PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127887 View Pathway	drug action Pralatrexate Action Pathway Homo sapiens Pralatrexate is a folate analog, used for the treatment of peripheral T-cell lymphoma. Administered intravenously it acts to inhibit dihydrofolate reductase, specifically in cancer cells that have an overexpression of a transporter known as reduced folate carrier protein-1. This transporter is responsible for moving folate that is required for DNA synthesis and replication, without the folate the cancer cells cannot rapidly replicate. Pralatrexate also is affected by folyopolyglutamate synthase, allowing the drug to stay within the body for a longer period of time. It is eliminated via the urine and has a half-life of 12-18 hours. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: June 15, 2023 at 17:34 Last Updated: June 15, 2023 at 17:34
PW145814 View Pathway	drug action Pralatrexate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:43 Last Updated: October 07, 2023 at 16:43
PW144844 View Pathway	drug action Pralidoxime Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:32 Last Updated: October 07, 2023 at 14:32
PW146943 View Pathway	drug action Pralsetinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:24 Last Updated: October 07, 2023 at 19:24
PW176120 View Pathway	metabolic Pralsetinib Predicted Metabolism Pathway new Homo sapiens Metabolites of Pralsetinib are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:06 Last Updated: November 29, 2023 at 14:06
PW144538 View Pathway	drug action Pramipexole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:51 Last Updated: October 07, 2023 at 13:51
PW128057 View Pathway	drug action Pramipexole Mechanism of Action Action Pathway Homo sapiens Pramipexole is indicated for the management of Parkinson's disease and symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS). Pramipexole likely restores balance to the dopaminergic system, controlling the symptoms of this condition. Restless legs syndrome is thought to occur, in part, through dysfunction of the dopaminergic system, resulting in unpleasant lower extremity symptoms. Pramipexole is considered a non-ergot dopamine agonist that shows specificity and strong activity at the D2 subfamily of dopamine receptors in vitro, binding selectively and dopamine D2 receptors and showing a preference for the dopamine D3 receptor subtype rather than other subtypes. Pramipexole's efficacy in PD is attributed to its D3 selectivity. It binds to presynaptic dopamine autoreceptors exerting negative feedback on endogenous dopamine synthesis. This process leads to a decrease in oxidative stress, which mitigates the damage to the nigrostriatal pathways BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 12, 2023 at 10:45 Last Updated: July 12, 2023 at 10:45
PW176286 View Pathway	metabolic Pramipexole Predicted Metabolism Pathway Homo sapiens Metabolites of Pramipexole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:41 Last Updated: December 04, 2023 at 14:41
PW146619 View Pathway	drug action Pramiracetam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:38 Last Updated: October 07, 2023 at 18:38
PW145355 View Pathway	drug action Pramlintide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:38 Last Updated: October 07, 2023 at 15:38