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Malate dehydrogenase, mitochondrial Lysine-specific demethylase 2A Hypoxia- inducible factor 1-alpha Mitochondrial pyruvate carrier 1 Mitochondrial dicarboxylate carrier Mitochondrial citrate transport protein Pyruvate dehydrogenase complex Citrate synthase, mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Oxoglutarate dehydrogenase complex Succinyl-CoA ligase Pyruvate carboxylase, mitochondrial Aconitate hydratase, mitochondrial Aconitate hydratase, mitochondrial Isocitrate dehydrogenase [NADP] cytoplasmic NADP+-specific isocitrate dehydrogenase Isocitrate dehydrogenase [NADP], mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Fumarate hydratase, mitochondrial Egl nine homolog 1 Egl nine homolog 2 Egl nine homolog 3 L-2- hydroxyglutarate dehydrogenase, mitochondrial Methylcytosine dioxygenase TET1 Pyruvic acid FADH2 Pyruvic acid Fumaric acid Citric acid Citric acid CoA NAD Acetyl-CoA CO2 NADH H2O Oxalacetic acid CoA Isocitric acid NAD Oxoglutaric acid CO2 NADH H+ NAD CoA Succinyl-CoA NADH H+ CO2 Pi GDP CoA GTP L-Malic acid NAD NADH H+ ATP HCO3- ADP Pi cis-Aconitic acid H2O H2O Isocitric acid NADP Oxoglutaric acid NADPH NADPH 2-Hydroxyglutarate NADP NADP Oxoglutaric acid NADPH Q FAD QH2 FADH2 H2O O2 Oxoglutaric acid L-Proline CO2 Succinic acid 4-Hydroxyproline NADP NADPH Oxygen Thiamine pyrophosphate Lipoamide FAD Magnesium Thiamine pyrophosphate Lipoamide FAD Biotin Manganese Fe2+ Ascorbic acid FAD Glycolysis Mitochondrial Electron Transport Chain Cytoplasmic aconitate hydratase Succinic acid 4Fe-4S 4Fe-4S Magnesium FAD 2Fe-2S Fumaric acid 4Fe-4S Inner mitochondrial membrane Mitochondrial intermembrane space Cytosol Mitochondrial matrix Mitochondrion Intracellular Space Inner mitochondrial membrane Outer mitochondrial membrane Epigenetic Regulation Oncogene Activation, Tumour-suppressor inactivation Pseudo-Hypoxia Mutant FH Citric acid Isocitric acid Oxoglutaric acid 2-Hydroxyglutarate TCA cycle Cytoplasmic aconitate hydratase Isocitrate dehydrogenase [NADP] cytoplasmic mutIDH1 Fumaric acid prolyl hydroxylase Hypoxia inducible factor 1-alpha Methylcytosine dioxygenase TET1 Lysine-specific demethylase 2A
Mitochondria MDH2 KDM2A HIF1A MPC1 SLC25A10 Unknown PDHA1 CS IDH3A IDH3B IDH3G OGDH SUCLG1 SUCLG2 PC ACO2 ACO2 IDH1 IDH1 IDH2 SDHA SDHB SDHC SDHD FH EGLN1 EGLN2 EGLN3 L2HGDH TET1 Pyruvic acid FADH Pyruvic acid Fumaric acid Citric acid Citric acid Coenzyme A NAD Acetyl-CoA Carbon dioxide NADH Water Oxalacetic acid Coenzyme A Isocitric acid NAD Oxoglutaric acid Carbon dioxide NADH Hydrogen Ion NAD Coenzyme A Succinyl-CoA NADH Hydrogen Ion Carbon dioxide Phosphate Guanosine diphosphate Coenzyme A Guanosine triphosphate L-Malic acid NAD NADH Hydrogen Ion Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Phosphate cis-Aconitic acid Water Water Isocitric acid NADP Oxoglutaric acid NADPH NADPH 2- Hydroxyglutarate NADP NADP Oxoglutaric acid NADPH Coenzyme Q10 FAD QH2 FADH Water Oxygen Oxoglutaric acid L-Proline Carbon dioxide Succinic acid 4- Hydroxyproline NADP NADPH Oxygen Glycolysis Mitochondrial Electron Transport Chain ACO1 Succinic acid Fumaric acid
MDH2 KDM2A HIF1A MPC1 SLC25A10 PDHA1 CS IDH3A IDH3B IDH3G OGDH SUCLG1 SUCLG2 PC ACO2 ACO2 IDH1 IDH1 IDH2 SDHA SDHB SDHC SDHD FH EGLN1 EGLN2 EGLN3 L2HGDH TET1 Pyr FADH2 Pyr Fumarat CA CA CoA NAD Ac-CoA CO2 NADH H2O Oaa CoA I-cita NAD AKG CO2 NADH H+ NAD CoA Suc-CoA NADH H+ CO2 Pi GDP CoA GTP Malate NAD NADH H+ ATP HCO3- ADP Pi Aconiti H2O H2O I-cita NADP AKG NADPH NADPH 2HG NADP NADP AKG NADPH Q FAD QH2 FADH2 H2O O2 AKG Pro CO2 Succini 4-HPro NADP NADPH O2 ThiamPP Lipoamd FAD Mg2+ ThiamPP Lipoamd FAD Biotin Mn2+ Fe2+ VitC FAD PW000146 PW000165 ACO1 Succini 4Fe-4S 4Fe-4S Mg2+ FAD 2Fe2S Fumarat 4Fe-4S Inner mitochondrial membrane Mitochondrial intermembrane space Cytosol Mitochondrial matrix Mitochondrion Intracellular Space Inner mitochondrial membrane Outer mitochondrial membrane Epigenetic Regulation Oncogene Activation, Tumour-suppressor inactivation Pseudo-Hypoxia Mutant FH Citric acid Isocitric acid Oxoglutaric acid 2-Hydroxyglutarate TCA cycle Cytoplasmic aconitate hydratase Isocitrate dehydrogenase [NADP] cytoplasmic mutIDH1 Fumaric acid prolyl hydroxylase Hypoxia inducible factor 1-alpha Methylcytosine dioxygenase TET1 Lysine-specific demethylase 2A
Mitochondria MDH2 KDM2A HIF1A MPC1 SLC25A10 PDHA1 CS IDH3A IDH3B IDH3G OGDH SUCLG1 SUCLG2 PC ACO2 ACO2 IDH1 IDH1 IDH2 SDHA SDHB SDHC SDHD FH EGLN1 EGLN2 EGLN3 L2HGDH TET1 Pyr FADH Pyr Fumarat CA CA CoA NAD Ac-CoA CO2 NADH H2O Oaa CoA I-cita NAD AKG CO2 NADH H+ NAD CoA Suc-CoA NADH H+ CO2 Pi GDP CoA GTP Malate NAD NADH H+ ATP HCO3 ADP Pi Aconiti H2O H2O I-cita NADP AKG NADPH NADPH 2HG NADP NADP AKG NADPH Coq FAD QH2 FADH H2O O2 AKG Pro CO2 Succini 4-HPro NADP NADPH O2 PW000146 PW000165 ACO1 Succini Fumarat