CHEBI:16015
ChEBI
388356
ChemSpider
6022
PubChem-compound
C23H38N7O17P3S
Acetyl-CoA
809.1258
937
ChemSpider
1.0
Cytidine triphosphate
CHEBI:16134
ChEBI
388352
ChemSpider
1.0
9271300
ChemSpider
UDP-N-acetylhexosamine pyrophosphorylase
Unknown
HMDB0003362
HMDB
HMDB0001062
HMDB
6133
PubChem-compound
CHEBI:62165
ChEBI
C00329
KEGG Compound
1.0
ATP
BioCyc
CHEBI:16264
ChEBI
53188-23-1
CAS
C15H26N2O12
Chitobiose
426.14856
C8H16NO9P
N-Acetyl-D-Glucosamine 6-Phosphate
301.05627
Putative N-acetylglucosamine-6-phosphate deacetylase
559142
ChemSpider
Sialin
N-acylneuraminate cytidylyltransferase
P46926
UniProt
1.0
5746
ChemSpider
5742
ChemSpider
1.0
17216232
ChemSpider
Hexokinase-1
Pyrophosphate
Cytidine monophosphate N-acetylneuraminic acid
Transport264
false
N-Acetylneuraminic acid (↔) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Lysosome
LEFT_TO_RIGHT
CHEBI:63154
ChEBI
6031
PubChem-compound
Q8TBE9
UniProt
C00461
KEGG Compound
439174
PubChem-compound
C01674
KEGG Compound
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
440273
PubChem-compound
440272
PubChem-compound
PPI
BioCyc
Sialic acid synthase
138-08-9
CAS
CHEBI:17029
ChEBI
O95394
UniProt
392810
ChemSpider
388319
ChemSpider
C5H10N2O3
L-Glutamine
146.06914
C00352
KEGG Compound
L-Glutamic acid
Cytosol
C00357
KEGG Compound
1.0
131-48-6
CAS
395082
ChemSpider
N-ACETYLNEURAMINATE
BioCyc
Phosphoenolpyruvic acid
Fructose 6-phosphate
C6H12O6
D-Fructose
180.06339
C00009
KEGG Compound
C00008
KEGG Compound
3616-42-0
CAS
C00128
KEGG Compound
C8H16NO9P
N-Acetyl-D-mannosamine 6-phosphate
301.05627
1.0
C00001
KEGG Compound
CTP
BioCyc
CHEBI:18361
ChEBI
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
1031
ChemSpider
4.0
C8H15NO6
N-Acetylmannosamine
221.08994
388775
ChemSpider
1.0
Adenosine triphosphate
C00010
KEGG Compound
FRUCTOSE-6P
BioCyc
C00015
KEGG Compound
C00014
KEGG Compound
C6H14NO8P
Glucosamine 6-phosphate
259.04572
C00013
KEGG Compound
CHEBI:7125
ChEBI
Q9NR45
UniProt
C00140
KEGG Compound
1.0
Q9BXD5
UniProt
D-GLUCOSAMINE-6-P
BioCyc
Pyruvic acid
N-Acetyl-D-mannosamine 6-phosphate
Chitin
C00022
KEGG Compound
56-65-5
CAS
C00025
KEGG Compound
SMILES
[H][C@]1(O[C@](C[C@H](O)[C@H]1NC(C)=O)(OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(N)=NC1=O)C(O)=O)[C@H](O)[C@H](O)CO
C00024
KEGG Compound
62713
ChemSpider
ACET
BioCyc
N-Acetyl-D-glucosamine
N-ACETYL-D-MANNOSAMINE
BioCyc
N-Acetylneuraminate 9-phosphate
577-76-4
CAS
C00033
KEGG Compound
C02336
KEGG Compound
N-ACETYL-D-GLUCOSAMINE-1-P
BioCyc
1.0
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Glucosamine 6-phosphate
HMDB0000250
HMDB
SMILES
OP(O)(=O)OP(O)(O)=O
HMDB0001341
HMDB
Q9Y223
UniProt
P06865
UniProt
2.0
C00043
KEGG Compound
L-Glutamine
56-85-9
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
N-acylglucosamine 2-epimerase
4.0
HMDB0000148
HMDB
PHOSPHO-ENOL-PYRUVATE
BioCyc
C9H14N2O12P2
Uridine 5'-diphosphate
404.0022
Uridine 5'-diphosphate
53477814
PubChem-compound
1.0
UTP
BioCyc
HMDB0000263
HMDB
SMILES
OC(=O)C(=C)OP(O)(O)=O
389821
ChemSpider
2.0
5903
ChemSpider
Fructose 6-phosphate
CHEBI:47977
ChEBI
Beta-hexosaminidase subunit alpha
399508
ChemSpider
SMILES
CC(O)=O
N-acylglucosamine 2-epimerase
Adenosine diphosphate
2.0
Hexokinase-1
7732-18-5
CAS
C24H41N3O16
Chitin
627.24866
