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  <cached-name>Glycine Biosynthesis</cached-name>
  <cached-description>Glycine biosynthesis is dependent on L-serine. L-serine is enters the cell through transporters (serine / threonine:H+ symporter TdcC, serine/threonine: Na symporter , serine:H+ symporter SdaC) and then proceeds through reversible reaction with a tetrahydrofolic acid through a serine hydroxymethyltransferase enzyme in order to produce glycine, 5,10-methylene tetrahydrofolate and water. 5,10-methylene tetrahydrofolate is a major source of one-carbon units used in other metabolic pathways.</cached-description>
  <cached-subject>Metabolic</cached-subject>
  <pw-id>PW000808</pw-id>
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          <id type="integer">572</id>
          <name>Glycine Biosynthesis</name>
          <description>Glycine biosynthesis is dependent on L-serine. L-serine is enters the cell through transporters (serine / threonine:H+ symporter TdcC, serine/threonine: Na symporter , serine:H+ symporter SdaC) and then proceeds through reversible reaction with a tetrahydrofolic acid through a serine hydroxymethyltransferase enzyme in order to produce glycine, 5,10-methylene tetrahydrofolate and water. 5,10-methylene tetrahydrofolate is a major source of one-carbon units used in other metabolic pathways.</description>
          <subject>Metabolic</subject>
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            <sub-pathway>
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              <altext>Endocytosis</altext>
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            <reference>
              <id type="integer">2296</id>
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              <text>Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.</text>
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            </reference>
          </references>
          <references>
            <reference>
              <id type="integer">332574</id>
              <pubmed-id>25988590</pubmed-id>
              <text>Sah S, Varshney U: Impact of Mutating the Key Residues of a Bifunctional 5,10-Methylenetetrahydrofolate Dehydrogenase-Cyclohydrolase from Escherichia coli on Its Activities. Biochemistry. 2015 Jun 9;54(22):3504-13. doi: 10.1021/acs.biochem.5b00400. Epub 2015 May 28.</text>
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          <cell-type>
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            <name>Cell</name>
            <ontology-id>CL:0000000</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">10</id>
            <name>Glial cell</name>
            <ontology-id>CL:0000125</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">3</id>
            <name>Neuron</name>
            <ontology-id>CL:0000540</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">5</id>
            <name>Hepatocyte</name>
            <ontology-id>CL:0000182</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">12</id>
            <name>Astrocyte</name>
            <ontology-id>CL:0000127</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">7</id>
            <name>Epithelial Cell</name>
            <ontology-id>CL:0000066</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">4</id>
            <name>Cardiomyocyte</name>
            <ontology-id>CL:0000746</ontology-id>
          </cell-type>
        </cell-types>
        <species>
          <species>
            <id type="integer">1</id>
            <name>Homo sapiens</name>
            <taxonomy-id>9606</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Human</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">3</id>
            <name>Escherichia coli</name>
            <taxonomy-id>562</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name></common-name>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">24</id>
            <name>Solanum lycopersicum</name>
            <taxonomy-id>4081</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Tomato</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">18</id>
            <name>Saccharomyces cerevisiae</name>
            <taxonomy-id>4932</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Yeast</common-name>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">4</id>
            <name>Arabidopsis thaliana</name>
            <taxonomy-id>3702</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Thale cress</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">23</id>
            <name>Pseudomonas aeruginosa</name>
            <taxonomy-id>287</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name></common-name>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">12</id>
            <name>Mus musculus</name>
            <taxonomy-id>10090</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Mouse</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">5</id>
            <name>Bos taurus</name>
            <taxonomy-id>9913</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Cattle</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">17</id>
            <name>Rattus norvegicus</name>
            <taxonomy-id>10116</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Rat</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">10</id>
            <name>Drosophila melanogaster</name>
            <taxonomy-id>7227</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Fruit fly</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">6</id>
            <name>Caenorhabditis elegans</name>
            <taxonomy-id>6239</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Roundworm</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">2</id>
            <name>Bacteria</name>
            <taxonomy-id>2</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name>Bacteria</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">21</id>
            <name>Xenopus laevis</name>
            <taxonomy-id>8355</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>African clawed frog</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">25</id>
            <name>Escherichia coli (strain K12)</name>
            <taxonomy-id>83333</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">60</id>
            <name>Nitzschia sp.</name>
            <taxonomy-id>0001</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Nitzschia4</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">202</id>
            <name>Spathaspora passalidarum</name>
            <taxonomy-id>340170</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Spathaspora passalidarum</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">19</id>
            <name>Schizosaccharomyces pombe</name>
            <taxonomy-id>4896</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name></common-name>
            <gram-stain>positive</gram-stain>
          </species>
          <species>
            <id type="integer">49</id>
            <name>Bathymodiolus platifrons</name>
            <taxonomy-id>220390</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Deep sea mussel</common-name>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">1155</id>
            <name>Escherichia coli O157:H7 str. Sakai</name>
            <taxonomy-id>386585</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1156</id>
            <name>Escherichia coli 536</name>
            <taxonomy-id>362663</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1157</id>
            <name>Escherichia coli APEC O1</name>
            <taxonomy-id>405955</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1158</id>
            <name>Escherichia coli E24377A</name>
            <taxonomy-id>331111</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1159</id>
