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Showing 76 - 150 of 1576 proteins

Protein ID

Protein Description

Pathway Class

Pathways

P62753

View in UniProt

40S ribosomal protein S6

Gene Name: RPS6

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Metabolic

P62081

View in UniProt

40S ribosomal protein S7

Gene Name: RPS7

Required for rRNA maturation.
Metabolic

P62241

View in UniProt

40S ribosomal protein S8

Gene Name: RPS8

Metabolic

P46781

View in UniProt

40S ribosomal protein S9

Gene Name: RPS9

Metabolic

P08865

View in UniProt

40S ribosomal protein SA

Gene Name: RPSA

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
Metabolic

P08195

View in UniProt

HMDBP03090

View in HMDB

4F2 cell-surface antigen heavy chain

Gene Name: SLC3A2

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier
Metabolic

Q8TCD5

View in UniProt

HMDBP00006

View in HMDB

5'(3')-deoxyribonucleotidase, cytosolic type

Gene Name: NT5C

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Metabolic

P21589

View in UniProt

HMDBP00001

View in HMDB

5'-nucleotidase

Gene Name: NT5E

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Metabolic

P17643

View in UniProt

HMDBP02139

View in HMDB

5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene Name: TYRP1

Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized
Metabolic

P13196

View in UniProt

HMDBP00022

View in HMDB

5-aminolevulinate synthase, nonspecific, mitochondrial

Gene Name: ALAS1

Metabolic

P49914

View in UniProt

HMDBP01408

View in HMDB

5-formyltetrahydrofolate cyclo-ligase

Gene Name: MTHFS

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
Metabolic

P08908

View in UniProt

HMDBP02566

View in HMDB

5-hydroxytryptamine receptor 1A

Gene Name: HTR1A

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity
Metabolic

P28335

View in UniProt

HMDBP02700

View in HMDB

5-hydroxytryptamine receptor 2C

Gene Name: HTR2C

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Metabolic

Q13639

View in UniProt

HMDBP02219

View in HMDB

5-hydroxytryptamine receptor 4

Gene Name: HTR4

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase
Metabolic

P50406

View in UniProt

HMDBP02713

View in HMDB

5-hydroxytryptamine receptor 6

Gene Name: HTR6

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs
Metabolic

P34969

View in UniProt

HMDBP02268

View in HMDB

5-hydroxytryptamine receptor 7

Gene Name: HTR7

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase
Metabolic

O14841

View in UniProt

HMDBP00855

View in HMDB

5-oxoprolinase

Gene Name: OPLAH

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Metabolic

P16118

View in UniProt

HMDBP00799

View in HMDB

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Gene Name: PFKFB1

Synthesis and degradation of fructose 2,6-bisphosphate.
Metabolic

P17858

View in UniProt

HMDBP00758

View in HMDB

6-phosphofructokinase, liver type

Gene Name: PFKL

Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
Metabolic

P08237

View in UniProt

HMDBP00762

View in HMDB

6-phosphofructokinase, muscle type

Gene Name: PFKM

Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
Metabolic

P52209

View in UniProt

HMDBP01039

View in HMDB

6-phosphogluconate dehydrogenase, decarboxylating

Gene Name: PGD

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).
Metabolic

O95336

View in UniProt

HMDBP00327

View in HMDB

6-phosphogluconolactonase

Gene Name: PGLS

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Metabolic

Q03393

View in UniProt

HMDBP00435

View in HMDB

6-pyruvoyl tetrahydrobiopterin synthase

Gene Name: PTS

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Metabolic

P05388

View in UniProt

60S acidic ribosomal protein P0

Gene Name: RPLP0

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Metabolic

P05386

View in UniProt

60S acidic ribosomal protein P1

Gene Name: RPLP1

Plays an important role in the elongation step of protein synthesis.
Metabolic

P05387

View in UniProt

60S acidic ribosomal protein P2

Gene Name: RPLP2

Plays an important role in the elongation step of protein synthesis.
Metabolic

P27635

View in UniProt

60S ribosomal protein L10

Gene Name: RPL10

Metabolic

P62906

View in UniProt

60S ribosomal protein L10a

Gene Name: RPL10A

Metabolic

P62913

View in UniProt

60S ribosomal protein L11

Gene Name: RPL11

Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).
Metabolic

P30050

View in UniProt

60S ribosomal protein L12

Gene Name: RPL12

Binds directly to 26S ribosomal RNA.
Metabolic

P26373

View in UniProt

60S ribosomal protein L13

