CHEBI:16015
ChEBI
439161
PubChem-compound
Mitochondrial pyruvate carrier 1
1.0
96860
ChemSpider
1.0
6-phosphofructokinase, liver type
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
CHEBI:30797
ChEBI
HMDB0001068
HMDB
439153
PubChem-compound
1.0
1.0
50
ChemSpider
C6H14O12P2
Fructose 1,6-bisphosphate
339.99606
D-Ribulose 5-phosphate
1.0
OXALACETIC_ACID
BioCyc
4.0
HMDB0001072
HMDB
1.0
HMDB0003498
HMDB
5743
ChemSpider
CHEBI:16238
ChEBI
P09622
UniProt
5746
ChemSpider
HCO3
BioCyc
CHEBI:15380
ChEBI
5742
ChemSpider
NADH
C25H40N7O19P3S
Succinyl-CoA
867.1312
439184
PubChem-compound
D-Ribose 5-phosphate
O95336
UniProt
CHEBI:16474
ChEBI
Glucose-6-phosphate 1-dehydrogenase
1.0
Transport139
false
L-Glutamine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
SMILES
OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O
97-67-6
CAS
C6H13O9P
Beta-D-Glucose 6-phosphate
260.02972
D-Sedoheptulose 7-phosphate
2646-35-7
CAS
FAD
1.0
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
1.0
CHEBI:30769
ChEBI
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
439167
PubChem-compound
1.0
C3H7O6P
D-Glyceraldehyde 3-phosphate
169.99803
138-08-9
CAS
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O
1161
ChemSpider
C00231
KEGG Compound
C00236
KEGG Compound
1.0
1.0
SUC
BioCyc
Reaction390
false
L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
REVERSIBLE
Monocarboxylate transporter 1
7664-38-2
CAS
6.0
1.0
C00009
KEGG Compound
C00008
KEGG Compound
SMILES
O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O
C00006
KEGG Compound
P29401
UniProt
Hydrogen Ion
CHEBI:18009
ChEBI
C00001
KEGG Compound
P15259
UniProt
Fructose 6-phosphate
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
439190
PubChem-compound
C00005
KEGG Compound
P52209
UniProt
C00004
KEGG Compound
C00003
KEGG Compound
NADPH
C00002
KEGG Compound
60.0
Coenzyme A
C6H11O9P
6-Phosphonoglucono-D-lactone
258.01407
C11378
KEGG Compound
C59H90O4
Coenzyme Q10
862.6839
388411
ChemSpider
C7H15O10P
D-Sedoheptulose 7-phosphate
290.04028
1.0
107689
PubChem-compound
P53985
UniProt
C00011
KEGG Compound
C00010
KEGG Compound
P49247
UniProt
FRUCTOSE-6P
BioCyc
C00016
KEGG Compound
C00014
KEGG Compound
CHEBI:17363
ChEBI
Transketolase
CHEBI:17138
ChEBI
H
Hydrogen Ion
1.007825
Phosphate
Neutral amino acid transporter B(0)
C00022
KEGG Compound
56-65-5
CAS
C01352
KEGG Compound
53-84-9
CAS
C00026
KEGG Compound
C00025
KEGG Compound
C00024
KEGG Compound
CHEBI:26078
ChEBI
O14521
UniProt
L-Glutamic acid
NADP
CHEBI:48928
ChEBI
4.0
P06733
UniProt
769
PubChem-compound
1.4.1.3
false
1.4.1.3
L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid
LEFT_TO_RIGHT
CL:0000000
CELL TYPE ONTOLOGY
SMILES
O[C@H](COP(O)(O)=O)[C@@H](O)C=O
C00031
KEGG Compound
C00279
KEGG Compound
C00036
KEGG Compound
CHEBI:18276
ChEBI
Transport1
false
Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix
LEFT_TO_RIGHT
C00035
KEGG Compound
HMDB0000134
HMDB
SMILES
OC(=O)CCC(O)=O
1.0
C00282
KEGG Compound
C00281
KEGG Compound
P50213
UniProt
1.0
Transaldolase
2.7.1.11
false
2.7.1.11
Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate
