SMPDB

Showing 1561 - 1580 of 1576 proteins

Protein ID	Protein Description	Pathway Class	Pathways
Q9BQB6 View in UniProt HMDBP02242 View in HMDB	Vitamin K epoxide reductase complex subunit 1 Gene Name: VKORC1 Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.	Metabolic	Acenocoumarol Action Pathway Alteplase Action Pathway Aminocaproic Acid Action Pathway Anistreplase Action Pathway Aprotinin Action Pathway Ardeparin Action Pathway Argatroban. Bivalirudin. Coagulation Coagulation Dicoumarol Action Pathway Dicumarol Action Pathway Enoxaparin. Fondaparinux. Heparin. Lepirudin Action Pathway Phenindione Action Pathway Phenprocoumon Action Pathway Reteplase Action Pathway Streptokinase Action Pathway Tenecteplase Action Pathway Tranexamic Acid Action Pathway Urokinase Action Pathway Vitamin K Metabolism Warfarin Action Pathway Warfarin Action Pathway (New) Ximelagatran Action Pathway ( show more show less )
P38435 View in UniProt HMDBP01691 View in HMDB	Vitamin K-dependent gamma-carboxylase Gene Name: GGCX Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	Metabolic	Acenocoumarol Action Pathway Alteplase Action Pathway Aminocaproic Acid Action Pathway Anistreplase Action Pathway Aprotinin Action Pathway Ardeparin Action Pathway Argatroban. Bivalirudin. Coagulation Coagulation Dicoumarol Action Pathway Dicumarol Action Pathway Enoxaparin. Fondaparinux. Heparin. Lepirudin Action Pathway Phenindione Action Pathway Phenprocoumon Action Pathway Reteplase Action Pathway Streptokinase Action Pathway Tenecteplase Action Pathway Tranexamic Acid Action Pathway Urokinase Action Pathway Vitamin K Metabolism Warfarin Action Pathway Warfarin Action Pathway (New) Ximelagatran Action Pathway ( show more show less )
Q9NY47 View in UniProt HMDBP07485 View in HMDB	Voltage-dependent calcium channel subunit alpha-2/delta-2 Gene Name: CACNA2D2 The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis	Metabolic	Dolasetron Serotonin antagonist Action Pathway Donepezil Action Pathway Dosulepin Serotonin antagonist Action Pathway 3-Methylthiofentanyl Action Pathway 3-Methylthiofentanyl Opioid Agonist Action Pathway Acebutolol Action Pathway Acebutolol Action Pathway Acepromazine - Serotonin Antagonist Action Pathway Acepromazine Dopamine Antagonist Action Pathway Aceprometazine H1 Antihistamine Neurological Sleep Action Pathway Agomelatine Serotonin Antagonist Action Pathway Ajmaline Action Pathway Alfentanil Action Pathway Alfentanil Opioid Agonist Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Alvimopan Action Pathway Alvimopan Opioid Antagonist Action Pathway Ambenonium Action Pathway (new) Amine Oxidase Serotonin Amiodarone Action Pathway Amiodarone Action Pathway (New) Amisulpride Serotonin Antagonist Action Pathway Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway Amitriptyline Serotonin Antagonist Action Pathway Amlodipine Action Pathway Amoxapine SSRI Action Pathway Anileridine Action Pathway Anileridineb Opioid Agonist Action Pathway Apomorphine Mechanism of Action Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Aripiprazole Dopamine agonist Action Pathway Aripiprazole Serotonin Agonist Action Pathway Asenapine Dopamine Antagonist Action Pathway Asenapine Serotonin antagonist Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Atomoxetine Action Pathway (New) Atropine M1/3/5 Muscarinic Poisoning Action Pathway Atropine M2 Cardiac Muscle Contraction Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzhydrocodone Opioid Agonist Action Pathway Benzocaine Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bethanechol Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bezitramide Opioid Agonist Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Brexpiprazole Dopamine Agonist Action Pathway Brexpiprazole Serotonin Action Action Pathway Bromocriptine Mechanism of Action Action Pathway Bromodiphenhydramine H1 Antihistamine Neurological Sleep Action Pathway Bromopride Dopamine Antagonist Action Pathway Buclizine H1 Antihistamine Neurological Sleep Action Pathway Bupivacaine Action Pathway Bupranolol Action Pathway Bupranolol Action Pathway Buprenorphine Action Pathway Bupropion Action Pathway Butorphanol Opioid Antagonist Action Pathway Cabergoline Mechanism of Action Action Pathway Caffeine Adrenergic A1 vasoconstriction Action Pathway Caffeine Cardiac Contraction Action Pathway Caffeine Vasodilation Action Pathway Carbamazepine Sodium Channel Analgesic Action Pathway Carbaryl Action Pathway Carfentanil Action Pathway Carfentanil Opioid Agonist Action Pathway Cariprazine Mechanism of Action Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Cetirizine H1 Antihistamine Neurological Sleep Action Pathway Cevimeline M1 Saliva Excretion Action Pathway Cevimeline M3 Salivary Gland Smooth Muscle Contraction Action Pathway Chloroprocaine Action Pathway Chlorpheniramine H1 Antihistamine Neurological Sleep Action Pathway Chlorpromazine - Dopamine Antagonist Action Pathway Chlorpromazine - Serotonin Antagonist Action Pathway Chlorpromazine H1 Antihistamine Neurological Sleep Action Pathway Chlorpropamide Action Pathway Chlorprothixene Dopamine Antagonist Action Pathway Chlorprothixene Serotonin Antagonist Action Pathway Citalopram Action Pathway Citalopram Mechanism of Action Action Pathway New Clemastine H1-Antihistamine Blood Vessel Constriction Action Pathway Clemastine H1-Antihistamine Immune Response Action Pathway Clemastine H1-Antihistamine Smooth Muscle Relaxation Action Pathway Clomipramine Action Pathway (New) Clozapine Dopamine Antagonist Action Pathway Clozapine H1 Antihistamine Neurological Sleep Action Pathway Clozapine Serotonin Antagonist Action Pathway Cocaine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cocaine Norepinephrine Reuptake Inhibitor Action Pathway Codeine Action Pathway Codeine Opioid Action Pathway Cyclizine H1 Antihistamine Neurological Sleep Action Pathway Cyclobenzaprine Serotonin antagonist Action Pathway Cyproheptadine H1 Antihistamine Neurological Sleep Action Pathway Cyproheptadine Serotonin Antagonist Action Pathway Darifenacin Action Pathway Demecarium Action Pathway (new) Desipramine Action Pathway Desipramine Action Pathway (New) Desomorphine Opioid Agonist Action Pathway Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dextromethorphan Nicotinic Acetylcholine Antagonism Action Pathway Dextromoramide Opioid Agonist Action Pathway Dextropropoxyphene Opioid Agonist Action Pathway Dezocine Action Pathway Dezocine Kappa Opioid Antagonism Action Pathway Dezocine Mu Opioid Agonism Action Pathway Diamorphine Action Pathway Dibucaine Action Pathway Difelikefalin Opioid Agonist Action Pathway Digoxin Cardiac Action Pathway Dihydrocodeine Opioid Agonist Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Dihydroetorphine Opioid Agonist Action Pathway Dihydromorphine Action Pathway Dihydromorphine Opioid Agonist Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Dimethylthiambutene Action Pathway Diphenhydramine H1 Antihistamine Neurological Sleep Action Pathway Diphenoxylate Action Pathway Diphenoxylate Opioid Agonist Action Pathway Diprenorphine Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Distigmine Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Dofetilide Action Pathway Domperidone Mechanism of Action Action Pathway Dopamine Action Pathway Dopamine Action Pathway Dosulepin H1 Antihistamine Neurological Sleep Action Pathway Doxepin H1 Antihistamine