Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Small Molecule Pathway Database.
Loading Pathway...
CHEBI:16015 ChEBI Transport351 false L-Alanine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 388356 ChemSpider 2.0 6022 PubChem-compound HMDB01469 HMDB Phosphocarrier protein HPr 923 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 ReactionCoupledTransportCatalysis178 ACTIVATION HMDB00250 HMDB HMDB01341 HMDB 1.0 1.3.1.98 false 1.3.1.98 Hydrogen ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate LEFT_TO_RIGHT 2.5.1.7 false 2.5.1.7 Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate LEFT_TO_RIGHT Reaction3314 false Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT 2.7.7.23 false 2.7.7.23 Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate LEFT_TO_RIGHT 1.0 5.4.2.10 false 5.4.2.10 Glucosamine 6-phosphate ↔ Glucosamine-1P REVERSIBLE 6133 PubChem-compound Glucosamine 6-phosphate H Hydrogen ion 1.007825 HMDB00148 HMDB Peptidoglycan synthase ftsI UDP-N-acetylmuramoylalanine--D-glutamate ligase ATP BioCyc PTS system mannose-specific EIIAB component CHEBI:16264 ChEBI Bifunctional protein glmU HMDB00263 HMDB 1.0 559142 ChemSpider CHEBI:42560 ChEBI 2.6.1.16 false 2.6.1.16 L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid REVERSIBLE HMDB01109 HMDB ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine Transport369 false L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 2.0 P0AD65 UniProt C00217 KEGG Compound P0AA04 UniProt P0AD68 UniProt 31867-59-1 CAS 5746 ChemSpider 1.0 D-Alanine HMDB01206 HMDB Transport371 false Hydrogen Ion (→), L-Glutamic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 5742 ChemSpider CHEBI:16474 ChEBI 2.4.2.- false 2.4.2.- 2 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine → a peptidoglycan dimer (meso-diaminopimelate containing) + Hydrogen Ion + Undecaprenyl diphosphate LEFT_TO_RIGHT 2.4.1.227 false 2.4.1.227 Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + Uridine diphosphate-N-acetylglucosamine → Hydrogen Ion + Uridine 5'-diphosphate + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine LEFT_TO_RIGHT 2.7.8.13 false 2.7.8.13 UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate → Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + Uridine 5'-monophosphate LEFT_TO_RIGHT 6.3.2.10 false 6.3.2.10 Adenosine triphosphate + D-Alanyl-D-alanine + UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine LEFT_TO_RIGHT 6.3.2.13 false 6.3.2.13 Adenosine triphosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-diaminopimelate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate LEFT_TO_RIGHT HMDB59597 HMDB Penicillin-binding protein 1A Penicillin-binding protein 1B 8140645 ChemSpider Reaction3455 false a peptidoglycan dimer (meso-diaminopimelate containing) → D-Alanine + a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) LEFT_TO_RIGHT C00105 KEGG Compound 6030 PubChem-compound 6031 PubChem-compound 5735 ChemSpider Acetyl-CoA D-alanine--D-alanine ligase A Proton glutamate symport protein C6H12N2O3 D-Alanyl-D-alanine 160.0848 1010 ChemSpider UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1.0 GLUCOSAMINE-1P BioCyc 440272 PubChem-compound PPI BioCyc biosynthetic peptidoglycan transglycosylase 6.3.2.8 false 6.3.2.8 Adenosine triphosphate + L-Alanine + UDP-N-acetyl-α-D-muramate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-acetylmuramoyl-L-alanine LEFT_TO_RIGHT SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O SMILES [H]C(N)(CCCC([H])(N=C(O)CC[C@@]([H])(N=C(O)[C@]([H])(C)N=C(O)C([H])(C)O[C@@]1([H])[C@]([H])(O)[C@@]([H])(CO)O[C@]([H])(OP(O)(=O)OP(O)(=O)OC[C@@]2([H])O[C@@]([H])(N3C=CC(O)=NC3=O)[C@]([H])(O)[C@]2([H])O)[C@]1([H])N=C(C)O)C(O)=O)C(O)=O)C(O)=O BiologicalState109 138-08-9 CAS 2.0 C6H14NO8P Glucosamine-1P 259.04572 1.0 HMDB01423 HMDB 1.0 Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion HMDB00217 HMDB P07862 UniProt C00352 KEGG Compound Cytosol UDP-N-acetylmuramate--L-alanine ligase β-D-fructofuranose Adenosine triphosphate Glucose-6-phosphate isomerase 1.0 1.0 2.0 C00009 KEGG Compound UDP-N-acetyl-α-D-glucosamine-enolpyruvate HMDB00221 HMDB C5H9NO4 D-Glutamic acid 147.05316 3616-42-0 CAS UDP-N-acetyl-α-D-muramate C00008 KEGG Compound HMDB01310 HMDB C00006 KEGG Compound ReactionCatalysis3271 ACTIVATION HMDB00588 HMDB 1.0 UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate CHEBI:18009 ChEBI Hydrogen Ion L-ALPHA-ALANINE BioCyc SMILES C[C@@H](N)C(=O)N[C@H](C)C(O)=O 25244658 PubChem-compound Phospho-N-acetylmuramoyl-pentapeptide-transferase C01330 KEGG Compound CHEBI:18361 ChEBI 56-41-7 CAS C00005 KEGG Compound 1.0 CHEBI:18367 ChEBI SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/COP(O)(O)=O 1032 ChemSpider Phosphocarrier protein HPr C00002 KEGG Compound P0A6W3 UniProt D-serine/D-alanine/glycine transporter Phosphoglucosamine mutase HMDB01429 HMDB 1.0 ReactionCatalysis3276 ACTIVATION 1.0 CHEBI:61388 ChEBI ReactionCatalysis3277 ACTIVATION CHEBI:61386 ChEBI ReactionCatalysis3278 ACTIVATION CHEBI:61387 ChEBI C6H12O6 β-D-fructofuranose 180.06339 Hydrogen ion C35H55N7O26P2 UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate 1051.2672 C20H26N3O19P2 UDP-N-acetyl-α-D-glucosamine-enolpyruvate 674.06525 ReactionCatalysis3282 ACTIVATION C20H28N3O19P2 UDP-N-acetyl-α-D-muramate 676.0809 D-Glutamic acid ReactionCatalysis3281 ACTIVATION C00133 KEGG Compound C00010 KEGG Compound C00015 KEGG Compound C6H14NO8P Glucosamine 6-phosphate 259.04572 C00013 KEGG Compound glycolysis and pyruvate dehydrogenase SubPathway CHEBI:7125 ChEBI P17443 UniProt UDP-N-acetylglucosamine 1-carboxyvinyltransferase NAD(P) BioCyc D-GLUCOSAMINE-6-P BioCyc 562 TAXONOMY C87H139N7O23P2 Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine 1711.9419 H Hydrogen Ion 1.007825 2.0 L-Glutamine SubPathwayInteraction1432 SubPathway1432Reaction SubPathwayReaction 56-65-5 CAS UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Glucosamine-1P L-Glutamic acid 1.0 338-69-2 CAS C00025 KEGG Compound Penicillin-binding protein 1C C00024 KEGG Compound 4573916 ChemSpider 23327 PubChem-compound 1.0 CHEBI:29101 ChEBI SMILES CC(NC(=O)C(C)NC(=O)C(CCCC([NH3+])C([O-])=O)NC(=O)CCC(NC(=O)C(C)NC(=O)C(C)OC1C(O)C(CO)OC(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)C1NC(C)=O)C([O-])=O)C([O-])=O SMILES OC[C@@]1([H])O[C@]([H])(O[C@]2([H])[C@@]([H])(CO)O[C@]([H])(OP(O)(=O)OP(O)(=O)OC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(/C)CC\C([H])=C(/C)CCC=C(C)C)[C@]([H])(N=C(C)[O-])[C@@]2([H])O[C@@](C)([H])C(O)=N[C@](C)([H])C(O)=N[C@]([H])(CCC([O-])=N[C@@]([H])(CCC[C@](N)([H])C(=O)O)C(O)=N[C@@](C)([H])C([O-])=N[C@@](C)([H])C(=O)O)C(=O)O)[C@]([H])(N=C(C)[O-])[C@](O)([H])[C@@]1(O)[H] 1.0 N-ACETYL-D-GLUCOSAMINE-1-P BioCyc 899 ChemSpider C03543 KEGG Compound L-Alanine C00041 KEGG Compound Glutamate racemase 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 5460362 PubChem-compound P0AF16 UniProt C00043 KEGG Compound Uridine 5'-diphosphate Mannose permease IID component Mannose permease IIC component 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 58-97-9 CAS 1.0 PHOSPHO-ENOL-PYRUVATE BioCyc ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 