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K+ K+ Ca+ Tropomyosin alpha-1 chain Tropomyosin beta chain Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 Muscarinic acetylcholine receptor M2 Beta-1 adrenergic receptor Adenylate cyclase type 1 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 cAMP-dependent protein kinase catalytic subunit alpha Inward rectifier potassium channel 2 cAMP Ca+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca+ Ca+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ ATP PPi ATP H2O Ca+ ADP Pi Ca+ Magnesium Ca+ Troponin Troponin G-protein signalling cascade Muscle Contraction Gs Signalling G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase Cardiac Muscle Striated Muscle Cell Nucleus Mitochondrion Myofibril Sarcoplasmic Reticulum Myofibril in Cardiac Myocyte Sarcolema Sarcoplasmic Reticulum Calcium binding to troponin displaces tropomyosin from the myosin binding sites on the actin filaments Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together. Many actin filaments pulled together at the same time leads to muscle contraction. Actin Filament Myosin Filament T-Tubule Depolarization Mitochondrion Single Sarcomere Functioning Unit
Mitochondria Potassium Potassium Calcium TPM1 TPM2 CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 ADRB1 ADCY1 KCNJ4 KCND3 KCNIP2 Unknown Unknown KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 Unknown KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 ATP2A2 PRKACA KCNJ2 cAMP Calcium Sodium Sodium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Calcium Calcium Sodium Sodium Sodium Sodium Potassium Potassium Sodium Sodium Calcium Calcium Calcium Calcium Calcium Sodium Sodium Adenosine triphosphate Pyrophosphate Adenosine triphosphate Water Calcium Adenosine diphosphate Phosphate Calcium Calcium Troponin Troponin G-protein signalling cascade Muscle Contraction Gs Signalling KCNJ3 KCNJ5 KCNH2 ALG10B
K+ K+ Ca+ TPM1 TPM2 CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 ADRB1 ADCY1 KCNJ4 KCND3 KCNIP2 KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 ATP2A2 PRKACA KCNJ2 cAMP Ca+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca+ Ca+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ ATP PPi ATP H2O Ca+ ADP Pi Ca+ Mg2+ Ca+ Troponi Troponi G-p s c Mus Con Gs Sign KCNJ3 KCNJ5 KCNH2 ALG10B Cardiac Muscle Striated Muscle Cell Nucleus Mitochondrion Myofibril Sarcoplasmic Reticulum Myofibril in Cardiac Myocyte Sarcolema Sarcoplasmic Reticulum Calcium binding to troponin displaces tropomyosin from the myosin binding sites on the actin filaments Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together. Many actin filaments pulled together at the same time leads to muscle contraction. Actin Filament Myosin Filament T-Tubule Depolarization Mitochondrion Single Sarcomere Functioning Unit
Mitochondria K+ K+ Ca2+ TPM1 TPM2 CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 ADRB1 ADCY1 KCNJ4 KCND3 KCNIP2 KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 ATP2A2 PRKACA KCNJ2 cAMP Ca2+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca2+ Ca2+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Na+ Na+ ATP Ppi ATP H2O Ca2+ ADP Pi Ca2+ Ca2+ Troponi Troponi G-p s c Mus Con Gs Sign KCNJ3 KCNJ5 KCNH2 ALG10B