Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Cytochrome P450
2C54
Cytochrome P450
2D9
Alcohol
dehydrogenase
[NADP(+)]
Short-chain
dehydrogenase/reductase
family 16C
member 6
Alcohol
dehydrogenase
[NADP(+)]
Steroid
21-hydroxylase
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
Cytochrome P450
2D9
3-beta-HSD 1
Steroid
21-hydroxylase
3-beta-HSD 1
Cytochrome P450
2C54
Steroid
21-hydroxylase
Cytochrome P450
2D9
Cytochrome P450
2D9
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
3-beta-HSD 1
3-beta-HSD 1
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Cytochrome P450
2D9
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
Short-chain
dehydrogenase/reductase
family 42E
member 1
Cholesterol
Progesterone
Progesterone
11b,21-Dihydroxy-3,20-oxo-
5b-pregnan-18-al
NADPH
3a,11b,21-Trihydroxy-20-oxo-
5b-pregnan-18-al
NADP
NADP
Aldosterone
NADPH
18-Hydroxycorticosterone
O2
H2O
Corticosterone
O2
H2O
11b,21-Dihydroxy-5b-
pregnane-3,20-dione
Tetrahydrocorticosterone
NADP
NADPH
11-Dehydrocorticosterone
21-Hydroxy-5b-pregnane-
3,11,20-trione
NADP
3a,21-Dihydroxy-5b-pregnane-
11,20-dione
NADPH
NADP
NADPH
11b-Hydroxyprogesterone
21-Deoxycortisol
Dissipation
Cortisol
Deoxycorticosterone
21-Hydroxypregnenolone
NAD
NADH
Pregnenolone
NAD
NADH
17-Hydroxyprogesterone
Cortexolone
17a-Hydroxypregnenolone
NAD
NADH
NADH
17α,21-Dihydroxypregnenolone
NAD
20a,22b-Dihydroxycholesterol
4-
Methylpentanal
17a,20a-Dihydroxycholesterol
22b-Hydroxycholesterol
20α-Hydroxycholesterol
17a,21-Dihydroxy-5b-
pregnane-3,11,20-trione
NADP
Cortisone
NADPH
Tetrahydrocortisone
NADP
NADPH
Dihydrocortisol
NADP
NADPH
Tetrahydrocortisol
NADP
NADPH
O2
11b,17a,21-Trihydroxypreg-
nenolone
H2O
NADPH
5a-Pregnane-3,20-dione
NADP
3a-Hydroxy-5b-pregnane-20-one
NADP
NADPH
NADP
NADPH
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Steroid
Biosynthesis
Adrenal Gland
Smooth Endoplasmic Reticulum
Smooth Endoplasmic Reticulum
ER Membrane
ER Membrane
ER Membrane
Mitochondrion
Mitochondrion
Mitochondrion
Mitochondrion
Intracellular Space
Extracellular Space
Inner mitochondria membrane
Outer mitochondria membrane