Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Unknown
type: Protein
entity reference: Unknown

Reaction2902
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040928/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001938/Stoichiometry/1.0
right: 2-iminopropanoate
spontaneous: true
left: 2-Aminoacrylic acid
name: 2-Aminoacrylic acid → 2-iminopropanoate
conversion direction: LEFT_TO_RIGHT

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reaction2903
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040928/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Ammonium
right: Pyruvic acid
spontaneous: true
left: Water
left: 2-iminopropanoate
left: Hydrogen Ion
name: 2-iminopropanoate + Hydrogen Ion + Water → Ammonium + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 123991
type: UnificationXref
id: 123991
db: PubChem-compound

Reference/HMDB HMDB0012199
type: UnificationXref
id: HMDB0012199
db: HMDB

NADH
type: SmallMolecule
entity reference: NADH

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayInput

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

Reference/CAS 120-72-9
type: UnificationXref
id: 120-72-9
db: CAS

2-Aminoacrylic acid
type: SmallMolecule
entity reference: 2-Aminoacrylic acid

NAD
type: SmallMolecule
entity reference: NAD

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000587
type: ChemicalStructure
structure format: SMILES
structure data: N1C=CC2=C1C=CC=C2

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Compound/PW C007748/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chorismate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 596320
type: UnificationXref
id: 596320
db: TAXONOMY

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/SMPDB SMP0644600
type: UnificationXref
id: SMP0644600
db: SMPDB

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

ChemicalStructure/PW C040925
type: ChemicalStructure
structure format: SMILES
structure data: OC1C(O)C(NC2=C(C=CC=C2)C([O-])=O)OC1COP([O-])([O-])=O

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ChemicalStructure/PW C040928
type: ChemicalStructure
structure format: SMILES
structure data: CC(=N)C([O-])=O

ChemicalStructure/PW C040927
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP([O-])([O-])=O)C(O)C1=CNC2=C1C=CC=C2

ChemicalStructure/PW C040926
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP([O-])([O-])=O)[C@@H](O)C(=O)CNC1=CC=CC=C1C([O-])=O

ChemicalStructure/PW C007748
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/KEGG Compound C00108
type: UnificationXref
id: C00108
db: KEGG Compound

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Compound/PW C000877/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminobenzoic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Reference/KEGG Compound C00463
type: UnificationXref
id: C00463
db: KEGG Compound

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/PathWhiz PW684945
type: UnificationXref
id: PW684945
db: PathWhiz

Neisseria flavescens SK114
type: BioSource
xref: Reference/TAXONOMY 596320

Reference/ChEBI CHEBI 17333
type: UnificationXref
id: CHEBI:17333
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Reference/CAS 1948-56-7
type: UnificationXref
id: 1948-56-7
db: CAS

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Protein/29154/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/SMPDB SMP0000792
type: UnificationXref
id: SMP0000792
db: SMPDB

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Ammonium
type: SmallMolecule
entity reference: Ammonium

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Compound/PW C000741/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

N-(5-phosphoribosyl)-anthranilate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18277
chemical formula: C12H13NO9P
molecular weight: 346.03442
structure: ChemicalStructure/PW C040925

1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58613
chemical formula: C12H13NO9P
molecular weight: 346.03442
structure: ChemicalStructure/PW C040926

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58866
chemical formula: C11H12NO6P
molecular weight: 285.04132
structure: ChemicalStructure/PW C040927

2-iminopropanoate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 77456
chemical formula: C3H4NO2
molecular weight: 86.02475
structure: ChemicalStructure/PW C040928

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/PathWhiz PW000779
type: UnificationXref
id: PW000779
db: PathWhiz

Reference/PubChem-compound 798
type: UnificationXref
id: 798
db: PubChem-compound

2-Aminobenzoic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00108
xref: Reference/ChEBI CHEBI 30754
xref: Reference/HMDB HMDB0001123
xref: Reference/ChemSpider 222
xref: Reference/CAS 118-92-3
xref: Reference/PubChem-compound 227
xref: Reference/BioCyc ANTHRANILATE
chemical formula: C7H7NO2
molecular weight: 137.04768
structure: ChemicalStructure/PW C000877

