2148
Pathway
L-Alanine Metabolism
L-alanine metabolized from pyruvate and glutamate reacting through a Alanine aminotransferase resulting in the release of a oxoglutaric acid and a alanine. Alanine is degraded by alanine aminotransferase to form pyruvic acid. Meanwhile, oxoglutaric acid is converted to L-glutamic acid also by alanine aminotransferase. Pyruvate is transported into mitochondria for further metabolism.
Metabolic
PW002373
Center
PathwayVisualizationContext2660
1598
1398
#000099
PathwayVisualization2131
2148
L-Alanine Metabolism
L-alanine metabolized from pyruvate and glutamate reacting through a Alanine aminotransferase resulting in the release of a oxoglutaric acid and a alanine. Alanine is degraded by alanine aminotransferase to form pyruvic acid. Meanwhile, oxoglutaric acid is converted to L-glutamic acid also by alanine aminotransferase. Pyruvate is transported into mitochondria for further metabolism.
Metabolic
18
110050
113255
SubPathway
109632
164
Compound
4954
19396236
Garcia-Campusano F, Anaya VH, Robledo-Arratia L, Quezada H, Hernandez H, Riego L, Gonzalez A: ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae. Can J Microbiol. 2009 Apr;55(4):368-74. doi: 10.1139/w08-150.
2148
Pathway
1
Cell
CL:0000000
6
Myocyte
CL:0000187
5
Hepatocyte
CL:0000182
3
Neuron
CL:0000540
1
Homo sapiens
9606
Eukaryote
Human
3
Escherichia coli
562
Prokaryote
17
Rattus norvegicus
10116
Eukaryote
Rat
12
Mus musculus
10090
Eukaryote
Mouse
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
23
Pseudomonas aeruginosa
287
Prokaryote
5
Bos taurus
9913
Eukaryote
Cattle
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
2
Bacteria
2
Prokaryote
Bacteria
24
Solanum lycopersicum
4081
Eukaryote
Tomato
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
21
Xenopus laevis
8355
Eukaryote
African clawed frog
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
49
Bathymodiolus platifrons
220390
Eukaryote
Deep sea mussel
7
Chlamydomonas reinhardtii
3055
Eukaryote
29
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
559292
Eukaryote
Baker's yeast
1
Cytosol
GO:0005829
3
Mitochondrial Matrix
GO:0005759
5
Cytoplasm
GO:0005737
11
Extracellular Space
GO:0005615
2
Mitochondrion
GO:0005739
31
Periplasmic Space
GO:0005620
10
Cell Membrane
GO:0005886
35
Chloroplast
GO:0009507
13
Endoplasmic Reticulum
GO:0005783
7
Endoplasmic Reticulum Membrane
GO:0005789
12
Mitochondrial Inner Membrane
GO:0005743
6
Lysosome
GO:0005764
24
Mitochondrial Intermembrane Space
GO:0005758
4
Peroxisome
GO:0005777
32
Inner Membrane
GO:0070258
25
Golgi apparatus
GO:0005794
15
Nucleus
GO:0005634
9
Muscle
BTO:0000887
141
18
8
Blood Vessel
BTO:0001102
74
11
1
Liver
BTO:0000759
72
9
24
Brain
BTO:0000142
89
16
2
1
1
1
PW_BS000002
4
3
1
1
PW_BS000004
8
5
1
1
PW_BS000008
50
9
5
1
6
PW_BS000050
51
8
1
PW_BS000051
26
1
1
1
5
PW_BS000026
15
11
1
PW_BS000015
3
2
1
1
PW_BS000003
117
1
3
1
PW_BS000117
103
3
3
1
PW_BS000103
118
1
17
1
PW_BS000118
120
3
17
1
PW_BS000120
132
1
12
1
PW_BS000132
133
3
12
1
PW_BS000133
107
31
3
PW_BS000107
108
1
3
PW_BS000108
105
11
3
PW_BS000105
85
24
10
1
1
PW_BS000085
225
35
4
1
PW_BS000024
151
1
4
1
PW_BS000151
31
1
5
1
1
PW_BS000031
18
13
1
1
PW_BS000018
222
3
4
1
PW_BS000024
320
11
23
PW_BS000024
318
31
23
PW_BS000024
315
1
23
PW_BS000024
346
9
5
12
6
PW_BS000028
327
1
1
12
5
PW_BS000028
326
8
12
PW_BS000028
111
5
12
1
PW_BS000111
112
2
12
1
PW_BS000112
114