            <name>Escherichia coli HS</name>
            <taxonomy-id>331112</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1160</id>
            <name>Escherichia coli str. K-12 substr. DH10B</name>
            <taxonomy-id>316385</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1161</id>
            <name>Escherichia coli O157:H7 str. EC4115</name>
            <taxonomy-id>444450</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1162</id>
            <name>Escherichia coli O127:H6 str. E2348/69</name>
            <taxonomy-id>574521</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1163</id>
            <name>Escherichia coli UMN026</name>
            <taxonomy-id>585056</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1165</id>
            <name>Escherichia coli IAI1</name>
            <taxonomy-id>585034</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1166</id>
            <name>Escherichia coli S88</name>
            <taxonomy-id>585035</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1167</id>
            <name>Escherichia coli ED1a</name>
            <taxonomy-id>585397</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1168</id>
            <name>Escherichia coli IAI39</name>
            <taxonomy-id>585057</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1169</id>
            <name>Escherichia coli O157:H7 str. TW14359</name>
            <taxonomy-id>544404</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1170</id>
            <name>Escherichia coli O103:H2 str. 12009</name>
            <taxonomy-id>585395</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1171</id>
            <name>Escherichia coli O26:H11 str. 11368</name>
            <taxonomy-id>573235</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1172</id>
            <name>Escherichia coli O111:H- str. 11128</name>
            <taxonomy-id>585396</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1173</id>
            <name>Escherichia coli O55:H7 str. CB9615</name>
            <taxonomy-id>701177</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">26</id>
            <name>Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)</name>
            <taxonomy-id>481805</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">27</id>
            <name>Escherichia coli (strain SMS-3-5 / SECEC)</name>
            <taxonomy-id>439855</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">28</id>
            <name>Escherichia coli (strain UTI89 / UPEC)</name>
            <taxonomy-id>364106</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">32</id>
            <name>Escherichia coli (strain 55989 / EAEC)</name>
            <taxonomy-id>585055</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">33</id>
            <name>Escherichia coli (strain SE11)</name>
            <taxonomy-id>409438</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">34</id>
            <name>Escherichia coli (strain K12 / MC4100 / BW2952)</name>
            <taxonomy-id>595496</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">35</id>
            <name>Escherichia coli (strain ATCC 55124 / KO11)</name>
            <taxonomy-id>595495</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">36</id>
            <name>Escherichia coli (strain B / REL606)</name>
            <taxonomy-id>413997</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">37</id>
            <name>Escherichia coli (strain B / BL21-DE3)</name>
            <taxonomy-id>469008</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">39</id>
            <name>Escherichia coli (strain MS 21-1)</name>
            <taxonomy-id>749527</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">76</id>
            <name>Escherichia coli DORA_B_14</name>
            <taxonomy-id>1403944</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain nil="true"/>
          </species>
          <species>
            <id type="integer">77</id>
            <name>Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)</name>
            <taxonomy-id>199310</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">255</id>
            <name>Escherichia coli str. K-12 substr. MG1655</name>
            <taxonomy-id>511145</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">335</id>
            <name>Escherichia coli O157:H7</name>
            <taxonomy-id>83334</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">346</id>
            <name>Escherichia coli K-12</name>
            <taxonomy-id>679895</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name>E. coli K-12</common-name>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">462</id>
            <name>Escherichia coli SE15</name>
            <taxonomy-id>431946</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1240</id>
            <name>Escherichia coli 042</name>
            <taxonomy-id>216592</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1241</id>
            <name>Escherichia coli W</name>
            <taxonomy-id>566546</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1243</id>
            <name>Escherichia coli IHE3034</name>
            <taxonomy-id>714962</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">1258</id>
            <name>Escherichia coli DH1</name>
            <taxonomy-id>536056</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain>negative</gram-stain>
          </species>
          <species>
            <id type="integer">2466</id>
            <name>Escherichia coli O113:H21</name>
            <taxonomy-id>1078021</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
            <gram-stain nil="true"/>
          </species>
        </species>
        <subcellular-locations>
          <subcellular-location>
            <id type="integer">5</id>
            <name>Cytoplasm</name>
            <ontology-id>GO:0005737</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">1</id>
            <name>Cytosol</name>
            <ontology-id>GO:0005829</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">3</id>
            <name>Mitochondrial Matrix</name>
            <ontology-id>GO:0005759</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">31</id>
            <name>Periplasmic Space</name>
            <ontology-id>GO:0005620</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">11</id>
            <name>Extracellular Space</name>
            <ontology-id>GO:0005615</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">2</id>
            <name>Mitochondrion</name>
            <ontology-id>GO:0005739</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">35</id>
            <name>Chloroplast</name>
            <ontology-id>GO:0009507</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">13</id>
            <name>Endoplasmic Reticulum</name>
            <ontology-id>GO:0005783</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">7</id>
            <name>Endoplasmic Reticulum Membrane</name>
            <ontology-id>GO:0005789</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">12</id>
            <name>Mitochondrial Inner Membrane</name>
            <ontology-id>GO:0005743</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">14</id>
            <name>Mitochondrial Outer Membrane</name>
            <ontology-id>GO:0005741</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">24</id>
            <name>Mitochondrial Intermembrane Space</name>
            <ontology-id>GO:0005758</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">4</id>
            <name>Peroxisome</name>
            <ontology-id>GO:0005777</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">10</id>
            <name>Cell Membrane</name>
            <ontology-id>GO:0005886</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">36</id>
            <name>Membrane</name>
            <ontology-id>GO:0016020</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">53</id>
            <name>Endoplasmic Reticulum Body</name>
            <ontology-id>GO:0010168</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">34</id>
            <name>Plant-Type Vacuole</name>
            <ontology-id>GO:0000325</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">32</id>
            <name>Inner Membrane</name>
            <ontology-id>GO:0070258</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">19</id>
            <name>Sarcoplasmic Reticulum</name>
            <ontology-id>GO:0016529</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">15</id>
            <name>Nucleus</name>
            <ontology-id>GO:0005634</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">6</id>
            <name>Lysosome</name>
            <ontology-id>GO:0005764</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">16</id>
            <name>Lysosomal Lumen</name>
            <ontology-id>GO:0043202</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">18</id>
            <name>Melanosome Membrane</name>
            <ontology-id>GO:0033162</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">25</id>
            <name>Golgi Apparatus</name>
            <ontology-id>GO:0005794</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">20</id>
            <name>Endoplasmic Reticulum Lumen</name>
            <ontology-id>GO:0005788</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">21</id>
            <name>Synapse</name>
            <ontology-id>GO:0045202</ontology-id>
          </subcellular-location>
          <subcellular-location>
            <id type="integer">40</id>
            <name>Periplasm</name>
            <ontology-id>GO:0042597</ontology-id>
          </subcellular-location>
        </subcellular-locations>
        <tissues>
          <tissue>
            <id type="integer">7</id>
            <name>Nervous System</name>
            <ontology-id>BTO:0001484</ontology-id>
            <visualization-template-id type="integer" nil="true"/>
            <drawable-image-id type="integer" nil="true"/>
          </tissue>
          <tissue>
            <id type="integer">1</id>
            <name>Liver</name>
            <ontology-id>BTO:0000759</ontology-id>
            <visualization-template-id type="integer">72</visualization-template-id>
            <drawable-image-id type="integer">9</drawable-image-id>
          </tissue>
          <tissue>
            <id type="integer">28</id>
            <name>Stomach</name>
            <ontology-id>BTO:0001307</ontology-id>
            <visualization-template-id type="integer">155</visualization-template-id>
            <drawable-image-id type="integer">26</drawable-image-id>
          </tissue>
          <tissue>
            <id type="integer">8</id>
            <name>Blood Vessel</name>
            <ontology-id>BTO:0001102</ontology-id>
            <visualization-template-id type="integer">74</visualization-template-id>
            <drawable-image-id type="integer">11</drawable-image-id>
          </tissue>
          <tissue>
            <id type="integer">24</id>
            <name>Brain</name>
            <ontology-id>BTO:0000142</ontology-id>
            <visualization-template-id type="integer">89</visualization-template-id>
            <drawable-image-id type="integer">16</drawable-image-id>
          </tissue>
          <tissue>
            <id type="integer">25</id>
            <name>Intestine</name>
            <ontology-id>BTO:0000648</ontology-id>
            <visualization-template-id type="integer" nil="true"/>
            <drawable-image-id type="integer" nil="true"/>
          </tissue>
          <tissue>
            <id type="integer">6</id>
            <name>Kidney</name>
            <ontology-id>BTO:0000671</ontology-id>
            <visualization-template-id type="integer">71</visualization-template-id>
            <drawable-image-id type="integer">8</drawable-image-id>
          </tissue>
          <tissue>
            <id type="integer">5</id>
            <name>cardiocyte</name>
            <ontology-id>BTO:0001539</ontology-id>
            <visualization-template-id type="integer" nil="true"/>
            <drawable-image-id type="integer" nil="true"/>
          </tissue>
          <tissue>
            <id type="integer">4</id>
            <name>Adrenal Medulla</name>
            <ontology-id>BTO:0000049</ontology-id>
            <visualization-template-id type="integer">71</visualization-template-id>
            <drawable-image-id type="integer">8</drawable-image-id>
          </tissue>
          <tissue>
            <id type="integer">11</id>
            <name>Heart</name>
            <ontology-id>BTO:0000562</ontology-id>
            <visualization-template-id type="integer">73</visualization-template-id>
            <drawable-image-id type="integer">10</drawable-image-id>
          </tissue>
        </tissues>
        <biological-states>
          <biological-state>
            <id type="integer">8</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">5</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000008</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">2</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">1</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000002</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">4</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">3</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000004</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">107</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">31</subcellular-location-id>
            <species-id type="integer">3</species-id>
            <cell-type-id type="integer" nil="true"/>
            <pwbs-id>PW_BS000107</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">108</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">1</subcellular-location-id>
            <species-id type="integer">3</species-id>
            <cell-type-id type="integer" nil="true"/>
            <pwbs-id>PW_BS000108</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">105</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">11</subcellular-location-id>
            <species-id type="integer">3</species-id>
            <cell-type-id type="integer" nil="true"/>
            <pwbs-id>PW_BS000105</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">147</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">1</subcellular-location-id>
            <species-id type="integer">24</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000147</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">163</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">2</subcellular-location-id>
            <species-id type="integer">18</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000163</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">201</id>
            <tissue-id type="integer">7</tissue-id>
            <subcellular-location-id type="integer">5</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">10</cell-type-id>
            <pwbs-id>PW_BS000024</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">202</id>
            <tissue-id type="integer">7</tissue-id>
            <subcellular-location-id type="integer">11</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">10</cell-type-id>
            <pwbs-id>PW_BS000024</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">71</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">11</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">3</cell-type-id>
            <pwbs-id>PW_BS000071</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">72</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">5</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">3</cell-type-id>
            <pwbs-id>PW_BS000072</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">160</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">1</subcellular-location-id>
            <species-id type="integer">18</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000160</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">3</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">2</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000003</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">15</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">11</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer" nil="true"/>
            <pwbs-id>PW_BS000015</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">166</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">1</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer" nil="true"/>
            <pwbs-id>PW_BS000166</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">224</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">2</subcellular-location-id>
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            <pwbs-id>PW_BS000024</pwbs-id>
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          <biological-state>
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            <tissue-id type="integer" nil="true"/>
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            <pwbs-id>PW_BS000024</pwbs-id>
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          <biological-state>
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            <pwbs-id>PW_BS000024</pwbs-id>
          </biological-state>
          <biological-state>
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            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">1</subcellular-location-id>
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            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000151</pwbs-id>
          </biological-state>
          <biological-state>
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            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">13</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000018</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">49</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">7</subcellular-location-id>
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            <cell-type-id type="integer">1</cell-type-id>
            <pwbs-id>PW_BS000049</pwbs-id>
          </biological-state>
          <biological-state>
            <id type="integer">318</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">31</subcellular-location-id>
            <species-id type="integer">23</species-id>
            <cell-type-id type="integer" nil="true"/>
            <pwbs-id>PW_BS000024</pwbs-id>
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          <biological-state>
            <id type="integer">315</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">1</subcellular-location-id>
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            <cell-type-id type="integer" nil="true"/>
            <pwbs-id>PW_BS000024</pwbs-id>
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          <biological-state>
            <id type="integer">111</id>
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            <pwbs-id>PW_BS000111</pwbs-id>
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          <biological-state>
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            <subcellular-location-id type="integer">3</subcellular-location-id>
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            <pwbs-id>PW_BS000133</pwbs-id>
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          <biological-state>
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          <biological-state>
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          <biological-state>
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          <biological-state>
            <id type="integer">398</id>
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          <biological-state>
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            <name>L-Serine</name>
            <hmdb-id>HMDB0000187</hmdb-id>
            <description>Serine is a nonessential amino acid derived from glycine. Like all the amino acid building blocks of protein and peptides, serine can become essential under certain conditions, and is thus important in maintaining health and preventing disease. Low-average concentration of serine compared to other amino acids is found in muscle. Serine is highly concentrated in all cell membranes. (http://www.dcnutrition.com/AminoAcids/) L-Serine may be derived from four possible sources: dietary intake; biosynthesis from the glycolytic intermediate 3-phosphoglycerate; from glycine ; and by protein and phospholipid degradation. Little data is available on the relative contributions of each of these four sources of l-serine to serine homoeostasis. It is very likely that the predominant source of l-serine will be very different in different tissues and during different stages of human development. In the biosynthetic pathway, the glycolytic intermediate 3-phosphoglycerate is converted into phosphohydroxypyruvate, in a reaction catalyzed by 3-phosphoglycerate dehydrogenase (3- PGDH; EC 1.1.1.95). Phosphohydroxypyruvate is metabolized to phosphoserine by phosphohydroxypyruvate aminotransferase (EC 2.6.1.52) and, finally, phosphoserine is converted into l-serine by phosphoserine phosphatase (PSP; EC 3.1.3.3). In liver tissue, the serine biosynthetic pathway is regulated in response to dietary and hormonal changes. Of the three synthetic enzymes, the properties of 3-PGDH and PSP are the best documented. Hormonal factors such as glucagon and corticosteroids also influence 3-PGDH and PSP activities in interactions dependent upon the diet. L-serine plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function. (PMID 12534373).</description>
            <cas>56-45-1</cas>
            <kegg-id>C00065</kegg-id>
            <pubchem-cid>5951</pubchem-cid>
            <chebi-id>17115</chebi-id>
            <biocyc-id>SER</biocyc-id>
            <chemspider-id>5736</chemspider-id>
            <drugbank-id>DB00133</drugbank-id>
            <moldb-smiles>N[C@@H](CO)C(O)=O</moldb-smiles>
            <moldb-formula>C3H7NO3</moldb-formula>
            <moldb-inchi>InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1</moldb-inchi>
            <moldb-inchikey>MTCFGRXMJLQNBG-REOHCLBHSA-N</moldb-inchikey>
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            <moldb-average-mass>105.0926</moldb-average-mass>
            <moldb-mono-mass>105.042593095</moldb-mono-mass>
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            <foodb-id>FDB012739</foodb-id>
            <synonyms>(-)-serine;(s)-2-amino-3-hydroxypropanoate;(s)-2-amino-3-hydroxypropanoic acid;(s)-2-amino-3-hydroxy-propanoate;(s)-2-amino-3-hydroxy-propanoic acid;(s)-serine;(s)-a-amino-b-hydroxypropionate;(s)-a-amino-b-hydroxypropionic acid;(s)-alpha-amino-beta-hydroxypropionate;(s)-alpha-amino-beta-hydroxypropionic acid;(s)-b-amino-3-hydroxypropionate;(s)-b-amino-3-hydroxypropionic acid;(s)-beta-amino-3-hydroxypropionate;(s)-beta-amino-3-hydroxypropionic acid;2-amino-3-hydroxypropanoate;2-amino-3-hydroxypropanoic acid;3-hydroxy-l-alanine;L-(-)-serine;L-3-hydroxy-2-aminopropionate;L-3-hydroxy-2-aminopropionic acid;L-3-hydroxy-alanine;L-ser;Serine;B-hydroxy-l-alanine;Beta-hydroxy-l-alanine;Beta-hydroxyalanine;(2s)-2-amino-3-hydroxypropanoic acid;(s)-(-)-serine;L-2-amino-3-hydroxypropionic acid;L-serin;S;Ser;(2s)-2-amino-3-hydroxypropanoate;(s)-α-amino-β-hydroxypropionate;(s)-α-amino-β-hydroxypropionic acid;β-hydroxy-l-alanine;B-hydroxyalanine;β-hydroxyalanine;L-2-amino-3-hydroxypropionate</synonyms>