Neurological Sleep Action Pathway Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) Doxylamine H1 Antihistamine Neurological Sleep Action Pathway Doxylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Doxylamine H1-Antihistamine Blood Vessel Constriction Action Pathway Doxylamine H1-Antihistamine Immune Response Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Droperidol Mechanism of Action Action Pathway Droxidopa A1-Adrenergic Vasoconstriction Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Echothiophate Action Pathway Edrophonium Action Pathway (new) Eletriptan Mechanism of Action Action Pathway Eluxadoline Action Pathway Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine A1-Adrenergic Vasoconstriction Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Escitalopram Action Pathway Escitalopram Mechanism of Action Action Pathway New Eslicarbazepine Acetate Action Pathway Esmirtazapine H1 Antihistamine Neurological Sleep Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Ethotoin Action Pathway Ethylmorphine Action Pathway Ethylmorphine Opioid Action Pathway Etorphine Opioid Agonist Action Pathway Felodipine Action Pathway Felodipine Metabolism Pathway Fenoldopam Mechanism of Action Action Pathway Fentanyl Action Pathway Fentanyl Opioid Agonist Action Pathway Fesoterodine Action Pathway Flecainide Action Pathway Flecainide Antiarrhythmic Action Pathway Flibanserin Serotonin Action Action Pathway Fluoxetine Action Pathway Flupentixol Dopamine Antagonist Action Pathway Flupentixol Serotonin Antagonist Action Pathway Fluphenazine Mechanism of Action Action Pathway Fluspirilene Mechanism of Action Action Pathway Fluvoxamine Mechanism of Action Action Pathway New Fosphenytoin (Antiarrhythmic) Action Pathway Fosphenytoin Action Pathway (New) Frovatriptan Mechanism of Action Action Pathway Gabapentin Action Pathway Galantamine Action Pathway (new, revision) Gi Serotonergic Vasoconstriction Glibenclamide Action Pathway Gliclazide Action Pathway Gliclazide Action Pathway (New) Glimepiride Action Pathway Glipizide Action Pathway Gliquidone Action Pathway Glyburide Action Pathway GnRH Signaling Pathway Granisetron Serotonin antagonist Action Pathway Haloperidol Dopamine Antagonist Action Pathway Histamine Muscle Contraction Pathway Histamine Neurological Sleep Pathway Hydrocodone Action Pathway Hydrocodone Opioid Agonist Action Pathway Hydromorphone Action Pathway Hydromorphone Opioid Agonist Action Pathway Hydroxyzine H1 Antihistamine Neurological Sleep Action Pathway Ibutilide Action Pathway Iloperidone Serotonin antagonist Action Pathway Imipramine Imipramine Action Pathway (New) Incretins - Insulin release Pathway Intestinal Serotonin pathway Ipratropium M3 Bronchodilation Action Pathway Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway Isoflurophate Action Pathway (new) Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isosorbide Dinitrate Action Pathway Isosorbide Mononitrate Action Pathway Isradipine Action Pathway Ketobemidone Action Pathway Ketobemidone Opioid Agonist Action Pathway Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Lacosamide Action Pathway Levacetylmethadol Opioid Agonist Action Pathway Levallorphan Action Pathway Levallorphan Action Pathway (New) Levetiracetam Action Pathway (New) Levobunolol Action Pathway Levobunolol Action Pathway Levobupivacaine Action Pathway Levodopa Pahway Levomethadyl Acetate Action Action Pathway Levomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Levorphanol Action Pathway Levorphanol Opioid Agonist Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Lidocaine NMDA Anesthetic Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Lisuride Dopamine Agonist Action Pathway Lofentanil Opioid Agonist Action Pathway Loperamide Action Pathway Lorpiprazole Serotonin antagonist Action Pathway Loxapine Dopamine Antagonist Action Pathway Lumateperone Dopamine Action Action Pathway Lumateperone Serotonin Antagonist Action Pathway Lumateperone SSRI Action Action Pathway Lurasidone Dopamine Antagonist Action Pathway Lurasidone Serotonin Antagonist Action Pathway Magnesium Sulfate Action Pathway Malathion Action Pathway Maprotiline Action Pathway Maprotiline H1 Antihistamine Neurological Sleep Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Meperidine opioid agonist Action Pathway Mepivacaine Action Pathway Mepyramine H1 Antihistamine Neurological Sleep Action Pathway Mesoridazine Dopamine Antagonist Action Pathway Mesoridazine Serotonin Antagonist Action Pathway Methacholine M3 Bronchoconstriction Action Pathway Methadone Action Pathway Methadone Opioid Agonist Action Pathway Methadyl Acetate Action Pathway Methadyl acetate Opioid Agonist Action Pathway Methotrimeprazine Dopamine Antagonist Action Pathway Methyldopa Action Pathway Methylergometrine Mechanism of Action Action Pathway Methylnaltrexone Opioid Antagonist Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Methylphosphinic Acid Action Pathway Methysergide Mechanism of Action Action Pathway Metipranolol Action Pathway Metoclopramide - Dopamine Antagonist Action Pathway Metoprolol Action Pathway Metoprolol Action Pathway (New) Metrifonate Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Milnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Minaprine Acetylcholinesterase Antidepressant Action Pathway Minaprine Serotonin Antagonist Action Pathway Minaprine Serotonin receptor Antidepressant Action Pathway Mirtazapine H1 Antihistamine Neurological Sleep Action Pathway Mirtazapine Serotonin Antagonist Action Pathway Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway Modafinil Action Pathway Moricizine Action Pathway Morphine Action Pathway Morphine Opioid Agonist Action Pathway Morphine Opioid Agonist Brain Action Pathway nAchR Smooth Muscle Contraction Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nalbuphine Action Pathway Nalbuphine Opioid Antagonist Action Pathway Naldemedine Opioid Antagonist Action Pathway Nalmefene Opioid Antagonist Action Pathway Naloxegol Action Pathway Naloxone Action Pathway Naloxone Opioid Antagonist Action Pathway Naltrexone Action Pathway Naltrexone Opioid Antagonist Action Pathway Naratriptan Mechanism of Action Action Pathway Nateglinide Action Pathway Nateglinide Action Pathway (New) Nebivolol Action Pathway Nebivolol Action Pathway (New) Neostigmine Action Pathway (new) Neuron Function Neuronal Dopamine Gs Cascade NGX267 Action Pathway Nicotine Action Pathway Nicotinic Acetylcholine Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Norepinephrine Neurological Normethadone Action Pathway Nortriptyline Action Pathway Olanzapine Dopamine Antagonist Action Pathway Olanzapine H1 Antihistamine Neurological Sleep Action Pathway Olanzapine Serotonin Antagonist Action Pathway Oliceridine Opioid Agonist Action Pathway Ondansetron Serotonin antagonist Action Pathway Oxcarbazepine Action Pathway (New) Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Oxybuprocaine Action Pathway Oxybutynin Action Pathway Oxycodone Action Pathway Oxycodone Opioid Agonist Action Pathway Oxymorphone Action Pathway Oxymorphone Opioid Agonist Action Pathway Oxyphenonium Action Pathway Oxytocin Action Pathway Paliperidone Dopamine Antagonist Action Pathway Paliperidone Serotonin Antagonist Action Pathway Palonosetron Serotonin antagonist Action Pathway Pancreas Function - Alpha Cell Pancreas Function - Beta Cell Pancreas Function - Delta