Gene Name: RPL13

Metabolic

P40429

View in UniProt

60S ribosomal protein L13a

Gene Name: RPL13A

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Metabolic

P50914

View in UniProt

60S ribosomal protein L14

Gene Name: RPL14

Metabolic

P61313

View in UniProt

60S ribosomal protein L15

Gene Name: RPL15

Metabolic

P18621

View in UniProt

60S ribosomal protein L17

Gene Name: RPL17

Metabolic

Q07020

View in UniProt

60S ribosomal protein L18

Gene Name: RPL18

Metabolic

Q02543

View in UniProt

60S ribosomal protein L18a

Gene Name: RPL18A

Metabolic

P84098

View in UniProt

60S ribosomal protein L19

Gene Name: RPL19

Metabolic

P46778

View in UniProt

60S ribosomal protein L21

Gene Name: RPL21

Metabolic

P35268

View in UniProt

HMDBP10729

View in HMDB

60S ribosomal protein L22

Gene Name: RPL22

Metabolic

P62829

View in UniProt

60S ribosomal protein L23

Gene Name: RPL23

Metabolic

P62750

View in UniProt

60S ribosomal protein L23a

Gene Name: RPL23A

This protein binds to a specific region on the 26S rRNA.
Metabolic

P83731

View in UniProt

60S ribosomal protein L24

Gene Name: RPL24

Metabolic

P61254

View in UniProt

60S ribosomal protein L26

Gene Name: RPL26

Metabolic

P61353

View in UniProt

60S ribosomal protein L27

Gene Name: RPL27

Metabolic

P46776

View in UniProt

60S ribosomal protein L27a

Gene Name: RPL27A

Metabolic

P46779

View in UniProt

60S ribosomal protein L28

Gene Name: RPL28

Metabolic

P47914

View in UniProt

HMDBP10728

View in HMDB

60S ribosomal protein L29

Gene Name: RPL29

Metabolic

P39023

View in UniProt

60S ribosomal protein L3

Gene Name: RPL3

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
Metabolic

P62888

View in UniProt

60S ribosomal protein L30

Gene Name: RPL30

Metabolic

P62899

View in UniProt

60S ribosomal protein L31

Gene Name: RPL31

Metabolic

P62910

View in UniProt

60S ribosomal protein L32

Gene Name: RPL32

Metabolic

P49207

View in UniProt

60S ribosomal protein L34

Gene Name: RPL34

Metabolic

P42766

View in UniProt

60S ribosomal protein L35

Gene Name: RPL35

Metabolic

P18077

View in UniProt

60S ribosomal protein L35a

Gene Name: RPL35A

Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.
Metabolic

Q9Y3U8

View in UniProt

60S ribosomal protein L36

Gene Name: RPL36

Metabolic

P83881

View in UniProt

60S ribosomal protein L36a

Gene Name: RPL36A

Metabolic

P61927

View in UniProt

60S ribosomal protein L37

Gene Name: RPL37

Binds to the 23S rRNA.
Metabolic

P61513

View in UniProt

60S ribosomal protein L37a

Gene Name: RPL37A

Metabolic

P63173

View in UniProt

60S ribosomal protein L38

Gene Name: RPL38

Metabolic

P62891

View in UniProt

60S ribosomal protein L39

Gene Name: RPL39

Metabolic

P36578

View in UniProt

60S ribosomal protein L4

Gene Name: RPL4

Metabolic

P62945

View in UniProt

60S ribosomal protein L41

Gene Name: RPL41

Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.
Metabolic

P46777

View in UniProt

60S ribosomal protein L5

Gene Name: RPL5

Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.
Metabolic

Q02878

View in UniProt

60S ribosomal protein L6

Gene Name: RPL6

Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
Metabolic

P18124

View in UniProt

60S ribosomal protein L7

Gene Name: RPL7

Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
Metabolic

P62424

View in UniProt

60S ribosomal protein L7a

Gene Name: RPL7A

Metabolic

P62917

View in UniProt

60S ribosomal protein L8

Gene Name: RPL8

Metabolic

P32969

View in UniProt

60S ribosomal protein L9

Gene Name: RPL9

Metabolic

Q9UNU6

View in UniProt

HMDBP06125

View in HMDB

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Gene Name: CYP8B1

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
Metabolic

Q9UBM7

View in UniProt

HMDBP00548

View in HMDB

7-dehydrocholesterol reductase

Gene Name: DHCR7

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
Metabolic

Q9NRR6

View in UniProt

HMDBP01572

View in HMDB

72 kDa inositol polyphosphate 5-phosphatase

Gene Name: INPP5E

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Metabolic

P08253

View in UniProt

HMDBP02804

View in HMDB

72 kDa type IV collagenase

Gene Name: MMP2

PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels
Metabolic

P11021

View in UniProt

78 kDa glucose-regulated protein

Gene Name: HSPA5

Metabolic

Q15118

View in UniProt

HMDBP01172

View in HMDB

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

Gene Name: PDK1

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism
Metabolic
Showing 76 - 150 of 1576 proteins