HMDB00538 HMDB UTP BioCyc SMILES OC(=O)C(=C)OP(O)(O)=O 17341-25-2 CAS CHEBI:70757 ChEBI 5903 ChemSpider UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase CHEBI:17047 ChEBI peptidoglycan biosynthesis I 56-86-0 CAS Penicillin-binding protein 2 P0A749 UniProt 1.0 HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:57791 ChEBI 445675 PubChem-compound P0AER8 UniProt SMILES C[C@@H](N)C(O)=O C00064 KEGG Compound 1.0 6866-69-9 CAS Sodium/glutamate symport carrier protein 3960 PubChem-compound L-Glutamic acid P0A6T1 UniProt SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O C00074 KEGG Compound 71080 PubChem-compound Transport426 false ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT Transport425 false ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT Transport424 false D-Alanine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT D-Alanine C3H7NO2 L-Alanine 89.047676 SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O 5800 ChemSpider L-Alanine SMILES OC1OC(COP([O-])([O-])=C)C(O)C(O)C1O 58-98-0 CAS P22188 UniProt Peptidoglycan synthase ftsI C00075 KEGG Compound Sodium Phosphate SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)N=C(O)C1=CC(Cl)=C(Cl)C=C1 SMILES [H][C@](C)(O[C@@]1([H])[C@]([H])(O)[C@@]([H])(CO)OC([H])(OP(O)(=O)OP(O)(=O)OC[C@@]2([H])O[C@@]([H])(N3C=CC(O)=NC3=O)[C@]([H])(O)[C@]2([H])O)[C@]1([H])N=C(C)O)C(O)=N[C@@]([H])(C)C(O)=O Bifunctional protein glmU C00080 KEGG Compound Periplasmic Space 9965052 PubChem-compound 1.0 1.0 UDP-N-acetylmuramoylalanine--D-glutamate ligase TransportCatalysis317 ACTIVATION 1.0 TransportCatalysis315 ACTIVATION SMILES N[C@@H](CCC(O)=O)C(O)=O 5809 ChemSpider 5808 ChemSpider CHEBI:44897 ChEBI 14265-44-2 CAS 58-64-0 CAS 2.0 52940208 PubChem-compound 1.0 P17952 UniProt 21814 ChemSpider 2.0 644102 PubChem-compound 444493 PubChem-compound SMILES [H][C@](N)(CCC[C@@]([H])(N)C(O)=O)C(O)=O P0AAE1 UniProt P0ABG4 UniProt C04582 KEGG Compound 22833512 PubChem-compound SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O 25245499 PubChem-compound ACETYL-COA BioCyc CHEBI:18050 ChEBI Proton glutamate symport protein 23724481 PubChem-compound SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O 1.0 Na Sodium 22.989769 UMP BioCyc L-Alanine CHEBI:57634 ChEBI 1.0 P46022 UniProt SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OP(O)(O)=O UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase PW000906 PathWhiz 980 ChemSpider ReactionCatalysis2925 ACTIVATION UDP-N-acetylmuramate--L-alanine ligase a peptidoglycan dimer (meso-diaminopimelate containing) a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 30572 ChemSpider 17215925 ChemSpider CHEBI:16932 ChEBI C7H14N2O4 meso-diaminopimelate 190.09535 CHEBI:15966 ChEBI Phospho-N-acetylmuramoyl-pentapeptide-transferase Pyrophosphate Glucose-6-phosphate isomerase GAMMA-GLUTAMYL-D-GLUTAMATE BioCyc P0A6J8 UniProt UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine SMILES [Na+] 1005 PubChem-compound 5961 PubChem-compound C3H7NO2 D-Alanine 89.047676 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine D-fructose-6-phosphate aminotransferase C55H92O7P2 Undecaprenyl diphosphate 926.63184 1.0 528-04-1 CAS P0ACC7 UniProt 6816 PubChem-compound 1.0 64234 ChemSpider Undecaprenyl diphosphate TransportCatalysis369 ACTIVATION ADP BioCyc TransportCatalysis368 ACTIVATION TransportCatalysis367 ACTIVATION 53-59-8 CAS D-alanine--D-alanine ligase B C95H152N8O28P2 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine 1915.0192 C41H61N9O28P2 UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine 1189.3124 1.0 