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3-ketoacyl-CoA synthase ELO1 Long-chain- fatty-acid-- CoA ligase 2 Very long-chain fatty acid transport protein long chain fatty acyl:CoA synthetase Long-chain- fatty-acid-- CoA ligase 1 Long-chain- fatty-acid-- CoA ligase 3 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase Peroxisomal acyl-coenzyme A thioester hydrolase 1 2-enoyl thioester reductase 3-ketoacyl-CoA synthase ELO1 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase 3-ketoacyl-CoA synthase ELO1 3-ketoacyl-CoA synthase ELO1 3-oxoacyl- [acyl- carrier- protein] reductase 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase 3-ketoacyl-CoA synthase ELO1 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase dihydrosphingosine C-4 hydroxylase 3- ketosphinganine reductase Serine palmitoyltransferase 1 Peroxisomal hydratase- dehydrogenase- epimerase Ceramide synthase subunit LIP1 Palmityl-CoA Malonyl-CoA H+ CO2 3- Oxooctadecanoyl- CoA CoA Palmitic acid ATP CoA AMP PPi H+ NADPH NADP (3R)-3- hydroxy- stearoyl-CoA (2E)- Octadecenoyl- CoA H2O H+ NADPH Stearoyl-CoA NADP H2O H+ CoA Stearic acid (2E)- eicosenoyl- CoA H+ NADPH Eicosanoyl-CoA NADP Malonyl-CoA H+ CoA CO2 3- oxodocosanoyl- CoA H+ NADPH NADP (3R)-3- hydroxy- docosanoyl- CoA H2O trans-docos- 2-enoyl-CoA H+ NADPH Docosanoyl-CoA NADP Malonyl-CoA H+ CoA CO2 3- oxotetracosanoyl- CoA H+ Malonyl-CoA 3- oxoicosanoyl- CoA CoA CO2 NADPH H+ (3R)-3- hydroxy- arachidoyl- CoA NADP NADPH H+ (3R)- hydroxytetracosanoyl- CoA NADP H2O (2E)- lignocerenoyl- CoA H+ NADPH NADP Tetracosanoyl- CoA Malonyl-CoA H+ CoA CO2 3- oxohexacosanoyl- CoA H+ NADPH NADP (3R)- hydroxyhexacosanoyl- CoA H2O (2E)- cerotenoyl- CoA H+ NADPH Hexacosanoyl- CoA NADP H+ O2 Sphinganine H2O Phytosphingosine H+ NADPH 3- Dehydrosphinganine NADP Palmityl-CoA L-Serine H+ CoA CO2 H2O H+ CoA N- hexacosanoyl- C20-4- hydroxysphinganine ferrocytochrome b5 ferricytochrome b5 Endocytosis