Ubiquitin-like
modifier-
activating
enzyme 1
Polyubiquitin-B
Ubiquitin D
Polyubiquitin-C
Ubiquitin-
conjugating
enzyme E2 E1
STIP1 homology
and U
box-containing
protein 1
Ubiquitin-like
modifier-
activating
enzyme 1
Ubiquitin-
conjugating
enzyme E2 E1
Proteasome
subunit alpha
type-1
Proteasome
subunit alpha
type-2
Proteasome
subunit alpha
type-3
Proteasome
subunit alpha
type-4
Proteasome
subunit alpha
type-5
Proteasome
subunit alpha
type-6
Proteasome
subunit alpha
type-7
Proteasome
subunit beta
type-1
Proteasome
subunit beta
type-2
Proteasome
subunit beta
type-3
Proteasome
subunit beta
type-4
Proteasome
subunit beta
type-5
Proteasome
subunit beta
type-6
Proteasome
subunit beta
type-7
26S proteasome
regulatory
subunit 4
26S proteasome
regulatory
subunit 7
26S proteasome
regulatory
subunit 6A
26S proteasome
regulatory
subunit 6B
26S proteasome
regulatory
subunit 8
26S proteasome
regulatory
subunit 10B
26S proteasome
non-ATPase
regulatory
subunit 13
26S proteasome
non-ATPase
regulatory
subunit 4
Polyubiquitin-B
Ubiquitin D
Polyubiquitin-C
Ubiquitin-like
modifier-
activating
enzyme 1
Polyubiquitin-B
Ubiquitin D
Polyubiquitin-C
Polyubiquitin-B
Ubiquitin D
Polyubiquitin-C
Ubiquitin-
conjugating
enzyme E2 E1
Polyubiquitin-B
Ubiquitin D
Polyubiquitin-C
Polyubiquitin-B
Ubiquitin D
Polyubiquitin-C
Proteasome
subunit alpha
type-1
Proteasome
subunit alpha
type-2
Proteasome
subunit alpha
type-3
Proteasome
subunit alpha
type-4
Proteasome
subunit alpha
type-5
Proteasome
subunit alpha
type-6
Proteasome
subunit alpha
type-7
Proteasome
subunit beta
type-1
Proteasome
subunit beta
type-2
Proteasome
subunit beta
type-3
Proteasome
subunit beta
type-4
Proteasome
subunit beta
type-5
Proteasome
subunit beta
type-6
Proteasome
subunit beta
type-7
26S proteasome
regulatory
subunit 4
26S proteasome
regulatory
subunit 7
26S proteasome
regulatory
subunit 6A
26S proteasome
regulatory
subunit 6B
26S proteasome
regulatory
subunit 8
26S proteasome
regulatory
subunit 10B
26S proteasome
non-ATPase
regulatory
subunit 13
26S proteasome
non-ATPase
regulatory
subunit 4
Polyubiquitin-B
Ubiquitin D
Polyubiquitin-C
AMP
ATP
ADP
Adenosine
triphosphate
Protein
Substrates
Peptide
Protein
Substrates
Protein
Substrates
Protein
Substrates
(This is one example of E2)
There are various types of
E2, which interact with
different types of protein
(for more details see
reference)
(This is one example of E3)
There are various types of
E3, which interact with
different types of proteins
(for more details see
reference)
Multiple Cycles
Cytoplasm