114634
Pathway
chebulagic acid Metabolism 1581167212
Signaling
PW123794
Center
PathwayVisualizationContext124070
2000
2000
#FFFFFF
PathwayVisualization114497
114634
chebulagic acid Metabolism 1581167212
Signaling
1
1
Cell
CL:0000000
3
Neuron
CL:0000540
4
Cardiomyocyte
CL:0000746
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
5
Bos taurus
9913
Eukaryote
Cattle
1
Homo sapiens
9606
Eukaryote
Human
3
Escherichia coli
562
Prokaryote
24
Solanum lycopersicum
4081
Eukaryote
Tomato
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
21
Xenopus laevis
8355
Eukaryote
African clawed frog
12
Mus musculus
10090
Eukaryote
Mouse
49
Bathymodiolus platifrons
220390
Eukaryote
Deep sea mussel
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
17
Rattus norvegicus
10116
Eukaryote
Rat
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
2
Bacteria
2
Prokaryote
Bacteria
62
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
62977
Prokaryote
143
Klebsiella pneumoniae
573
Prokaryote
Klebsiella
1
Cytosol
GO:0005829
35
Chloroplast
GO:0009507
5
Cytoplasm
GO:0005737
10
Cell Membrane
GO:0005886
36
Membrane
GO:0016020
3
Mitochondrial Matrix
GO:0005759
4
Peroxisome
GO:0005777
32
Inner Membrane
GO:0070258
14
Mitochondrial Outer Membrane
GO:0005741
8
Blood Vessel
BTO:0001102
74
11
24
Brain
BTO:0000142
89
16
151
1
4
1
PW_BS000151
225
35
4
1
PW_BS000024
164
4
PW_BS000164
122
5
5
1
PW_BS000122
285
10
4
1
PW_BS000024
293
4
1
PW_BS000024
152
8
4
PW_BS000152
1
1
PW_BS000001
228
36
1
PW_BS000024
8
5
1
1
PW_BS000008
4
3
1
1
PW_BS000004
2
1
1
1
PW_BS000002
14
10
1
PW_BS000014
73
10
1
3
PW_BS000073
85
24
10
1
1
PW_BS000085
103
3
3
1
PW_BS000103
155
3
24
1
PW_BS000155
161
3
18
1
PW_BS000161
178
3
21
1
PW_BS000178
222
3
4
1
PW_BS000024
115
10
12
PW_BS000115
198
5
18
1
PW_BS000024
290
5
49
1
PW_BS000024
133
3
12
1
PW_BS000133
111
5
12
1
PW_BS000111
132
1
12
1
PW_BS000132
368
3
60
1
PW_BS000028
308
10
1
1
PW_BS000024
253
5
4
1
PW_BS000024
406
3
5
1
PW_BS000115
124
1
5
1
PW_BS000124
120
3
17
1
PW_BS000120
135
5
17
1
PW_BS000135
118
1
17
1
PW_BS000118
479
3
10
1
PW_BS000115
297
5
10
1
PW_BS000024
299
1
10
1
PW_BS000024
501
3
6
1
PW_BS000115
205
5
6
1
PW_BS000024
388
1
6
1
PW_BS000112
5
4
1
1
PW_BS000005
216
4
18
1
PW_BS000024
226
4
4
1
PW_BS000024
334
4
12
1
PW_BS000028
408
4
5
1
PW_BS000115
374
4
17
1
PW_BS000053
117
1
3
1
PW_BS000117
372
10
2
PW_BS000028
657
10
62
PW_BS000508
421
36
5
PW_BS000115
109
32
3
PW_BS000109
101
5
3
1
PW_BS000101
730
32
143
PW_BS000512
737
10
62
1
PW_BS000512
41
8
1
1
PW_BS000041
288
14
4
1
PW_BS000024
211
10
18
PW_BS000024
653
1
62
4
PW_BS000508
771
1
PW_BS000518
51
8
1
PW_BS000051
40939
(2Z)-2-aminobut-2-enoate
(2Z)-2-Aminobut-2-enoate belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon) (2Z)-2-Aminobut-2-enoate is soluble (in water) and a moderately acidic compound (based on its pKa) (2Z)-2-Aminobut-2-enoate may be a unique E.coli metabolite. Conjugate base of 2-aminobut-2-enoic acid.