LEFT_TO_RIGHT
1.0
P06744
UniProt
D-Erythrose 4-phosphate
C00044
KEGG Compound
C00042
KEGG Compound
L-Glutamine
648
ChemSpider
1.0
3.5.1.2
false
3.5.1.2
L-Glutamine + Water → Ammonia + L-Glutamic acid
LEFT_TO_RIGHT
4.1.2.13
false
4.1.2.13
Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate
REVERSIBLE
C00288
KEGG Compound
56-85-9
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
604-98-8
CAS
HMDB0000148
HMDB
1.0
P51553
UniProt
HMDB0001473
HMDB
SMILES
OC(=O)C(=C)OP(O)(O)=O
Reaction812
false
D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH
REVERSIBLE
C3H7O7P
3-Phosphoglyceric acid
185.99294
FUM
BioCyc
SMILES
OC(=O)CC(=O)C(O)=O
CHEBI:4170
ChEBI
CHEBI:18012
ChEBI
HMDB0001487
HMDB
HMDB0000156
HMDB
6-phosphogluconolactonase
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Q99798
UniProt
Glucose-6-phosphate 1-dehydrogenase
1.0
HMDB0001248
HMDB
Pyruvic acid
1.0
P21912
UniProt
1.0
24.0
C10H16N5O13P3
Adenosine triphosphate
506.99576
Phosphoric acid
DPG
BioCyc
DIHYDROXY-ACETONE-PHOSPHATE
BioCyc
6-phosphofructokinase, liver type
P30613
UniProt
SMILES
COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC
C00064
KEGG Compound
1.0
NAD
SMILES
CC(=O)C(O)=O
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
663
ChemSpider
C00074
KEGG Compound
SMILES
O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
Mitochondrial pyruvate carrier 1
6.4.1.1
false
6.4.1.1
Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
LEFT_TO_RIGHT
3-Phosphoglyceric acid
962
PubChem-compound
1.0
724
PubChem-compound
Transaldolase
CO2
Carbon dioxide
43.98983
C00080
KEGG Compound
C00085
KEGG Compound
C01172
KEGG Compound
729
PubChem-compound
Q9Y5U8
UniProt
HMDB0002111
HMDB
BiologicalState4
Homo sapiens, Cell, Mitochondrial Matrix
BiologicalState2
Homo sapiens, Cell, Cytosol
Adenosine diphosphate
HMDB0001022
HMDB
14265-44-2
CAS
Glucose-6-phosphate isomerase
PYRUVATE
BioCyc
QH2
BioCyc
C5H11O8P
D-Ribulose 5-phosphate
230.01915
1.0
C00092
KEGG Compound
Transketolase
C00091
KEGG Compound
G3P
BioCyc
Glucose-6-phosphate isomerase
1.0
CHEBI:4167
ChEBI
HMDB0001270
HMDB
HMDB0001273
HMDB
Isocitric acid
2.0
L-Glutamine
1.0
HMDB0000190
HMDB
Succinic acid
XYLULOSE-5-PHOSPHATE
BioCyc
Coenzyme Q10
CHEBI:18050
ChEBI
1.0
FADH2
BioCyc
HMDB0000193
HMDB
393165
ChemSpider
NADH
BioCyc
C5H11O8P
Xylulose 5-phosphate
230.01915
1.0
P17858
UniProt
970
PubChem-compound
HMDB0001058
HMDB
Acetyl-CoA
O75390
UniProt
Citrate synthase, mitochondrial
CHO3
Hydrogen carbonate
60.99257
820-11-1
CAS
SMILES
[H][H]
HMDB0002142
HMDB
30572
ChemSpider
17215925
ChemSpider
446013
PubChem-compound
CHEBI:15721
ChEBI
L-Malic acid
1.0
6-phosphogluconate dehydrogenase, decarboxylating
SMILES
OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O
Glyceraldehyde-3-phosphate dehydrogenase
21883788
PubChem-compound
Guanosine triphosphate
H3N
Ammonia
17.026548
1.0
HMDB0000538
HMDB
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
5961
PubChem-compound
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
643-13-0
CAS
1981-49-3
CAS
1.0
6816
PubChem-compound
C3H7O6P
Dihydroxyacetone phosphate