Cell Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway Paroxetine Mechanism of Action Action Pathway New Penbutolol Action Pathway Penbutolol Action Pathway (New) Pentazocine Action Pathway Pentazocine Opioid Antagonist Action Pathway Pergolide Mechanism of Action Action Pathway Perphenazine Mechanism of Action Action Pathway Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway Pheniramine H1 Antihistamine Neurological Sleep Action Pathway Phenserine Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Phenytoin Action Pathway (New) Physostigmine Action Pathway Physostigmine Action Pathway (new) Pilocarpine Action Pathway Pilocarpine M1 Saliva Excretion Action Pathway Pilocarpine M3 Iris Sphincter Muscle Constriction Action Pathway Pimozide Mechanism of Action Action Pathway Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Pipotiazine Dopamine Antagonist Action Pathway Pipotiazine Serotonin antagonist Action Pathway Piritramide Opioid Agonist Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Pramipexole Mechanism of Action Action Pathway Prilocaine Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Procaine Action Pathway Prochlorperazine - Dopamine Antagonist Action Pathway Prochlorperazine Mechanism of Action Action Pathway Procyclidine M1 Antispasmodic Action Pathway Promazine Mechanism of Action Action Pathway Promethazine H1 Antihistamine Neurological Sleep Action Pathway Propafenone Action Pathway Propantheline Action Pathway Proparacaine Action Pathway Propiomazine H1 Antihistamine Neurological Sleep Action Pathway Propoxyphene Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Pseudoephedrine Action Pathway Pyridostigmine Action Pathway Quetiapine Dopamine Antagonist Action Pathway Quetiapine Serotonin Antagonist Action Pathway Quinagolide Mechanism of Action Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway Ranolazine Action Pathway Remifentanil Action Pathway Remifentanil Opioid Analgesic Action Pathway Remifentanil Opioid Anasthetic Action Pathway Remoxipride Mechanism of Action Action Pathway Repaglinide Action Pathway Repaglinide Action Pathway (New) Risperidone Dopamine Antagonist Action Pathway Risperidone Serotonin Antagonist Action Pathway Rivastigmine Action Pathway (new) Rizatriptan Mechanism of Action Action Pathway Ropinirole Mechanism of Action Action Pathway Ropivacaine Action Pathway Rotigotine Dopamine Agonist Action Pathway Samidorphan Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sertraline Mechanism of Action Action Pathway New Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solifenacin M3 Bladder Muscle Relaxation Action Pathway Solriamfetol Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Sufentanil Action Pathway Sufentanil Opioid Agonist Action Pathway Sulpiride Mechanism of Action Action Pathway Sumatriptan Mechanism of Action Action Pathway Tacrine Action Pathway (new) Tamsulosin Action Pathway Tapentadol Opioid Agonist Action Pathway Thiethylperazine Dopamine Antagonist Action Pathway Thiethylperazine Serotonin Antagonist Action Pathway Thioridazine Dopamine Antagonist Action Pathway Thioridazine Serotonin Antagonist Action Pathway Thiothixene Dopamine Antagonist Action Pathway Tiapride Dopamine Antagonist Action Pathway Tiapride Serotonin Antagonist Action Pathway Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Tizanidine Tocainide Action Pathway Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Tolazamide Action Pathway Tolbutamide Action Pathway Tolterodine Action Pathway Topiramate Action Pathway (New) Tramadol Action Action Pathway Tramadol Opioid Agonist Action Pathway Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway Trazodone H1 Antihistamine Neurological Sleep Action Pathway Trifluoperazine Dopamine Antagonist Action Pathway Triflupromazine - Dopamine Antagonist Action Pathway Triflupromazine Mechanism of Action Action Pathway Triflupromazine Serotonin Antagonist Action Pathway Trihexyphenidyl Action Pathway Trimebutine M3 Receptor Intestine Relaxation Action Pathway Trimebutine Opioid Action Pathway Trimipramine Action Pathway Trimipramine H1 Antihistamine Neurological Sleep Action Pathway Triprolidine H1 Antihistamine Neurological Sleep Action Pathway Tropisetron Serotonin antagonist Action Pathway Trospium Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Vortioxetine Serotonin Action Action Pathway Ziconotide Analgesia Action Pathway Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway Ziprasidone Dopamine Antagonist Action Pathway Ziprasidone Serotonin Action Action Pathway Zolmitriptan Mechanism of Action Action Pathway Zuclopenthixol Dopamine Antagonist Action Pathway Zuclopenthixol H1 Antihistamine Neurological Sleep Action Pathway ( show more show less )
Q13936 View in UniProt HMDBP02220 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1C Gene Name: CACNA1C Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function	Metabolic	Acebutolol Action Pathway Acebutolol Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Ambenonium Action Pathway (new) Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Bupranolol Action Pathway Bupranolol Action Pathway Cadmium Induces DNA Synthesis and Proliferation in Macrophages Caffeine Cardiac Contraction Action Pathway Caffeine Vasodilation Action Pathway Carbaryl Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Digoxin Cardiac Action Pathway Diltiazem Action Pathway Disopyramide Action Pathway Distigmine Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Dofetilide Action Pathway Dopamine Action Pathway Dopamine Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Edrophonium Action Pathway (new) Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Felodipine Action Pathway Felodipine Metabolism Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway GnRH Signaling Pathway Ibutilide Action Pathway Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isosorbide Dinitrate Action Pathway Isosorbide Mononitrate Action Pathway Isradipine Action Pathway Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Lacidipine Action Pathway Levobunolol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Malathion Action Pathway Methylphosphinic Acid Action Pathway Methysergide Mechanism of Action Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Metoprolol Action Pathway (New) Mexiletine Action Pathway Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nebivolol Action Pathway Nebivolol Action Pathway (New) Neostigmine Action Pathway (new) Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Penbutolol Action Pathway Penbutolol Action Pathway (New) Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Procainamide (Antiarrhythmic) Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Pyridostigmine Action Pathway Quinidine Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Tocainide Action Pathway Verapamil Action Pathway ( show more show less )
Q01668 View in UniProt HMDBP01990 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1D Gene Name: CACNA1D Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)	Metabolic	Ambenonium Action Pathway (new) Cadmium Induces DNA Synthesis and Proliferation in Macrophages Carbaryl Action Pathway Distigmine Action Pathway Edrophonium Action Pathway (new) GnRH Signaling Pathway Lacidipine Action Pathway Malathion Action Pathway Methylphosphinic Acid Action Pathway Neostigmine Action Pathway (new) Pyridostigmine Action Pathway ( show more show less )