58739
CC=C(N)C([O-])=O
C4H6NO2
InChI=1S/C4H7NO2/c1-2-3(5)4(6)7/h2H,5H2,1H3,(H,6,7)/p-1
PAWSVPVNIXFKOS-UHFFFAOYSA-M
2-aminobut-2-enoate
100.098
100.040402017
0.45
1
2-aminobut-2-enoate
-1
0
PW_C040939
22A2E
6591
151
8381
225
11923
164
79237
122
80053
285
80144
293
42939
2-C-Methyl-D-erythritol-2,4-cyclodiphosphate
2-c-Methyl-D-erythritol-2,4-cyclodiphosphate, also known as me-2,4cpp, belongs to the class of organic compounds known as organic pyrophosphates. These are organic compounds containing the pyrophosphate oxoanion, with the structure OP([O-])(=O)OP(O)([O-])=O. 2-c-Methyl-D-erythritol-2,4-cyclodiphosphate is soluble (in water) and a moderately acidic compound (based on its pKa). 2-c-Methyl-D-erythritol-2,4-cyclodiphosphate may be a unique E.coli metabolite.
58483
[H][C@@]1(O)COP([O-])(=O)OP([O-])(=O)O[C@@]1(C)CO
C5H10O9P2
InChI=1S/C5H12O9P2/c1-5(3-6)4(7)2-12-15(8,9)14-16(10,11)13-5/h4,6-7H,2-3H2,1H3,(H,8,9)(H,10,11)/p-2/t4-,5+/m1/s1
SFRQRNJMIIUYDI-UHNVWZDZSA-L
(6S,7R)-7-hydroxy-6-(hydroxymethyl)-6-methyl-2,4-dioxo-1,3,5,2lambda5,4lambda5-trioxadiphosphocane-2,4-bis(olate)
276.075
275.980004942
-0.76
2
(6S,7R)-7-hydroxy-6-(hydroxymethyl)-6-methyl-2,4-dioxo-1,3,5,2lambda5,4lambda5-trioxadiphosphocane-2,4-bis(olate)
-2
-2
Me-2,4cpp;2-c-methyl-d-erythritol 2,4-cyclodiphosphate;2-c-methyl-d-erythritol-2,4-cyclodiphosphate
PW_C042939
ME24CPP
6599
152
12616
164
80145
293
44587
2-(2-methylpyridin-3-yl)ethanol
2-(2-Methylpyridin-3-yl)ethanol belongs to the class of organic compounds known as methylpyridines. These are organic compounds containing a pyridine ring substituted at one or more positions by a methyl group. 2-(2-Methylpyridin-3-yl)ethanol is soluble (in water) and an extremely weak acidic (essentially neutral) compound (based on its pKa).
