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Myosin light chain kinase, smooth muscle Myosin LC-P Myosin light chain 3 Inositol 1,4,5- trisphosphate receptor type 1 Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent L-type calcium channel subunit alpha-1C Myosin light chain phosphatase Calmodulin Calmodulin Voltage- dependent calcium channel subunit alpha-2/delta-1 Lacidipine Ca+ Ca+ Ca+ Lacidipine Ca+ Muscle Contraction Muscle Relaxation G Protein Signalling Cascade Magnesium Calcium Manganese Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Lacidipine binds and inhibits calcium channels preventing calcium influx Activation or inhibition of the receptors linked to the G protein signalling cascade can alter calcium levels in the cell. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Relaxation Actin Myosin Lacidipine is administered as an oral tablet
MYLK MYL3 MYL3 ITPR1 CACNB1 CACNA1C PPP1CB CALM1 CALM1 CACNA2D1 Lacidipine Calcium Calcium Calcium Lacidipine Calcium Muscle Contraction Muscle Relaxation G Protein Signalling Cascade
MYLK MYL3 MYL3 ITPR1 CACNB1 CACNA1C PPP1CB CALM1 CALM1 CACNA2D1 Lacid Ca+ Ca+ Ca+ Lacid Ca+ Mus Con Mus Rel G P S C Mg2+ Ca2+ Mn2+ Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Lacidipine binds and inhibits calcium channels preventing calcium influx Activation or inhibition of the receptors linked to the G protein signalling cascade can alter calcium levels in the cell. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Relaxation Actin Myosin Lacidipine is administered as an oral tablet
MYLK MYL3 MYL3 ITPR1 CACNB1 CACNA1C PPP1CB CALM1 CALM1 CACNA2D1 Lacid Ca2+ Ca2+ Ca2+ Lacid Ca2+ Mus Con Mus Rel G P S C