169.99803
51
PubChem-compound
FADH
SMILES
OC([O-])=O
CHEBI:46245
ChEBI
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Neutral amino acid transporter B(0)
Isocitrate dehydrogenase [NADP] cytoplasmic
Oxoglutarate dehydrogenase complex
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
HMDB0001401
HMDB
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
274
ChemSpider
O4P
Phosphate
94.95342
6830
PubChem-compound
CHEBI:15946
ChEBI
TransportCatalysis228
ACTIVATION
TransportCatalysis227
ACTIVATION
P40925
UniProt
NADPH
BioCyc
Carbon dioxide
217
ChemSpider
58-68-4
CAS
HMDB0001423
HMDB
SMILES
[O-]P([O-])([O-])=O
6-phosphogluconolactonase
C6H13O9P
Fructose 6-phosphate
260.02972
CHEBI:30915
ChEBI
Q96HY7
UniProt
1.0
C6H12O6
D-Glucose
180.06339
L-Glutamine
ReactionCatalysis4
ACTIVATION
HMDB0001429
HMDB
GO:0005759
GENE ONTOLOGY
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
Q96I99
UniProt
1.0
C4H4O4
Fumaric acid
116.010956
Pyruvate kinase PKM
P14618
UniProt
CHEBI:15741
ChEBI
Oxoglutaric acid
Fumarate hydratase, mitochondrial
Malate dehydrogenase, cytoplasmic
SMILES
O=C=O
1.0
1110
PubChem-compound
Ribose-5-phosphate isomerase
HMDB0001201
HMDB
HMDB0000595
HMDB
5958
PubChem-compound
C21H29N7O14P2
NADH
665.12476
5957
PubChem-compound
HMDB0001206
HMDB
P21399
UniProt
CHEBI:15996
ChEBI
Warburg Effec
L-lactate dehydrogenase A chain
SMILES
OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O
Alpha-enolase
HMDB0000122
HMDB
HMDB0000124
HMDB
60.0
GO:0005737
GENE ONTOLOGY
1.0
C6H8O7
Citric acid
192.02701
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
L-lactate dehydrogenase A chain
SMILES
OCC1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]1O
1.0
82615
ChemSpider
SMILES
COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O
5682
ChemSpider
1.2.4.2
false
1.2.4.2
Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
LEFT_TO_RIGHT
CHEBI:52742
ChEBI
2.3.3.1
false
2.3.3.1
Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A
LEFT_TO_RIGHT
Mitochondrial Matrix
Reaction593
false
Guanosine diphosphate + Phosphate + Succinyl-CoA ↔ Coenzyme A + Guanosine triphosphate + Succinic acid
REVERSIBLE
1.2.4.1
false
1.2.4.1
Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH
LEFT_TO_RIGHT
D-Glucose
2.0
D-SEDOHEPTULOSE-7-P
BioCyc
CO-A
BioCyc
Monocarboxylate transporter 1
222656
PubChem-compound
5675
ChemSpider
72-89-9
CAS
1078
ChemSpider
Phosphoglycerate mutase 2
Fructose-bisphosphate aldolase B
ReactionCatalysis658
ACTIVATION
ReactionCatalysis659
ACTIVATION
2.7.1.40
false
2.7.1.40
Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid
REVERSIBLE
Cell
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
ReactionCatalysis692
ACTIVATION
Citrate synthase, mitochondrial
6557
ChemSpider
643975
PubChem-compound
Beta-D-Glucose 6-phosphate
127-17-3
CAS
CHEBI:17719
ChEBI
D-6-P-GLUCONO-DELTA-LACTONE
BioCyc
Water
1.1.1.27
false
1.1.1.27
L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid
REVERSIBLE
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Dihydrolipoyl dehydrogenase, mitochondrial
SMILES
