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K+
K+
Ca+
Tropomyosin
alpha-1 chain
Tropomyosin
beta chain
Voltage-
dependent
L-type calcium
channel subunit
alpha-1C
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Ryanodine
receptor 2
Muscarinic
acetylcholine
receptor M2
Beta-1
adrenergic
receptor
Adenylate
cyclase type 1
Inward
rectifier
potassium
channel 4
Potassium
voltage-gated
channel
subfamily D
member 3
Kv channel-
interacting
protein 2
Potassium
voltage-gated
channel
subfamily A
member 5
Disks large
homolog 1
Potassium
voltage-gated
channel
subfamily KQT
member 1
Potassium
voltage-gated
channel
subfamily E
member 1
Potassium
voltage-gated
channel
subfamily E
member 2
ATP-binding
cassette
sub-family C
member 8
ATP-sensitive
inward
rectifier
potassium
channel 8
ATP-sensitive
inward
rectifier
potassium
channel 11
ATP-binding
cassette
sub-family C
member 9
Potassium
channel
subfamily K
member 1
Sodium/calcium
exchanger 1
Potassium/sodium
hyperpolarization-
activated
cyclic
nucleotide-
gated channel 4
Sodium channel
protein type 5
subunit alpha
Beta-2-
syntrophin
Beta-1-
syntrophin
Alpha-1-
syntrophin
Voltage-
dependent
T-type calcium
channel subunit
alpha-1H
Voltage-
dependent
T-type calcium
channel subunit
alpha-1G
Sodium/calcium
exchanger 1
Sarcoplasmic/endoplasmic
reticulum
calcium ATPase
2
cAMP-dependent
protein kinase
catalytic
subunit alpha
Inward
rectifier
potassium
channel 2
cAMP
Ca+
Na+
Na+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
Ca+
Ca+
Na+
Na+
Na+
Na+
K+
K+
Na+
Na+
Ca+
Ca+
Ca+
Ca+
Ca+
Na+
Na+
ATP
PPi
ATP
H2 O
Ca+
ADP
Pi
Ca+
Magnesium
Ca+
Troponin
Troponin
G-protein
signalling
cascade
Muscle
Contraction
Gs Signalling
G protein-
activated
inward
rectifier
potassium
channel 1
G protein-
activated
inward
rectifier
potassium
channel 4
Potassium
voltage-gated
channel
subfamily H
member 2
Putative Dol-P-
Glc:Glc(2)Man(9)GlcNAc(2)-
PP-Dol
alpha-1,2-
glucosyltransferase
Cardiac Muscle
Striated Muscle Cell
Nucleus
Mitochondrion
Myofibril
Sarcoplasmic Reticulum
Myofibril in Cardiac Myocyte
Sarcolema
Sarcoplasmic Reticulum
Calcium binding to troponin
displaces tropomyosin from
the myosin binding sites on
the actin filaments
Myosin, with an ADP and
phosphate attached, binds to
actin to form a cross
bridge. Myosin performs a
powerstroke, drawing the
actin filaments together.
Many actin filaments pulled
together at the same time
leads to muscle contraction.
Actin Filament
Myosin Filament
T-Tubule
Depolarization
Mitochondrion
Single Sarcomere Functioning
Unit
Mitochondria
Potassium
Potassium
Calcium
TPM1
TPM2
CACNA1C
CACNA2D2
CACNB1
RYR2
CHRM2
ADRB1
ADCY1
KCNJ4
KCND3
KCNIP2
Unknown
Unknown
KCNQ1
KCNE1
KCNE2
ABCC8
KCNJ8
KCNJ11
Unknown
KCNK1
SLC8A1
HCN4
SCN5A
SNTB2
SNTB1
SNTA1
CACNA1H
CACNA1G
SLC8A1
ATP2A2
PRKACA
KCNJ2
cAMP
Calcium
Sodium
Sodium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Potassium
Calcium
Calcium
Sodium
Sodium
Sodium
Sodium
Potassium
Potassium
Sodium
Sodium
Calcium
Calcium
Calcium
Calcium
Calcium
Sodium
Sodium
Adenosine
triphosphate
Pyrophosphate
Adenosine
triphosphate
Water
Calcium
Adenosine
diphosphate
Phosphate
Calcium
Calcium
Troponin
Troponin
G-protein
signalling
cascade
Muscle
Contraction
Gs Signalling
KCNJ3
KCNJ5
KCNH2
ALG10B
K+
K+
Ca+
TPM1
TPM2
CACNA1C
CACNA2D2
CACNB1
RYR2
CHRM2
ADRB1
ADCY1
KCNJ4
KCND3
KCNIP2
KCNQ1
KCNE1
KCNE2
ABCC8
KCNJ8
KCNJ11
KCNK1
SLC8A1
HCN4
SCN5A
SNTB2
SNTB1
SNTA1
CACNA1H
CACNA1G
SLC8A1
ATP2A2
PRKACA
KCNJ2
cAMP
Ca+
Na+
Na+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
Ca+
Ca+
Na+
Na+
Na+
Na+
K+
K+
Na+
Na+
Ca+
Ca+
Ca+
Ca+
Ca+
Na+
Na+
ATP
PPi
ATP
H2 O
Ca+
ADP
Pi
Ca+
Mg2+
Ca+
Troponi
Troponi
G-p s c
Mus Con
Gs Sign
KCNJ3
KCNJ5
KCNH2
ALG10B
Cardiac Muscle
Striated Muscle Cell
Nucleus
Mitochondrion
Myofibril
Sarcoplasmic Reticulum
Myofibril in Cardiac Myocyte
Sarcolema
Sarcoplasmic Reticulum
Calcium binding to troponin
displaces tropomyosin from
the myosin binding sites on
the actin filaments
Myosin, with an ADP and
phosphate attached, binds to
actin to form a cross
bridge. Myosin performs a
powerstroke, drawing the
actin filaments together.
Many actin filaments pulled
together at the same time
leads to muscle contraction.
Actin Filament
Myosin Filament
T-Tubule
Depolarization
Mitochondrion
Single Sarcomere Functioning
Unit
Mitochondria
K+
K+
Ca2+
TPM1
TPM2
CACNA1C
CACNA2D2
CACNB1
RYR2
CHRM2
ADRB1
ADCY1
KCNJ4
KCND3
KCNIP2
KCNQ1
KCNE1
KCNE2
ABCC8
KCNJ8
KCNJ11
KCNK1
SLC8A1
HCN4
SCN5A
SNTB2
SNTB1
SNTA1
CACNA1H
CACNA1G
SLC8A1
ATP2A2
PRKACA
KCNJ2
cAMP
Ca2+
Na+
Na+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
K+
Ca2+
Ca2+
Na+
Na+
Na+
Na+
K+
K+
Na+
Na+
Ca2+
Ca2+
Ca2+
Ca2+
Ca2+
Na+
Na+
ATP
Ppi
ATP
H2O
Ca2+
ADP
Pi
Ca2+
Ca2+
Troponi
Troponi
G-p s c
Mus Con
Gs Sign
KCNJ3
KCNJ5
KCNH2
ALG10B