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C040927/Stoichiometry/1.0
type: Stoichiometry
physical entity: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003609
type: UnificationXref
id: HMDB0003609
db: HMDB

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Compound/PW C040928/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-iminopropanoate
stoichiometric coefficient: 1.0

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/PathWhiz PW000769
type: UnificationXref
id: PW000769
db: PathWhiz

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C000190/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C000120/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

2-Aminoacrylic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 110510
xref: Reference/CAS 1948-56-7
xref: Reference/KEGG Compound C02218
xref: Reference/HMDB HMDB0003609
xref: Reference/PubChem-compound 123991
xref: Reference/ChEBI CHEBI 17123
chemical formula: C3H5NO2
molecular weight: 87.03203
structure: ChemicalStructure/PW C001938

4.2.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040927/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000587/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869/Stoichiometry/1.0
right: D-Glyceraldehyde 3-phosphate
right: Indole
spontaneous: false
EC number: 4.2.1.20
left: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
name: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate → D-Glyceraldehyde 3-phosphate + Indole
conversion direction: LEFT_TO_RIGHT

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 227
type: UnificationXref
id: 227
db: PubChem-compound

TCA Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway407125
pathway component: SubPathwayInteraction407125
xref: Reference/SMPDB SMP0000802
xref: Reference/PathWhiz PW000779
name: SubPathway

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/KEGG Compound C00251
type: UnificationXref
id: C00251
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChEBI CHEBI 17123
type: UnificationXref
id: CHEBI:17123
db: ChEBI

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

2-Aminobenzoic acid
type: SmallMolecule
entity reference: 2-Aminobenzoic acid

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reaction744778
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040927/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040926/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Water
right: Carbon dioxide
right: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
spontaneous: false
left: Hydrogen Ion
left: 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate
name: 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + Hydrogen Ion → (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + Carbon dioxide + Water
conversion direction: LEFT_TO_RIGHT

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Compound/PW C000587/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indole
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Unknown
type: ProteinReference

4.1.1.48
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040925/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040926/Stoichiometry/1.0
right: 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate
spontaneous: false
EC number: 4.1.1.48
left: N-(5-phosphoribosyl)-anthranilate
name: N-(5-phosphoribosyl)-anthranilate → 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate
conversion direction: LEFT_TO_RIGHT

4.1.3.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000877/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040925/Stoichiometry/1.0
right: N-(5-phosphoribosyl)-anthranilate
right: Pyrophosphate
spontaneous: false
EC number: 4.1.3.27
left: 2-Aminobenzoic acid
left: Phosphoribosyl pyrophosphate
name: 2-Aminobenzoic acid + Phosphoribosyl pyrophosphate → N-(5-phosphoribosyl)-anthranilate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

4.1.3.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007748/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000877/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-Glutamic acid
right: Hydrogen Ion
right: Pyruvic acid
right: 2-Aminobenzoic acid
spontaneous: false
EC number: 4.1.3.27
left: L-Glutamine
left: Chorismate
name: Chorismate + L-Glutamine → 2-Aminobenzoic acid + Hydrogen Ion + L-Glutamic acid + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Phosphoribosyl pyrophosphate
type: SmallMolecule
entity reference: Phosphoribosyl pyrophosphate

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
entity reference: D-Glyceraldehyde 3-phosphate

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

L-Tryptophan
type: SmallMolecule
entity reference: L-Tryptophan

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Reference/ChemSpider 222
type: UnificationXref
id: 222
db: ChemSpider

SubPathwayInteraction407124
type: Interaction
name: SubPathway407124Reaction
name: SubPathwayReaction
participant: L-Glutamine

SubPathwayInteraction407125
type: Interaction
name: SubPathway407125Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

SubPathwayInteraction407126
type: Interaction
name: SubPathwayReaction
name: SubPathway407126Reaction
participant: L-Tryptophan

ChemicalStructure/PW C001938
type: ChemicalStructure
structure format: SMILES
structure data: NC(=C)C(O)=O

