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Showing 1 - 20 of 1569 proteins

Protein ID

Protein

Pathways

Q04446

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1,4-alpha-glucan-branching enzyme

Gene Name: GBE1

Required for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells.

Q99943

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HMDBP01581

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1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha

Gene Name: AGPAT1

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Q9NUQ2

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HMDBP03003

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1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Gene Name: AGPAT5

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.

Q9NQ66

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HMDBP00222

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Gene Name: PLCB1

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Q8N3E9

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HMDBP04457

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Gene Name: PLCD3

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.

P19174

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HMDBP00244

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Gene Name: PLCG1

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

Q9Y2I7

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HMDBP01276

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1-phosphatidylinositol-3-phosphate 5-kinase

Gene Name: PIKFYVE

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes

Q9NRX4

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HMDBP11578

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14 kDa phosphohistidine phosphatase

Gene Name: PHPT1

Exhibits phosphohistidine phosphatase activity.

Q8TDX5

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HMDBP00261

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2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Gene Name: ACMSD

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

O75600

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HMDBP00049

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2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

Gene Name: GCAT

Q96SZ5

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HMDBP08667

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2-aminoethanethiol dioxygenase

Gene Name: ADO

Q9H2A2

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2-aminomuconic semialdehyde dehydrogenase

Gene Name: ALDH8A1

Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.

Q9UJ83

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HMDBP08729

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2-hydroxyacyl-CoA lyase 1

Gene Name: HACL1

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.

Q16880

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HMDBP01101

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2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Gene Name: UGT8

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.

Q5HYK3

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HMDBP07419

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2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene Name: COQ5

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity).

Q02218

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HMDBP00439

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2-oxoglutarate dehydrogenase, mitochondrial

Gene Name: OGDH

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

P12694

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HMDBP00300

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2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Gene Name: BCKDHA

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

P21953

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HMDBP00299

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2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

Gene Name: BCKDHB

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

Q9NYL5

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HMDBP05845

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24-hydroxycholesterol 7-alpha-hydroxylase

Gene Name: CYP39A1

Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.

O75881

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HMDBP01629

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25-hydroxycholesterol 7-alpha-hydroxylase

Gene Name: CYP7B1

Showing 1 - 20 of 1569 proteins