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Malate dehydrogenase, mitochondrial Methylcytosine dioxygenase TET1 Lysine-specific demethylase 2A Mitochondrial pyruvate carrier 1 Mitochondrial citrate transport protein Pyruvate dehydrogenase complex Citrate synthase, mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Oxoglutarate dehydrogenase complex Succinyl-CoA ligase Fumarate hydratase, mitochondrial Pyruvate carboxylase, mitochondrial Succinate dehydrogenase Aconitate hydratase, mitochondrial Aconitate hydratase, mitochondrial Glutamate dehydrogenase 1, mitochondrial Glutaminase liver isoform, mitochondrial Isocitrate dehydrogenase [NADP] cytoplasmic NADP+-specific isocitrate dehydrogenase L-2- hydroxyglutarate dehydrogenase, mitochondrial L-2- hydroxyglutarate dehydrogenase, mitochondrial mutant Isocitrate dehydrogenase 2 [NADP], mitochondrial Isocitrate dehydrogenase [NADP] cytoplasmic Pyruvic acid FADH2 Pyruvic acid Citric acid Citric acid CoA NAD Acetyl-CoA CO2 NADH H2O Oxalacetic acid CoA Isocitric acid NAD Oxoglutaric acid CO2 NADH H+ NAD CoA Succinyl-CoA NADH H+ CO2 Pi GDP Succinic acid CoA GTP L-Malic acid Fumaric acid H2O NAD NADH H+ ATP HCO3- ADP Pi Q FAD QH2 cis-Aconitic acid H2O H2O NADPH Ammonium H+ L-Glutamic acid H2O NADP L-Glutamine H2O NH3 Isocitric acid NADP Oxoglutaric acid NADPH NADPH NADP NADH Oxoglutaric acid NAD NADP 2-Hydroxyglutarate NADPH NADPH NADP NAD H+ NADH H+ CO2 Thiamine pyrophosphate Lipoamide FAD Thiamine pyrophosphate Lipoamide FAD Biotin Manganese Magnesium FAD Glycolysis Mitochondrial Electron Transport Chain Magnesium 4Fe-4S 4Fe-4S Cytoplasmic aconitate hydratase L-2-Hydroxyglutaric acid 4Fe-4S Inner mitochondrial membrane Mitochondrial intermembrane space Cytosol Mitochondrial matrix Mitochondrion Intracellular Space Inner mitochondrial membrane Outer mitochondrial membrane Epigenetic Regulation Oncogene Activation, Tumour-suppressor inactivation TCA cycle Citric acid Isocitric acid Oxoglutaric acid L-2-Hydroxyglutaric acid 2-Hydroxyglutarate Oxoglutaric acid Cytoplasmic aconitate hydratase Isocitrate dehydrogenase [NADP] cytoplasmic mutIDH2 L-2-hydroxyglutarate dehydrogenase, mitochondrial L-2-hydroxyglutarate dehydrogenase, mitochondrial Lysine-specific demethylase 2A Methylcytosine dioxygenase TET1
Mitochondria MDH2 TET1 KDM2A MPC1 Unknown PDHA1 CS IDH3A IDH3B IDH3G OGDH SUCLG1 SUCLG2 FH PC SDHA SDHB SDHC SDHD ACO2 ACO2 GLUD1 GLS2 IDH1 IDH1 L2HGDH L2HGDH IDH2 IDH1 Pyruvic acid FADH Pyruvic acid Citric acid Citric acid Coenzyme A NAD Acetyl-CoA Carbon dioxide NADH Water Oxalacetic acid Coenzyme A Isocitric acid NAD Oxoglutaric acid Carbon dioxide NADH Hydrogen Ion NAD Coenzyme A Succinyl-CoA NADH Hydrogen Ion Carbon dioxide Phosphate Guanosine diphosphate Succinic acid Coenzyme A Guanosine triphosphate L-Malic acid Fumaric acid Water NAD NADH Hydrogen Ion Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Phosphate Coenzyme Q10 FAD QH(2) cis-Aconitic acid Water Water NADPH Ammonium Hydrogen Ion L-Glutamic acid Water NADP L-Glutamine Water Ammonia Isocitric acid NADP Oxoglutaric acid NADPH NADPH NADP NADH Oxoglutaric acid NAD NADP 2- Hydroxyglutarate NADPH NADPH NADP NAD Hydrogen Ion NADH Hydrogen Ion Carbon dioxide Glycolysis Mitochondrial Electron Transport Chain ACO1 L-2- Hydroxyglutaric acid
MDH2 TET1 KDM2A MPC1 PDHA1 CS IDH3A IDH3B IDH3G OGDH SUCLG1 SUCLG2 FH PC SDHA SDHB SDHC SDHD ACO2 ACO2 GLUD1 GLS2 IDH1 IDH1 L2HGDH L2HGDH IDH2 IDH1 Pyr FADH2 Pyr CA CA CoA NAD Ac-CoA CO2 NADH H2O Oaa CoA I-cita NAD AKG CO2 NADH H+ NAD CoA Suc-CoA NADH H+ CO2 Pi GDP Succini CoA GTP Malate Fumarat H2O NAD NADH H+ ATP HCO3- ADP Pi Q FAD QH2 Aconiti H2O H2O NADPH Ammon H+ Glu H2O NADP Gln H2O NH3 I-cita NADP AKG NADPH NADPH NADP NADH AKG NAD NADP 2HG NADPH NADPH NADP NAD H+ NADH H+ CO2 ThiamPP Lipoamd FAD ThiamPP Lipoamd FAD Biotin Mn2+ Mg2+ FAD PW000146 PW000165 Mg2+ 4Fe-4S 4Fe-4S ACO1 L2HGA 4Fe-4S Inner mitochondrial membrane Mitochondrial intermembrane space Cytosol Mitochondrial matrix Mitochondrion Intracellular Space Inner mitochondrial membrane Outer mitochondrial membrane Epigenetic Regulation Oncogene Activation, Tumour-suppressor inactivation TCA cycle Citric acid Isocitric acid Oxoglutaric acid L-2-Hydroxyglutaric acid 2-Hydroxyglutarate Oxoglutaric acid Cytoplasmic aconitate hydratase Isocitrate dehydrogenase [NADP] cytoplasmic mutIDH2 L-2-hydroxyglutarate dehydrogenase, mitochondrial L-2-hydroxyglutarate dehydrogenase, mitochondrial Lysine-specific demethylase 2A Methylcytosine dioxygenase TET1
Mitochondria MDH2 TET1 KDM2A MPC1 PDHA1 CS IDH3A IDH3B IDH3G OGDH SUCLG1 SUCLG2 FH PC SDHA SDHB SDHC SDHD ACO2 ACO2 GLUD1 GLS2 IDH1 IDH1 L2HGDH L2HGDH IDH2 IDH1 Pyr FADH Pyr CA CA CoA NAD Ac-CoA CO2 NADH H2O Oaa CoA I-cita NAD AKG CO2 NADH H+ NAD CoA Suc-CoA NADH H+ CO2 Pi GDP Succini CoA GTP Malate Fumarat H2O NAD NADH H+ ATP HCO3 ADP Pi Coq FAD QH(2) Aconiti H2O H2O NADPH Ammon H+ Glu H2O NADP Gln H2O NH3 I-cita NADP AKG NADPH NADPH NADP NADH AKG NAD NADP 2HG NADPH NADPH NADP NAD H+ NADH H+ CO2 PW000146 PW000165 ACO1 L2HGA