115230
Pathway
biosynthesis novo 1607575986
Metabolic
PW124389
Center
PathwayVisualizationContext124665
2450
2950
#000099
PathwayVisualization115093
115230
biosynthesis novo 1607575986
Metabolic
1
1
Cell
CL:0000000
4
Cardiomyocyte
CL:0000746
3
Neuron
CL:0000540
1
Homo sapiens
9606
Eukaryote
Human
12
Mus musculus
10090
Eukaryote
Mouse
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
5
Bos taurus
9913
Eukaryote
Cattle
17
Rattus norvegicus
10116
Eukaryote
Rat
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
157
Acinetobacter baumannii
107673
Prokaryote
138
human
0046323
Eukaryote
190
Saccharomyces cerevisae
15
Prokaryote
Yeast
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
2
Bacteria
2
Prokaryote
Bacteria
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
62
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
62977
Prokaryote
25
Escherichia coli (strain K12)
83333
Prokaryote
5
Cytoplasm
GO:0005737
1
Cytosol
GO:0005829
36
Membrane
GO:0016020
10
Cell Membrane
GO:0005886
11
Extracellular Space
GO:0005615
14
Mitochondrial Outer Membrane
GO:0005741
3
Mitochondrial Matrix
GO:0005759
39
Mitochondrial membrane
GO:0031966
6
Kidney
BTO:0000671
71
8
8
Blood Vessel
BTO:0001102
74
11
24
Brain
BTO:0000142
89
16
1
Liver
BTO:0000759
72
9
8
5
1
1
PW_BS000008
111
5
12
1
PW_BS000111
205
5
6
1
PW_BS000024
122
5
5
1
PW_BS000122
135
5
17
1
PW_BS000135
297
5
10
1
PW_BS000024
2
1
1
1
PW_BS000002
228
36
1
PW_BS000024
14
10
1
PW_BS000014
869
6
11
1
1
PW_BS000552
897
6
11
157
1
PW_BS000552
978
6
11
138
1
PW_BS000569
1132
6
11
190
1
PW_BS000581
151
1
4
1
PW_BS000151
41
8
1
1
PW_BS000041
288
14
4
1
PW_BS000024
372
10
2
PW_BS000028
211
10
18
PW_BS000024
653
1
62
4
PW_BS000508
771
1
PW_BS000518
811
24
11
157
3
PW_BS000548
237
10
25
PW_BS000024
812
24
1
157
3
PW_BS000548
810
10
157
4
PW_BS000548
308
10
1
1
PW_BS000024
656
11
62
PW_BS000508
166
1
1
PW_BS000166
336
1
12
1
PW_BS000028
4
3
1
1
PW_BS000004
309
39
1
1
PW_BS000024
240
2-Hydroxyestradiol
HMDB0000338
2-Hydroxyestradiol is generated from estradiol by a Cytochrome P450. 2-Hydroxyestradiol binds, with a low affinity, to estrogen receptors. It inhbits catechol-O-methyltransferase (COMT) activity. Inactivity of COMT blocks inactivation of catechol hormones and catecholamine neutransmitters. 2-Hydroxyestradiol is also reported to inhibit angiongensis and tumor cell growth (PMID: 9472688).
362-05-0
C05301
247304
28744
2-HYDROXY-ESTRADIOL
216475
DB07706
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(O)=C3
C18H24O3
InChI=1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1
DILDHNKDVHLEQB-XSSYPUMDSA-N
288.3814
288.172544634
FDB021962
(17b)-estra-1,3, 5(10)-triene-2,3,17-triol;(17beta)- estra-1,3, 5 (10)-triene-2,3,17-triol;(17beta)-estra-1,3,5(10)-triene-2,3,17-triol;1,3,5(10)-estratriene-2,3,17beta-triol;17beta-2-hydroxyestradiol;2,3,17b-trihydroxyestra-1,3,5(10)-triene;2-hydroxy-17beta-estradiol;2-hydroxy-estradiol;2-hydroxyestradiol;2-oh-estradiol;Ecs;Estra-1,3,5 (10)-triene-2,3,17.beta.-triol;Estra-1,3,5(10)-triene-2,3,17-beta-triol;Estra-1,3,5(10)-triene-2,3,17-triol (acd/name 4.0);Estra-1,3,5(10)-triene-2,3,17b-triol;Estra-1,3,5(10)-triene-2,3,17beta-triol;2-hydroxyestradiol-17beta;2-oh-e2;(17b)-estra-1,3,5(10)-triene-2,3,17-triol;(17β)-estra-1,3,5(10)-triene-2,3,17-triol;2-hydroxy-17b-estradiol;2-hydroxy-17β-estradiol;2-hydroxyestradiol-17b;2-hydroxyestradiol-17β
PW_C000240
Ecs
2955
Tetrahydrofolyl-[Glu](n)
HMDB0006826
Tetrahydrofolyl-[Glu](n) is involved in the folate biosynthesis pathway. Tetrahydrofolyl-[Glu](n) can be reversibly converted into Tetrahydrofolyl-[Glu](2) by folylpolyglutamate synthase [EC:6.3.2.17]. Tetrahydrofolyl-[Glu](n) can be irreversibly converted into tetrahydrofolate by gamma-glutamyl hydrolase [EC:3.4.19.9]. Sample structure image shows the case when n=3.