            <pwc-id>PW_C000120</pwc-id>
            <short-name>Ser</short-name>
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          <compound>
            <id type="integer">458</id>
            <name>Sodium</name>
            <hmdb-id>HMDB0000588</hmdb-id>
            <description>Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste." Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.</description>
            <cas>17341-25-2</cas>
            <kegg-id>C01330</kegg-id>
            <pubchem-cid>923</pubchem-cid>
            <chebi-id>29101</chebi-id>
            <biocyc-id nil="true"/>
            <chemspider-id>899</chemspider-id>
            <drugbank-id nil="true"/>
            <moldb-smiles>[Na+]</moldb-smiles>
            <moldb-formula>Na</moldb-formula>
            <moldb-inchi>InChI=1S/Na/q+1</moldb-inchi>
            <moldb-inchikey>FKNQFGJONOIPTF-UHFFFAOYSA-N</moldb-inchikey>
            <moldb-iupac nil="true"/>
            <moldb-average-mass>22.9898</moldb-average-mass>
            <moldb-mono-mass>22.989769675</moldb-mono-mass>
            <moldb-alogps-logs nil="true"/>
            <moldb-donor-count nil="true"/>
            <moldb-traditional-iupac nil="true"/>
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            <moldb-physiological-charge type="integer" nil="true"/>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB003523</foodb-id>
            <synonyms>Sodium;Sodium ion;Na(+);Na+</synonyms>
            <pwc-id>PW_C000458</pwc-id>
            <short-name>Na+</short-name>
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                <biological-state-id type="integer">15</biological-state-id>
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                <biological-state-id type="integer">2</biological-state-id>
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              <element-state>
                <id type="integer">2724</id>
                <biological-state-id type="integer">60</biological-state-id>
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              <element-state>
                <id type="integer">2725</id>
                <biological-state-id type="integer">61</biological-state-id>
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              <element-state>
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                <biological-state-id type="integer">71</biological-state-id>
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                <biological-state-id type="integer">72</biological-state-id>
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                <biological-state-id type="integer">74</biological-state-id>
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                <biological-state-id type="integer">51</biological-state-id>
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                <biological-state-id type="integer">8</biological-state-id>
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                <biological-state-id type="integer">107</biological-state-id>
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                <biological-state-id type="integer">108</biological-state-id>
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                <id type="integer">7149</id>
                <biological-state-id type="integer">187</biological-state-id>
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                <id type="integer">7150</id>
                <biological-state-id type="integer">188</biological-state-id>
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                <biological-state-id type="integer">318</biological-state-id>
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                <biological-state-id type="integer">315</biological-state-id>
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                <id type="integer">78239</id>
                <biological-state-id type="integer">353</biological-state-id>
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              <element-state>
                <id type="integer">78243</id>
                <biological-state-id type="integer">326</biological-state-id>
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              <element-state>
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                <biological-state-id type="integer">352</biological-state-id>
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                <biological-state-id type="integer">132</biological-state-id>
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                <biological-state-id type="integer">436</biological-state-id>
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                <biological-state-id type="integer">437</biological-state-id>
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                <biological-state-id type="integer">416</biological-state-id>
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                <biological-state-id type="integer">124</biological-state-id>
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                <biological-state-id type="integer">472</biological-state-id>
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                <biological-state-id type="integer">452</biological-state-id>
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                <biological-state-id type="integer">471</biological-state-id>
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                <biological-state-id type="integer">118</biological-state-id>
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                <biological-state-id type="integer">790</biological-state-id>
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                <biological-state-id type="integer">834</biological-state-id>
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                <biological-state-id type="integer">46</biological-state-id>
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                <biological-state-id type="integer">788</biological-state-id>
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                <id type="integer">140741</id>
                <biological-state-id type="integer">597</biological-state-id>
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            <id type="integer">1221</id>
            <name>Tetrahydrofolic acid</name>
            <hmdb-id>HMDB0001846</hmdb-id>
