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Bifunctional
protein folC
GTP
cyclohydrolase
1
Dihydroneopterin
triphosphate
pyrophosphatase
Dihydroneopterin
aldolase
2-amino-4-
hydroxy-6-
hydroxymethyldihydropteridine
pyrophosphokinase
Dihydropteroate
synthase
Aminodeoxychorismate
lyase
Para-
aminobenzoate
synthase
component 1
Para-
aminobenzoate
synthase
glutamine
amidotransferase
component II
Dihydrofolate
reductase folM
Tetrahydrofolic
acid
Guanosine
triphosphate
Chorismate
H
2
O
Formic acid
H
+
7,8-
dihydroneopterin
3'-triphosphate
H
2
O
PP
i
H
+
7,8-
dihydroneopterin
3'-phosphate
H
2
O
P
i
7,8-
Dihydroneopterin
Glycolaldehyde
6-
hydroxymethyl-
7,8-
dihydropterin
ATP
AMP
H
+
(2-amino-4-
hydroxy-7,8-
dihydropteridin-
6-yl)methyl
diphosphate
p-Aminobenzoic
acid
PP
i
7,8-
Dihydropteroic
acid
4-amino-4-
deoxychorismate
Pyruvic acid
H
+
L-Glutamine
L-Glutamic acid
ATP
L-Glutamic acid
ADP
P
i
H
+
7,8-
dihydrofolate
monoglutamate
H
+
NADPH
NADP
Magnesium
Magnesium
Potassium
Magnesium
One Carbon Pool
by Folate
Purine
Nucleotides De
Novo
Biosynthesis
Chorismate
Biosynthesis
Dihydrofolate
reductase
Magnesium
folC
folE
nudB
folB
folK
folP
pabC
pabB
pabA
folM
Tetrahydrofolic
acid
Guanosine
triphosphate
Chorismate
Water
Formic acid
Hydrogen Ion
7,8-
dihydroneopterin
3'-triphosphate
Water
Pyrophosphate
Hydrogen Ion
7,8-
dihydroneopterin
3'-phosphate
Water
Phosphate
7,8-
Dihydroneopterin
Glycolaldehyde
6-
hydroxymethyl-
7,8-
dihydropterin
Adenosine
triphosphate
Adenosine
monophosphate
Hydrogen Ion
(2-amino-4-
hydroxy-7,8-
dihydropteridin-
6-yl)methyl
diphosphate
p-Aminobenzoic
acid
Pyrophosphate
7,8-
Dihydropteroic
acid
4-amino-4-
deoxychorismate
Pyruvic acid
Hydrogen Ion
L-Glutamine
L-Glutamic acid
Adenosine
triphosphate
L-Glutamic acid
Adenosine
diphosphate
Phosphate
Hydrogen Ion
7,8-
dihydrofolate
monoglutamate
Hydrogen Ion
NADPH
NADP
One Carbon Pool
by Folate
Purine
Nucleotides De
Novo
Biosynthesis
Chorismate
Biosynthesis
folA