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Showing 1 - 10 of 605359 pathways
SMPDB ID Pathway Name and Description Pathway Class Chemical Compounds Proteins

SMP0122275

Missing View Pathway

zs

Signaling

SMP0125119

Missing View Pathway

Zechuan Lin

Signaling

SMP0089953

Missing View Pathway

Wnt/LRP6 Signalling

Canonical Wnt/β-catenin signaling has central roles in development and diseases, and is initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3) initiates Wnt/β-catenin signaling. Both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction.
Signaling

SMP0124899

Missing View Pathway

Wnt/beta catenin pathway

Signaling

SMP0125564

Missing View Pathway

Wnt-beta-catenine_pathway

Signaling

SMP0077591

Pw078607 View Pathway

WNT Signaling Pathway

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities.The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting complexity of signaling regulation, function and biological output. To date major signaling branches downstream of the Fz receptor have been identified including a canonical or Wnt/β-catenin dependent pathway and the non-canonical or β-catenin-independent pathway which can be further divided into the Planar Cell Polarity and the Wnt/Ca2+ pathways, and these branches are being actively dissected at the molecular and biochemical levels.
Signaling

SMP0002280

Missing View Pathway

Wnt pathway

Signaling

SMP0125145

Missing View Pathway

Wnt 1645270206

Signaling

SMP0122543

Missing View Pathway

Wnt 1586270741

WNT MTOR
Signaling

SMP0000862

Pw000842 View Pathway

Wnt

Signaling
Showing 1 - 10 of 344 pathways