O60840 View in UniProt HMDBP07494 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1F Gene Name: CACNA1F Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)	Metabolic	Ambenonium Action Pathway (new) Cadmium Induces DNA Synthesis and Proliferation in Macrophages Carbaryl Action Pathway Distigmine Action Pathway Edrophonium Action Pathway (new) GnRH Signaling Pathway Lacidipine Action Pathway Malathion Action Pathway Methylphosphinic Acid Action Pathway Neostigmine Action Pathway (new) Pyridostigmine Action Pathway ( show more show less )
Q13698 View in UniProt HMDBP07498 View in HMDB	Voltage-dependent L-type calcium channel subunit alpha-1S Gene Name: CACNA1S Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle	Metabolic	Ambenonium Action Pathway (new) Cadmium Induces DNA Synthesis and Proliferation in Macrophages Carbaryl Action Pathway Distigmine Action Pathway Edrophonium Action Pathway (new) GnRH Signaling Pathway Lacidipine Action Pathway Malathion Action Pathway Methylphosphinic Acid Action Pathway Neostigmine Action Pathway (new) Pyridostigmine Action Pathway ( show more show less )
Q02641 View in UniProt HMDBP07499 View in HMDB	Voltage-dependent L-type calcium channel subunit beta-1 Gene Name: CACNB1 The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	Metabolic	Amifampridine Action Pathway Dolasetron Serotonin antagonist Action Pathway Donepezil Action Pathway Dosulepin Serotonin antagonist Action Pathway 3-Methylthiofentanyl Action Pathway 3-Methylthiofentanyl Opioid Agonist Action Pathway Acebutolol Action Pathway Acebutolol Action Pathway Acepromazine - Serotonin Antagonist Action Pathway Acepromazine Dopamine Antagonist Action Pathway Agomelatine Serotonin Antagonist Action Pathway Ajmaline Action Pathway Alfentanil Action Pathway Alfentanil Opioid Agonist Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Alverine Serotonin Antagonist Action Pathway Alvimopan Action Pathway Alvimopan Opioid Antagonist Action Pathway Ambenonium Action Pathway (new) Amine Oxidase Serotonin Amiodarone Action Pathway Amiodarone Action Pathway (New) Amisulpride Serotonin Antagonist Action Pathway Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway Amitriptyline Serotonin Antagonist Action Pathway Amlodipine Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Amoxapine SSRI Action Pathway Anileridine Action Pathway Anileridineb Opioid Agonist Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Arformoterol Action Pathway Aripiprazole Dopamine agonist Action Pathway Aripiprazole Serotonin Agonist Action Pathway Asenapine Serotonin antagonist Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Atomoxetine Action Pathway (New) Atropine M1/3/5 Muscarinic Poisoning Action Pathway Atropine M2 Cardiac Muscle Contraction Action Pathway Benzhydrocodone Opioid Agonist Action Pathway Benzocaine Action Pathway Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bethanechol Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bezitramide Opioid Agonist Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Brexpiprazole Dopamine Agonist Action Pathway Brexpiprazole Serotonin Action Action Pathway Bromopride Dopamine Antagonist Action Pathway Bupivacaine Action Pathway Bupranolol Action Pathway Bupranolol Action Pathway Buprenorphine Action Pathway Butorphanol Opioid Antagonist Action Pathway Caffeine Adrenergic A1 vasoconstriction Action Pathway Caffeine Cardiac Contraction Action Pathway Caffeine Nervous Action Pathway Caffeine Vasodilation Action Pathway Carbamazepine Sodium Channel Analgesic Action Pathway Carbaryl Action Pathway Carfentanil Action Pathway Carfentanil Opioid Agonist Action Pathway Cariprazine Mechanism of Action Action Pathway Carteolol Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cevimeline M1 Saliva Excretion Action Pathway Cevimeline M3 Salivary Gland Smooth Muscle Contraction Action Pathway Chloroprocaine Action Pathway Chlorpromazine - Dopamine Antagonist Action Pathway Chlorpromazine - Serotonin Antagonist Action Pathway Chlorpropamide Action Pathway Chlorprothixene Dopamine Antagonist Action Pathway Chlorprothixene Serotonin Antagonist Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Citalopram Action Pathway Citalopram Mechanism of Action Action Pathway New Clemastine H1-Antihistamine Blood Vessel Constriction Action Pathway Clemastine H1-Antihistamine Immune Response Action Pathway Clemastine H1-Antihistamine Smooth Muscle Relaxation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Clomipramine Action Pathway (New) Clozapine Dopamine Antagonist Action Pathway Clozapine Serotonin Antagonist Action Pathway Cocaine Action Pathway Codeine Action Pathway Codeine Opioid Action Pathway Cyclandelate Action Pathway Cyclobenzaprine Serotonin antagonist Action Pathway Cyproheptadine Serotonin Antagonist Action Pathway Dalfampridine Action Pathway Darifenacin Action Pathway Demecarium Action Pathway (new) Desipramine Action Pathway Desipramine Action Pathway (New) Desomorphine Opioid Agonist Action Pathway Dextromethorphan Nicotinic Acetylcholine Antagonism Action Pathway Dextromoramide Opioid Agonist Action Pathway Dextropropoxyphene Opioid Agonist Action Pathway Dezocine Action Pathway Dezocine Kappa Opioid Antagonism Action Pathway Dezocine Mu Opioid Agonism Action Pathway Diamorphine Action Pathway Dibucaine Action Pathway Difelikefalin Opioid Agonist Action Pathway Digoxin Cardiac Action Pathway Dihydrocodeine Opioid Agonist Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Dihydroetorphine Opioid Agonist Action Pathway Dihydromorphine Action Pathway Dihydromorphine Opioid Agonist Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Diphenoxylate Opioid Agonist Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Diprenorphine Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Distigmine Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Dofetilide Action Pathway Domperidone Mechanism of Action Action Pathway Dopamine Action Pathway Dopamine Action Pathway Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) Doxylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Doxylamine H1-Antihistamine Blood Vessel Constriction Action Pathway Doxylamine H1-Antihistamine Immune Response Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Droperidol Mechanism of Action Action Pathway Droxidopa A1-Adrenergic Vasoconstriction Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Echothiophate Action Pathway Edrophonium Action Pathway (new) Eletriptan Mechanism of Action Action Pathway Eluxadoline Action Pathway Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine A1-Adrenergic Vasoconstriction Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epinephrine Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergotamine Mechanism of Action Action Pathway Escitalopram Action Pathway Escitalopram Mechanism of Action Action Pathway New Eslicarbazepine Acetate Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Etafedrine Action Pathway Ethotoin Action Pathway Ethylmorphine Action Pathway Ethylmorphine Opioid Action Pathway Etorphine Opioid Agonist Action Pathway Felodipine Action Pathway Felodipine Action Pathway (New) Felodipine Metabolism Pathway Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Fentanyl Action Pathway Fentanyl Opioid Agonist Action Pathway Fesoterodine Action Pathway Flavoxate Action Pathway Flecainide Action Pathway Flecainide Antiarrhythmic Action Pathway