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3-ketoacyl-CoA
synthase ELO1
Acyl-CoA
synthase
Acyl-CoA
synthase
Acyl-CoA
synthase
Acyl-CoA
synthase
Acyl-CoA
synthase
3-oxoacyl-
[acyl- carrier-
protein]
reductase
Peroxisomal
hydratase-
dehydrogenase-
epimerase
2-enoyl
thioester
reductase
acyl-CoA
thioesterase
3-ketoacyl-CoA
synthase ELO1
3-oxoacyl-
[acyl- carrier-
protein]
reductase
dihydrosphingosine
C-4 hydroxylase
3-
ketosphinganine
reductase
Ceramide
synthase
subunit LIP1
Serine
palmitoyltransferase
1
2-enoyl
thioester
reductase
Peroxisomal
hydratase-
dehydrogenase-
epimerase
Palmityl-CoA
Malonyl-CoA
H
+
CO
2
3-
Oxooctadecanoyl-
CoA
CoA
Palmitic acid
ATP
CoA
AMP
PP
i
H
+
NADPH
NADP
(3R)-3-
hydroxy-
stearoyl-CoA
(2E)-
Octadecenoyl-
CoA
H
2
O
H
+
NADPH
Stearoyl-CoA
NADP
H
2
O
H
+
CoA
Stearic acid
H
+
Malonyl-CoA
3-
oxoicosanoyl-
CoA
CoA
CO
2
NADPH
H
+
(3R)-3-
hydroxy-
arachidoyl- CoA
NADP
H
+
O
2
Sphinganine
H
2
O
Phytosphingosine
H
+
NADPH
3-
Dehydrosphinganine
NADP
Eicosanoyl-CoA
H
+
CoA
N-
icosanoylphytosphingosine
Palmityl-CoA
L-Serine
H
+
CoA
CO
2
(2E)-
eicosenoyl- CoA
H
+
NADPH
NADP
H
2
O
ferrocytochrome
b5
ferricytochrome
b5
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
LIP1
LCB1
Unknown
Unknown
Palmityl-CoA
Malonyl-CoA
Hydrogen Ion
Carbon dioxide
3-
Oxooctadecanoyl-
CoA
Coenzyme A
Palmitic acid
Adenosine
triphosphate
Coenzyme A
Adenosine
monophosphate
Pyrophosphate
Hydrogen Ion
NADPH
NADP
(3R)-3-
hydroxy-
stearoyl-CoA
(2E)-
Octadecenoyl-
CoA
Water
Hydrogen Ion
NADPH
Stearoyl-CoA
NADP
Water
Hydrogen Ion
Coenzyme A
Stearic acid
Hydrogen Ion
Malonyl-CoA
3-
oxoicosanoyl-
CoA
Coenzyme A
Carbon dioxide
NADPH
Hydrogen Ion
(3R)-3-
hydroxy-
arachidoyl- CoA
NADP
Hydrogen Ion
Oxygen
Sphinganine
Water
Phytosphingosine
Hydrogen Ion
NADPH
3-
Dehydrosphinganine
NADP
Eicosanoyl-CoA
Hydrogen Ion
Coenzyme A
N-
icosanoylphytosphingosine
Palmityl-CoA
L-Serine
Hydrogen Ion
Coenzyme A
Carbon dioxide
(2E)-
eicosenoyl- CoA
Hydrogen Ion
NADPH
NADP
Water
ferrocytochrome
b5
ferricytochrome
b5