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Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta Biotin carboxylase Biotin carboxyl carrier protein of acetyl-CoA carboxylase Malonyl CoA-acyl carrier protein transacylase 3-oxoacyl- [acyl- carrier- protein] synthase 3 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase Enoyl-[acyl- carrier- protein] reductase [NADH] 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase Enoyl-[acyl- carrier- protein] reductase [NADH] 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase Enoyl-[acyl- carrier- protein] reductase [NADH] 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase Enoyl-[acyl- carrier- protein] reductase [NADH] 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase Enoyl-[acyl- carrier- protein] reductase [NADH] 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase Enoyl-[acyl- carrier- protein] reductase [NADH] Acetyl-CoA Octanoyl- [acyl-carrier protein] Palmitic acid Palmitic acid Palmitic acid HCO3- ATP ADP Pi H+ Malonyl-CoA CoA H+ Acetyl-CoA CO2 CoA H+ NADPH NADP H2O H+ NADH NAD H+ CO2 H+ NADPH NADP H2O H+ NADH NAD H+ CO2 H+ NADPH NADP H2O H+ NADH NAD H+ CO2 H+ NADPH NADP H2O H+ NADH NAD CO2 H+ NADPH NADP H2O H+ NADH NAD H+ CO2 H+ NADPH NADP H2O H+ NADH NAD H+ CO2 H+ NADPH NADP H2O H+ NADH NAD H2O H+ Dodecanoate (N-C12:0) H2O H+ a holo-[acyl- carrier protein] a malonyl-[acp] acetoacetyl- [acp] (R)-3- hydroxybutanoyl- [acp] crotonyl-[acp] butyryl-[acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- hexanoyl- [acp] (R)-3- hydroxyhexanoyl- [acp] trans hex-2-enoyl- [acp] hexanoyl- [acyl- carrier- protein] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- octanoyl- [acp] (R)-3- hydroxyoctanoyl- [acp] trans oct-2-enoyl- [acp] Octanoyl- [acyl-carrier protein] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- decanoyl- [acp] an (R)-3- hydroxydecanoyl- [acp] a trans-Δ2- decenoyl- [acp] decanoyl-[acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- dodecanoyl- [acp] (R)-3- hydroxydodecanoyl- [acp] trans dodec-2- enoyl-[acp] dodecanoyl- [acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- myristoyl- [acp] (3R)-3- hydroxymyristoyl- [acp] trans tetradec-2- enoyl-[acp] myristoyl-[acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- palmitoyl- [acp] (R)-3- hydroxypalmitoyl- [acp] trans hexadecenoyl- [acp] palmitoyl-[acp] a holo-[acyl- carrier protein] a holo-[acyl- carrier protein] Lipoic Acid Metabolism Glycolysis and Pyruvate Dehydrogenase Lipoic Acid Metabolism
accA accD accC accB fabD fabH fabG fabZ fabI fabB fabG fabZ fabI fabB fabG fabZ fabI fabB fabG fabZ fabI fabB fabG fabZ fabI fabB fabG fabZ fabB fabB fabG fabZ fabI Acetyl-CoA Octanoyl- [acyl-carrier protein] Palmitic acid Palmitic acid Palmitic acid Hydrogen carbonate Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion Malonyl-CoA Coenzyme A Hydrogen Ion Acetyl-CoA Carbon dioxide Coenzyme A Hydrogen Ion NADPH NADP Water Hydrogen Ion NADH NAD Hydrogen Ion Carbon dioxide Hydrogen Ion NADPH NADP Water Hydrogen Ion NADH NAD Hydrogen Ion Carbon dioxide Hydrogen Ion NADPH NADP Water Hydrogen Ion NADH NAD Hydrogen Ion Carbon dioxide Hydrogen Ion NADPH NADP Water Hydrogen Ion NADH NAD Carbon dioxide Hydrogen Ion NADPH NADP Water Hydrogen Ion NADH NAD Hydrogen Ion Carbon dioxide Hydrogen Ion NADPH NADP Water Hydrogen Ion NADH NAD Hydrogen Ion Carbon dioxide Hydrogen Ion NADPH NADP Water Hydrogen Ion NADH NAD Water Hydrogen Ion Dodecanoate (N-C12:0) Water Hydrogen Ion a holo-[acyl- carrier protein] a malonyl-[acp] acetoacetyl- [acp] (R)-3- hydroxybutanoyl- [acp] crotonyl-[acp] butyryl-[acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- hexanoyl- [acp] (R)-3- hydroxyhexanoyl- [acp] trans hex-2-enoyl- [acp] hexanoyl- [acyl- carrier- protein] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- octanoyl- [acp] (R)-3- hydroxyoctanoyl- [acp] trans oct-2-enoyl- [acp] Octanoyl- [acyl-carrier protein] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- decanoyl- [acp] an (R)-3- hydroxydecanoyl- [acp] a trans-Δ2- decenoyl- [acp] decanoyl-[acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- dodecanoyl- [acp] (R)-3- hydroxydodecanoyl- [acp] trans dodec-2- enoyl-[acp] dodecanoyl- [acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- myristoyl- [acp] (3R)-3- hydroxymyristoyl- [acp] trans tetradec-2- enoyl-[acp] myristoyl-[acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- palmitoyl- [acp] (R)-3- hydroxypalmitoyl- [acp] trans hexadecenoyl- [acp] palmitoyl-[acp] a holo-[acyl- carrier protein] a holo-[acyl- carrier protein] Lipoic Acid Metabolism Glycolysis and Pyruvate Dehydrogenase Lipoic Acid Metabolism