Reference/SMPDB SMP0000802
type: UnificationXref
id: SMP0000802
db: SMPDB

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02218
type: UnificationXref
id: C02218
db: KEGG Compound

Tryptophan Metabolism
type: Pathway
pathway order: PathwaySubPathway/407125
pathway order: PathwaySubPathway/407126
pathway order: PathwaySubPathway/407124
pathway order: PathwayEnzymeReaction/5822792
pathway order: PathwayEnzymeReaction/5822798
pathway order: PathwayEnzymeReaction/5822794
pathway order: PathwayEnzymeReaction/5822793
pathway order: PathwayEnzymeReaction/5822795
pathway order: PathwayEnzymeReaction/5822805
pathway order: PathwayEnzymeReaction/5822802
pathway order: PathwayEnzymeReaction/5822801
pathway order: PathwayEnzymeReaction/5822804
pathway order: PathwayEnzymeReaction/5822803
pathway component: 4.2.1.20
pathway component: Reaction2902
pathway component: ReactionCatalysis745759
pathway component: Reaction2903
pathway component: TCA Cycle
pathway component: ReactionCatalysis745757
pathway component: ReactionCatalysis745758
pathway component: ReactionCatalysis745756
pathway component: ReactionCatalysis745753
pathway component: ReactionCatalysis745754
pathway component: ReactionCatalysis745751
pathway component: SubPathway
pathway component: ReactionCatalysis745752
pathway component: D-Glutamine and D-Glutamate Metabolism
pathway component: Reaction744778
pathway component: 1.2.4.1
pathway component: 4.1.99.1
pathway component: 4.1.1.48
pathway component: 4.1.3.27
xref: Reference/SMPDB SMP0644600
xref: Reference/PathWhiz PW684945
organism: Neisseria flavescens SK114

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Reference/ChEBI CHEBI 58613
type: UnificationXref
id: CHEBI:58613
db: ChEBI

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

SubPathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway407126
pathway component: SubPathwayInteraction407126

Reference/ChEBI CHEBI 18277
type: UnificationXref
id: CHEBI:18277
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChemSpider 776
type: UnificationXref
id: 776
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

D-Glutamine and D-Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway407124
pathway component: SubPathwayInteraction407124
xref: Reference/PathWhiz PW000769
xref: Reference/SMPDB SMP0000792
name: SubPathway

Water
type: SmallMolecule
entity reference: Water

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan
name: SubPathwayInput

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Chorismate
type: SmallMoleculeReference
xref: Reference/CAS 617-12-9
xref: Reference/BioCyc CPD-9517
xref: Reference/KEGG Compound C00251
xref: Reference/PubChem-compound 12039
xref: Reference/ChEBI CHEBI 17333
xref: Reference/ChemSpider 11542
xref: Reference/HMDB HMDB0012199
chemical formula: C10H10O6
molecular weight: 226.04774
structure: ChemicalStructure/PW C007748

Reference/ChEBI CHEBI 58866
type: UnificationXref
id: CHEBI:58866
db: ChEBI

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Protein/29154/Stoichiometry/60.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 60.0

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

anthranilate synthase
type: Complex
component stoichiometry: Protein/29154/Stoichiometry/2.0
component: Unknown

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

tryptophan synthase, β subunit dimer
type: Complex
component stoichiometry: Protein/29154/Stoichiometry/2.0
component: Unknown

tryptophanase / L-cysteine desulfhydrase
type: Complex
component stoichiometry: Protein/29154/Stoichiometry/4.0
component: Unknown

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
right: NADH
right: Carbon dioxide
right: Acetyl-CoA
spontaneous: false
EC number: 1.2.4.1
left: Coenzyme A
left: Pyruvic acid
left: NAD
name: Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH
conversion direction: LEFT_TO_RIGHT

4.1.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000587/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001938/Stoichiometry/1.0
right: Hydrogen Ion
right: 2-Aminoacrylic acid
right: Indole
spontaneous: false
EC number: 4.1.99.1
left: L-Tryptophan
name: L-Tryptophan → 2-Aminoacrylic acid + Hydrogen Ion + Indole
conversion direction: LEFT_TO_RIGHT

