SMPDB

Showing 1561 - 1580 of 1576 proteins

Protein ID	Protein	Pathways
Q9BQB6 View in UniProt HMDBP02242 View in HMDB	Vitamin K epoxide reductase complex subunit 1 Gene Name: VKORC1 Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.	Acenocoumarol Action Pathway Alteplase Action Pathway Aminocaproic Acid Action Pathway Anistreplase Action Pathway Aprotinin Action Pathway Ardeparin Action Pathway Argatroban Action Pathway Bivalirudin Action Pathway Coagulation Dicoumarol Action Pathway Dicumarol Action Pathway Enoxaparin Action Pathway Fondaparinux Action Pathway Heparin Action Pathway Lepirudin Action Pathway Phenindione Action Pathway Phenprocoumon Action Pathway Reteplase Action Pathway Streptokinase Action Pathway Tenecteplase Action Pathway Tranexamic Acid Action Pathway Urokinase Action Pathway Vitamin K Metabolism Warfarin Action Pathway Ximelagatran Action Pathway ( show more show less )
P38435 View in UniProt HMDBP01691 View in HMDB	Vitamin K-dependent gamma-carboxylase Gene Name: GGCX Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	Acenocoumarol Action Pathway Alteplase Action Pathway Aminocaproic Acid Action Pathway Anistreplase Action Pathway Aprotinin Action Pathway Ardeparin Action Pathway Argatroban Action Pathway Bivalirudin Action Pathway Coagulation Dicoumarol Action Pathway Dicumarol Action Pathway Enoxaparin Action Pathway Fondaparinux Action Pathway Heparin Action Pathway Lepirudin Action Pathway Phenindione Action Pathway Phenprocoumon Action Pathway Reteplase Action Pathway Streptokinase Action Pathway Tenecteplase Action Pathway Tranexamic Acid Action Pathway Urokinase Action Pathway Vitamin K Metabolism Warfarin Action Pathway Ximelagatran Action Pathway ( show more show less )
Q9NY47 View in UniProt HMDBP07485 View in HMDB	Voltage-dependent calcium channel subunit alpha-2/delta-2 Gene Name: CACNA2D2 The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis	3-Methylthiofentanyl Action Pathway Acebutolol Action Pathway Alfentanil Action Pathway Alprenolol Action Pathway Alvimopan Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Anileridine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Benzocaine Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupivacaine Action Pathway Bupranolol Action Pathway Buprenorphine Action Pathway Carfentanil Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Chloroprocaine Action Pathway Citalopram Action Pathway Cocaine Action Pathway Codeine Action Pathway Desipramine Action Pathway Dezocine Action Pathway Dibucaine Action Pathway Dihydromorphine Action Pathway Diltiazem Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Epinephrine Action Pathway Escitalopram Action Pathway Esmolol Action Pathway Ethylmorphine Action Pathway Felodipine Action Pathway Felodipine Metabolism Pathway Fentanyl Action Pathway Flecainide Action Pathway Fluoxetine Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Glibenclamide Action Pathway Gliclazide Action Pathway GnRH Signaling Pathway Hydrocodone Action Pathway Hydromorphone Action Pathway Ibutilide Action Pathway Imipramine Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Ketobemidone Action Pathway Labetalol Action Pathway Levallorphan Action Pathway Levobunolol Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Mepivacaine Action Pathway Methadone Action Pathway Methadyl Acetate Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Morphine Action Pathway Nadolol Action Pathway Nalbuphine Action Pathway Naloxone Action Pathway Naltrexone Action Pathway Nateglinide Action Pathway Nebivolol Action Pathway Neuron Function Nicotine Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Oxybuprocaine Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Pancreas Function - Alpha Cell Pancreas Function - Beta Cell Pancreas Function - Delta Cell Penbutolol Action Pathway Pentazocine Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Prilocaine Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procaine Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Propranolol Action Pathway Quinidine Action Pathway Remifentanil Action Pathway Repaglinide Action Pathway Ropivacaine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Sufentanil Action Pathway Timolol Action Pathway Tocainide Action Pathway Tramadol Action Action Pathway Verapamil Action Pathway ( show more show less )
Q13936 View in UniProt HMDBP02220 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1C Gene Name: CACNA1C Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function	Acebutolol Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Cadmium Induces DNA Synthesis and Proliferation in Macrophages Carteolol Action Pathway Carvedilol Action Pathway Diltiazem Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Felodipine Metabolism Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway GnRH Signaling Pathway Ibutilide Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Propranolol Action Pathway Quinidine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Verapamil Action Pathway ( show more show less )
Q01668 View in UniProt HMDBP01990 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1D Gene Name: CACNA1D Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)	Cadmium Induces DNA Synthesis and Proliferation in Macrophages GnRH Signaling Pathway
O60840 View in UniProt HMDBP07494 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1F Gene Name: CACNA1F Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)	Cadmium Induces DNA Synthesis and Proliferation in Macrophages GnRH Signaling Pathway
Q13698 View in UniProt HMDBP07498 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1S Gene Name: CACNA1S Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle	Cadmium Induces DNA Synthesis and Proliferation in Macrophages GnRH Signaling Pathway
