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Unknown
Unknown
5-
aminolevulinate
synthase,
nonspecific,
mitochondrial
Delta-
aminolevulinic
acid
dehydratase
Porphobilinogen
deaminase
Uroporphyrinogen-
III synthase
Uroporphyrinogen
decarboxylase
Uroporphyrinogen
decarboxylase
Coproporphyrinogen-
III oxidase,
mitochondrial
Ferritin,
mitochondrial
Ferrochelatase,
mitochondrial
Protoheme IX
farnesyltransferase,
mitochondrial
Cytochrome c
oxidase
assembly
protein COX15
homolog
Heme oxygenase
1
Biliverdin
reductase A
UDP-
glucuronosyltransferase
2B11
Beta-
glucuronidase
Protoporphyrinogen
oxidase
Glycine
Coproporphyrinogen
III
Coproporphyrinogen
III
Protoporphyrin
IX
Protoporphyrin
IX
Heme
Heme
Succinyl-CoA
5-
Aminolevulinic
acid
CO
2
Porphobilinogen
H
2
O
H
2
O
Hydroxymethylbilane
NH
3
Uroporphyrinogen
III
H
2
O
Uroporphyrin
III
Uroporphyrinogen
I
Coproporphyrinogen
I
CO
2
Coproporphyrin
I
Uroporphyrin I
CO
2
Coproporphyrin
III
O
2
H
+
Protoporphyrinogen
IX
CO
2
H
2
O
Fe2+
H
+
O
2
Fe3+
H
2
O
H
+
Farnesyl
pyrophosphate
Heme O
Heme A
Heme
O
2
Biliverdin
Fe2+
Carbon monoxide
H
2
O
NAD
Bilirubin
NADH
Uridine
diphosphate
glucuronic acid
Bilirubin
diglucuronide
Uridine
5'-diphosphate
H
2
O
Urobilinogen
O
2
H
2
O
2
Pyridoxal
5'-phosphate
Zinc
2Fe-2S
Zinc
FAD
AH2
A
Alcohol
Glycine and
Serine
Metabolism
Intracellular Space
Mitochondria
Outer mitochondrial membrane
Inner mitochondrial membrane
Microsome
Microsome
Lysosome