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ATP phosphoribosyltransferase Histidine biosynthesis bifunctional protein hisIE Histidine biosynthesis bifunctional protein hisIE 1-(5- phosphoribosyl)- 5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase Histidine biosynthesis bifunctional protein hisB Histidinol- phosphate aminotransferase Histidine biosynthesis bifunctional protein hisB Histidinol dehydrogenase Histidinol dehydrogenase Imidazole glycerol phosphate synthase subunit hisH Imidazole glycerol phosphate synthase subunit hisF L-Histidine Phosphoribosyl pyrophosphate H+ PPi Phosphoribosyl- ATP H2O H+ PPi Phosphoribosyl- AMP H2O 1-(5'- Phosphoribosyl)- 5-amino-4- imidazolecarboxamide PhosphoribosylformiminoAICAR- phosphate D-Erythro- imidazole- glycerol- phosphate H2O Imidazole acetol-phosphate L-Glutamic acid Oxoglutaric acid L-histidinol- phosphate H2O Pi L-Histidinol NAD NADH H+ Histidinal H2O NAD H+ NADH L-Glutamine 5- Aminoimidazole- 4-carboxamide H+ L-Glutamic acid PRPP Biosynthesis Cytoplasm Inner Membrane Periplasmic Space Gram-Negative Bacteria Outer Membrane
hisG hisI hisI hisA hisB hisC hisB hisD hisD hisH hisF L-Histidine Phosphoribosyl pyrophosphate Hydrogen Ion Pyrophosphate Phosphoribosyl- ATP Water Hydrogen Ion Pyrophosphate Phosphoribosyl- AMP Water 1-(5'- Phosphoribosyl)- 5-amino-4- imidazolecarboxamide PhosphoribosylformiminoAICAR- phosphate D-Erythro- imidazole- glycerol- phosphate Water Imidazole acetol-phosphate L-Glutamic acid Oxoglutaric acid L-histidinol- phosphate Water Phosphate L-Histidinol NAD NADH Hydrogen Ion Histidinal Water NAD Hydrogen Ion NADH L-Glutamine 5- Aminoimidazole- 4-carboxamide Hydrogen Ion L-Glutamic acid PRPP Biosynthesis