11
12
PW_BS000114
135
5
17
1
PW_BS000135
122
5
5
1
PW_BS000122
124
1
5
1
PW_BS000124
406
3
5
1
PW_BS000115
423
9
5
5
6
PW_BS000115
424
1
1
5
5
PW_BS000115
416
8
5
PW_BS000115
409
11
5
PW_BS000115
407
2
5
1
PW_BS000115
458
9
5
17
6
PW_BS000115
459
1
1
17
5
PW_BS000115
452
8
17
PW_BS000115
137
11
17
PW_BS000137
119
2
17
1
PW_BS000119
297
5
10
1
PW_BS000024
299
1
10
1
PW_BS000024
479
3
10
1
PW_BS000115
481
2
10
1
PW_BS000115
205
5
6
1
PW_BS000024
388
1
6
1
PW_BS000112
501
3
6
1
PW_BS000115
206
2
6
1
PW_BS000024
95
1
7
2
1
PW_BS000095
147
1
24
1
PW_BS000147
155
3
24
1
PW_BS000155
156
12
24
1
PW_BS000156
161
3
18
1
PW_BS000161
160
1
18
1
PW_BS000160
1
1
PW_BS000001
178
3
21
1
PW_BS000178
177
1
21
1
PW_BS000177
220
1
4
PW_BS000024
249
13
4
1
PW_BS000024
368
3
60
1
PW_BS000028
367
1
60
1
PW_BS000028
94
3
PW_BS000094
121
12
17
1
PW_BS000121
14
10
1
PW_BS000014
9
6
1
1
PW_BS000009
42
24
1
1
PW_BS000042
54
1
3
1
5
PW_BS000054
113
6
12
1
PW_BS000113
157
2
24
1
PW_BS000157
187
31
18
PW_BS000024
188
1
18
PW_BS000024
72
5
1
3
PW_BS000072
71
11
1
3
PW_BS000071
207
6
6
1
PW_BS000024
224
2
4
1
PW_BS000024
198
5
18
1
PW_BS000024
289
2
49
1
PW_BS000024
290
5
49
1
PW_BS000024
253
5
4
1
PW_BS000024
347
1
3
12
5
PW_BS000028
345
24
12
1
PW_BS000028
126
6
5
1
PW_BS000126
418
24
5
1
PW_BS000115
425
1
3
5
5
PW_BS000115
443
6
17
1
PW_BS000115
454
24
17
1
PW_BS000115
460
1
3
17
5
PW_BS000115
301
6
10
1
PW_BS000024
489
24
10
1
PW_BS000115
506
24
6
1
PW_BS000115
5
4
1
1
PW_BS000005
129
1
5
12
1
PW_BS000129
334
4
12
1
PW_BS000028
414
1
5
5
1
PW_BS000115
408
4
5
1
PW_BS000115
450
1
5
17
1
PW_BS000115
374
4
17
1
PW_BS000053
482
4
10
1
PW_BS000115
502
4
6
1
PW_BS000115
162
12
18
1
PW_BS000162
189
32
18
PW_BS000024
163
2
18
1
PW_BS000163
210
13
18
1
PW_BS000024
211
10
18
PW_BS000024
212
1
7
18
1
PW_BS000024
213
7
18
1
PW_BS000024
214
25
18
1
PW_BS000024
215
6
18
1
PW_BS000024
190
11
18
PW_BS000024
216
4
18
1
PW_BS000024
217
15
18
PW_BS000024
218
15
18
1
PW_BS000024
254
5
18
PW_BS000024
277
1
2
18
PW_BS000024
644
1
7
1
PW_BS000508
646
2
7
1
PW_BS000508
226
4
4
1
PW_BS000024
693
7
4
1
PW_BS000512
708
1
29
1
PW_BS000512
105
L-Alanine
HMDB0000161
Alanine is a non-essential amino acid made in the body from either the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. It is highly concentrated in muscle and is one of the most important amino acids released by muscle, functioning as a major energy source. Plasma alanine is often decreased when the BCAA (branched-chain amino acids) are deficient. This finding may relate to muscle metabolism. Alanine is highly concentrated in meat products and other high-protein foods like wheat germ and cottage cheese. Alanine is an important participant as well as a regulator of glucose metabolism. Alanine levels parallel blood sugar levels in both diabetes and hypoglycemia, and alanine reduces both severe hypoglycemia and the ketosis of diabetes. It is an important amino acid for lymphocyte reproduction and immunity. Alanine therapy has helped dissolve kidney stones in experimental animals. Normal alanine metabolism, like that of other amino acids, is highly dependent upon enzymes that contain vitamin B6. Alanine, like GABA, taurine, and glycine, is an inhibitory neurotransmitter in the brain (http://www.dcnutrition.com/AminoAcids/). L-Alanine has been found to be associated with glucagon deficiency, which is an inborn error of metabolism.