            <description>Tetrahydrofolate is a soluble coenzyme (vitamin B9) that is synthesized de novo by plants and microorganisms, and absorbed from the diet by animals. It is composed of three distinct parts: a pterin ring, a p-ABA (p-aminobenzoic acid) and a polyglutamate chain with a number of residues varying between 1 and 8. Only the tetra-reduced form of the molecule serves as a coenzyme for C1 transfer reactions. In biological systems, the C1-units exist under various oxidation states and the different tetrahydrofolate derivatives constitute a family of related molecules named indistinctly under the generic term folate. (PMID 16042593). Folate is important for cells and tissues that rapidly divide. Cancer cells divide rapidly, and drugs that interfere with folate metabolism are used to treat cancer. Methotrexate is a drug often used to treat cancer because it inhibits the production of the active form, tetrahydrofolate. Unfortunately, methotrexate can be toxic, producing side effects such as inflammation in the digestive tract that make it difficult to eat normally. -- Wikipedia; Signs of folic acid deficiency are often subtle. Diarrhea, loss of appetite, and weight loss can occur. Additional signs are weakness, sore tongue, headaches, heart palpitations, irritability, and behavioral disorders. Women with folate deficiency who become pregnant are more likely to give birth to low birth weight and premature infants, and infants with neural tube defects. In adults, anemia is a sign of advanced folate deficiency. In infants and children, folate deficiency can slow growth rate. Some of these symptoms can also result from a variety of medical conditions other than folate deficiency. It is important to have a physician evaluate these symptoms so that appropriate medical care can be given. -- Wikipedia; Folinic acid is a form of folate that can help 'rescue' or reverse the toxic effects of methotrexate. Folinic acid is not the same as folic acid. Folic acid supplements have little established role in cancer chemotherapy. There have been cases of severe adverse effects of accidental substitution of folic acid for folinic acid in patients receiving methotrexate cancer chemotherapy. It is important for anyone receiving methotrexate to follow medical advice on the use of folic or folinic acid supplements. -- Wikipedia. Low concentrations of folate, vitamin B12, or vitamin B6 may increase the level of homocysteine, an amino acid normally found in blood. There is evidence that an elevated homocysteine level is an independent risk factor for heart disease and stroke. The evidence suggests that high levels of homocysteine may damage coronary arteries or make it easier for blood clotting cells called platelets to clump together and form a clot. However, there is currently no evidence available to suggest that lowering homocysteine with vitamins will reduce your risk of heart disease. Clinical intervention trials are needed to determine whether supplementation with folic acid, vitamin B12 or vitamin B6 can lower your risk of developing coronary heart disease. -- Wikipedia.</description>
            <cas>135-16-0</cas>
            <kegg-id>C00101</kegg-id>
            <pubchem-cid>13781857</pubchem-cid>
            <chebi-id>20506</chebi-id>
            <biocyc-id>THF</biocyc-id>
            <chemspider-id>18714427</chemspider-id>
            <drugbank-id>DB00116</drugbank-id>
            <moldb-smiles>NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1</moldb-smiles>
            <moldb-formula>C19H23N7O6</moldb-formula>
            <moldb-inchi>InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11-,12?/m0/s1</moldb-inchi>
            <moldb-inchikey>MSTNYGQPCMXVAQ-PXYINDEMSA-N</moldb-inchikey>
            <moldb-iupac nil="true"/>
            <moldb-average-mass>445.4292</moldb-average-mass>
            <moldb-mono-mass>445.170981503</moldb-mono-mass>
            <moldb-alogps-logs nil="true"/>
            <moldb-donor-count nil="true"/>
            <moldb-traditional-iupac nil="true"/>
            <moldb-formal-charge type="integer" nil="true"/>
            <moldb-physiological-charge type="integer" nil="true"/>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB022705</foodb-id>
            <synonyms>(6s)-tetrahydrofolate;(6s)-tetrahydrofolic acid;5,6,7,8-tetrahydrofolate;5,6,7,8-tetrahydrofolic acid;Tetra-h-folate;Tetrahydrafolate;Tetrahydrofolate;Tetrahydrofolic acid;Tetrahydropteroyl mono-l-glutamate;Tetrahydropteroylglutamate</synonyms>
            <pwc-id>PW_C001221</pwc-id>
            <short-name>THFA</short-name>
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              <element-state>
                <id type="integer">448</id>
                <biological-state-id type="integer">4</biological-state-id>
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              <element-state>
                <id type="integer">571</id>
                <biological-state-id type="integer">8</biological-state-id>
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                <biological-state-id type="integer">3</biological-state-id>
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                <biological-state-id type="integer">2</biological-state-id>
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                <biological-state-id type="integer">111</biological-state-id>
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                <biological-state-id type="integer">135</biological-state-id>
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                <id type="integer">5786</id>
                <biological-state-id type="integer">108</biological-state-id>
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                <id type="integer">6009</id>
                <biological-state-id type="integer">147</biological-state-id>
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                <biological-state-id type="integer">205</biological-state-id>
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                <biological-state-id type="integer">206</biological-state-id>
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                <biological-state-id type="integer">163</biological-state-id>
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                <biological-state-id type="integer">198</biological-state-id>
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                <biological-state-id type="integer">315</biological-state-id>
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                <biological-state-id type="integer">133</biological-state-id>
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                <biological-state-id type="integer">388</biological-state-id>
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            <id type="integer">1178</id>
            <name>5,10-Methylene-THF</name>
            <hmdb-id>HMDB0001533</hmdb-id>
            <description>5,10-Methylene-THF is an intermediate in glycine, serine and threonine metabolism and one carbon metabolism. 5,10-CH2-THF can also be used as a coenzyme in the biosynthesis of thymidine. More specifically it is the C1-donor in the reactions catalyzed by thymidylate synthase and thymidylate synthase (FAD). It also acts as a coenzyme in the synthesis of serine from glycine via the enzyme serine hydroxymethyl transferase. 5,10-Methylene-THF is a substrate for Methylenetetrahydrofolate reductase. This enzyme converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This reaction is required for the multistep process that converts the amino acid homocysteine to methionine. The body uses methionine to make proteins and other important compounds. 5,10-CH2-THF is a substrate for many enzymes including Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (mitochondrial), Aminomethyltransferase (mitochondrial), Serine hydroxymethyltransferase (mitochondrial), Methylenetetrahydrofolate reductase, C-1-tetrahydrofolate synthase (cytoplasmic), Serine hydroxymethyltransferase (cytosolic) and Thymidylate synthase.</description>
            <cas>3432-99-3</cas>
            <kegg-id>C00143</kegg-id>
            <pubchem-cid>439175</pubchem-cid>
            <chebi-id>15636</chebi-id>
            <biocyc-id>METHYLENE-THF</biocyc-id>
            <chemspider-id>388320</chemspider-id>
            <drugbank-id nil="true"/>
            <moldb-smiles>[H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O</moldb-smiles>
            <moldb-formula>C20H23N7O6</moldb-formula>
            <moldb-inchi>InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12-,13?/m1/s1</moldb-inchi>
            <moldb-inchikey>QYNUQALWYRSVHF-PZORYLMUSA-N</moldb-inchikey>
