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Showing 55641 - 55660 of 55723 compounds

Compound ID

Compound

Pathways

PW_C096717

Image HMDB0092883: View Metabocard

CL(i-14:0/i-17:0/i-17:0/i-19:0)

CL(i-14:0/i-17:0/i-17:0/i-19:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-17:0/i-19:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isoheptadecanoic acid at the C-3 position, and one chain of isononadecanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096718

Image HMDB0092899: View Metabocard

CL(i-14:0/i-17:0/i-17:0/i-20:0)

CL(i-14:0/i-17:0/i-17:0/i-20:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-17:0/i-20:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isoheptadecanoic acid at the C-3 position, and one chain of isoeicosanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096719

Image HMDB0092890: View Metabocard

CL(i-14:0/i-17:0/i-17:0/i-21:0)

CL(i-14:0/i-17:0/i-17:0/i-21:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-17:0/i-21:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isoheptadecanoic acid at the C-3 position, and one chain of isoheneicosanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096720

Image HMDB0092810: View Metabocard

CL(i-14:0/i-17:0/i-17:0/i-22:0)

CL(i-14:0/i-17:0/i-17:0/i-22:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-17:0/i-22:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isoheptadecanoic acid at the C-3 position, and one chain of isodocosanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096721

Image HMDB0092811: View Metabocard

CL(i-14:0/i-17:0/i-17:0/i-24:0)

CL(i-14:0/i-17:0/i-17:0/i-24:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-17:0/i-24:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isoheptadecanoic acid at the C-3 position, and one chain of isotetracosanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096722

Image HMDB0092832: View Metabocard

CL(i-14:0/i-17:0/i-18:0/a-13:0)

CL(i-14:0/i-17:0/i-18:0/a-13:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-18:0/a-13:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isooctadecanoic acid at the C-3 position, and one chain of anteisotridecanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096723

Image HMDB0092878: View Metabocard

CL(i-14:0/i-17:0/i-18:0/i-12:0)

CL(i-14:0/i-17:0/i-18:0/i-12:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-18:0/i-12:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isooctadecanoic acid at the C-3 position, and one chain of isododecanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096724

Image HMDB0092804: View Metabocard

CL(i-14:0/i-17:0/i-18:0/i-13:0)

CL(i-14:0/i-17:0/i-18:0/i-13:0) is a cardiolipin (CL). Cardiolipins (bisphosphatidyl glycerol) are an important component of the inner mitochondrial membrane, where they constitute about 20% of the total lipid. Cardiolipins are a "double" phospholipid because they have four fatty acid tails, instead of the usual two. While most lipids are made in the endoplasmic reticulum, cardiolipin is synthesized on the matrix side of the inner mitochondrial membrane. They are highly abundant in metabolically active cells (heart, muscle) and play an important role in the blood clotting process. CL(i-14:0/i-17:0/i-18:0/i-13:0), in particular, consists of one chain of isotetradecanoic acid at the C-1 position, one chain of isoheptadecanoic acid at the C-2 position, one chain of isooctadecanoic acid at the C-3 position, and one chain of isotridecanoic acid at the C-4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin. A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). BTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238).

PW_C096732

Image HMDB0240216: View Metabocard

Lafutidine

Lafutidine, also known as protecadin or FRG 8813, belongs to the class of organic compounds known as alkyl aryl ethers. These are organic compounds containing the alkyl aryl ether functional group with the generic formula R-O-R' , where R is an alkyl group and R' is an aryl group. Lafutidine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, lafutidine is involved in the lafutidine H2-antihistamine action pathway. Lafutidine is a histamine H2-receptor antagonist that inhibits histamine-stimulated gastric acid secretion. Due to the resulting reduction in gastric volume and acidity, lafutidine can be used to treat ulcers and reflux.

PW_C096742

Image HMDB0240218: View Metabocard

Dexchlorpheniramine

Dexchlorpheniramine, also known as polaramin or dapriton, belongs to the class of organic compounds known as pheniramines. Pheniramines are compounds containing a pheniramine moiety, which is structurally characterized by the presence of a 2-benzylpyridine linked to an dimethyl(propyl)amine to form a dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine skeleton. Dexchlorpheniramine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, dexchlorpheniramine is involved in the dexchlorpheniramine H1-antihistamine action pathway. Dexchlorpheniramine is the S-enantiomer of chlorphenamine (chloropheniramine) and is a first-generation alkylamine H1-antihistamine.

PW_C096744

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Talastine

Talastine, also known as aganon or HL 2186, belongs to the class of organic compounds known as phthalazinones. Phthalazinones are compounds containing a phthalazine bearing a ketone group. Talastine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, talastine is involved in the talastine H1-antihistamine action pathway. Talastine is a first-generation alkylamine H1-antihistamine.

PW_C096745

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Histapyrrodine

Histapyrrodine, also known as domistan or luvistin, belongs to the class of organic compounds known as phenylbenzamines. These are aromatic compounds consisting of a benzyl group that is N-linked to a benzamine. Histapyrrodine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, histapyrrodine is involved in the histapyrrodine H1-antihistamine action pathway. Histapyrrodine is a first-generation ethylenediamine H1-antihistamine.

PW_C096746

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Methapyrilene

Methapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979 (DB04819). Methapyrilene is a first-generation ethylenediamine H1-antihistamine.

PW_C096747

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Thonzylamine

Thonzylamine, also known as tonamil or neohetramine, belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof. Thonzylamine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, thonzylamine is involved in the thonzylamine H1-antihistamine action pathway. Thonzylamine is a first-generation ethylenediamine H1-antihistamine.

PW_C096748

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Chlorphenoxamine

Chlorphenoxamine, also known as systral or phenoxene, belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups. Chlorphenoxamine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, chlorphenoxamine is involved in the chlorphenoxamine H1-antihistamine action pathway. Chlorphenoxamine is a first-generation ethanolamine H1-antihistamine.

PW_C096749

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Phenyltoloxamine

Phenyltoloxamine, also known as phenoxadrin or antin, belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups. Phenyltoloxamine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, phenyltoloxamine is involved in the phenyltoloxamine H1-antihistamine action pathway. Phenyltoloxamine is a first-generation ethanolamine H1-antihistamine.

PW_C096750

Image HMDB0240224: View Metabocard

Chlorcyclizine

Chlorcyclizine, also known as di-paralene or histachlorazine, belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups. Chlorcyclizine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, chlorcyclizine is involved in the chlorcyclizine H1-antihistamine action pathway. Chlorcyclizine is a first-generation piperazine H1-antihistamine.

PW_C096751

Image HMDB0240225: View Metabocard

Oxatomide

Oxatomide, also known as celtect or tinset, belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups. Oxatomide is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, oxatomide is involved in the oxatomide H1-antihistamine action pathway. Oxatomide is a first-generation piperazine H1-antihistamine.

PW_C096754

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Levocetirizine

Levocetirizine, also known as xazal or xusal, belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups. Levocetirizine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, levocetirizine is involved in the levocetirizine H1-antihistamine action pathway. Levocetirizine is a second-generation piperazine H1-antihistamine. It has also been labeled as a third-generation antihistamine because it is developed from a second-generation antihistamine (cetirizine).

PW_C096755

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Phenbenzamine

Phenbenzamine, also known as viternum or cyproheptadine, belongs to the class of organic compounds known as phenylbenzamines. These are aromatic compounds consisting of a benzyl group that is N-linked to a benzamine. Phenbenzamine is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, phenbenzamine is involved in the phenbenzamine H1-antihistamine action pathway. Promethazine is a first-generation ethylenediamine H1-antihistamine.
Showing 55641 - 55660 of 55723 compounds