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CHEBI:16015 ChEBI 6.0 30572 ChemSpider 17215925 ChemSpider 937 ChemSpider HMDB00491 HMDB 57 ChemSpider SMILES O 50 ChemSpider 1.0 73-32-5 CAS http://identifiers.org/smpdb/SMP00837 SMPDB HMDB00148 HMDB http://identifiers.org/smpdb/SMP00831 SMPDB H4N Ammonium 18.034374 1.0 Unknown 51 PubChem-compound 46 ChemSpider Pyruvic acid 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT 19796801 PubChem-compound 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 Reaction7225 false (S)-2-Aceto-2-hydroxybutanoic acid + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT 2.2.1.6 false 2.2.1.6 2-Ketobutyric acid + Hydrogen Ion + Pyruvic acid → (S)-2-Aceto-2-hydroxybutanoic acid + Carbon dioxide LEFT_TO_RIGHT Reaction7227 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Isoleucine + Oxoglutaric acid LEFT_TO_RIGHT Reaction7226 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT 6288 PubChem-compound 562-43-6 CAS 53-59-8 CAS Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc 1038 PubChem-compound CHEBI:16474 ChEBI ReactionCatalysis7209 ACTIVATION HMDB59597 HMDB 274 ChemSpider Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 HMDB00243 HMDB HMDB06900 HMDB HMDB00005 HMDB ReactionCatalysis7210 ACTIVATION C00109 KEGG Compound Threonine dehydratase biosynthetic, chloroplastic NADPH SMILES CC=C(N)C([O-])=O 1010 ChemSpider C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 (R) 2,3-Dihydroxy-3-methylvalerate HMDB41827 HMDB 600-18-0 CAS NADP C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis7214 ACTIVATION ReactionCatalysis7213 ACTIVATION ReactionCatalysis7212 ACTIVATION ReactionCatalysis7211 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis7215 ACTIVATION 1.0 NADPH BioCyc Ammonium CHEBI:16857 ChEBI Hydrogen Ion HMDB00217 HMDB 218 ChemSpider (S)-2-Aceto-2-hydroxybutanoic acid SMILES CCC(C)C(=O)C(O)=O 72-19-5 CAS L-Glutamic acid CHEBI:27512 ChEBI 1.0 SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS HMDB00208 HMDB CHEBI:30915 ChEBI Reaction5890 true 3-Methyl-2-oxovaleric acid ↔ 2-Keto-3-methyl-valerate REVERSIBLE 1.0 1.0 HMDB00221 HMDB 2-iminobutanoate C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound 1460-34-0 CAS C00005 KEGG Compound 2-OXOBUTANOATE BioCyc C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 6051 ChemSpider (2Z)-2-aminobut-2-enoate threonine biosynthesis SubPathway SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O GLT BioCyc 53-57-6 CAS Q9ZSS6 UniProt SubPathwayInteraction3849 SubPathway3849Reaction SubPathwayReaction C4H6NO2 2-iminobutanoate 100.040405 1.0 C01342 KEGG Compound C00011 KEGG Compound SMILES O=C=O CHEBI:28938 ChEBI SMILES C[C@@H](O)[C@H](N)C(O)=O Leucine Biosynthesis SubPathway NAD(P) BioCyc Unknown SMILES CC[C@H](C)[C@H](N)C(O)=O 47 PubChem-compound H Hydrogen Ion 1.007825 1.0 C00022 KEGG Compound C06006 KEGG Compound 6067 ChemSpider SubPathwayInteraction3850 SubPathway3850Reaction SubPathwayReaction C06007 KEGG Compound C00026 KEGG Compound 440875 PubChem-compound C00025 KEGG Compound SMILES CCC(=O)C(O)=O 1.0 http://identifiers.org/smpdb/SMP02430 SMPDB 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound 2.0 6306 PubChem-compound CHEBI:30831 ChEBI 328-50-7 CAS Water 1.0 395044 ChemSpider 5675 ChemSpider ILE BioCyc 14798-03-9 CAS CHEBI:58739 ChEBI CHEBI:17191 ChEBI Threonine dehydratase biosynthetic, chloroplastic 7732-18-5 CAS 1.0 acetohydroxybutanoate synthase / acetolactate synthase acetohydroxybutanoate synthase / acetolactate synthase 2 C6H10O4 (S)-2-Aceto-2-hydroxybutanoic acid 146.0579 threonine deaminase 127-17-3 CAS 1.0 56-86-0 CAS 389708 ChemSpider dihydroxy acid dehydratase branched-chain amino-acid