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Mitochondria Phosphatidylethanolamine N- methyltransferase Phosphatidyl- N- methylethanolamine N- methyltransferase Phosphatidyl- N- methylethanolamine N- methyltransferase Phospholipid- transporting ATPase DNF1 Phospholipid- transporting ATPase DNF2 Alkylphosphocholine resistance protein LEM3 Phospholipid- transporting ATPase DNF1 Phospholipid- transporting ATPase DNF2 Alkylphosphocholine resistance protein LEM3 Ale1p acyltransferase Ale1p acyltransferase Phospholipid- transporting ATPase DNF1 Phospholipid- transporting ATPase DNF2 Alkylphosphocholine resistance protein LEM3 Phospholipid- transporting ATPase DNF1 Phospholipid- transporting ATPase DNF2 Alkylphosphocholine resistance protein LEM3 Phospholipid- transporting ATPase DNF1 Phospholipid- transporting ATPase DNF2 Alkylphosphocholine resistance protein LEM3 Phospholipid- transporting ATPase DNF1 Phospholipid- transporting ATPase DNF2 Alkylphosphocholine resistance protein LEM3 Ale1p acyltransferase Ale1p acyltransferase Ale1p acyltransferase Ale1p acyltransferase PE(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) S- Adenosylmethionine PE- NMe(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) H+ S- Adenosylhomocysteine S- Adenosylmethionine PE- NMe2(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) S- Adenosylhomocysteine H+ S- Adenosylmethionine S- Adenosylhomocysteine H+ PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) ATP H2O LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0) LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0) ADP Pi ATP H2O LysoPE(14:0/0:0) LysoPE(14:0/0:0) ADP Pi ATP H2O Lyso- PS(14:0/0:0) Lyso- PS(14:0/0:0) ADP Pi Lyso- PI(14:0/0:0) Lyso- PI(14:0/0:0) ATP H2O ADP Pi Lyso- PS(0:0/14:0) Lyso- PS(0:0/14:0) ATP H2O ADP Pi ATP H2O Lyso- PI(0:0/14:0) Lyso- PI(0:0/14:0) ADP Pi PS(14:0/14:0) PI(14:0/14:0) PS(14:0/14:0) PI(14:0/14:0) Endoplasmic Reticulum Cytoplasm
Mitochondria CHO2 OPI3 OPI3 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 ALE1 ALE1 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 ALE1 ALE1 ALE1 ALE1 PE(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) S- Adenosylmethionine PE- NMe(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) Hydrogen Ion S- Adenosylhomocysteine S- Adenosylmethionine PE- NMe2(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) S- Adenosylhomocysteine Hydrogen Ion S- Adenosylmethionine S- Adenosylhomocysteine Hydrogen Ion PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) Adenosine triphosphate Water LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0) LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0) Adenosine diphosphate Phosphate Adenosine triphosphate Water LysoPE(14:0/0:0) LysoPE(14:0/0:0) Adenosine diphosphate Phosphate Adenosine triphosphate Water Lyso- PS(14:0/0:0) Lyso- PS(14:0/0:0) Adenosine diphosphate Phosphate Lyso- PI(14:0/0:0) Lyso- PI(14:0/0:0) Adenosine triphosphate Water Adenosine diphosphate Phosphate Lyso- PS(0:0/14:0) Lyso- PS(0:0/14:0) Adenosine triphosphate Water Adenosine diphosphate Phosphate Adenosine triphosphate Water Lyso- PI(0:0/14:0) Lyso- PI(0:0/14:0) Adenosine diphosphate Phosphate PS(14:0/14:0) PI(14:0/14:0) PS(14:0/14:0) PI(14:0/14:0)
Mitochondria CHO2 OPI3 OPI3 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 ALE1 ALE1 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 DNF1 DNF2 LEM3 ALE1 ALE1 ALE1 ALE1 PE40:8 SAMe MMPE H+ SAH SAMe DMPE SAH H+ SAMe SAH H+ Dapc ATP H2O