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Pathway Description
Curcumin Degradation
Escherichia coli
Metabolic Pathway
Curcumin is metabolized by being reduced through a NADPH dependent curcumin reductase resulting in a dihydrocurcumin. This compound is then reduced again through a NADPH-dependent dihydrocurcumin reductase resulting in a tetrahydrocurcumin. It is not know yet how this compound enters E.coli
References
Curcumin Degradation References
Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M: Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20. doi: 10.1073/pnas.1016217108. Epub 2011 Apr 5.
Pubmed: 21467222
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