1816
Pathway
glycolysis and tca cycle
Metabolic
PW002047
Center
PathwayVisualizationContext2334
2000
2000
#000099
PathwayVisualization1800
1816
glycolysis and tca cycle
Metabolic
18
1
Cell
CL:0000000
3
Neuron
CL:0000540
1
Homo sapiens
9606
Eukaryote
Human
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
12
Mus musculus
10090
Eukaryote
Mouse
5
Bos taurus
9913
Eukaryote
Cattle
17
Rattus norvegicus
10116
Eukaryote
Rat
127
kjhkjh
0989088
Eukaryote
1
Cytosol
GO:0005829
8
Blood Vessel
BTO:0001102
74
11
24
Brain
BTO:0000142
89
16
1
1
PW_BS000001
41
8
1
1
PW_BS000041
152
8
4
PW_BS000152
51
8
1
PW_BS000051
2
1
1
1
PW_BS000002
132
1
12
1
PW_BS000132
124
1
5
1
PW_BS000124
118
1
17
1
PW_BS000118
879
24
1
127
3
PW_BS000552
1
1-Methylhistidine
HMDB0000001
One-methylhistidine (1-MHis) is derived mainly from the anserine of dietary flesh sources, especially poultry. The enzyme, carnosinase, splits anserine into b-alanine and 1-MHis. High levels of 1-MHis tend to inhibit the enzyme carnosinase and increase anserine levels. Conversely, genetic variants with deficient carnosinase activity in plasma show increased 1-MHis excretions when they consume a high meat diet. Reduced serum carnosinase activity is also found in patients with Parkinson's disease and multiple sclerosis and patients following a cerebrovascular accident. Vitamin E deficiency can lead to 1-methylhistidinuria from increased oxidative effects in skeletal muscle.
332-80-9
C01152
7020397
50599
CPD-1823
83153
DB04151
CN1C=NC(C[C@H](N)C(O)=O)=C1
C7H11N3O2
InChI=1S/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1
BRMWTNUJHUMWMS-LURJTMIESA-N
(2S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid
169.1811
169.085126611
-1.39
2
1 methylhistidine
0
0
FDB012119
1 methylhistidine;1-mhis;1-methyl histidine;1-methyl-histidine;1-methyl-l-histidine;1-n-methyl-l-histidine;L-1-methylhistidine;N1-methyl-l-histidine;Pi-methylhistidine;(2s)-2-amino-3-(1-methyl-1h-imidazol-4-yl)propanoic acid;1-methylhistidine;(2s)-2-amino-3-(1-methyl-1h-imidazol-4-yl)propanoate
PW_C000001
1-Mhis
6660
1
6661
41
7367
152
7437
51
42263
2
78158
132
121055
124
123619
118
140688
879
2686856
1
156
false
35
215
10
regular
100
110
3136
2686856
103730
490
405
1.0
1.0
0
2
1
490
240
4291
M311 217 C311 167 361 117 411 117 C599 117 845 117 1033 117 C1083 117 1133 167 1133 217 C1133 330 1133 477 1133 590 C1133 640 1083 690 1033 690 C845 690 599 690 411 690 C361 690 311 640 311 590 C311 477 311 330 311 217
1
true
6
822.0
573.0
466387
M211 175 C261 225 153 464 316 267
1
false
6
105.0
92.0