O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O
1.0
GLC-6-P
BioCyc
C5H11O8P
D-Ribose 5-phosphate
230.01915
ReactionCatalysis678
ACTIVATION
9606
TAXONOMY
1333-74-0
CAS
CHEBI:17544
ChEBI
P08559
UniProt
2-KETOGLUTARATE
BioCyc
392413
ChemSpider
SMILES
OC(COP(O)(O)=O)C(O)=O
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
110-15-6
CAS
Phosphoglycerate kinase 1
1.0
CHEBI:15377
ChEBI
Fumarate hydratase, mitochondrial
CHEBI:15378
ChEBI
SMILES
[H+]
Glucose-6-phosphate isomerase
Isocitrate dehydrogenase
6569
ChemSpider
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
CHEBI:17552
ChEBI
Pyruvate carboxylase, mitochondrial
CHEBI:422
ChEBI
CHEBI:30744
ChEBI
Isocitrate dehydrogenase [NADP] cytoplasmic
Dihydrolipoyl dehydrogenase, mitochondrial
5793
PubChem-compound
L-Glutamine
SMILES
OC(COP(O)(O)=O)C=O
P05062
UniProt
1198
PubChem-compound
1.0
2.7.1.1
false
2.7.1.1
Adenosine triphosphate + D-Glucose → Adenosine diphosphate + Glucose 6-phosphate
LEFT_TO_RIGHT
1.0
FAD
BioCyc
3-METHYLBENZYLSUCCINYL-COA
BioCyc
1.1.1.41
false
1.1.1.41
Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid
LEFT_TO_RIGHT
86-01-1
CAS
P53597
UniProt
1.0
1.0
109096
ChemSpider
Mitochondrial citrate transport protein
CHEBI:15351
ChEBI
Solute carrier family 2, facilitated glucose transporter member 2
SMILES
O[C@H]1[C@H](O)[C@@H](COP(O)(O)=O)OC(=O)[C@@H]1O
85-61-0
CAS
6022
PubChem-compound
Q9UI32
UniProt
C23H38N7O17P3S
Acetyl-CoA
809.1258
937
ChemSpider
C00311
KEGG Compound
CHEBI:16134
ChEBI
439278
PubChem-compound
Phosphoglycerate mutase 2
110-17-8
CAS
ReactionCatalysis702
ACTIVATION
HMDB0000094
HMDB
ReactionCatalysis700
ACTIVATION
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Pyruvate kinase PKLR
SubPathwayInhibition
2641-81-8
CAS
1.0
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
ATP
BioCyc
2.7.2.3
false
2.7.2.3
Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate
LEFT_TO_RIGHT
ReactionCatalysis936
ACTIVATION
1.1.1.49
false
1.1.1.49
Beta-D-Glucose 6-phosphate + NADP ↔ 6-Phosphonoglucono-D-lactone + Hydrogen Ion + NADPH
REVERSIBLE
1.1.1.42
false
1.1.1.42
Isocitric acid + NADP → Carbon dioxide + NADPH + Oxoglutaric acid
LEFT_TO_RIGHT
Reaction1246
false
3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid
REVERSIBLE
HMDB0001197
HMDB
388330
ChemSpider
2280-44-6
CAS
ALPHA-GLUCOSE-16-BISPHOSPHATE
BioCyc
1.1.1.44
false
1.1.1.44
6-Phosphogluconic acid + NADP → Carbon dioxide + D-Ribulose 5-phosphate + NADPH
LEFT_TO_RIGHT
1.0
5281915
PubChem-compound
ReactionCatalysis960
ACTIVATION
C27H35N9O15P2
FADH
787.1728
HMDB0003391
HMDB
Carbon dioxide
709
ChemSpider
704
ChemSpider
945
ChemSpider
C00345
KEGG Compound
1010
ChemSpider
C10H15N5O11P2
Guanosine diphosphate
443.02432
O75874
UniProt
488-69-7
CAS
CHEBI:30887
ChEBI
ReactionCatalysis958
ACTIVATION
ReactionCatalysis713
ACTIVATION
ReactionCatalysis714
ACTIVATION
ReactionCatalysis953
ACTIVATION
C00117
KEGG Compound
388313
ChemSpider
1.0
C10H16N5O14P3
Guanosine triphosphate
522.99066
1.0
1.0
C5H10N2O3
L-Glutamine
146.06914
CPD-2961
BioCyc
C3H8O10P2
Glyceric acid 1,3-biphosphate
265.95926
388559
ChemSpider