D-Alanine penicillin-binding protein 1B 1038 PubChem-compound C04256 KEGG Compound penicillin-binding protein 1A Penicillin-binding protein 1C GO:0005829 GENE ONTOLOGY fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase UDP-N-acetylmuramate-alanine ligase 1.0 393240 ChemSpider 1.0 UDP-N-acetylglucosamine 1-carboxyvinyltransferase UDP-N-acetylenolpyruvoylglucosamine reductase CHEBI:15713 ChEBI O4P Phosphate 94.95342 NADPH GO:0070258 GENE ONTOLOGY CHEBI:58247 ChEBI ReactionCatalysis3419 ACTIVATION SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 mannose PTS permease NADPH BioCyc PW000785 PathWhiz CHEBI:16977 ChEBI P69797 UniProt C9H15N2O15P3 Uridine triphosphate 483.96854 L-Glutamic acid Mannose permease IID component SMILES [O-]P([O-])([O-])=O UDP-N-acetylmuramoyl-L-alanyl-D-glutamate a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) C17H27N3O17P2 Uridine diphosphate-N-acetylglucosamine 607.08154 C9H13N2O9P Uridine 5'-monophosphate 324.03586 a peptidoglycan dimer (meso-diaminopimelate containing) TransportCatalysis297 ACTIVATION D-ALANINE BioCyc β-D-fructofuranose 6-phosphate β-D-glucose 6-phosphate UDP-N-acetylmuramoyl-L-alanine 1.0 Inner Membrane N-Acetyl-glucosamine 1-phosphate SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O C8H16NO9P N-Acetyl-glucosamine 1-phosphate 301.05627 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc GLT BioCyc Mannose permease IIC component 53-57-6 CAS SMP00924 SMPDB 1.0 C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 SMILES C[C@H](N)C(O)=O C7H13O8P β-D-glucose 6-phosphate 256.0359 5950 PubChem-compound 1.0 C23H36N4O20P2 UDP-N-acetylmuramoyl-L-alanine 750.13983 SMP00807 SMPDB C22H32Cl2N2O4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate 458.17392 Uridine diphosphate-N-acetylglucosamine O7P2 Pyrophosphate 173.91193 Sodium/glutamate symport carrier protein Uridine 5'-monophosphate CHEBI:68483 ChEBI 5957 PubChem-compound 1.0 GO:0005620 GENE ONTOLOGY Penicillin-binding protein 2 Uridine triphosphate meso-diaminopimelate CHEBI:15873 ChEBI 1.0 Reaction2958 false β-D-glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate REVERSIBLE Penicillin-binding protein 1B Penicillin-binding protein 1A Adenosine diphosphate C3H5O6P Phosphoenolpyruvic acid 167.98238 D-alanine ligase C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase Phosphoenolpyruvic acid 1.0 1.0 CHEBI:28639 ChEBI D-alanine--D-alanine ligase A CPD-8587 BioCyc SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O UDP BioCyc 6893-26-1 CAS CHEBI:1146900 ChEBI P11880 UniProt 14000-31-8 CAS 2.0 CO-A BioCyc 5675 ChemSpider 72-89-9 CAS β-D-fructofuranose 6-phosphate CHEBI:15570 ChEBI lipid II flippase essential cell division protein FtsW; lipid II flippase Coenzyme A 1.0 1.0 C21H36N7O16P3S Coenzyme A 767.11523 1.0 ReactionCoupledTransport144 false HPr - phosphorylated + β-D-fructofuranose → HPr + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT P31120 UniProt biosynthetic peptidoglycan transglycosylase CHEBI:15422 ChEBI 6557 ChemSpider P08373 UniProt Phosphoglucosamine mutase SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N D-serine/D-alanine/glycine transporter 1.0 439217 PubChem-compound C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 1.0 3.0 1.0 6.3.2.9 false 6.3.2.9 Adenosine triphosphate + D-Glutamic acid + UDP-N-acetylmuramoyl-L-alanine → Adenosine diphosphate + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate LEFT_TO_RIGHT 1.0 UDP-N-ACETYL-D-GLUCOSAMINE BioCyc CHEBI:16761 ChEBI P21345 UniProt 5.1.1.3 false 5.1.1.3 L-Glutamic acid ↔ D-Glutamic acid REVERSIBLE 