            <moldb-iupac nil="true"/>
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            <moldb-physiological-charge type="integer" nil="true"/>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB022675</foodb-id>
            <synonyms>(6r)-5,10-methylenetetrahydrofolate;5,10-methenyltetrahydropteroylglutamate;5,10-methylene-6-hydrofolate;5,10-methylene-6-hydrofolic acid;5,10-methylene-thf;5,10-methylenetetrahydrofolate;5,10-methylenetetrahydrofolic acid;N5&gt;,n10-methylenetetrahydrofolate;(6r)-5,10-methylenetetrahydrofolic acid</synonyms>
            <pwc-id>PW_C001178</pwc-id>
            <short-name>5XM-THF</short-name>
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            <name>Glycine</name>
            <hmdb-id>HMDB0000123</hmdb-id>
            <description>Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895).</description>
            <cas>56-40-6</cas>
            <kegg-id>C00037</kegg-id>
            <pubchem-cid>5257127</pubchem-cid>
            <chebi-id>15428</chebi-id>
            <biocyc-id>GLY</biocyc-id>
            <chemspider-id>730</chemspider-id>
            <drugbank-id>DB00145</drugbank-id>
            <moldb-smiles>NCC(O)=O</moldb-smiles>
            <moldb-formula>C2H5NO2</moldb-formula>
            <moldb-inchi>InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)</moldb-inchi>
            <moldb-inchikey>DHMQDGOQFOQNFH-UHFFFAOYSA-N</moldb-inchikey>
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            <moldb-physiological-charge type="integer" nil="true"/>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB000484</foodb-id>
            <synonyms>2-aminoacetate;2-aminoacetic acid;Aciport;Amino-acetate;Amino-acetic acid;Aminoacetate;Aminoacetic acid;Aminoethanoate;Aminoethanoic acid;Glicoamin;Glycocoll;Glycolixir;Glycosthene;Gyn-hydralin;Padil;Aminoessigsaeure;G;Gly;Glycin;Glykokoll;Glyzin;H2n-ch2-cooh;Hgly;Leimzucker</synonyms>
            <pwc-id>PW_C000078</pwc-id>
            <short-name>Gly</short-name>
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            <name>Water</name>
            <hmdb-id>HMDB0002111</hmdb-id>
            <description>Water is a chemical substance that is essential to all known forms of life. It appears colorless to the naked eye in small quantities, though it is actually slightly blue in color. It covers 71% of Earth's surface. Current estimates suggest that there are 1.4 billion cubic kilometers (330 million m3) of it available on Earth, and it exists in many forms. It appears mostly in the oceans (saltwater) and polar ice caps, but it is also present as clouds, rain water, rivers, freshwater aquifers, lakes, and sea ice. Water in these bodies perpetually moves through a cycle of evaporation, precipitation, and runoff to the sea. Clean water is essential to human life. In many parts of the world, it is in short supply. From a biological standpoint, water has many distinct properties that are critical for the proliferation of life that set it apart from other substances. It carries out this role by allowing organic compounds to react in ways that ultimately allow replication. All known forms of life depend on water. Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic processes within the body. Metabolism is the sum total of anabolism and catabolism. In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). Water is thus essential and central to these metabolic processes. Water is also central to photosynthesis and respiration. Photosynthetic cells use the sun's energy to split off water's hydrogen from oxygen. Hydrogen is combined with CO2 (absorbed from air or water) to form glucose and release oxygen. All living cells use such fuels and oxidize the hydrogen and carbon to capture the sun's energy and reform water and CO2 in the process (cellular respiration). Water is also central to acid-base neutrality and enzyme function. An acid, a hydrogen ion (H+, that is, a proton) donor, can be neutralized by a base, a proton acceptor such as hydroxide ion (OH-) to form water. Water is considered to be neutral, with a pH (the negative log of the hydrogen ion concentration) of 7. Acids have pH values less than 7 while bases have values greater than 7. Stomach acid (HCl) is useful to digestion. However, its corrosive effect on the esophagus during reflux can temporarily be neutralized by ingestion of a base such as aluminum hydroxide to produce the neutral molecules water and the salt aluminum chloride. Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (Wikipedia).</description>
            <cas>7732-18-5</cas>
            <kegg-id>C00001</kegg-id>
            <pubchem-cid>962</pubchem-cid>
            <chebi-id>15377</chebi-id>
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            <chemspider-id>937</chemspider-id>
            <drugbank-id nil="true"/>
            <moldb-smiles>O</moldb-smiles>
            <moldb-formula>H2O</moldb-formula>
            <moldb-inchi>InChI=1S/H2O/h1H2</moldb-inchi>
            <moldb-inchikey>XLYOFNOQVPJJNP-UHFFFAOYSA-N</moldb-inchikey>
            <moldb-iupac nil="true"/>
            <moldb-average-mass>18.0153</moldb-average-mass>
            <moldb-mono-mass>18.010564686</moldb-mono-mass>
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            <moldb-physiological-charge type="integer" nil="true"/>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB013390</foodb-id>
            <synonyms>Dihydrogen oxide;Steam;[oh2];Acqua;Agua;Aqua;Bound water;Dihydridooxygen;Eau;H2o;Hoh;Hydrogen hydroxide;Wasser</synonyms>
            <pwc-id>PW_C001420</pwc-id>
            <short-name>H2O</short-name>
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                <id type="integer">178518</id>
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            <name>Serine/threonine transporter sstT</name>
            <uniprot-id>P0AGE5</uniprot-id>
            <description>Involved in sodium:dicarboxylate symporter activity. Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).</description>
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            <drugbank-id nil="true"/>
            <genbank-id>AE005174</genbank-id>
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            <ec-numbers></ec-numbers>
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              <element-state>
                <id type="integer">8553</id>
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              <element-state>
                <id type="integer">174162</id>
                <biological-state-id type="integer">8267</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">174232</id>
                <biological-state-id type="integer">8327</biological-state-id>
              </element-state>
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                <id type="integer">174235</id>
                <biological-state-id type="integer">8333</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">174239</id>
                <biological-state-id type="integer">5657</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">174248</id>
                <biological-state-id type="integer">8342</biological-state-id>
              </element-state>
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                <id type="integer">174300</id>
                <biological-state-id type="integer">8402</biological-state-id>
              </element-state>
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                <id type="integer">174325</id>
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              </element-state>
              <element-state>
                <id type="integer">174326</id>
                <biological-state-id type="integer">5002</biological-state-id>