Q02641 View in UniProt HMDBP07499 View in HMDB	Voltage-dependent L-type calcium channel subunit beta-1 Gene Name: CACNB1 The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	3-Methylthiofentanyl Action Pathway Acebutolol Action Pathway Alfentanil Action Pathway Alprenolol Action Pathway Alvimopan Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Anileridine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Benzocaine Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupivacaine Action Pathway Bupranolol Action Pathway Buprenorphine Action Pathway Carfentanil Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Chloroprocaine Action Pathway Citalopram Action Pathway Cocaine Action Pathway Codeine Action Pathway Desipramine Action Pathway Dezocine Action Pathway Dibucaine Action Pathway Dihydromorphine Action Pathway Diltiazem Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Epinephrine Action Pathway Escitalopram Action Pathway Esmolol Action Pathway Ethylmorphine Action Pathway Felodipine Action Pathway Felodipine Metabolism Pathway Fentanyl Action Pathway Flecainide Action Pathway Fluoxetine Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Glibenclamide Action Pathway Gliclazide Action Pathway GnRH Signaling Pathway Hydrocodone Action Pathway Hydromorphone Action Pathway Ibutilide Action Pathway Imipramine Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Ketobemidone Action Pathway Labetalol Action Pathway Levallorphan Action Pathway Levobunolol Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Mepivacaine Action Pathway Methadone Action Pathway Methadyl Acetate Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Morphine Action Pathway Nadolol Action Pathway Nalbuphine Action Pathway Naloxone Action Pathway Naltrexone Action Pathway Nateglinide Action Pathway Nebivolol Action Pathway Neuron Function Nicotine Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Oxybuprocaine Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Pancreas Function - Alpha Cell Pancreas Function - Beta Cell Pancreas Function - Delta Cell Penbutolol Action Pathway Pentazocine Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Prilocaine Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procaine Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Propranolol Action Pathway Quinidine Action Pathway Remifentanil Action Pathway Repaglinide Action Pathway Ropivacaine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Sufentanil Action Pathway Timolol Action Pathway Tocainide Action Pathway Tramadol Action Action Pathway Verapamil Action Pathway ( show more show less )
O00555 View in UniProt HMDBP07491 View in HMDB	Voltage-dependent P/Q-type calcium channel subunit alpha-1A Gene Name: CACNA1A Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA)	3-Methylthiofentanyl Action Pathway Alfentanil Action Pathway Alvimopan Action Pathway Anileridine Action Pathway Benzocaine Action Pathway Bupivacaine Action Pathway Buprenorphine Action Pathway Carfentanil Action Pathway Chloroprocaine Action Pathway Citalopram Action Pathway Cocaine Action Pathway Codeine Action Pathway Desipramine Action Pathway Dezocine Action Pathway Dibucaine Action Pathway Dihydromorphine Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Escitalopram Action Pathway Ethylmorphine Action Pathway Fentanyl Action Pathway Fluoxetine Action Pathway Glibenclamide Action Pathway Gliclazide Action Pathway Hydrocodone Action Pathway Hydromorphone Action Pathway Imipramine Action Pathway Ketobemidone Action Pathway Levallorphan Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Mepivacaine Action Pathway Methadone Action Pathway Methadyl Acetate Action Pathway Morphine Action Pathway Nalbuphine Action Pathway Naloxone Action Pathway Naltrexone Action Pathway Nateglinide Action Pathway Neuron Function Nicotine Action Pathway Oxybuprocaine Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Pancreas Function - Alpha Cell Pancreas Function - Beta Cell Pancreas Function - Delta Cell Pentazocine Action Pathway Prilocaine Action Pathway Procaine Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Remifentanil Action Pathway Repaglinide Action Pathway Ropivacaine Action Pathway Sufentanil Action Pathway Tramadol Action Action Pathway ( show more show less )
O43497 View in UniProt HMDBP07495 View in HMDB	Voltage-dependent T-type calcium channel subunit alpha-1G Gene Name: CACNA1G Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes	Acebutolol Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Diltiazem Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Ibutilide Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Propranolol Action Pathway Quinidine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Verapamil Action Pathway ( show more show less )
O95180 View in UniProt HMDBP07496 View in HMDB	Voltage-dependent T-type calcium channel subunit alpha-1H Gene Name: CACNA1H Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes	Acebutolol Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Diltiazem Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Ibutilide Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Propranolol Action Pathway Quinidine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Verapamil Action Pathway ( show more show less )
Q92558 View in UniProt	Wiskott-Aldrich syndrome protein family member 1 Gene Name: WASF1	Rac 1 Cell Motility Signaling Pathway
P47989 View in UniProt HMDBP00181 View in HMDB	Xanthine dehydrogenase/oxidase Gene Name: XDH Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Caffeine Metabolism Doxorubicin Metabolism Pathway Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mercaptopurine Metabolism Pathway Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Nitric Oxide Signaling Pathway Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type II ( show more show less )
Q9UM01 View in UniProt HMDBP03080 View in HMDB	Y+L amino acid transporter 1 Gene Name: SLC7A7 Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes	Amiloride Action Pathway Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway Ethacrynic Acid Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Glutaminolysis and Cancer Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function- Proximal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway Polythiazide Action Pathway Quinethazone Action Pathway Spironolactone Action Pathway Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway ( show more show less )
Q92536 View in UniProt HMDBP09098 View in HMDB	Y+L amino acid transporter 2 Gene Name: SLC7A6 Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells	Amiloride Action Pathway Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway Ethacrynic Acid Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function- Proximal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway Polythiazide Action Pathway Quinethazone Action Pathway Spironolactone Action Pathway Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway ( show more show less )
Q9C0K1 View in UniProt HMDBP11941 View in HMDB	Zinc transporter ZIP8 Gene Name: SLC39A8 Acts as a zinc-influx transporter.	Selenoamino Acid Metabolism

Showing 1561 - 1580 of 1576 proteins