Flibanserin Serotonin Action Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Fluoxetine Action Pathway Flupentixol Dopamine Antagonist Action Pathway Flupentixol Serotonin Antagonist Action Pathway Fluphenazine Mechanism of Action Action Pathway Fluspirilene Mechanism of Action Action Pathway Fluvoxamine Mechanism of Action Action Pathway New Formoterol Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Fosphenytoin Action Pathway (New) Frovatriptan Mechanism of Action Action Pathway Galantamine Action Pathway (new, revision) Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Glibenclamide Action Pathway Gliclazide Action Pathway Gliclazide Action Pathway (New) Glimepiride Action Pathway Glipizide Action Pathway Gliquidone Action Pathway Glyburide Action Pathway GnRH Signaling Pathway Gq Adrenergic Smooth Muscle Contraction Gq Histaminic Smooth Muscle Contraction Gq Muscarinic Smooth Muscle Contraction Granisetron Serotonin antagonist Action Pathway Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Haloperidol Dopamine Antagonist Action Pathway Histamine Muscle Contraction Pathway Hydrocodone Action Pathway Hydrocodone Opioid Agonist Action Pathway Hydromorphone Action Pathway Hydromorphone Opioid Agonist Action Pathway Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Ibutilide Action Pathway Iloperidone Serotonin antagonist Action Pathway Imipramine Imipramine Action Pathway (New) Incretins - Insulin release Pathway Indacaterol Action Pathway Intestinal Serotonin pathway Ipratropium M3 Bronchodilation Action Pathway Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway Isoetharine Action Pathway Isoflurophate Action Pathway (new) Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isosorbide Dinitrate Action Pathway Isosorbide Mononitrate Action Pathway Isradipine Action Pathway Isradipine Action Pathway (New) Ketobemidone Action Pathway Ketobemidone Opioid Agonist Action Pathway Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Lacidipine Action Pathway Lacosamide Action Pathway Lercanidipine Action Pathway Levacetylmethadol Opioid Agonist Action Pathway Levallorphan Action Pathway Levallorphan Action Pathway (New) Levamlodipine Action Pathway Levetiracetam Action Pathway (New) Levobunolol Action Pathway Levobunolol Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Levorphanol Opioid Agonist Action Pathway Levosalbutamol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Lidocaine NMDA Anesthetic Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Lisuride Dopamine Agonist Action Pathway Lofentanil Opioid Agonist Action Pathway Loperamide Action Pathway Lorpiprazole Serotonin antagonist Action Pathway Loxapine Dopamine Antagonist Action Pathway Lumateperone Dopamine Action Action Pathway Lumateperone Serotonin Antagonist Action Pathway Lumateperone SSRI Action Action Pathway Lurasidone Dopamine Antagonist Action Pathway Lurasidone Serotonin Antagonist Action Pathway Magnesium Sulfate Action Pathway Malathion Action Pathway Manidipine Action Pathway Maprotiline Action Pathway Meperidine opioid agonist Action Pathway Mepivacaine Action Pathway Mesoridazine Dopamine Antagonist Action Pathway Mesoridazine Serotonin Antagonist Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methacholine M3 Bronchoconstriction Action Pathway Methadone Action Pathway Methadone Opioid Agonist Action Pathway Methadyl Acetate Action Pathway Methadyl acetate Opioid Agonist Action Pathway Methotrimeprazine Dopamine Antagonist Action Pathway Methyldopa Action Pathway Methylergometrine Mechanism of Action Action Pathway Methylnaltrexone Opioid Antagonist Action Pathway Methylphosphinic Acid Action Pathway Methysergide Mechanism of Action Action Pathway Metipranolol Action Pathway Metipranolol Action Pathway (New) Metoclopramide - Dopamine Antagonist Action Pathway Metoclopramide Serotonergic Smooth Muscle Contraction Metoprolol Action Pathway Metoprolol Action Pathway (New) Metrifonate Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Minaprine Acetylcholinesterase Antidepressant Action Pathway Minaprine Serotonin Antagonist Action Pathway Minaprine Serotonin receptor Antidepressant Action Pathway Mirabegron Action Pathway Mirtazapine Serotonin Antagonist Action Pathway Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway Modafinil Action Pathway Moricizine Action Pathway Morphine Action Pathway Morphine Opioid Agonist Action Pathway Morphine Opioid Agonist Brain Action Pathway nAchR Smooth Muscle Contraction Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nadolol B2-Adrenergic Vasoconstriction Action Pathway Nalbuphine Action Pathway Nalbuphine Opioid Antagonist Action Pathway Naldemedine Opioid Antagonist Action Pathway Nalmefene Opioid Antagonist Action Pathway Naloxegol Action Pathway Naloxone Action Pathway Naloxone Opioid Antagonist Action Pathway Naltrexone Action Pathway Naltrexone Opioid Antagonist Action Pathway Naratriptan Mechanism of Action Action Pathway Nateglinide Action Pathway Nateglinide Action Pathway (New) Nebivolol Action Pathway Nebivolol Action Pathway (New) Neostigmine Action Pathway (new) Neuron Function NGX267 Action Pathway Nicardipine Action Pathway Nicotine Action Pathway Nicotinic Acetylcholine Nifedipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway Nisoldipine Action Pathway (New) Nitrendipine Action Pathway Nitrendipine Action Pathway (New) Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Normethadone Action Pathway Nortriptyline Action Pathway Nylidrin Action Pathway Olanzapine Dopamine Antagonist Action Pathway Olanzapine Serotonin Antagonist Action Pathway Oliceridine Opioid Agonist Action Pathway Olodaterol Action Pathway Ondansetron Serotonin antagonist Action Pathway Orciprenaline Action Pathway Oxcarbazepine Action Pathway (New) Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Oxybuprocaine Action Pathway Oxybutynin Action Pathway Oxycodone Action Pathway Oxycodone Opioid Agonist Action Pathway Oxymorphone Action Pathway Oxymorphone Opioid Agonist Action Pathway Oxyphenonium Action Pathway Oxytocin Action Pathway Paliperidone Dopamine Antagonist Action Pathway Paliperidone Serotonin Antagonist Action Pathway Palonosetron Serotonin antagonist Action Pathway Pancreas Function - Alpha Cell Pancreas Function - Beta Cell Pancreas Function - Delta Cell Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway Paroxetine Mechanism of Action Action Pathway New Penbutolol Action Pathway Penbutolol Action Pathway (New) Pentazocine Action Pathway Pentazocine Opioid Antagonist Action Pathway Perphenazine Mechanism of Action Action Pathway Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway Phenserine Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Phenytoin Action Pathway (New) Physostigmine Action Pathway Physostigmine Action Pathway (new) Pilocarpine Action Pathway Pilocarpine M1 Saliva Excretion Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pilocarpine M3 Iris Sphincter Muscle Constriction Action Pathway Pimozide Mechanism of Action Action Pathway Pinaverium Action Pathway Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pipotiazine Dopamine Antagonist Action Pathway Pipotiazine Serotonin antagonist Action Pathway Pirbuterol Action Pathway Piritramide Opioid Agonist Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Pregabalin Action Pathway Prilocaine Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Procaine Action Pathway