              </element-state>
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                <id type="integer">174327</id>
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                <id type="integer">174328</id>
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              </element-state>
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                <id type="integer">174329</id>
                <biological-state-id type="integer">5012</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">174330</id>
                <biological-state-id type="integer">5027</biological-state-id>
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                <id type="integer">174332</id>
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                <id type="integer">174333</id>
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              </element-state>
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                <id type="integer">174334</id>
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              </element-state>
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                <biological-state-id type="integer">5067</biological-state-id>
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                <id type="integer">174336</id>
                <biological-state-id type="integer">5057</biological-state-id>
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                <biological-state-id type="integer">5087</biological-state-id>
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                <id type="integer">174339</id>
                <biological-state-id type="integer">5082</biological-state-id>
              </element-state>
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                <id type="integer">174340</id>
                <biological-state-id type="integer">5072</biological-state-id>
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                <id type="integer">174341</id>
                <biological-state-id type="integer">5077</biological-state-id>
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                <id type="integer">174342</id>
                <biological-state-id type="integer">5092</biological-state-id>
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                <id type="integer">174349</id>
                <biological-state-id type="integer">8619</biological-state-id>
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                <id type="integer">174350</id>
                <biological-state-id type="integer">8624</biological-state-id>
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                <id type="integer">174352</id>
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                <id type="integer">174353</id>
                <biological-state-id type="integer">8646</biological-state-id>
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                <id type="integer">178730</id>
                <biological-state-id type="integer">8321</biological-state-id>
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                <id type="integer">223922</id>
                <biological-state-id type="integer">234</biological-state-id>
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                <id type="integer">224068</id>
                <biological-state-id type="integer">8273</biological-state-id>
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                <id type="integer">224162</id>
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                <biological-state-id type="integer">8291</biological-state-id>
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                <biological-state-id type="integer">8297</biological-state-id>
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            <name>Serine hydroxymethyltransferase</name>
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            <description>Involved in catalytic activity. Interconversion of serine and glycine.</description>
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            <gene-name>glyA</gene-name>
            <locus>b2551</locus>
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            <ec-numbers>2.1.2.1</ec-numbers>
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              <element-state>
                <id type="integer">8686</id>
                <biological-state-id type="integer">101</biological-state-id>
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              <element-state>
                <id type="integer">135947</id>
                <biological-state-id type="integer">304</biological-state-id>
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                <id type="integer">178729</id>
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                <id type="integer">178773</id>
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                <id type="integer">178787</id>
                <biological-state-id type="integer">1864</biological-state-id>
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                <id type="integer">178858</id>
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                <id type="integer">178998</id>
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                <id type="integer">248272</id>
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                <id type="integer">248283</id>
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                <id type="integer">248406</id>
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            </element-states>
          </protein>
          <protein>
            <id type="integer">7026</id>
            <name>Serine transporter</name>
            <uniprot-id>P0AAD6</uniprot-id>
            <description>Involved in transporter activity. Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with drcB. May also be involved in ampicillin sensitivity.</description>
            <hmdbp-id nil="true"/>
            <gene-name>sdaC</gene-name>
            <locus>b2796</locus>
            <drugbank-id nil="true"/>
            <genbank-id>AP009048</genbank-id>
            <species-id type="integer">3</species-id>
            <ec-numbers></ec-numbers>
            <synonyms nil="true"/>
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            <name>serine / threonine:H+ symporter TdcC</name>
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                <protein-id type="integer">6990</protein-id>
                <stoichiometry type="integer" nil="true"/>
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          <protein-complex>
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                <protein-id type="integer">6909</protein-id>
                <stoichiometry type="integer" nil="true"/>
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            </protein_complex-proteins>
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          <protein-complex>
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            <name>glycine hydroxymethyltransferase</name>
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                <stoichiometry type="integer" nil="true"/>
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          <protein-complex>
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              <protein-complex-protein>
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                <stoichiometry type="integer" nil="true"/>
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                <right-biological-state-id type="integer">108</right-biological-state-id>
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