C03541
45479706
27650
21231977
NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1
C29H37N9O12
InChI=1S/C29H37N9O12/c30-29-37-23-22(25(44)38-29)33-15(12-32-23)11-31-14-3-1-13(2-4-14)24(43)36-18(28(49)50)6-9-20(40)34-16(26(45)46)5-8-19(39)35-17(27(47)48)7-10-21(41)42/h1-4,15-18,31,33H,5-12H2,(H,34,40)(H,35,39)(H,36,43)(H,41,42)(H,45,46)(H,47,48)(H,49,50)(H4,30,32,37,38,44)
RXWVHRYZTWZATH-UHFFFAOYSA-N
703.6572
703.256167693
FDB024106
Thf-l-glutamic acid;Thf-polyglutamate;Tetrahydrofolyl-[glu](n+1);Tetrahydropteroyl-[gamma-glu]n;Tetrahydropteroyl-[gamma-glu]n+1
PW_C002955
ThGluN
968
8
5342
111
7180
205
120690
122
123298
135
125768
297
1766
Tumor necrosis factor
P01375
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
HMDBP02070
TNF
6p21.3
X01394
1
4244
2
80343
228
80488
8
134406
14
140575
869
140887
897
142015
978
143279
1132
1
5'-nucleotidase
P21589
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
HMDBP00001
NT5E
6q14-q21
AF069067
1
3.1.3.5
6000
151
6662
41
8754
14
80043
288
135604
372
136165
211
138718
653
139122
771
140386
811
141419
237
142215
812
142216
810
142341
2
142349
308
142350
656
142575
166
143303
336
7866
Unknown
Unknown
1
6221
166
6241
168
15333
2
15341
308
15344
22
15346
18
15366
309
15369
49
80322
8
139441
90
139654
59
139662
768
140044
17
140045
14
140277
23
140532
53
140697
721
140929
48
140943
60
142080
75
142091
58
142130
995
142134
55
142146
973
14374
THF-polyglutamate transporter
1
PW_P014374
24318
7866
10869
PW_T010869
11249
2955
1
Compound
4
2
Right
2039
14374
2020-07-14T18:11:42-06:00
2020-07-14T18:11:42-06:00
309
3095414
240
81
false
465
65
10
large
200
190
3098150
2955
4
3
false
249
375
10
regular
100
110
3098151
2955
2
3
false
609
325
10
regular
100
110
1194039
1766
869
97
false
760
105
8
protein
large
150
70
1194040
1
2
false
205
110
8
subunit
regular
150
70
1196066
1
2
false
89
0
8
subunit
regular
150
70
4226069
M349 430 C379 430 404 55 434 55
83
false
18
4226070
M609 380 C579 380 294 55 264 55
83
false
18
true
M 114.94685504416483 13.26155629629604 L 100 12 L 106.38088772118584 25.575134323078345
false
98308
10869
115093
198143
3098150
4226069
Left
198144
3098151
4226070
Right
3832
3095414
4928
1194039
4929
1194040
4991
1196066
470238
940
35
0.2
0.2
0
1
127
798
1186
470239
930
385
1.0
1.0
0
2
73
382
58
466805
M0 120 C32 95 1801 50 1853 120
1
false
6
1853.0
0.0