6.3.2.4 false 6.3.2.4 Adenosine triphosphate + 2 D-Alanine → Adenosine diphosphate + D-Alanyl-D-alanine + Phosphate LEFT_TO_RIGHT 923-16-0 CAS SMILES CC(OC1C(O)C(CO)OC(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)C1NC(C)=O)C([O-])=O CHEBI:16576 ChEBI SMILES CC(=O)NC1C(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)OC(CO)C(O)C1OC(=C)C([O-])=O essential cell division protein FtsW; lipid II flippase 389248 ChemSpider 1.0 lipid II flippase 392413 ChemSpider UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase HMDB00290 HMDB D-Alanyl-D-alanine 1.0 1.0 HMDB00295 HMDB 1.0 C00993 KEGG Compound CHEBI:16695 ChEBI di-trans,octa-cis-undecaprenyl phosphate ReactionCatalysis3426 ACTIVATION ReactionCatalysis3427 ACTIVATION ReactionCatalysis3424 ACTIVATION ReactionCatalysis3425 ACTIVATION 1.0 ReactionCatalysis3428 ACTIVATION ReactionCatalysis3429 ACTIVATION ReactionCatalysis3422 ACTIVATION SMILES CC(NC(=O)C(C)NC(=O)C(CCCC([NH3+])C([O-])=O)NC(=O)C(CCC([O-])=O)NC(=O)C(C)NC(=O)C(C)OC1C(O)C(CO)OC(OP([O-])(=O)OP([O-])(=O)OCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C1NC(C)=O)C([O-])=O 5280604 PubChem-compound ReactionCatalysis3423 ACTIVATION ReactionCatalysis3420 ACTIVATION ReactionCatalysis3421 ACTIVATION Sodium CHEBI:15378 ChEBI SMILES [H+] HMDB03459 HMDB HMDB03339 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound Glutamate racemase D-alanine--D-alanine ligase B ReactionCatalysis3430 ACTIVATION ReactionCatalysis3431 ACTIVATION HMDB01367 HMDB 4444213 ChemSpider 2.0 SMILES N[C@@H](CCC(N)=O)C(O)=O UDP-N-acetylenolpyruvoylglucosamine reductase SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OP(O)(O)=O P02919 UniProt 1.0 P02918 UniProt P17169 UniProt 63-39-8 CAS 1061 PubChem-compound SMILES [H+] HMDB00288 HMDB CHEBI:17659 ChEBI Hydrogen Ion 1.0 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase ReactionCatalysis2480 ACTIVATION UNDECAPRENYL-DIPHOSPHATE BioCyc HMDB00161 HMDB D-ALA-D-ALA BioCyc C55H91O4P di-trans,octa-cis-undecaprenyl phosphate 846.6655 PTS system mannose-specific EIIAB component CHEBI:15351 ChEBI P14900 UniProt SMILES N[C@H](CCC(O)=O)C(O)=O HMDB01254 HMDB HMDB00285 HMDB P22634 UniProt P69801 UniProt 1.0 ReactionCatalysis2482 ACTIVATION P69805 UniProt 85-61-0 CAS P76577 UniProt ReactionCatalysis2485 ACTIVATION D-serine/D- alanine/glycine transporter Sodium/glutamate symport carrier protein Proton glutamate symport protein D-serine/D- alanine/glycine transporter lipid II flippase essential cell division protein FtsW; lipid II flippase Glucose-6- phosphate isomerase Glucosamine-- fructose-6- phosphate aminotransferase [isomerizing] Phosphoglucosamine mutase Bifunctional protein glmU Bifunctional protein glmU UDP-N- acetylglucosamine 1- carboxyvinyltransferase UDP-N- acetylenolpyruvoylglucosamine reductase UDP-N- acetylmuramate- -L-alanine ligase UDP-N- acetylmuramoylalanine- -D-glutamate ligase Glutamate racemase UDP-N- acetylmuramoyl- L-alanyl-D- glutamate-- 2,6- diaminopimelate ligase UDP-N- acetylmuramoyl- tripeptide-- D-alanyl-D- alanine ligase Phospho-N- acetylmuramoyl- pentapeptide- transferase D-alanine--D- alanine ligase B D-alanine--D- alanine ligase A UDP-N- acetylglucosamine- -N- acetylmuramyl- (pentapeptide) pyrophosphoryl- undecaprenol N- acetylglucosamine transferase Phosphocarrier protein HPr Phosphocarrier protein HPr Mannose permease IID component Mannose permease IIC component PTS system mannose- specific EIIAB component L-Alanine L-Alanine H + H + L-Glutamic acid L-Glutamic acid Na + Na + H + H + L-Glutamic acid L-Glutamic acid D-Alanine D-Alanine H + H + ditrans,octacis- undecaprenyldiphospho- N-acetyl-(N- acetylglucosaminyl)muramoyl- L-alanyl-γ-D- glutamyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine ditrans,octacis- undecaprenyldiphospho- N-acetyl-(N- acetylglucosaminyl)muramoyl- L-alanyl-γ-D- glutamyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine ditrans,octacis- undecaprenyldiphospho- N-acetyl-(N- acetylglucosaminyl)muramoyl- L-alanyl-γ-D- glutamyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine β-D-glucose 6-phosphate β-D- fructofuranose 6-phosphate L-Glutamine Glucosamine 6-phosphate L-Glutamic acid Glucosamine-1P Acetyl-CoA N-Acetyl- glucosamine 1-phosphate CoA H + Uridine triphosphate H + Uridine diphosphate- N- acetylglucosamine PP i Phosphoenolpyruvic acid P i UDP-N-acetyl- α-D- glucosamine- enolpyruvate NADPH Hydrogen ion NADP UDP-N-acetyl- α-D-muramate L-Alanine ATP ADP P i H + UDP-N- acetylmuramoyl- L-alanine ATP D-Glutamic acid ADP P i UDP-N- acetylmuramoyl- L-alanyl-D- glutamate L-Glutamic acid meso- diaminopimelate ATP ADP P i H + UDP-N- Acetylmuramoyl- L-alanyl-D- gamma- glutamyl- meso-2,6- diaminopimelate D-Alanyl-D- alanine ATP ADP P i H + UDP-N-acetyl- α-D-muramoyl- L-alanyl-γ-D- glutamyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine di- trans,octa- cis- undecaprenyl phosphate Uridine 5'- monophosphate Undecaprenyl- diphospho-N- acetylmuramoyl- L-alanyl-D- glutamyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine D-Alanine ATP ADP P i Uridine diphosphate- N- acetylglucosamine Uridine 5'-diphosphate H + ditrans,octacis- undecaprenyldiphospho- N-acetyl-(N- acetylglucosaminyl)muramoyl- L-alanyl-γ-D- glutamyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine Undecaprenyl diphosphate H + D-Alanine β-D- fructofuranose Magnesium Manganese Cobalt Manganese a peptidoglycan dimer (meso- diaminopimelate containing) a peptidoglycan with D,D cross-links (meso- diaminopimelate containing) glycolysis and pyruvate dehydrogenase Penicillin- binding protein 1C biosynthetic peptidoglycan transglycosylase Penicillin- binding protein 1A Penicillin- binding protein 1B Penicillin- binding protein 2 Peptidoglycan synthase ftsI Penicillin- binding protein 1A Penicillin- binding protein 1B Calcium
CHEBI:16015 ChEBI Transport351 false L-Alanine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 388356 ChemSpider 2.0 6022 PubChem-compound HMDB01469 HMDB Phosphocarrier protein HPr 923 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 ReactionCoupledTransportCatalysis178 ACTIVATION HMDB00250 HMDB HMDB01341 HMDB 1.0 1.3.1.98 false 1.3.1.98 Hydrogen ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate LEFT_TO_RIGHT 2.5.1.7 false 2.5.1.7 Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate LEFT_TO_RIGHT Reaction3314 false Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT 2.7.7.23 false 2.7.7.23 Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate LEFT_TO_RIGHT 1.0 5.4.2.10 false 5.4.2.10 Glucosamine 6-phosphate ↔ Glucosamine-1P REVERSIBLE 6133 PubChem-compound Glucosamine 6-phosphate H Hydrogen ion 1.007825 HMDB00148 HMDB Peptidoglycan synthase ftsI UDP-N-acetylmuramoylalanine--D-glutamate ligase ATP BioCyc PTS system mannose-specific EIIAB component CHEBI:16264 ChEBI Bifunctional protein glmU HMDB00263 HMDB 1.0 559142 ChemSpider CHEBI:42560 ChEBI 2.6.1.16 false 2.6.1.16 L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid REVERSIBLE HMDB01109 HMDB ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine Transport369 false L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 2.0 P0AD65 UniProt C00217