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Pathway Description
Methylphosphonate Degradation I
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-10-09
Last Updated: 2019-08-13
The pathway of methylphosphonate degradation starts with methylphosphonate being degrade by an ATP driven methylphosphonate degradation complex resulting in a alpha-D-ribose-1-methylphosphonate-5-triphosphate. This compound in turn is degraded by a water driven RPnTP hydrolase resulting in the release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The latter compound is then involved with a carbon-phosphorous lyase resulting in the release of a methane and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.
References
Methylphosphonate Degradation I References
Huang J, Su Z, Xu Y: The evolution of microbial phosphonate degradative pathways. J Mol Evol. 2005 Nov;61(5):682-90. doi: 10.1007/s00239-004-0349-4. Epub 2005 Oct 20.
Pubmed: 16245012
Kamat SS, Williams HJ, Raushel FM: Intermediates in the transformation of phosphonates to phosphate by bacteria. Nature. 2011 Nov 16;480(7378):570-3. doi: 10.1038/nature10622.
Pubmed: 22089136
Makino K, Kim SK, Shinagawa H, Amemura M, Nakata A: Molecular analysis of the cryptic and functional phn operons for phosphonate use in Escherichia coli K-12. J Bacteriol. 1991 Apr;173(8):2665-72.
Pubmed: 1840580
Podzelinska K, He SM, Wathier M, Yakunin A, Proudfoot M, Hove-Jensen B, Zechel DL, Jia Z: Structure of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate degradation. J Biol Chem. 2009 Jun 19;284(25):17216-26. doi: 10.1074/jbc.M808392200. Epub 2009 Apr 14.
Pubmed: 19366688
Wanner BL, Boline JA: Mapping and molecular cloning of the phn (psiD) locus for phosphonate utilization in Escherichia coli. J Bacteriol. 1990 Mar;172(3):1186-96.
Pubmed: 2155195
Wanner BL: Molecular genetics of carbon-phosphorus bond cleavage in bacteria. Biodegradation. 1994 Dec;5(3-4):175-84.
Pubmed: 7765831
Chen CM, Ye QZ, Zhu ZM, Wanner BL, Walsh CT: Molecular biology of carbon-phosphorus bond cleavage. Cloning and sequencing of the phn (psiD) genes involved in alkylphosphonate uptake and C-P lyase activity in Escherichia coli B. J Biol Chem. 1990 Mar 15;265(8):4461-71.
Pubmed: 2155230
Makino K, Kim SK, Shinagawa H, Amemura M, Nakata A: Molecular analysis of the cryptic and functional phn operons for phosphonate use in Escherichia coli K-12. J Bacteriol. 1991 Apr;173(8):2665-72. doi: 10.1128/jb.173.8.2665-2672.1991.
Pubmed: 1840580
Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. doi: 10.1093/nar/23.12.2105.
Pubmed: 7610040
Hove-Jensen B, McSorley FR, Zechel DL: Physiological role of phnP-specified phosphoribosyl cyclic phosphodiesterase in catabolism of organophosphonic acids by the carbon-phosphorus lyase pathway. J Am Chem Soc. 2011 Mar 16;133(10):3617-24. doi: 10.1021/ja1102713. Epub 2011 Feb 22.
Pubmed: 21341651
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