268518
CC1=C(CCO)C=CC=N1
C8H11NO
InChI=1S/C8H11NO/c1-7-8(4-6-10)3-2-5-9-7/h2-3,5,10H,4,6H2,1H3
MFPDJTXHKIFPNP-UHFFFAOYSA-N
2-(2-methylpyridin-3-yl)ethan-1-ol
137.182
137.084063978
-0.19
1
2-(2-methylpyridin-3-yl)ethanol
0
0
3-pyridineethanol
PW_C044587
mpetol
80403
1
80411
228
986
Guanosine triphosphate
HMDB0001273
Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
86-01-1
C00044
6830
15996
GTP
6569
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
C10H16N5O14P3
InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
XKMLYUALXHKNFT-UUOKFMHZSA-N
({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
523.1804
522.990659781
-1.84
8
triphosphate, guanosine
0
-3
FDB022527
5'-gtp;Gtg;Gtp;Guanosine 5'-(tetrahydrogen triphosphate);Guanosine 5'-triphosphate;Guanosine 5'-triphosphorate;Guanosine 5'-triphosphoric acid;Guanosine triphosphate;Guanosine mono(tetrahydrogen triphosphate) (ester);H4gtp;Guanosine-5'-triphosphate
PW_C000986
GTP
81
8
240
4
1939
2
4091
14
4153
73
5006
85
5384
103
6043
155
6103
161
6490
178
7478
222
11753
115
11769
198
11981
151
12725
290
69327
1
76962
225
77144
133
77544
111
77951
132
80025
368
80088
308
80121
164
89113
253
119985
406
120066
122
121204
124
122768
120
122818
135
123774
118
125365
479
125443
297
126480
299
126907
501
126982
205
128051
388
195
Uric acid
HMDB0000289
Uric acid is a heterocyclic purine derivative that is the final oxidation product of purine metabolism. It is produced by the enzyme xanthine oxidase, which oxidizes oxypurines such as xanthine into uric acid. In most mammals, except humans and higher primates, the enzyme uricase further oxidizes uric acid to allantoin. Uric acid is also the end product of nitrogen metabolism in birds and reptiles. In such species, it is excreted in feces as a dry mass. Humans produce only small quantities of uric acid with excess accumulation leading to a type of arthritis known as gout. The loss of uricase in higher primates parallels the similar loss of the ability to synthesize ascorbic acid vitamin C. This may be because in higher primates uric acid partially replaces ascorbic acid.
69-93-2
C00366
1175
17775
URATE
1142
DB01696
O=C1NC2=C(N1)C(=O)NC(=O)N2
C5H4N4O3
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
LEHOTFFKMJEONL-UHFFFAOYSA-N
2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione
168.1103
168.028340014
-1.98
4
uric acid
0
0
DBMET00498
FDB015350
1h-purine-2,6,8-triol;2,6,8-trihydroxypurine;2,6,8-trioxopurine;2,6,8-trioxypurine;Lithate;Lithic acid;Purine-2,6,8(1h,3h,9h)-trione;Urate;Uric acid
PW_C000195
Urate
1873
5
11820
216
12444
151
12459
226
78699
334
121892
408
124445
374
353
Calcium
HMDB0000464
Calcium is essential for the normal growth and maintenance of bones and teeth, and calcium requirements must be met throughout life. Requirements are greatest during periods of growth, such as childhood, during pregnancy and when breast-feeding. Long-term calcium deficiency can lead to osteoporosis, in which the bone deteriorates and there is an increased risk of fractures. Adults need between 1,000 and 1,300 mg of calcium in their daily diet. Calcium is essential for living organisms, particularly in cell physiology, and is the most common metal in many animals. Physiologically, it exists as an ion in the body. Calcium combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Calcium is an important component of a healthy diet. A deficit can affect bone and tooth formation, while overretention can cause kidney stones. Vitamin D is needed to absorb calcium. Dairy products, such as milk and cheese, are a well-known source of calcium. However, some individuals are allergic to dairy products and even more people, particularly those of non-European descent, are lactose-intolerant, leaving them unable to consume dairy products. Fortunately, many other good sources of calcium exist. These include: seaweeds such as kelp, wakame and hijiki; nuts and seeds (like almonds and sesame); beans; amaranth; collard greens; okra; rutabaga; broccoli; kale; and fortified products such as orange juice and soy milk. Calcium has also been found to assist in the production of lymphatic fluids.