C00111
KEGG Compound
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Cytosol
Alpha-enolase
C00597
KEGG Compound
C00354
KEGG Compound
O43837
UniProt
SMP63802
SMPDB
Glyceraldehyde-3-phosphate dehydrogenase
Transport72
false
Citric acid (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix
LEFT_TO_RIGHT
1.0
Fructose 1,6-bisphosphate
Transport279
false
D-Glucose (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
5.3.1.9
false
5.3.1.9
Fructose 6-phosphate ↔ Glucose 6-phosphate
REVERSIBLE
5.3.1.9
false
5.3.1.9
Beta-D-Glucose 6-phosphate ↔ Glucose 6-phosphate
REVERSIBLE
1.0
Transport281
false
L-Glutamine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix
LEFT_TO_RIGHT
1.0
559059
ChemSpider
C00122
KEGG Compound
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1
122357
PubChem-compound
4.0
921-62-0
CAS
Transport280
false
L-Lactic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
2.0
NADH
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
CHEBI:18367
ChEBI
1032
ChemSpider
1910-41-4
CAS
1031
ChemSpider
2.2.1.1
false
2.2.1.1
D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate ↔ D-Ribose 5-phosphate + Xylulose 5-phosphate
REVERSIBLE
5.3.1.6
false
5.3.1.6
D-Ribulose 5-phosphate ↔ D-Ribose 5-phosphate
REVERSIBLE
2.2.1.2
false
2.2.1.2
D-Erythrose 4-phosphate + Fructose 6-phosphate ↔ D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate
REVERSIBLE
Pyruvic acid
C27H33N9O15P2
FAD
785.1571
388538
ChemSpider
C21H28N7O14P2
NAD
664.11694
HMDB0000902
HMDB
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Extracellular Space
NAD(P)
BioCyc
SubPathwayControl57812
SubPathway57812Control
InhibitorySubPathwayControl
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
C00149
KEGG Compound
388307
ChemSpider
P52789
UniProt
Pyruvate carboxylase, mitochondrial
C01236
KEGG Compound
62713
ChemSpider
Q6LAP8
UniProt
Fumaric acid
C00390
KEGG Compound
1.0
Ribose-5-phosphate isomerase
Pyruvate carboxylase, mitochondrial
56275-39-9
CAS
C00158
KEGG Compound
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
328-50-7
CAS
HMDB0000254
HMDB
L-Lactic acid
Transketolase
D-Glucose
L-Lactic acid
HMDB0001341
HMDB
4.0
P07954
UniProt
1.0
4445197
ChemSpider
303-98-0
CAS
HMDB0001112
HMDB
SMILES
OC(=O)CC(O)(CC(O)=O)C(O)=O
762
ChemSpider
PHOSPHO-ENOL-PYRUVATE
BioCyc
Pyruvate kinase isozymes R/L
HMDB0000263
HMDB
Succinyl-CoA
10197150
ChemSpider
668
PubChem-compound
Ammonia
Hexokinase-2
PW064795
PathWhiz
7732-18-5
CAS
Aconitate hydratase, mitochondrial
591-59-3
CAS
Cytoplasmic aconitate hydratase
22833559
PubChem-compound
HMDB0001127
HMDB
AMMONIA
BioCyc
SMILES
N
56-86-0
CAS
585-18-2
CAS
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
HMDB0001362
HMDB
Glutamate dehydrogenase 1, mitochondrial
1.0
NAD
C00186
KEGG Compound
305
ChemSpider
445557
PubChem-compound
C3H7O7P
2-Phospho-D-glyceric acid
185.99294
CHEBI:17050
ChEBI
SMILES
OCC(=O)COP(O)(O)=O
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
P11168
UniProt
5800
ChemSpider
RIBULOSE-5P
BioCyc
C00199
KEGG Compound
979
ChemSpider
QH2
Water
H3O4P
Phosphoric acid
97.9769
HMDB0000051