56-41-7
C00041
5950
16977
L-ALPHA-ALANINE
5735
DB00160
C[C@H](N)C(O)=O
C3H7NO2
InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
QNAYBMKLOCPYGJ-REOHCLBHSA-N
(2S)-2-aminopropanoic acid
89.0932
89.047678473
0.70
2
L-alanine
0
0
FDB000556
(2s)-2-aminopropanoate;(2s)-2-aminopropanoic acid;(s)-(+)-alanine;(s)-2-aminopropanoate;(s)-2-aminopropanoic acid;(s)-2-amino-propanoate;(s)-2-amino-propanoic acid;(s)-alanine;2-aminopropanoate;2-aminopropanoic acid;2-aminopropionate;2-aminopropionic acid;2-ammoniopropanoate;2-ammoniopropanoic acid;Ala;Alanine;L-(+)-alanine;L-2-aminopropanoate;L-2-aminopropanoic acid;L-2-aminopropionate;L-2-aminopropionic acid;L-a-alanine;L-a-aminopropionate;L-a-aminopropionic acid;L-alpha-alanine;L-alpha-aminopropionate;L-alpha-aminopropionic acid;A-alanine;A-aminopropionate;A-aminopropionic acid;Alpha-alanine;Alpha-aminopropanoate;Alpha-aminopropanoic acid;Alpha-aminopropionate;Alpha-aminopropionic acid;A;L-alanin;L-α-alanine
PW_C000105
Ala
10
2
29
4
316
8
1446
50
1453
51
1454
26
3022
15
3439
3
5407
117
5418
103
5431
118
5452
120
5557
132
5578
133
5637
107
5638
108
5883
105
6529
85
8350
225
12271
151
12620
31
12627
18
15230
222
42452
320
42453
318
42534
315
77969
346
77975
327
77988
326
78008
111
78092
112
79165
114
80693
135
119910
122
120015
124
120026
406
121145
423
121151
424
121164
416
121220
409
122139
407
123717
458
123723
459
123736
452
123790
137
124691
119
125300
297
125393
299
125404
479
126296
481
126850
205
126933
388
126944
501
127860
206
164
Pyruvic acid
HMDB0000243
Pyruvic acid is an intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed.) Biological Source: Intermediate in primary metabolism including fermentation processes. Present in muscle in redox equilibrium with Lactic acid. A common constituent, as a chiral cyclic acetal linked to saccharide residues, of bacterial polysaccharides. Isolated from cane sugar fermentation broth and peppermint. Constituent of Bauhinia purpurea, Cicer arietinum (chickpea), Delonix regia, Pisum sativum (pea) and Trigonella caerulea (sweet trefoil) Use/Importance: Reagent for regeneration of carbonyl compdounds from semicarbazones, phenylhydrazones and oximes. Flavoring ingredient (Dictionary of Organic Compounds).