aminotransferase acetolactate synthase / acetohydroxybutanoate synthase 3 acetohydroxy acid isomeroreductase C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] 6857401 PubChem-compound CHEBI:16526 ChEBI C00188 KEGG Compound 4.0 1.0 CHEBI:35146 ChEBI SMILES CC(=O)C(O)=O 1.0 CHEBI:35932 ChEBI HMDB01967 HMDB SMILES CC[C@H](C)C(=O)C([O-])=O 962 PubChem-compound C4H9NO3 L-Threonine 119.05824 4.0 2-KETOGLUTARATE BioCyc SMILES CCC(=N)C([O-])=O 2-KETO-3-METHYL-VALERATE BioCyc CO2 Carbon dioxide 43.98983 HMDB00172 HMDB C03465 KEGG Compound HMDB02111 HMDB C00080 KEGG Compound Oxoglutaric acid SMILES CC[C@](O)(C(C)=O)C(O)=O 3-Methyl-2-oxovaleric acid C6H13NO2 L-Isoleucine 131.09464 PW000811 PathWhiz 1.0 CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000817 PathWhiz CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc 2-Keto-3-methyl-valerate C00407 KEGG Compound 5886 PubChem-compound 2-Ketobutyric acid 1.0 1.0 280 PubChem-compound C4H6O3 2-Ketobutyric acid 102.03169 isoleucine biosynthesis C6H9O3 2-Keto-3-methyl-valerate 129.05518 16741146 PubChem-compound 22833512 PubChem-compound HMDB12140 HMDB L-Isoleucine H2O Water 18.010565 PW002537 PathWhiz 1.0 1060 PubChem-compound HMDB00167 HMDB Carbon dioxide L-Threonine CHEBI:27681 ChEBI Unknown Threonine dehydratase biosynthetic, chloroplastic 2- hydroxyacyl- CoA lyase acetohydroxybutanoate synthase / acetolactate synthase acetohydroxybutanoate synthase / acetolactate synthase 2 acetohydroxybutanoate synthase / acetolactate synthase 2 acetolactate synthase / acetohydroxybutanoate synthase 3 acetohydroxy acid isomeroreductase dihydroxy acid dehydratase branched-chain amino-acid aminotransferase L-Threonine H + H 2 O (2Z)-2- aminobut-2- enoate 2- iminobutanoate H 2 O H + Ammonium 2-Ketobutyric acid H + Pyruvic acid CO 2 (S)-2-Aceto- 2- hydroxybutanoic acid NADPH H + NADP (R) 2,3- Dihydroxy-3- methylvalerate H 2 O 3-Methyl-2- oxovaleric acid L-Glutamic acid Oxoglutaric acid L-Isoleucine 2-Keto-3- methyl- valerate threonine biosynthesis
CHEBI:16015 ChEBI 6.0 30572 ChemSpider 17215925 ChemSpider 937 ChemSpider HMDB00491 HMDB 57 ChemSpider SMILES O 50 ChemSpider 1.0 73-32-5 CAS http://identifiers.org/smpdb/SMP00837 SMPDB HMDB00148 HMDB http://identifiers.org/smpdb/SMP00831 SMPDB H4N Ammonium 18.034374 1.0 Unknown 51 PubChem-compound 46 ChemSpider Pyruvic acid 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT 19796801 PubChem-compound 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 Reaction7225 false (S)-2-Aceto-2-hydroxybutanoic acid + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT 2.2.1.6 false 2.2.1.6 2-Ketobutyric acid + Hydrogen Ion + Pyruvic acid → (S)-2-Aceto-2-hydroxybutanoic acid + Carbon dioxide LEFT_TO_RIGHT Reaction7227 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Isoleucine + Oxoglutaric acid LEFT_TO_RIGHT Reaction7226 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT 6288 PubChem-compound 562-43-6 CAS 53-59-8 CAS Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc 1038 PubChem-compound CHEBI:16474 ChEBI ReactionCatalysis7209 ACTIVATION HMDB59597 HMDB 274 ChemSpider Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 HMDB00243 HMDB HMDB06900 HMDB HMDB00005 HMDB ReactionCatalysis7210 ACTIVATION C00109 KEGG Compound Threonine dehydratase biosynthetic, chloroplastic NADPH SMILES CC=C(N)C([O-])=O 1010 ChemSpider C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 (R) 2,3-Dihydroxy-3-methylvalerate HMDB41827 HMDB 600-18-0 CAS NADP C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis7214 ACTIVATION ReactionCatalysis7213 ACTIVATION ReactionCatalysis7212 ACTIVATION ReactionCatalysis7211 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis7215 