Browsing Pathways
Showing 1 -
10 of 605359 pathways
SMPDB ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
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SMP0122275View Pathway |
zs |
Signaling
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SMP0125119View Pathway |
Zechuan Lin |
Signaling
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SMP0089953View Pathway |
Wnt/LRP6 SignallingCanonical Wnt/β-catenin signaling has central roles in development and diseases, and is initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3) initiates Wnt/β-catenin signaling. Both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction.
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Signaling
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SMP0124899View Pathway |
Wnt/beta catenin pathway |
Signaling
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SMP0125564View Pathway |
Wnt-beta-catenine_pathway |
Signaling
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SMP0077591View Pathway |
WNT Signaling PathwayThe Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities.The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting complexity of signaling regulation, function and biological output. To date major signaling branches downstream of the Fz receptor have been identified including a canonical or Wnt/β-catenin dependent pathway and the non-canonical or β-catenin-independent pathway which can be further divided into the Planar Cell Polarity and the Wnt/Ca2+ pathways, and these branches are being actively dissected at the molecular and biochemical levels.
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Signaling
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SMP0002280View Pathway |
Wnt pathway |
Signaling
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SMP0125145View Pathway |
Wnt 1645270206 |
Signaling
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SMP0122543View Pathway |
Wnt 1586270741WNT MTOR
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Signaling
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SMP0000862View Pathway |
Wnt |
Signaling
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Showing 1 -
10 of 344 pathways