4.2.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000587/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120/Stoichiometry/1.0
right: Water
right: L-Tryptophan
spontaneous: false
EC number: 4.2.1.20
left: L-Serine
left: Indole
name: Indole + L-Serine → L-Tryptophan + Water
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Reference/ChemSpider 11542
type: UnificationXref
id: 11542
db: ChemSpider

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Chorismate
type: SmallMolecule
entity reference: Chorismate

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 617-12-9
type: UnificationXref
id: 617-12-9
db: CAS

Reference/HMDB HMDB0001123
type: UnificationXref
id: HMDB0001123
db: HMDB

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

2-iminopropanoate
type: SmallMolecule
entity reference: 2-iminopropanoate

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/29154/Stoichiometry/60.0
component: Unknown

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

N-(5-phosphoribosyl)-anthranilate
type: SmallMolecule
entity reference: N-(5-phosphoribosyl)-anthranilate

1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate
type: SmallMolecule
entity reference: 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
type: SmallMolecule
entity reference: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C040925/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-(5-phosphoribosyl)-anthranilate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16881
type: UnificationXref
id: CHEBI:16881
db: ChEBI

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/BioCyc CPD-9517
type: UnificationXref
id: CPD-9517
db: BioCyc

Reference/BioCyc INDOLE
type: UnificationXref
id: INDOLE
db: BioCyc

ReactionCatalysis745759
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: 1.2.4.1
control type: ACTIVATION

Indole
type: SmallMoleculeReference
xref: Reference/ChemSpider 776
xref: Reference/PubChem-compound 798
xref: Reference/BioCyc INDOLE
xref: Reference/CAS 120-72-9
xref: Reference/KEGG Compound C00463
xref: Reference/HMDB HMDB0000738
xref: Reference/ChEBI CHEBI 16881
chemical formula: C8H7N
molecular weight: 117.057846
structure: ChemicalStructure/PW C000587

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

ReactionCatalysis745757
type: Catalysis
controller: tryptophan synthase, β subunit dimer
controlled: 4.2.1.20
control type: ACTIVATION

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

ReactionCatalysis745758
type: Catalysis
controller: tryptophanase / L-cysteine desulfhydrase
controlled: 4.1.99.1
control type: ACTIVATION

Reference/BioCyc ANTHRANILATE
type: UnificationXref
id: ANTHRANILATE
db: BioCyc

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ReactionCatalysis745756
type: Catalysis
controller: Unknown
controlled: 4.2.1.20
control type: ACTIVATION

ReactionCatalysis745753
type: Catalysis
controller: Unknown
controlled: 4.1.1.48
control type: ACTIVATION

ReactionCatalysis745754
type: Catalysis
controller: Unknown
controlled: Reaction744778
control type: ACTIVATION

ReactionCatalysis745751
type: Catalysis
controller: anthranilate synthase
controlled: 4.1.3.27
control type: ACTIVATION

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

ReactionCatalysis745752
type: Catalysis
controller: Unknown
controlled: 4.1.3.27
control type: ACTIVATION

Reference/ChEBI CHEBI 30754
type: UnificationXref
id: CHEBI:30754
db: ChEBI

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChEBI CHEBI 77456
type: UnificationXref
id: CHEBI:77456
db: ChEBI

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C040926/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

Reference/HMDB HMDB0000738
type: UnificationXref
id: HMDB0000738
db: HMDB

Compound/PW C022608/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

L-Serine
type: SmallMolecule
entity reference: L-Serine

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

Compound/PW C000869/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine
name: SubPathwayOutput

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Compound/PW C001938/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminoacrylic acid
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

ChemicalStructure/PW C000877
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=CC=C1C(O)=O

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

Protein/29154/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Indole
type: SmallMolecule
entity reference: Indole

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 12039
type: UnificationXref
id: 12039
db: PubChem-compound

Reference/ChemSpider 110510
type: UnificationXref
id: 110510
db: ChemSpider

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/CAS 118-92-3
type: UnificationXref
id: 118-92-3
db: CAS

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS