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) 1046.4897 9543736 PubChem-compound 266 ChemSpider Reaction143078 false Inhibitor of nuclear factor kappa-B kinase subunit beta + Nuclear factor NF-kappa-B p105 subunit → Nuclear factor NF-kappa-B p105 subunit LEFT_TO_RIGHT Mitogen-activated protein kinase 1 Inhibitor of nuclear factor kappa-B kinase subunit alpha P17252 UniProt HMDB0007112 HMDB 9606 TAXONOMY Mitogen-activated protein kinase 1 Transport6542 false Nuclear factor NF-kappa-B p105 subunit (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Nucleus LEFT_TO_RIGHT 145068 PubChem-compound C00076 KEGG Compound Prostaglandin E2 SUC BioCyc 110-15-6 CAS CA%2b2 BioCyc 2.0 Succinate receptor 1 SMILES O[C@@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@H]1OP(O)(O)=O GO:0005886 GENE ONTOLOGY 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS BioCyc PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) Ca Calcium 39.96259 Mitogen-activated protein kinase 11 HMDB0001143 HMDB Cell Membrane Cyclic AMP-responsive element-binding protein 1 Phosphatidylinositols BioCyc Mitogen-activated protein kinase 11 SMILES [N]=O O15111 UniProt ReactionCatalysis130870 ACTIVATION Prostaglandin G/H synthase 1 271 PubChem-compound Nuclear factor NF-kappa-B p105 subunit 388561 ChemSpider 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Succinic acid HMDB0000464 HMDB P16220 UniProt Nitric oxide synthase, endothelial NF-kappa-B essential modulator Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY SMILES CCCCCC\C=C/CCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC CHEBI:15741 ChEBI 4444059 ChemSpider C00533 KEGG Compound 1110 PubChem-compound P23219 UniProt 10102-43-9 CAS 1.0 Cyclic AMP-responsive element-binding protein 1 14127-61-8 CAS SMILES [Ca++] Protein kinase C alpha type Inhibitor of nuclear factor kappa-B kinase subunit alpha 7822686 ChemSpider Q15759 UniProt NF-kappa-B essential modulator C4H6O4 Succinic acid 118.02661 C39H68O5 DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) 616.50665 Nucleus 24767959 ChemSpider 98102-63-7 CAS CHEBI:18228 ChEBI 1.0 Inositol 1,3,4-trisphosphate Interaction964 Succinic acid activates Succinate receptor 1 P27361 UniProt Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI O14920 UniProt SMP0084634 SMPDB Succinate receptor 1 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Mitogen- activated protein kinase 11 Nitric oxide synthase, endothelial Protein kinase C alpha type Mitogen- activated protein kinase 3 Mitogen- activated protein kinase 1 Prostaglandin G/H synthase 1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator Cyclic AMP-responsive element-binding protein 1 Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p105 subunit Inhibitor of nuclear factor kappa-B kinase subunit beta Succinic acid Inositol 1,3,4- trisphosphate Ca + NO DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) Prostaglandin E2 PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) Magnesium DNA Transcription Nucleus Cytoplasm Extracellular
DIACYLGLYCEROL BioCyc Q9BXA5 UniProt Interaction973 Succinate receptor 1 activates Phospholipase C, beta 1 C01243 KEGG Compound 127983 ChemSpider Interaction975 Calcium activates Mitogen-activated protein kinase 11 Interaction974 Inositol 1,3,4-trisphosphate activates Calcium 5280360 PubChem-compound Interaction977 Nitric-oxide synthase, endothelial activates Nitric oxide Interaction976 Calcium activates Nitric-oxide synthase, endothelial C20H32O5 Prostaglandin E2 352.22498 Interaction979 Protein kinase C activates ERK1, ERK2 P28482 UniProt Interaction978 DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) activates Protein kinase C HMDB0000254 HMDB direct_interaction 3.1.4.11 false 3.1.4.11 PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) → DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) + Inositol 1,3,4-trisphosphate LEFT_TO_RIGHT SMILES OC(=O)CCC(O)=O Nitric-oxide synthase, endothelial Calcium Inhibitor of nuclear factor kappa-B kinase DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) Nitric oxide CHEBI:77096 ChEBI SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC 1.0 53480273 PubChem-compound HMDB0001220 HMDB Inhibitor of nuclear factor kappa-B kinase subunit beta Interaction980 ERK1, ERK2 activates COX1 homodimer complex Interaction982 Protein kinase C activates Inhibitor of nuclear factor kappa-B kinase Interaction981 COX1 homodimer complex activates Prostaglandin E2 1.0 C00165 KEGG Compound Interaction983 Mitogen-activated protein kinase 11 activates Cyclic AMP-responsive element-binding protein 1 ReactionCatalysis133147 ACTIVATION 1.0 C00042 KEGG Compound 1078 ChemSpider NITRIC-OXIDE BioCyc Q9Y6K9 UniProt 1.0 HMDB0003378 HMDB Cytoplasm P29474 UniProt SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Nitric oxide synthase, endothelial Mitogen-activated protein kinase 11 Homo sapiens Succinate receptor 1 INOSITOL-1-3-4-TRIPHOSPHATE BioCyc 439455 PubChem-compound PW085652 PathWhiz Q9NQ66 UniProt C6H15O15P3 Inositol 1,3,4-trisphosphate 419.96237 Succinate Signaling During Inflammation ERK1, ERK2 Protein kinase C alpha type HMDB0010082 HMDB Succinate receptor 1 C00626 KEGG Compound CHEBI:16480 ChEBI C00584 KEGG Compound P19838 UniProt Nuclear factor NF-kappa-B p105 subunit Prostaglandin G/H synthase 1 Inhibitor of nuclear factor kappa-B kinase subunit beta NO Nitric oxide 29.997988 Mitogen-activated protein kinase 3 CHEBI:15551 ChEBI 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 363-24-6 CAS C47H85O19P3 PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) 1046.4897 9543736 PubChem-compound 266 ChemSpider Reaction143078 false Inhibitor of nuclear factor kappa-B kinase subunit beta + Nuclear factor NF-kappa-B p105 subunit → Nuclear factor NF-kappa-B p105 subunit LEFT_TO_RIGHT Mitogen-activated protein kinase 1 Inhibitor of nuclear factor kappa-B kinase subunit alpha P17252 UniProt HMDB0007112 HMDB 9606 TAXONOMY Mitogen-activated protein kinase 1 Transport6542 false Nuclear factor NF-kappa-B p105 subunit (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Nucleus LEFT_TO_RIGHT 145068 PubChem-compound C00076 KEGG Compound Prostaglandin E2 SUC BioCyc 110-15-6 CAS CA%2b2 BioCyc 2.0 Succinate receptor 1 SMILES O[C@@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@H]1OP(O)(O)=O GO:0005886 GENE ONTOLOGY 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS BioCyc PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) Ca Calcium 39.96259 Mitogen-activated protein kinase 11 HMDB0001143 HMDB Cell Membrane Cyclic AMP-responsive element-binding protein 1 Phosphatidylinositols BioCyc Mitogen-activated protein kinase 11 SMILES [N]=O O15111 UniProt ReactionCatalysis130870 ACTIVATION Prostaglandin G/H synthase 1 271 PubChem-compound Nuclear factor NF-kappa-B p105 subunit 388561 ChemSpider 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Succinic acid HMDB0000464 HMDB P16220 UniProt Nitric oxide synthase, endothelial NF-kappa-B essential modulator Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY SMILES CCCCCC\C=C/CCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC CHEBI:15741 ChEBI 4444059 ChemSpider C00533 KEGG Compound 1110 PubChem-compound P23219 UniProt 10102-43-9 CAS 1.0 Cyclic AMP-responsive element-binding protein 1 14127-61-8 CAS SMILES [Ca++] Protein kinase C alpha type Inhibitor of nuclear factor kappa-B kinase subunit alpha 7822686 ChemSpider Q15759 UniProt NF-kappa-B essential modulator C4H6O4 Succinic acid 118.02661 C39H68O5 DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) 616.50665 Nucleus 24767959 ChemSpider 98102-63-7 CAS CHEBI:18228 ChEBI 1.0 Inositol 1,3,4-trisphosphate Interaction964 Succinic acid activates Succinate receptor 1 P27361 UniProt Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI O14920 UniProt SMP0084634 SMPDB SUCNR1 PLCB1 MAPK11 NOS3 PRKCA MAPK3 MAPK1 PTGS1 CHUK IKBKB IKBKG CREB1 NFKB1 NFKB1 NFKB1 IKBKB Succinic acid Inositol 1,3,4- trisphosphate Calcium Nitric oxide DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) Prostaglandin E2 PIP2(18:1(11Z)/20:3(8Z,11Z,14Z))