127-17-3
C00022
1060
32816
PYRUVATE
1031
DB00119
CC(=O)C(O)=O
C3H4O3
InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
LCTONWCANYUPML-UHFFFAOYSA-N
2-oxopropanoic acid
88.0621
88.016043994
0.18
1
pyruvic acid
0
-1
FDB008293
2-oxopropanoate;2-oxopropanoic acid;2-oxopropionate;2-oxopropionic acid;Acetylformate;Acetylformic acid;Bts;Pyroracemate;Pyroracemic acid;Pyruvate;A-ketopropionate;A-ketopropionic acid;Alpha-ketopropionate;Alpha-ketopropionic acid;2-ketopropionic acid;2-oxopropansaeure;2-oxopropionsaeure;Acide pyruvique;Alpha-oxopropionsaeure;Brenztraubensaeure;Ch3cocooh;2-ketopropionate;α-ketopropionate;α-ketopropionic acid;A-oxopropionsaeure;α-oxopropionsaeure
PW_C000164
Pyr
17
2
20
4
422
8
1181
3
1449
50
1457
26
5365
103
5405
117
5440
118
5444
120
5566
132
5570
133
5893
95
5920
147
5951
151
6022
155
6067
156
6074
161
6126
160
6383
1
6467
178
6510
177
6532
85
7457
222
7495
220
8200
225
12622
31
15292
249
15349
18
77310
111
77972
346
77978
327
78090
112
80004
368
80042
367
80695
135
112879
94
115683
121
119950
406
120011
124
120175
122
120878
407
121148
423
121154
424
123454
119
123720
458
123726
459
125340
479
125390
299
125534
297
125854
481
126883
501
126931
388
127067
205
127858
206
95
L-Glutamic acid
HMDB0000148
Glutamic acid (Glu), also referred to as glutamate (the anion), is one of the 20 proteinogenic amino acids. It is not among the essential amino acids. Glutamate is a key molecule in cellular metabolism. In humans, dietary proteins are broken down by digestion into amino acids, which serves as metabolic fuel or other functional roles in the body. Glutamate is the most abundant fast excitatory neurotransmitter in the mammalian nervous system. At chemical synapses, glutamate is stored in vesicles. Nerve impulses trigger release of glutamate from the pre-synaptic cell. In the opposing post-synaptic cell, glutamate receptors, such as the NMDA receptor, bind glutamate and are activated. Because of its role in synaptic plasticity, it is believed that glutamic acid is involved in cognitive functions like learning and memory in the brain. Glutamate transporters are found in neuronal and glial membranes. They rapidly remove glutamate from the extracellular space. In brain injury or disease, they can work in reverse and excess glutamate can accumulate outside cells. This process causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death, and is called excitotoxicity. The mechanisms of cell death include: * Damage to mitochondria from excessively high intracellular Ca2+. * Glu/Ca2+-mediated promotion of transcription factors for pro-apoptotic genes, or downregulation of transcription factors for anti-apoptotic genes. Excitotoxicity due to glutamate occurs as part of the ischemic cascade and is associated with stroke and diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. glutamic acid has been implicated in epileptic seizures. Microinjection of glutamic acid into neurons produces spontaneous depolarization around one second apart, and this firing pattern is similar to what is known as paroxysmal depolarizing shift in epileptic attacks. This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage activated calcium channels, leading to glutamic acid release and further depolarization. (http://en.wikipedia.org/wiki/Glutamic_acid).
56-86-0
C00025
33032
16015
GLT
30572
DB00142
N[C@@H](CCC(O)=O)C(O)=O
C5H9NO4
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
WHUUTDBJXJRKMK-VKHMYHEASA-N
(2S)-2-aminopentanedioic acid
147.1293
147.053157781
-0.26
3
L-glutamic acid
0
-1
FDB012535
(2s)-2-aminopentanedioate;(2s)-2-aminopentanedioic acid;(s)-(+)-glutamate;(s)-(+)-glutamic acid;(s)-2-aminopentanedioate;(s)-2-aminopentanedioic acid;(s)-glutamate;(s)-glutamic acid;1-amino-propane-1,3-dicarboxylate;1-amino-propane-1,3-dicarboxylic acid;1-aminopropane-1,3-dicarboxylate;1-aminopropane-1,3-dicarboxylic acid;2-aminoglutarate;2-aminoglutaric acid;2-aminopentanedioate;2-aminopentanedioic acid;Aciglut;Aminoglutarate;Aminoglutaric acid;E;Glt;Glu;Glusate;Glut;Glutacid;Glutamicol;Glutamidex;Glutaminate;Glutaminic acid;Glutaminol;Glutaton;L-(+)-glutamate;L-(+)-glutamic acid;L-glu;L-glutamate;L-glutaminate;L-glutaminic acid;L-a-aminoglutarate;L-a-aminoglutaric acid;L-alpha-aminoglutarate;L-alpha-aminoglutaric acid;A-aminoglutarate;A-aminoglutaric acid;A-glutamate;A-glutamic acid;Alpha-aminoglutarate;Alpha-aminoglutaric acid;Alpha-glutamate;Alpha-glutamic acid;Acide glutamique;Acido glutamico;Acidum glutamicum;Glutamate;Glutamic acid;L-glutaminsaeure