Sialic acid synthase
Glucosamine-6-phosphate isomerase 1
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
11096158
PubChem-compound
HMDB0001367
HMDB
N-Acetylneuraminic acid
C00063
KEGG Compound
AMMONIA
BioCyc
SMILES
N
56-86-0
CAS
HMDB0001129
HMDB
Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N-acetylmannosamine kinase
SMILES
[H][C@]1(O[C@@](O)(C[C@H](O)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO
SMILES
CC(=O)N[C@H]1[C@H](O)CC(O)(O[C@@H]1[C@H](O)[C@H](O)COP(O)(O)=O)C(O)=O
Adenosine diphosphate
14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
BioCyc
HMDB0001121
HMDB
Uridine diphosphate-N-acetylglucosamine
C10H16N5O13P3
Adenosine triphosphate
506.99576
Q06210
UniProt
445675
PubChem-compound
C00064
KEGG Compound
6866-69-9
CAS
1.0
Pyrophosphate
HMDB0003556
HMDB
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
SMILES
CC(=O)C(O)=O
Q8NFW8
UniProt
65-47-4
CAS
C00074
KEGG Compound
Ammonia
Adenosine triphosphate
HMDB0000042
HMDB
1.0
HMDB0001254
HMDB
HMDB0000285
HMDB
C19910
KEGG Compound
962
PubChem-compound
5800
ChemSpider
58-98-0
CAS
C00075
KEGG Compound
Transport10405
false
N-Acetyl-D-glucosamine (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Lysosome
LEFT_TO_RIGHT
C00085
KEGG Compound
HMDB0000290
HMDB
HMDB0000051
HMDB
HMDB0002111
HMDB
Q9Y303
UniProt
SMILES
N[C@@H](CCC(O)=O)C(O)=O
HMDB0000295
HMDB
5809
ChemSpider
Glutamine--fructose-6-phosphate aminotransferase
CHEBI:44897
ChEBI
CHEBI:45744
ChEBI
14265-44-2
CAS
6176
PubChem-compound
PYRUVATE
BioCyc
1.0
58-64-0
CAS
22833609
PubChem-compound
CMP-N-ACETYL-NEURAMINATE
BioCyc
644102
PubChem-compound
444493
PubChem-compound
5941
ChemSpider
P51606
UniProt
SMILES
CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O
ACETYL-COA
BioCyc
CHEBI:18050
ChEBI
H2O
Water
18.010565
SMILES
OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O
SMILES
N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
Glucosamine
7772-94-3
CAS
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O
Nucleus
N-Acetyl-D-Glucosamine 6-Phosphate
1.0
Glucosamine-6-phosphate isomerase 1
102029-88-9
CAS
1.0
1.0
SMILES
CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OP(O)(O)=O
N-Acetyl-D-glucosamine
3063-71-6
CAS
980
ChemSpider
6.0
HMDB0000082
HMDB
1.0
HMDB0001176
HMDB
30572
ChemSpider
2.7.1.1
false
2.7.1.1
Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate
LEFT_TO_RIGHT
N-acylneuraminate cytidylyltransferase
CPD-535
BioCyc
2.7.1.1
false
2.7.1.1
Adenosine triphosphate + Glucosamine → Adenosine diphosphate + Glucosamine 6-phosphate
LEFT_TO_RIGHT
C2H4O2
Acetic acid
60.02113
5.1.3.8
false
5.1.3.8
N-Acetyl-D-glucosamine ↔ N-Acetylmannosamine
REVERSIBLE
Reaction637
false
Uridine diphosphate-N-acetylglucosamine + Water → N-Acetylmannosamine + Uridine 5'-diphosphate
LEFT_TO_RIGHT
Reaction635
false
N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine
LEFT_TO_RIGHT
N-Acetylmannosamine
C11H20NO12P
N-Acetylneuraminate 9-phosphate
389.07233
64-19-7
CAS
Chitobiose
SMILES
O
5.4.2.3
false
5.4.2.3
N-Acetyl-D-Glucosamine 6-Phosphate ↔ N-Acetyl-glucosamine 1-phosphate
REVERSIBLE
H3N
Ammonia
17.026548
2.6.1.16
false
2.6.1.16
Fructose 6-phosphate + L-Glutamine → Glucosamine 6-phosphate + L-Glutamic acid
LEFT_TO_RIGHT
C11H19NO9
N-Acetylneuraminic acid
309.106
21252321
