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3-methyl-2- oxobutanoate hydroxymethyltransferase 2- dehydropantoate 2-reductase Pantothenate synthetase Pantothenate kinase Coenzyme A biosynthesis bifunctional protein coaBC Coenzyme A biosynthesis bifunctional protein coaBC Phosphopantetheine adenylyltransferase Dephospho-CoA kinase 2-(5''- triphosphoribosyl)- 3'- dephosphocoenzyme- A synthase Dihydroxy-acid dehydratase Aspartate 1-decarboxylase α- Ketoisovaleric acid L-Aspartic acid 5,10- Methylene-THF H2O Tetrahydrofolic acid 2- dehydropantoate NADPH H+ NADP (R)-pantoate β-Alanine ATP AMP PPi H+ Pantothenic acid ATP ADP H+ D-4'- Phosphopantothenate Cytidine triphosphate L-Cysteine Cytidine monophosphate PPi H+ 4'- Phosphopantothenoylcysteine H+ CO2 4'- phosphopantetheine ATP H+ PPi Dephospho-CoA ATP H+ ADP Coenzyme A ATP H+ Adenine 2'-(5- Triphosphoribosyl)- 3'-dephospho- CoA 2,3- Dihydroxyisovaleric acid H2O H+ CO2 Valine Biosynthesis Aspartate Metabolism Ketol-acid reductoisomerase
panB panE panC coaA coaBC coaBC coaD coaE citG ilvD panD α- Ketoisovaleric acid L-Aspartic acid 5,10- Methylene-THF Water Tetrahydrofolic acid 2- dehydropantoate NADPH Hydrogen Ion NADP (R)-pantoate β-Alanine Adenosine triphosphate Adenosine monophosphate Pyrophosphate Hydrogen Ion Pantothenic acid Adenosine triphosphate Adenosine diphosphate Hydrogen Ion D-4'- Phosphopantothenate Cytidine triphosphate L-Cysteine Cytidine monophosphate Pyrophosphate Hydrogen Ion 4'- Phosphopantothenoylcysteine Hydrogen Ion Carbon dioxide 4'- phosphopantetheine Adenosine triphosphate Hydrogen Ion Pyrophosphate Dephospho-CoA Adenosine triphosphate Hydrogen Ion Adenosine diphosphate Coenzyme A Adenosine triphosphate Hydrogen Ion Adenine 2'-(5- Triphosphoribosyl)- 3'-dephospho- CoA 2,3- Dihydroxyisovaleric acid Water Hydrogen Ion Carbon dioxide Valine Biosynthesis Aspartate Metabolism