PW_C000095
Glu
16
2
44
3
65
8
119
1
138
4
164
14
969
9
1105
42
1448
50
1456
26
1462
54
5323
111
5344
113
5415
117
5439
118
5565
132
5631
107
5632
108
5859
105
6006
147
6071
157
6191
94
6531
85
6838
187
6844
188
7092
72
7093
71
7165
205
7182
207
7514
224
7518
151
8208
225
8373
220
11792
198
11855
161
12004
222
12621
31
12683
289
12697
290
42348
315
42349
318
42845
320
77020
253
77332
133
77525
112
77971
346
77977
327
77981
347
78291
345
80649
135
120023
124
120040
122
120086
407
120347
406
120692
126
120816
418
121147
423
121153
424
121157
425
122833
119
122997
120
123299
443
123401
454
123719
458
123725
459
123729
460
125401
299
125418
297
125457
481
125667
479
125769
301
125802
489
126941
388
126995
206
127162
501
127257
506
134
Oxoglutaric acid
HMDB0000208
Oxoglutaric acid, also known as alpha-ketoglutarate, alpha-ketoglutaric acid, AKG, or 2-oxoglutaric acid, is classified as a gamma-keto acid or a gamma-keto acid derivative. gamma-Keto acids are organic compounds containing an aldehyde substituted with a keto group on the C4 carbon atom. alpha-Ketoglutarate is considered to be soluble (in water) and acidic. alpha-Ketoglutarate is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process (PMID: 26759695). In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. Additionally, AKG can be generated from isocitrate by oxidative decarboxylation catalyzed by the enzyme known as isocitrate dehydrogenase (IDH). In addition to these routes of production, AKG can be produced from glutamate by oxidative deamination via glutamate dehydrogenase, and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor. AKG is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. In particular, AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in skeletal muscles (PMID: 26759695). Interestingly, enteric feeding of AKG supplements can significantly increase circulating plasma levels of hormones such as insulin, growth hormone, and insulin-like growth factor-1 (PMID: 26759695). It has recently been shown that AKG can extend the lifespan of adult C. elegans by inhibiting ATP synthase and TOR (PMID: 24828042). In combination with molecular oxygen, alpha-ketoglutarate is required for the hydroxylation of proline to hydroxyproline in the production of type I collagen. A recent study has shown that alpha-ketoglutarate promotes TH1 differentiation along with the depletion of glutamine thereby favouring Treg (regulatory T-cell) differentiation (PMID: 26420908). alpha-Ketoglutarate has been found to be associated with fumarase deficiency, 2-ketoglutarate dehydrogenase complex deficiency, and D-2-hydroxyglutaric aciduria, which are all inborn errors of metabolism (PMID: 8338207).
328-50-7
C00026
51
30915
2-KETOGLUTARATE
50
DB02926
OC(=O)CCC(=O)C(O)=O
C5H6O5
InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
KPGXRSRHYNQIFN-UHFFFAOYSA-N
2-oxopentanedioic acid
146.0981
146.021523302
-0.44
2
oxoglutarate
0
-2
FDB003361
2-ketoglutarate;2-ketoglutaric acid;2-oxo-1,5-pentanedioate;2-oxo-1,5-pentanedioic acid;2-oxoglutarate;2-oxoglutaric acid;2-oxopentanedioate;2-oxopentanedioic acid;Oxoglutarate;Alpha-ketoglutaric acid;Oxoglutaric acid;A-ketoglutarate;A-ketoglutaric acid;Alpha-ketoglutarate;α-ketoglutarate;α-ketoglutaric acid
PW_C000134
AKG
15
2
42
3
141
4
146
8
499
18
673
31
1108
42
1263
5
1447
50
1455
26
1467
54
5375
103
5414
117
5438
118
5564
132
6008
147
6036
155
6069
157
6092
161
6482
178
6530
85
7471
222
7515
224
7519
151
8209
225
8374
220
11863
198
12681
289
77054
253
77135
133
77481
111
77523
112
77746
129
77967
345
77970
346
77976
327
77984
347
78425
334
80018
368
80694
135
113162
94
119972
406
120022
124
120084
407
120174
122
120552
414
120814
418
120989
408
121146
423
121152
424
121160
425
122757
120
122831
119
123186
450
123399
454
123554
374
123718
458
123724
459
123732
460
125357
479
125400
299
125455
481
125533
297
125800
489
125929
482
126900
501
126940
388
126993
206
127066
205
127255
506
127388
502
9969
Unknown
Unknown
18
1.3.1.71
6083
161
6121
162
6845
189
6885
160
7036
163
7063
188
7210
210
7213
211
7217
212
7223
213
7237
214
7241
215
7283
190
7301
198
7305
216
7392
217
7412
218
9275
254
11854
277
136087
644
136098
646
136985
253
136986
226
136987
693
136988
249
137079
708
10472
Probable kynurenine--oxoglutarate transaminase BNA3
P47039
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA).
