Tyrosine
aminotransferase
Aspartate
aminotransferase,
cytoplasmic
4-
hydroxyphenylpyruvate
dioxygenase
Maleylacetoacetate
isomerase
Fumarylacetoacetase
Aromatic-L-
amino-acid
decarboxylase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Tyrosinase
Dopamine beta-
hydroxylase
Aromatic-L-
amino-acid
decarboxylase
Tyrosinase
Tyrosinase
Tyrosinase
L-dopachrome
tautomerase
Tyrosinase
Phenylethanolamine
N-
methyltransferase
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Alcohol
dehydrogenase
1A
Homogentisate
1,2-dioxygenase
Macrophage
migration
inhibitory
factor
Amiloride-
sensitive amine
oxidase
[copper-
containing]
Amine oxidase
[flavin-
containing] A
Tyrosinase
Catechol O-
methyltransferase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Catechol O-
methyltransferase
Catechol O-
methyltransferase
Catechol O-
methyltransferase
Catechol O-
methyltransferase
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
3-
hydroxyanthranilate
3,4-dioxygenase
Catechol O-
methyltransferase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Accumulation
L-Tyrosine
Oxoglutaric acid
4-Hydroxyphenylpyruvic acid
L-Glutamic acid
L-Aspartic acid
Oxalacetic acid
O2
Homogentisic acid
CO2
Accumulation
Maleylacetoacetic acid
Accumulation
4-Fumarylacetoacetic acid
H2O
Acetoacetic acid
Fumaric acid
Tyramine
CO2
Homovanillin
NADP
H2O
p-Hydroxyphenylacetic acid
NADPH
O2
Dopamine
H2O
Ascorbic acid
O2
Norepinephrine
Dehydroascorbic acid
H2O
L-Dopa
Tetrahydrobiopterin
4a-Hydroxytetrahydrobiopterin
O2
Dopaquinone
H2O
Leucodopachrome
L-Dopachrome
O2
5,6-Dihydroxyindole
H2O
O2
Indole-5,6-quinone
H2O
Melanin
5,6-Dihydroxyindole-2-
carboxylic acid
O2
H2O
S-Adenosylmethionine
S-Adenosylhomocysteine
Epinephrine
H2O
O2
3,4-Dihydroxymandelaldehyde
NH3
H2O2
H2O
O2
Methylamine
H2O2
Normetanephrine
H2O
O2
3-Methoxy-4-
hydroxyphenylglycolaldehyde
NH3
H2O2
Metanephrine
H2O
O2
NH3
H2O2
NAD
H2O
3,4-Dihydroxymandelic acid
NADH
H+
NAD
NADH
3,4-Dihydroxyphenylglycol
O2
2-Hydroxy-3-(4-
hydroxyphenyl)propenoic acid
H2O
O2
H2O2
NH3
H2O
O2
H2O2
NH3
O2
H2O
Guaiacol
Pyrocatechol
NADP
H2O
Vanillylmandelic acid
NADPH
Guaiacol
Pyrocatechol
Guaiacol
Vanylglycol
Pyrocatechol
Guaiacol
Pyrocatechol
Guaiacol
3-Methoxytyramine
Pyrocatechol
H2O
O2
3,4-
Dihydroxyphenylacetaldehyde
NH3
H2O2
H2O
O2
Homovanillin
H2O2
NH3
NAD
H2O
3,4-Dihydroxybenzeneacetic
acid
NADH
H+
Guaiacol
Homovanillic acid
Pyrocatechol
NAD
H2O
NADH
H+
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Pyrroloquinoline
quinone
Copper
Copper
Copper
Copper
FAD
FAD
Zinc
Topaquinone
Copper
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
FAD
FAD
Fe2+
Magnesium
Phenylalanine
and Tyrosine
Metabolism
Thyroid Hormone
Synthesis
Fe3+
Magnesium
Copper
Pyridoxal
5'-phosphate
Zinc
Copper
FAD
FAD
Iron
Copper
Calcium
FAD
Calcium
Cytosol
Extracellular space
Melanosome
Melanosome
Melanosome