PubChem-compound
N-acylglucosamine 2-epimerase
439709
PubChem-compound
N-ACETYL-D-MANNOSAMINE-6P
BioCyc
2.7.7.43
false
2.7.7.43
Cytidine triphosphate + N-Acetylneuraminic acid ↔ Cytidine monophosphate N-acetylneuraminic acid + Pyrophosphate
REVERSIBLE
HMDB0000538
HMDB
1005
PubChem-compound
1.0
5961
PubChem-compound
448209
PubChem-compound
Amino Sugar Metabolism
643-13-0
CAS
528-04-1
CAS
6816
PubChem-compound
Water
HMDB0001514
HMDB
Reaction643
false
N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvic acid + Water ↔ N-Acetylneuraminate 9-phosphate + Phosphate
REVERSIBLE
3.1.3.29
false
3.1.3.29
N-Acetylneuraminate 9-phosphate + Water → N-Acetylneuraminic acid + Phosphate
LEFT_TO_RIGHT
4.1.3.3
false
4.1.3.3
N-Acetylneuraminic acid → N-Acetylmannosamine + Pyruvic acid
LEFT_TO_RIGHT
TransportCatalysis1571
ACTIVATION
2.7.1.59
false
2.7.1.59
Adenosine triphosphate + N-Acetyl-D-glucosamine ↔ Adenosine diphosphate + N-Acetyl-D-Glucosamine 6-Phosphate
REVERSIBLE
ADP
BioCyc
Reaction642
false
Adenosine triphosphate + N-Acetylmannosamine → Adenosine diphosphate + N-Acetyl-D-mannosamine 6-phosphate
LEFT_TO_RIGHT
C3H4O3
Pyruvic acid
88.016045
Reaction640
false
N-Acetylmannosamine + Phosphoenolpyruvic acid + Water → N-Acetylneuraminic acid + Phosphate
LEFT_TO_RIGHT
HMDB0000660
HMDB
N-Acetylneuraminic acid
ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
BioCyc
Lysosome
N-ACETYL-D-GLUCOSAMINE-6-P
BioCyc
1.0
Chitotriosidase-1
C04256
KEGG Compound
N-acetyl-D-glucosamine kinase
C04257
KEGG Compound
1.0
GO:0005829
GENE ONTOLOGY
Phosphoacetylglucosamine mutase
393240
ChemSpider
CHITOBIOSE
BioCyc
1.0
Glucosamine 6-phosphate
1.0
CHEBI:15713
ChEBI
H3O4P
Phosphate
97.9769
D-Fructose
2.0
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O
CHEBI:15946
ChEBI
Acetyl-CoA
C8H15NO6
N-Acetyl-D-glucosamine
221.08994
TransportCatalysis221
ACTIVATION
Q16222
UniProt
N-acetylneuraminate lyase
873185-52-5
CAS
Phosphoacetylglucosamine mutase
217
ChemSpider
C9H15N2O15P3
Uridine triphosphate
483.96854
HMDB0001423
HMDB
N-acylneuraminate cytidylyltransferase
HMDB0000215
HMDB
SMILES
OP(O)(O)=O
C6H13NO5
Glucosamine
179.07938
1398-61-4
CAS
C6H13O9P
Fructose 6-phosphate
260.02972
SMP0000045
SMPDB
GO:0005764
GENE ONTOLOGY
C17H27N3O17P2
Uridine diphosphate-N-acetylglucosamine
607.08154
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
HMDB0001429
HMDB
SMILES
CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
C8H16NO9P
N-Acetyl-glucosamine 1-phosphate
301.05627
GLN
BioCyc
7664-41-7
CAS
GLT
BioCyc
GO:0005634
GENE ONTOLOGY
69507
PubChem-compound
445063
PubChem-compound
Chitotriosidase-1
UDP-N-acetylhexosamine pyrophosphorylase
Sialin
222
PubChem-compound
H4O7P2
Pyrophosphate
177.94322
C06241
KEGG Compound
1.0
5957
PubChem-compound
HMDB0001206
HMDB
C9H16N3O14P3
Cytidine triphosphate
482.9845
GO:0005741
GENE ONTOLOGY
1.0
HMDB0000230
HMDB
3.5.99.6
false
3.5.99.6
Glucosamine 6-phosphate + Water → Ammonia + Fructose 6-phosphate
LEFT_TO_RIGHT
3.5.1.25
false
3.5.1.25
N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate
LEFT_TO_RIGHT
CHEBI:15873
ChEBI
2.3.1.4
false
2.3.1.4
Acetyl-CoA + Glucosamine 6-phosphate → Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphate
LEFT_TO_RIGHT
3.2.1.52
false
3.2.1.52
Chitobiose + Water → 2 N-Acetyl-D-glucosamine