Procaterol Action Pathway Prochlorperazine - Dopamine Antagonist Action Pathway Prochlorperazine Mechanism of Action Action Pathway Procyclidine M1 Antispasmodic Action Pathway Promazine Mechanism of Action Action Pathway Propafenone Action Pathway Propantheline Action Pathway Proparacaine Action Pathway Propiverine Action Pathway Propoxyphene Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Pseudoephedrine Action Pathway Pyridostigmine Action Pathway Quetiapine Dopamine Antagonist Action Pathway Quetiapine Serotonin Antagonist Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranolazine Action Pathway Remifentanil Action Pathway Remifentanil Opioid Analgesic Action Pathway Remifentanil Opioid Anasthetic Action Pathway Remoxipride Mechanism of Action Action Pathway Repaglinide Action Pathway Repaglinide Action Pathway (New) Risperidone Dopamine Antagonist Action Pathway Risperidone Serotonin Antagonist Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rivastigmine Action Pathway (new) Rizatriptan Mechanism of Action Action Pathway Ropinirole Mechanism of Action Action Pathway Ropivacaine Action Pathway Rotigotine Dopamine Agonist Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Samidorphan Action Pathway Sertraline Mechanism of Action Action Pathway New Sitagliptin Action Pathway Solifenacin M3 Bladder Muscle Relaxation Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Sufentanil Action Pathway Sufentanil Opioid Agonist Action Pathway Sulpiride Mechanism of Action Action Pathway Sumatriptan Mechanism of Action Action Pathway Tacrine Action Pathway (new) Tamsulosin Action Pathway Tapentadol Opioid Agonist Action Pathway Terbutaline Action Pathway Thiethylperazine Dopamine Antagonist Action Pathway Thiethylperazine Serotonin Antagonist Action Pathway Thioridazine Dopamine Antagonist Action Pathway Thioridazine Serotonin Antagonist Action Pathway Thiothixene Dopamine Antagonist Action Pathway Tiapride Dopamine Antagonist Action Pathway Tiapride Serotonin Antagonist Action Pathway Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Tocainide Action Pathway Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Tolazamide Action Pathway Tolbutamide Action Pathway Tolterodine Action Pathway Topiramate Action Pathway (New) Tramadol Action Action Pathway Tramadol Opioid Agonist Action Pathway Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway Trifluoperazine Dopamine Antagonist Action Pathway Triflupromazine - Dopamine Antagonist Action Pathway Triflupromazine Mechanism of Action Action Pathway Triflupromazine Serotonin Antagonist Action Pathway Trihexyphenidyl Action Pathway Trimebutine M3 Receptor Intestine Relaxation Action Pathway Trimebutine Opioid Action Pathway Trimipramine Action Pathway Tropisetron Serotonin antagonist Action Pathway Trospium Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Vortioxetine Serotonin Action Action Pathway Ziconotide Analgesia Action Pathway Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway Ziprasidone Dopamine Antagonist Action Pathway Ziprasidone Serotonin Action Action Pathway Zolmitriptan Mechanism of Action Action Pathway Zuclopenthixol Dopamine Antagonist Action Pathway ( show more show less )
O00555 View in UniProt HMDBP07491 View in HMDB	Voltage-dependent P/Q-type calcium channel subunit alpha-1A Gene Name: CACNA1A Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA)	Metabolic	Dolasetron Serotonin antagonist Action Pathway Dosulepin Serotonin antagonist Action Pathway 3-Methylthiofentanyl Action Pathway Acepromazine - Serotonin Antagonist Action Pathway Acepromazine Dopamine Antagonist Action Pathway Agomelatine Serotonin Antagonist Action Pathway Ajmaline Action Pathway Alfentanil Action Pathway Alprazolam Action Pathway Alvimopan Action Pathway Amantadine NMDA Antagonist Action Pathway Amine Oxidase Serotonin Amisulpride Serotonin Antagonist Action Pathway Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway Amitriptyline Serotonin Antagonist Action Pathway Amobarbital Action Pathway Amoxapine SSRI Action Pathway Anileridine Action Pathway Aripiprazole Dopamine agonist Action Pathway Aripiprazole Serotonin Agonist Action Pathway Asenapine Serotonin antagonist Action Pathway Atomoxetine Action Pathway (New) Atropine M1/3/5 Muscarinic Poisoning Action Pathway Atropine M2 Cardiac Muscle Contraction Action Pathway Benzocaine Action Pathway Bethanechol Action Pathway Brexanolone Action Pathway Brexpiprazole Dopamine Agonist Action Pathway Brexpiprazole Serotonin Action Action Pathway Bromazepam Action Pathway Bromopride Dopamine Antagonist Action Pathway Bupivacaine Action Pathway Buprenorphine Action Pathway Butabarbital Action Pathway Butalbital Action Pathway Butobarbital Action Pathway Caffeine Adrenergic A1 vasoconstriction Action Pathway Caffeine Cardiac Contraction Action Pathway Carbamazepine Sodium Channel Analgesic Action Pathway Carfentanil Action Pathway Cariprazine Mechanism of Action Action Pathway Cevimeline M1 Saliva Excretion Action Pathway Cevimeline M3 Salivary Gland Smooth Muscle Contraction Action Pathway Chlordiazepoxide Action Pathway Chloroprocaine Action Pathway Chlorpromazine - Dopamine Antagonist Action Pathway Chlorpromazine - Serotonin Antagonist Action Pathway Chlorpropamide Action Pathway Chlorprothixene Dopamine Antagonist Action Pathway Chlorprothixene Serotonin Antagonist Action Pathway Citalopram Action Pathway Citalopram Mechanism of Action Action Pathway New Clemastine H1-Antihistamine Blood Vessel Constriction Action Pathway Clemastine H1-Antihistamine Immune Response Action Pathway Clemastine H1-Antihistamine Smooth Muscle Relaxation Action Pathway Clobazam Action Pathway Clomipramine Action Pathway (New) Clonazepam Action Pathway Clorazepic Acid Action Pathway Clotiazepam Action Pathway Clozapine Dopamine Antagonist Action Pathway Clozapine Serotonin Antagonist Action Pathway Cocaine Action Pathway Codeine Action Pathway Cyclobenzaprine Serotonin antagonist Action Pathway Cyproheptadine Serotonin Antagonist Action Pathway Darifenacin Action Pathway Desflurane GABA(A) Anesthetic Action Pathway Desipramine Action Pathway Desipramine Action Pathway (New) Dextromethorphan Nicotinic Acetylcholine Antagonism Action Pathway Dextromethorphan NMDA Antagonism Action Pathway Dezocine Action Pathway Diazepam Action Pathway Dibucaine Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Dihydromorphine Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Disopyramide Cardiac Action Pathway Domperidone Mechanism of Action Action Pathway Dopamine Action Pathway Dopamine Action Pathway Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) Doxylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Doxylamine H1-Antihistamine Blood Vessel Constriction Action Pathway Doxylamine H1-Antihistamine Immune Response Action Pathway Droperidol Mechanism of Action Action Pathway Droxidopa A1-Adrenergic Vasoconstriction Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Eletriptan Mechanism of Action Action Pathway Ephedrine A1-Adrenergic Vasoconstriction Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergotamine Mechanism of Action Action Pathway Escitalopram Action Pathway Escitalopram Mechanism of Action Action Pathway New Esketamine Action Pathway Eslicarbazepine Acetate Action Pathway Estazolam Action Pathway Eszopiclone Action Pathway Ethanol GABA Agonist Action Pathway Ethanol Glycine Agonist Action Pathway Ethanol NMDA Antagonist Action Pathway Ethosuximide Action Pathway Ethotoin Action Pathway Ethylmorphine Action Pathway Etizolam Action Pathway Etomidate Action Pathway Felbamate NMDA Antagonist Action Pathway Fenoldopam Mechanism of Action Action Pathway Fentanyl Action Pathway Fesoterodine Action Pathway Flecainide Antiarrhythmic Action Pathway Flibanserin Serotonin Action Action Pathway Flumazenil Action Pathway Flunitrazepam Action Pathway Fluoxetine Action Pathway Flupentixol Dopamine Antagonist Action Pathway Flupentixol Serotonin Antagonist Action Pathway Fluphenazine Mechanism of Action Action Pathway Flurazepam Action Pathway Fluspirilene Mechanism of Action Action Pathway Fluvoxamine Mechanism of Action Action Pathway New Fosphenytoin Action Pathway (New) Fospropofol Action Pathway Frovatriptan Mechanism of Action Action Pathway GABA Gamma-Aminobutyric Acid Biosynthesis Ganaxolone Action Pathway Gi Serotonergic Vasoconstriction Glibenclamide Action Pathway Gliclazide Action Pathway Gliclazide Action Pathway (New) Glimepiride Action Pathway Glipizide Action Pathway Gliquidone Action Pathway Glutethimide Action Pathway Glyburide Action Pathway Granisetron Serotonin antagonist Action Pathway Haloperidol Dopamine Antagonist Action Pathway Haloperidol NMDA Antagonist Action Pathway Halothane GABA(A) Anesthetic Action Pathway Halothane NMDA Antagonist Action Pathway Histamine Muscle Contraction Pathway Hydrocodone Action Pathway Hydromorphone Action Pathway Iloperidone Serotonin antagonist Action Pathway Imipramine Imipramine Action Pathway (New) Incretins - Insulin release Pathway Intestinal Serotonin pathway Ipratropium M3 Bronchodilation Action Pathway Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway Isoflurane GABA(A) Anesthetic Action Pathway Ketamine NMDA Antagonist Action Pathway Ketazolam Action Pathway Ketobemidone Action Pathway Lacosamide Action Pathway Levallorphan Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Lidocaine NMDA Anesthetic Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Lisuride Dopamine Agonist Action Pathway Lorazepam Action Pathway Lormetazepam Action Pathway Lorpiprazole Serotonin antagonist Action Pathway Loxapine Dopamine Antagonist Action Pathway Lumateperone Dopamine Action Action Pathway Lumateperone Serotonin Antagonist Action Pathway Lumateperone SSRI Action Action Pathway Lurasidone Dopamine Antagonist Action Pathway Lurasidone Serotonin Antagonist Action Pathway Maprotiline Action Pathway Memantine Action Pathway Mepivacaine Action Pathway Meprobamate Action Pathway Mesoridazine Dopamine Antagonist Action Pathway Mesoridazine Serotonin Antagonist Action Pathway Methacholine M3 Bronchoconstriction Action Pathway Methadone Action Pathway Methadone NMDA Antagonism Action Pathway Methadyl Acetate Action Pathway Methotrimeprazine Dopamine Antagonist Action Pathway Methsuximide Action Pathway Methyldopa Action Pathway Methylergometrine Mechanism of Action Action Pathway Methylphenobarbital Action Pathway Methysergide Mechanism of Action Action Pathway Metoclopramide - Dopamine Antagonist Action Pathway Mexiletine Action Pathway (New) Midazolam Action Pathway Minaprine Serotonin Antagonist Action Pathway Minaprine Serotonin receptor Antidepressant Action Pathway Mirtazapine Serotonin Antagonist Action Pathway Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway Moricizine Action Pathway Morphine Action Pathway nAchR Smooth Muscle Contraction Nalbuphine Action Pathway Naloxone Action Pathway Naltrexone Action Pathway Naratriptan Mechanism of Action Action Pathway Nateglinide Action Pathway Nateglinide Action Pathway (New) Neuron Function Nicotine Action Pathway Nicotinic Acetylcholine Nitrazepam Action Pathway NMDA Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway Nortriptyline Action Pathway Olanzapine Dopamine Antagonist Action Pathway Olanzapine Serotonin Antagonist Action Pathway Ondansetron Serotonin antagonist Action Pathway Orphenadrine NMDA Antagonist Action Pathway Oxazepam Action Pathway Oxcarbazepine Action Pathway (New) Oxybuprocaine Action Pathway Oxybutynin Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Oxyphenonium Action Pathway Oxytocin Action Pathway Paliperidone Dopamine Antagonist Action Pathway Paliperidone Serotonin Antagonist Action Pathway Palonosetron Serotonin antagonist Action Pathway Pancreas Function - Alpha Cell Pancreas Function - Beta Cell Pancreas Function - Delta Cell Paramethadione Action Pathway Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway Paroxetine Mechanism of Action Action Pathway New Pentazocine Action Pathway Pentobarbital Action Pathway Perphenazine Mechanism of Action Action Pathway Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway Phenobarbital Action Pathway Phenytoin Action Pathway (New) Pilocarpine Action Pathway Pilocarpine M1 Saliva Excretion Action Pathway Pilocarpine M3 Iris Sphincter Muscle Constriction Action Pathway Pimozide Mechanism of Action Action Pathway Pipotiazine Dopamine Antagonist Action Pathway Pipotiazine Serotonin antagonist Action Pathway Prazepam Action Pathway Prilocaine Action Pathway Primidone Action Pathway Procainamide Action Pathway (New) Procaine Action Pathway Procaine NMDA Antagonist Action Pathway Prochlorperazine - Dopamine Antagonist Action Pathway Prochlorperazine Mechanism of Action Action Pathway Procyclidine M1 Antispasmodic Action Pathway Profenamine Action Pathway Promazine Mechanism of Action Action Pathway Propafenone Action Pathway Propantheline Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Pseudoephedrine Action Pathway Quazepam Action Pathway Quetiapine Dopamine Antagonist Action Pathway Quetiapine Serotonin Antagonist Action Pathway Quinidine Action Pathway (New) Quinidine barbiturate Action Pathway Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway Ranolazine Action Pathway Remifentanil Action Pathway Remimazolam Action Pathway Remoxipride Mechanism of Action Action Pathway Repaglinide Action Pathway Repaglinide Action Pathway (New) Risperidone Dopamine Antagonist Action Pathway Risperidone Serotonin Antagonist Action Pathway Rizatriptan Mechanism of Action Action Pathway Ropinirole Mechanism of Action Action Pathway Ropivacaine Action Pathway Rotigotine Dopamine Agonist Action Pathway Secobarbital Action Pathway Sertraline Mechanism of Action Action Pathway New Sevoflurane GABA(A) Anesthetic Action Pathway Sitagliptin Action Pathway Solifenacin M3 Bladder Muscle Relaxation Action Pathway Stiripentol GABA(A) Antiepileptic Action Pathway Sufentanil Action Pathway Sulpiride Mechanism of Action Action Pathway Sumatriptan Mechanism of Action Action Pathway Talbutal Action Pathway Tamsulosin Action Pathway Temazepam Action Pathway Thiethylperazine Dopamine Antagonist Action Pathway Thiethylperazine Serotonin Antagonist Action Pathway Thiocolchicoside Action Pathway (New) Thiopental Action Pathway Thioridazine Dopamine Antagonist Action Pathway Thioridazine Serotonin Antagonist Action Pathway Thiothixene Dopamine Antagonist Action Pathway Tiapride Dopamine Antagonist Action Pathway Tiapride Serotonin Antagonist Action Pathway Timolol Action Pathway (New) Tizanidine Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Tolazamide Action Pathway Tolbutamide Action Pathway Tolterodine Action Pathway Topiramate Action Pathway (New) Tramadol Action Action Pathway Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway Triazolam Action Pathway Trifluoperazine Dopamine Antagonist Action Pathway Triflupromazine - Dopamine Antagonist Action Pathway Triflupromazine Mechanism of Action Action Pathway Triflupromazine Serotonin Antagonist Action Pathway Trimebutine M3 Receptor Intestine Relaxation Action Pathway Trimethadione Action Pathway Trimipramine Action Pathway Tropisetron Serotonin antagonist Action Pathway Trospium Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Vortioxetine Serotonin Action Action Pathway Zaleplon Action Pathway Ziprasidone Dopamine Antagonist Action Pathway Ziprasidone Serotonin Action Action Pathway Zolmitriptan Mechanism of Action Action Pathway Zolpidem Action Pathway (New) Zopiclone Action Pathway Zuclopenthixol Dopamine Antagonist Action Pathway ( show more show less )