14127-61-8
C00076
271
29108
CA%2b2
266
DB01373
[Ca++]
Ca
InChI=1S/Ca/q+2
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
calcium(2+) ion
40.078
39.962591155
0
calcium(2+) ion
2
2
FDB003513
Ca;Calcium element;Ca(2+);Ca2+;Calcium ion;Calcium, doubly charged positive ion
PW_C000353
Ca2+
276
16
303
8
553
14
601
2
941
15
993
21
997
35
1046
3
1163
46
1164
47
1478
49
1491
42
1552
43
2116
58
2138
17
2796
18
2937
9
3159
71
3160
72
3942
29
4186
66
4782
10
4822
28
5340
111
5780
101
7179
205
7232
211
7258
160
7281
190
11774
213
11837
198
11842
210
12198
164
12215
285
15288
151
15350
308
69336
1
77389
331
77600
115
78154
132
78266
356
78526
345
78724
130
78908
114
80413
74
80589
228
81826
51
120220
122
120465
405
121049
124
121300
418
121377
419
121850
383
121923
125
122370
409
122895
135
123099
376
123613
118
123870
454
123936
455
124403
398
124476
136
124924
137
125571
297
125711
478
125981
489
126009
299
126050
490
126533
495
127203
209
127434
506
127460
388
127502
507
128105
390
295
1,2-Diacyl-sn-glycerol
Compound
3149
Compound
PW_EC000293
C00641
KEGG Compound
1,2DSG
185
DNA-directed RNA polymerase omega protein
DNA
PW_NA000185
rpoZ
DDRPOP
138166
117
19610
Protein kinase C, brain isozyme
Q9V7V7
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
Pkc53E
10
2.7.11.13
132069
297
135580
372
135928
14
138253
657
19618
Ras-related C3 botulinum toxin substrate 1
Q3ZBW9
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In pituitary cells, may mediate the activation of KCNH2 potassium channel by thyroid hormone. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3 (By similarity).
RAC1
5
131906
122
132983
124
19448
Aurora kinase A
Q2TA06
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Necessary for proper cilia disassembly prior to mitosis (By similarity). Interacts with SIRT2 (By similarity).
AURKA
5
2.7.11.1
131890
421
131902
122
132945
124
7788
succinate:quinone oxidoreductase, FAD binding protein
P0AC41
SdhA
3
8588
109
135552
285
135929
308
137247
101
138070
730
138254
737
1
5'-nucleotidase
P21589
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
HMDBP00001
NT5E
6q14-q21
AF069067
1
3.1.3.5
6000
151
6662
41
8754
14
80043
288
135604
372
136165
211
138718
653
139122
771
1279
Protein kinase C beta type
P05771
Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser- 652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage:in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters
HMDBP01372
PRKCB
16p11.2
FJ907246
1
2.7.11.13
69388
8
80052
164
80414
74
1598
Ras-related C3 botulinum toxin substrate 1
P63000
Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP- dependent manner, suggesting that the insertion does not completely abolish effector interaction
HMDBP01778
RAC1
7p22
BT007121
1
3729
14
4226
2
80295
8
134678
166
1067
Mitogen-activated protein kinase kinase kinase 1
Q13233
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway
HMDBP01134
MAP3K1
5q11.2
AC008937
1
2.7.11.25
4097
2
80348
228
80357
8
134682
14
6638
protein kinase C beta
1
PW_P006638
14380
1279
744
353
3
69387
8
7921
Activated Ras-related C3 botulinum toxin substrate 1
1
PW_P007921
16033
1598
816
986
85720
8
7833
Mitogen-activated protein kinase kinase kinase 1 without Magnesium
1
PW_P007833
15876
1067
80887
8
164287
PW_R164287
Unknown
616949
40939
1
Compound
false
616950
42939
1
Compound
false
616951
44587
1
Compound
false
243
Activation
PW_I000243
485
295
ElementCollection
1
486
6638
ProteinComplex
1
812
Activation
PW_I000812
1623
7921
ProteinComplex
1
1624
7833
ProteinComplex
1
3077969
40939
51
3
false
380
825
10
regular
100
120
3077970
42939
308
3
false
215
540
10
regular
100
130
3077971
44587
51
3
false
660
772
10
regular
100
120
3077972
986
9
false
340
155
10
regular
100
35
3077973
195
157
false
385
380
10
regular
200
190
23267
295
37
14
false
505
105
12
regular
100
90
4285
185
12
false
1035
115
14
150
nucleic_acid
regular
150
70
1185544
19610
14
2
false
395
15
8
subunit
regular
150
70
1185545
19618
2
false
20
600
8
subunit
regular
150
70
1185546
19448
2
false
1300
267
8
subunit
regular
150
70
1185547
7788
308
247
false
740
550
7
subunit
regular
175
155
1185548
1
2
false
1005
230
8
subunit
regular
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