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spermidine
synthase
Spermine
Synthase
Aldehyde
dehydrogenase
[NAD(P)+] 2
pantoate
β-alanine
ligase
pantothenate
kinase
phosphopantothenate-
cysteine ligase
pantetheine-
phosphate
adenylyltransferase
dephospho-CoA
kinase
S-
adenosylmethionine
synthetase
S-
AdenosylMethionine
requiring
S-
adenosylmethionine
decarboxylase
Polyamine
oxidase
Coenzyme A
biosynthesis
protein 3
Phosphopantothenoylcysteine
decarboxylase
subunit VHS3
Phosphopantothenoylcysteine
decarboxylase
subunit SIS2
ornithine
decarboxylase
Putrescine
S-
Adenosylmethioninamine
H
+
5'-
Methylthioadenosine
Spermidine
S-
Adenosylmethioninamine
H
+
5'-
Methylthioadenosine
Spermine
3-Aminopropanal
H
2
O
NADP
β-Alanine
H
+
NADPH
(R)-pantoate
ATP
Pantothenic
acid
AMP
PP
i
H
+
ATP
D-4'-
Phosphopantothenate
ADP
H
+
Cytidine
triphosphate
L-Cysteine
Cytidine
monophosphate
PP
i
H
+
4'-
Phosphopantothenoylcysteine
4'-
phosphopantetheine
ATP
H
+
PP
i
Dephospho-CoA
ATP
H
+
ADP
Coenzyme A
L-Methionine
ATP
H
2
O
P
i
PP
i
S-
Adenosylmethionine
H
+
CO
2
H
2
O
O
2
H
2
O
2
Spermidine
H
+
CO
2
Ornithine
H
+
CO
2
Endocytosis
SPE3
SPE4
ALD3
PAN6
CAB1
CAB2
CAB4
CAB5
SAM1
SAM2
SPE2
FMS1
CAB3
VHS3
SIS2
SPE1
Putrescine
S-
Adenosylmethioninamine
Hydrogen Ion
5'-
Methylthioadenosine
Spermidine
S-
Adenosylmethioninamine
Hydrogen Ion
5'-
Methylthioadenosine
Spermine
3-Aminopropanal
Water
NADP
β-Alanine
Hydrogen Ion
NADPH
(R)-pantoate
Adenosine
triphosphate
Pantothenic
acid
Adenosine
monophosphate
Pyrophosphate
Hydrogen Ion
Adenosine
triphosphate
D-4'-
Phosphopantothenate
Adenosine
diphosphate
Hydrogen Ion
Cytidine
triphosphate
L-Cysteine
Cytidine
monophosphate
Pyrophosphate
Hydrogen Ion
4'-
Phosphopantothenoylcysteine
4'-
phosphopantetheine
Adenosine
triphosphate
Hydrogen Ion
Pyrophosphate
Dephospho-CoA
Adenosine
triphosphate
Hydrogen Ion
Adenosine
diphosphate
Coenzyme A
L-Methionine
Adenosine
triphosphate
Water
Phosphate
Pyrophosphate
S-
Adenosylmethionine
Hydrogen Ion
Carbon dioxide
Water
Oxygen
Hydrogen
peroxide
Spermidine