BNA3
29
2.6.1.7
7842
160
10474
alanine aminotransferase
P52893
ALT1
29
2.6.1.2
7843
160
4198
glutamate-pyruvate aminotransferase
18
PW_P004198
11243
9969
2
11244
10472
2
4203
alanine aminotransferase
18
PW_P004203
11249
10474
6249
false
PW_R006249
Right
25556
164
1
Compound
true
25557
95
1
Compound
false
25558
134
1
Compound
false
25559
105
1
Compound
true
6178
4198
2.6.1.2
6254
false
PW_R006254
Both
25578
105
1
Compound
false
25579
134
1
Compound
true
25580
164
1
Compound
false
25581
95
1
Compound
true
6183
4203
2.6.1.2
77237
105
3
false
402
1077
10
regular
100
100
77244
164
3
false
402
477
10
regular
100
100
77245
95
3
false
302
622
10
regular
100
110
77246
134
3
false
317
937
10
regular
100
110
77260
134
3
false
562
1167
10
regular
100
110
77261
164
3
false
987
1077
10
regular
100
100
77262
95
3
false
852
1167
10
regular
100
110
37228
9969
160
6
false
397
782
8
subunit
regular
160
80
37229
10472
160
6
false
372
802
8
subunit
regular
160
80
37234
10474
160
2
false
672
1089
8
subunit
regular
150
70
30350
4198
2131
36569
37228
36570
37229
30355
4203
2131
36575
37234
111315
M452 577 C452 607 452 772 452 802
5
false
18
111316
M352 732 C452 737 452 772 452 802
5
false
18
111317
M367 937 C436 935 452 912 452 882
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
111318
M452 1077 C452 1047 452 912 452 882
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
111345
M502 1127 C532 1127 642 1126 672 1126
5
false
18
true
M 261.94685504416486 1258.261556296296 L 247 1257 L 253.38088772118584 1270.5751343230784
false
111346
M612 1167 C612 1125 642 1124 672 1124
5
false
18
true
M 261.94685504416486 1258.261556296296 L 247 1257 L 253.38088772118584 1270.5751343230784
false
111347
M987 1125 C957 1125 852 1124 822 1124
5
false
18
true
M 261.94685504416486 1258.261556296296 L 247 1257 L 253.38088772118584 1270.5751343230784
false
111348
M902 1167 C902 1122 852 1124 822 1124
5
false
18
true
M 261.94685504416486 1258.261556296296 L 247 1257 L 253.38088772118584 1270.5751343230784
false
3666516
M452 477 C452 447 451 417 451 387
5
false
18
22850
2131
6249
87665
77244
111315
Left
87666
77245
111316
Left
87667
77246
111317
Right
87668
77237
111318
Right
22685
6178
30350
22855
2131
6254
87685
77237
111345
Left
87686
77260
111346
Left
87687
77261
111347
Right
87688
77262
111348
Right
22690
6183
30355
109734
110050
2131
14
false
376
317
16
regular
106408
77244
3666516
Right
186633
577
484
1.0
1.0
0
2
90
484
497
4199
M224 326 C224 276 274 226 324 226 C551 226 846 226 1073 226 C1123 226 1173 276 1173 326 C1173 613 1173 985 1173 1272 C1173 1322 1123 1372 1073 1372 C846 1372 551 1372 324 1372 C274 1372 224 1322 224 1272 C224 985 224 613 224 326
1
true
6
949.0
1146.0
4200
M125 225 C125 175 175 125 225 125 C512 125 886 125 1173 125 C1223 125 1273 175 1273 225 C1273 573 1273 1025 1273 1373 C1273 1423 1223 1473 1173 1473 C886 1473 512 1473 225 1473 C175 1473 125 1423 125 1373 C125 1025 125 573 125 225
1
true
6
1148.0
1348.0