9606
TAXONOMY
213039
PubChem-compound
1.0
Darunavir Action Pathway
Reaction219248
false
Gag-Pol polyprotein → HIV-1 protease + Integrase + Reverse Transcriptase
LEFT_TO_RIGHT
Gag-Pol polyprotein
1.0
Q9QBZ5
UniProt
Cytosol
PW127509
PathWhiz
1.0
184733
ChemSpider
Reverse transcriptase protein
direct_interaction
SMILES
[H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CC(C)C)S(=O)(=O)C1=CC=C(N)C=C1
Integrase
DNA
GO:0005886
GENE ONTOLOGY
Cell Membrane
HIV-1 protease
Q9WJQ2
UniProt
ReactionCatalysis208708
ACTIVATION
ReactionCatalysis208707
ACTIVATION
Gag-Pol polyprotein
Reverse transcriptase/RNaseH
HMDB0015393
HMDB
Transport14836
true
HIV-1 DNA (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
REVERSIBLE
Reverse transcriptase/RNaseH
Integrase
GO:0005634
GENE ONTOLOGY
Q7ZJM1
UniProt
CHEBI:367163
ChEBI
Integrase
Reverse transcriptase protein
Homo sapiens
HIV-1 DNA
ReactionCatalysis208714
ACTIVATION
HIV-1 protease
AF033819.3
INSDC
Darunavir
DNA
C27H37N3O7S
Darunavir
547.2352
GO:0005829
GENE ONTOLOGY
Single strand RNA
2.0
HIV-1 protease
Gag-Pol polyprotein
1.0
SMP0125937
SMPDB
Nucleus
1.0
HIV-1 DNA
O90777
UniProt
12.0
1.0
1.0
Interaction4328
Darunavir inhibits HIV-1 protease
Reaction219242
false
Single strand RNA → HIV-1 DNA
LEFT_TO_RIGHT
Reaction219241
false
HIV-1 DNA → DNA
LEFT_TO_RIGHT
Q72547
UniProt
HIV-1 DNA
1.0
Single strand RNA