HMDB
SMILES
N[C@@H](CCC(O)=O)C(O)=O
Isocitrate dehydrogenase [NADP] cytoplasmic
4.0
146-14-5
CAS
CHEBI:44897
ChEBI
58-64-0
CAS
Glutaminase liver isoform, mitochondrial
GTP
BioCyc
1.0
RIBOSE-5P
BioCyc
P11177
UniProt
SMILES
OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
C3H6O3
L-Lactic acid
90.03169
P04406
UniProt
Phosphoglycerate kinase 1
444493
PubChem-compound
56-73-5
CAS
2-PG
BioCyc
SMILES
OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
1.0
22833512
PubChem-compound
ACETYL-COA
BioCyc
H2O
Water
18.010565
SMILES
OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O
Hydrogen carbonate
NAD
BioCyc
2.0
HMDB0059597
HMDB
1.0
Glyceraldehyde-3-phosphate dehydrogenase
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Glutamate dehydrogenase 1, mitochondrial
749
ChemSpider
71-52-3
CAS
Glutamate dehydrogenase 1, mitochondrial
SMILES
OC(=O)\C=C\C(O)=O
Q99643
UniProt
980
ChemSpider
146-91-8
CAS
C4H6O5
L-Malic acid
134.02153
Succinate dehydrogenase
2-Phospho-D-glyceric acid
1.0
6-phosphofructokinase, liver type
C4H4O5
Oxalacetic acid
132.00587
Succinyl-CoA ligase
Adenosine triphosphate
Cytoplasmic aconitate hydratase
1.0
2.0
1.0
SMILES
O
CIT
BioCyc
58838673
PubChem-compound
P11498
UniProt
(C5H8)nC14H20O4
QH2
1004
PubChem-compound
1005
PubChem-compound
1.0
TransportCatalysis6
ACTIVATION
Pyruvate kinase PKM
Pyruvate kinase isozymes R/L
328-42-7
CAS
Aconitate hydratase, mitochondrial
2.0
SMILES
O[C@@H](CC(O)=O)C(O)=O
C6H13O10P
6-Phosphogluconic acid
276.02463
1.0
CHEBI:15846
ChEBI
P00367
UniProt
CHEBI:16938
ChEBI
ADP
BioCyc
6-Phosphogluconic acid
C3H4O3
Pyruvic acid
88.016045
ReactionCatalysis38
ACTIVATION
2.0
6-Phosphonoglucono-D-lactone
1.0
53-59-8
CAS
C6H8O7
Isocitric acid
192.02701
1038
PubChem-compound
GO:0005829
GENE ONTOLOGY
C5H6O5
Oxoglutaric acid
146.02153
CHEBI:16905
ChEBI
393487
ChemSpider
Citric acid
CHEBI:16908
ChEBI
Pyruvate dehydrogenase complex
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
77-92-9
CAS
ReactionCatalysis43
ACTIVATION
6-phosphogluconate dehydrogenase, decarboxylating
1.0
C21H30N7O17P3
NADPH
745.0911
L-LACTATE
BioCyc
C21H29N7O17P3
NADP
744.08325
Pyruvate kinase PKM
SubPathwayInhibitor
TransportCatalysis101
ACTIVATION
Hexokinase-2
P37837
UniProt
Solute carrier family 2, facilitated glucose transporter member 2
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Tyrosine kinase regulation
InhibitorySubPathway
HMDB0000208
HMDB
Mitochondrial citrate transport protein
683
PubChem-compound
Phosphoenolpyruvic acid
3.1.1.31
false
3.1.1.31
6-Phosphonoglucono-D-lactone + Water → 6-Phosphogluconic acid + Hydrogen
LEFT_TO_RIGHT
HMDB0001304
HMDB
SMILES
OC(=O)CCC(=O)C(O)=O
HMDB0001548
HMDB
HMDB0000217
HMDB
6-phosphogluconate dehydrogenase, decarboxylating
1.0
124-38-9
CAS
Guanosine diphosphate
P00558
UniProt
ReactionCatalysis69
ACTIVATION
CHEBI:17835
ChEBI
Fructose-bisphosphate aldolase B
GLC
BioCyc
1.0
ReactionCatalysis62
ACTIVATION
4.2.1.3
false
4.2.1.3
Citric acid → Isocitric acid
LEFT_TO_RIGHT
ReactionCatalysis67
ACTIVATION
ReactionCatalysis68
ACTIVATION
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