LEFT_TO_RIGHT
3.2.1.14
false
3.2.1.14
Chitin → N-Acetyl-D-glucosamine
LEFT_TO_RIGHT
3.2.1.14
false
3.2.1.14
Chitin → Chitobiose
LEFT_TO_RIGHT
Beta-hexosaminidase subunit alpha
N-acetylneuraminate lyase
N-acylneuraminate-9-phosphatase
2.0
N-Acetylneuraminic acid
440996
PubChem-compound
N-acetylneuraminate lyase
Glucosamine-6-phosphate isomerase 1
Uridine triphosphate
HMDB0000243
HMDB
C3H5O6P
Phosphoenolpyruvic acid
167.98238
HMDB0000124
HMDB
C10H15N5O10P2
Adenosine diphosphate
427.02942
GO:0005737
GENE ONTOLOGY
Coenzyme A
Mitochondrial Outer Membrane
Glucosamine 6-phosphate N-acetyltransferase
CPD-8587
BioCyc
SMILES
N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
Putative N-acetylglucosamine-6-phosphate deacetylase
UDP
BioCyc
CHEBI:1146900
ChEBI
P19367
UniProt
CHEBI:28645
ChEBI
1.0
Glucosamine 6-phosphate N-acetyltransferase
1.0
14000-31-8
CAS
CO-A
BioCyc
72-89-9
CAS
C21H36N7O16P3S
Coenzyme A
767.11523
1.0
1.0
Cytoplasm
1.0
1.0
1.0
CHEBI:15784
ChEBI
CHEBI:15422
ChEBI
6557
ChemSpider
Homo sapiens
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
1.0
439213
PubChem-compound
127-17-3
CAS
3416-24-8
CAS
439217
PubChem-compound
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
Q9NRA2
UniProt
Water
Glucosamine 6-phosphate N-acetyltransferase
N-acetyl-D-glucosamine kinase
N-acylneuraminate-9-phosphatase
UDP-N-ACETYL-D-GLUCOSAMINE
BioCyc
SMILES
CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
SMILES
CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(O)=O)[C@@H]1O
CHEBI:16761
ChEBI
GLUCOSAMINE
BioCyc
CHEBI:506227
ChEBI
HMDB0006268
HMDB
9606
TAXONOMY
CHEBI:15366
ChEBI
ReactionCatalysis113
ACTIVATION
ReactionCatalysis114
ACTIVATION
389249
ChemSpider
ReactionCatalysis111
ACTIVATION
389248
ChemSpider
ReactionCatalysis112
ACTIVATION
ReactionCatalysis110
ACTIVATION
Q13231
UniProt
392413
ChemSpider
1.0
SMILES
CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O)[C@H]2NC(C)=O)[C@@H]1O
Q96EK6
UniProt
1.0
N-Acetyl-glucosamine 1-phosphate
N-acetyl-D-glucosamine kinase
ReactionCatalysis108
ACTIVATION
ReactionCatalysis109
ACTIVATION
171
ChemSpider
CHEBI:32816
ChEBI
ReactionCatalysis107
ACTIVATION
1.0
CHEBI:15377
ChEBI
CHEBI:17677
ChEBI
Unknown
C20H31N4O16P
Cytidine monophosphate N-acetylneuraminic acid
614.1473
C00645
KEGG Compound
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
4.0
1.0
Phosphate
1.0
PW000008
PathWhiz
1.0
CHEBI:16556
ChEBI
Q9UJ70
UniProt
Acetic acid
SMILES
N[C@@H](CCC(N)=O)C(O)=O
1.0
30776539
ChemSpider
ReactionCatalysis128
ACTIVATION
ReactionCatalysis129
ACTIVATION
ReactionCatalysis126
ACTIVATION
ReactionCatalysis127
ACTIVATION
ReactionCatalysis124
ACTIVATION
1060
PubChem-compound
63-39-8
CAS
1061
PubChem-compound
ReactionCatalysis125
ACTIVATION
ReactionCatalysis122
ACTIVATION
ReactionCatalysis123
ACTIVATION
ReactionCatalysis120
ACTIVATION
CHEBI:17659
ChEBI
ReactionCatalysis121
ACTIVATION
N-Acetylneuraminic acid
SMILES
CC(=O)N[C@@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
CHEBI:15351
ChEBI
SMILES
OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
1.0
176
PubChem-compound
HMDB0000641
HMDB
SMILES
CC(=O)N[C@@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
85-61-0
CAS
ReactionCatalysis119
ACTIVATION
7512-17-6
CAS
ReactionCatalysis116
ACTIVATION