ACTIVATION 1.0 NADPH BioCyc Ammonium CHEBI:16857 ChEBI Hydrogen Ion HMDB00217 HMDB 218 ChemSpider (S)-2-Aceto-2-hydroxybutanoic acid SMILES CCC(C)C(=O)C(O)=O 72-19-5 CAS L-Glutamic acid CHEBI:27512 ChEBI 1.0 SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS HMDB00208 HMDB CHEBI:30915 ChEBI Reaction5890 true 3-Methyl-2-oxovaleric acid ↔ 2-Keto-3-methyl-valerate REVERSIBLE 1.0 1.0 HMDB00221 HMDB 2-iminobutanoate C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound 1460-34-0 CAS C00005 KEGG Compound 2-OXOBUTANOATE BioCyc C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 6051 ChemSpider (2Z)-2-aminobut-2-enoate SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O GLT BioCyc 53-57-6 CAS Q9ZSS6 UniProt SubPathwayInteraction3849 SubPathway3849Reaction SubPathwayReaction C4H6NO2 2-iminobutanoate 100.040405 1.0 C01342 KEGG Compound C00011 KEGG Compound SMILES O=C=O CHEBI:28938 ChEBI SMILES C[C@@H](O)[C@H](N)C(O)=O NAD(P) BioCyc Unknown SMILES CC[C@H](C)[C@H](N)C(O)=O 47 PubChem-compound H Hydrogen Ion 1.007825 1.0 C00022 KEGG Compound C06006 KEGG Compound 6067 ChemSpider SubPathwayInteraction3850 SubPathway3850Reaction SubPathwayReaction C06007 KEGG Compound C00026 KEGG Compound 440875 PubChem-compound C00025 KEGG Compound SMILES CCC(=O)C(O)=O 1.0 http://identifiers.org/smpdb/SMP02430 SMPDB 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound 2.0 6306 PubChem-compound CHEBI:30831 ChEBI 328-50-7 CAS Water 1.0 395044 ChemSpider 5675 ChemSpider ILE BioCyc 14798-03-9 CAS CHEBI:58739 ChEBI CHEBI:17191 ChEBI Leucine Biosynthesis SubPathway Threonine dehydratase biosynthetic, chloroplastic threonine biosynthesis SubPathway 7732-18-5 CAS 1.0 acetohydroxybutanoate synthase / acetolactate synthase acetohydroxybutanoate synthase / acetolactate synthase 2 C6H10O4 (S)-2-Aceto-2-hydroxybutanoic acid 146.0579 threonine deaminase 127-17-3 CAS 1.0 56-86-0 CAS 389708 ChemSpider dihydroxy acid dehydratase branched-chain amino-acid aminotransferase acetolactate synthase / acetohydroxybutanoate synthase 3 acetohydroxy acid isomeroreductase C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] 6857401 PubChem-compound CHEBI:16526 ChEBI C00188 KEGG Compound 4.0 1.0 CHEBI:35146 ChEBI SMILES CC(=O)C(O)=O 1.0 CHEBI:35932 ChEBI HMDB01967 HMDB SMILES CC[C@H](C)C(=O)C([O-])=O 962 PubChem-compound C4H9NO3 L-Threonine 119.05824 4.0 2-KETOGLUTARATE BioCyc SMILES CCC(=N)C([O-])=O 2-KETO-3-METHYL-VALERATE BioCyc CO2 Carbon dioxide 43.98983 HMDB00172 HMDB C03465 KEGG Compound HMDB02111 HMDB C00080 KEGG Compound Oxoglutaric acid SMILES CC[C@](O)(C(C)=O)C(O)=O 3-Methyl-2-oxovaleric acid C6H13NO2 L-Isoleucine 131.09464 PW000811 PathWhiz 1.0 CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000817 PathWhiz CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc 2-Keto-3-methyl-valerate C00407 KEGG Compound 5886 PubChem-compound 2-Ketobutyric acid 1.0 1.0 280 PubChem-compound C4H6O3 2-Ketobutyric acid 102.03169 isoleucine biosynthesis C6H9O3 2-Keto-3-methyl-valerate 129.05518 16741146 PubChem-compound 22833512 PubChem-compound HMDB12140 HMDB L-Isoleucine H2O Water 18.010565 PW002537 PathWhiz 1.0 1060 PubChem-compound HMDB00167 HMDB Carbon dioxide L-Threonine CHEBI:27681 ChEBI Lysosome Unknown OMR1 HACL Unknown Unknown Unknown Unknown Unknown Unknown Unknown L-Threonine Hydrogen Ion Water (2Z)-2- aminobut-2- enoate 2- iminobutanoate Water Hydrogen Ion Ammonium 2-Ketobutyric acid Hydrogen Ion Pyruvic acid Carbon dioxide (S)-2-Aceto- 2- hydroxybutanoic acid NADPH Hydrogen Ion NADP (R) 2,3- Dihydroxy-3- methylvalerate Water 3-Methyl-2- oxovaleric acid L-Glutamic acid Oxoglutaric acid L-Isoleucine 2-Keto-3- methyl- valerate threonine biosynthesis