HMDB0000223
HMDB
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
GLN
BioCyc
HMDB0001316
HMDB
Hydrogen
GLT
BioCyc
7664-41-7
CAS
1.0
57-04-5
CAS
69507
PubChem-compound
P31040
UniProt
H2
Hydrogen
2.01565
53-57-6
CAS
1.0
ReactionCatalysis75
ACTIVATION
C4H9O7P
D-Erythrose 4-phosphate
200.00859
4.0
ReactionCatalysis78
ACTIVATION
4444052
ChemSpider
ReactionCatalysis79
ACTIVATION
222
PubChem-compound
Hydrogen Ion
SMILES
OP(O)(O)=O
1.0
HMDB0001321
HMDB
ReactionCatalysis70
ACTIVATION
5280344
PubChem-compound
C4H6O4
Succinic acid
118.02661
P00338
UniProt
60802-29-1
CAS
320-77-4
CAS
threo-d(s)-iso-citrate
BioCyc
ERYTHROSE-4P
BioCyc
Glucose-6-phosphate 1-dehydrogenase
HMDB0000243
HMDB
ReactionCatalysis1315
ACTIVATION
C3H5O6P
Phosphoenolpyruvic acid
167.98238
Adenosine triphosphate
C10H15N5O10P2
Adenosine diphosphate
427.02942
SMILES
OC(C(CC(O)=O)C(O)=O)C(O)=O
GO:0005615
GENE ONTOLOGY
1.0
SMILES
C[C@H](O)C(O)=O
4151-19-3
CAS
D-Glyceraldehyde 3-phosphate
Malate dehydrogenase, cytoplasmic
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
CPD-8587
BioCyc
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
19782904
PubChem-compound
HMDB0000807
HMDB
Dihydroxyacetone phosphate
CHEBI:1146900
ChEBI
Oxalacetic acid
17216052
ChemSpider
1.3.5.1
false
1.3.5.1
Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2
REVERSIBLE
C6H13O9P
Glucose 6-phosphate
260.02972
2.0
Fumarate hydratase, mitochondrial
P11413
UniProt
CHEBI:17877
ChEBI
2.0
C21H36N7O16P3S
Coenzyme A
767.11523
Adenosine diphosphate
SMILES
OC(COP(O)(O)=O)C(=O)OP(O)(O)=O
Isocitric acid
Cytoplasm
4.2.1.11
false
4.2.1.11
2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water
REVERSIBLE
91493
PubChem-compound
439427
PubChem-compound
1.0
CHEBI:15422
ChEBI
5589
ChemSpider
1.0
Homo sapiens
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
388299
ChemSpider
1.0
1.0
TransportCatalysis36
ACTIVATION
CHEBI:48153
ChEBI
79-33-4
CAS
439452
PubChem-compound
1.0
FRUCTOSE-16-DIPHOSPHATE
BioCyc
P36957
UniProt
CHEBI:16526
ChEBI
8977
PubChem-compound
CHEBI:16761
ChEBI
4.2.1.2
false
4.2.1.2
L-Malic acid ↔ Fumaric acid + Water
REVERSIBLE
1.0
1.0
Glucose 6-phosphate
1.0
Oxoglutaric acid
C00631
KEGG Compound
8630
ChemSpider
5893
PubChem-compound
CHEBI:16332
ChEBI
P10515
UniProt
Citrate synthase, mitochondrial
CHEBI:32816
ChEBI
ReactionCatalysis349
ACTIVATION
Glutaminase liver isoform, mitochondrial
ReactionCatalysis342
ACTIVATION
Xylulose 5-phosphate
CHEBI:16108
ChEBI
5886
PubChem-compound
60.0
Glyceric acid 1,3-biphosphate
HMDB0000618
HMDB
SMILES
OC[C@@H](OP(O)(O)=O)C(O)=O
9606
Taxonomy
280
PubChem-compound
HMDB0000868
HMDB
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
SMILES
N[C@@H](CCC(N)=O)C(O)=O
ReactionCatalysis2237
ACTIVATION
ReactionCatalysis2239
ACTIVATION
Citric acid
193317
ChemSpider
Q15758
UniProt
GAP
BioCyc
1060
PubChem-compound
1061
PubChem-compound
C00661
KEGG Compound
HMDB0001967
HMDB
Transaldolase
HMDB0000641
HMDB
ReactionCatalysis2240
ACTIVATION
ReactionCatalysis2242
ACTIVATION
UBIQUINONE-10
BioCyc
4300-28-1
CAS
ReactionCatalysis2241
ACTIVATION