Practolol (also known as Eraldin or Dalzic) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Practolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to decreased blood pressure, heart rate and cardiac output. Practolol can also bind beta-2 adrenergic receptors in juxtaglomerular apparatus and bronchiole smooth muscle. In juxtaglomerular apparatus, practolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction. In bronchiole smooth muscle, binding of practolol to beta-2 adrenergic receptors can also prevent vasoconstriction.

Practolol Pathway References

Striated Muscle Contraction References