O43497 View in UniProt HMDBP07495 View in HMDB	Voltage-dependent T-type calcium channel subunit alpha-1G Gene Name: CACNA1G Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes	Metabolic	Acebutolol Action Pathway Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Bupranolol Action Pathway Bupranolol Action Pathway Caffeine Cardiac Contraction Action Pathway Carbamazepine Sodium Channel Analgesic Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Dofetilide Action Pathway Dopamine Action Pathway Dopamine Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Epinephrine Action Pathway Eslicarbazepine Acetate Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Ethosuximide Action Pathway Ethotoin Action Pathway Felodipine Action Pathway Flecainide Action Pathway Flecainide Antiarrhythmic Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Fosphenytoin Action Pathway (New) Gi Muscarinic Cardiac Muscle Contraction Ibutilide Action Pathway Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isradipine Action Pathway Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Lacosamide Action Pathway Lamotrigine Action Pathway Levobunolol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine NMDA Anesthetic Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Manidipine Action Pathway Methsuximide Action Pathway Methysergide Mechanism of Action Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Metoprolol Action Pathway (New) Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nebivolol Action Pathway Nebivolol Action Pathway (New) Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Oxcarbazepine Action Pathway (New) Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Paramethadione Action Pathway Penbutolol Action Pathway Penbutolol Action Pathway (New) Phenytoin (Antiarrhythmic) Action Pathway Phenytoin Action Pathway (New) Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Rufinamide Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Trimethadione Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Zonisamide Action Pathway ( show more show less )
O95180 View in UniProt HMDBP07496 View in HMDB	Voltage-dependent T-type calcium channel subunit alpha-1H Gene Name: CACNA1H Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes	Metabolic	Acebutolol Action Pathway Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Bupranolol Action Pathway Bupranolol Action Pathway Caffeine Cardiac Contraction Action Pathway Carbamazepine Sodium Channel Analgesic Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Dofetilide Action Pathway Dopamine Action Pathway Dopamine Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Epinephrine Action Pathway Eslicarbazepine Acetate Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Ethosuximide Action Pathway Ethotoin Action Pathway Felodipine Action Pathway Flecainide Action Pathway Flecainide Antiarrhythmic Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Fosphenytoin Action Pathway (New) Gi Muscarinic Cardiac Muscle Contraction Ibutilide Action Pathway Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isradipine Action Pathway Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Lacosamide Action Pathway Lamotrigine Action Pathway Levobunolol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine NMDA Anesthetic Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Manidipine Action Pathway Methsuximide Action Pathway Methysergide Mechanism of Action Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Metoprolol Action Pathway (New) Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nebivolol Action Pathway Nebivolol Action Pathway (New) Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Oxcarbazepine Action Pathway (New) Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Paramethadione Action Pathway Penbutolol Action Pathway Penbutolol Action Pathway (New) Phenytoin (Antiarrhythmic) Action Pathway Phenytoin Action Pathway (New) Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Rufinamide Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Trimethadione Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Zonisamide Action Pathway ( show more show less )
Q92558 View in UniProt	Wiskott-Aldrich syndrome protein family member 1 Gene Name: WASF1	Metabolic	Rac 1 Cell Motility Signaling Pathway
P47989 View in UniProt HMDBP00181 View in HMDB	Xanthine dehydrogenase/oxidase Gene Name: XDH Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Allopurinol Action Pathway (New) Azathioprine Action Pathway Caffeine Metabolism Doxorubicin Metabolism Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Isosorbide Dinitrate Action Pathway Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mercaptopurine Metabolism Pathway Metabolism and Physiological Effects of Uric acid Metabolism and Physiological Effects of Xanthine Metabolism and Physiological Effects of Xanthosine Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Nitric Oxide Signaling Pathway Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
Q9UM01 View in UniProt HMDBP03080 View in HMDB	Y+L amino acid transporter 1 Gene Name: SLC7A7 Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes	Metabolic	Amiloride Action Pathway Argininemia Argininosuccinic Aciduria Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Glutaminolysis and Cancer Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Hyperphenylalaninemia Due to DHPR-Deficiency Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Iminoglycinuria Indapamide Action Pathway Kidney Function- Proximal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA) Metabolism and Physiological Effects of Phenylacetic Acid Metabolism and Physiological Effects of Phenylacetylglutamine Metabolism and Physiological Effects of Symmetric dimethylarginine (SDMA) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Phenylketonuria Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Tyrosinemia Type 3 (TYRO3) ( show more show less )
Q92536 View in UniProt HMDBP09098 View in HMDB	Y+L amino acid transporter 2 Gene Name: SLC7A6 Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells	Metabolic	Amiloride Action Pathway Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function- Proximal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Metabolism and Physiological Effects of Creatinine Metabolism and Physiological Effects of Indole Acetic Acid Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway ( show more show less )
Q9C0K1 View in UniProt HMDBP11941 View in HMDB	Zinc transporter ZIP8 Gene Name: SLC39A8 Acts as a zinc-influx transporter.	Metabolic	Selenoamino Acid Metabolism

Showing 1561 - 1580 of 1576 proteins