P62753
View in UniProt
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40S ribosomal protein S6
Gene Name: RPS6
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
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Metabolic
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P62081
View in UniProt
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40S ribosomal protein S7
Gene Name: RPS7
Required for rRNA maturation.
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Metabolic
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P62241
View in UniProt
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40S ribosomal protein S8
Gene Name: RPS8
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Metabolic
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P46781
View in UniProt
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40S ribosomal protein S9
Gene Name: RPS9
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Metabolic
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P08865
View in UniProt
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40S ribosomal protein SA
Gene Name: RPSA
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
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Metabolic
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P08195
View in UniProt
HMDBP03090
View in HMDB
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4F2 cell-surface antigen heavy chain
Gene Name: SLC3A2
Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier
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Metabolic
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Q8TCD5
View in UniProt
HMDBP00006
View in HMDB
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5'(3')-deoxyribonucleotidase, cytosolic type
Gene Name: NT5C
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
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Metabolic
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P21589
View in UniProt
HMDBP00001
View in HMDB
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5'-nucleotidase
Gene Name: NT5E
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
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Metabolic
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P17643
View in UniProt
HMDBP02139
View in HMDB
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5,6-dihydroxyindole-2-carboxylic acid oxidase
Gene Name: TYRP1
Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized
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Metabolic
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P13196
View in UniProt
HMDBP00022
View in HMDB
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5-aminolevulinate synthase, nonspecific, mitochondrial
Gene Name: ALAS1
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Metabolic
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P49914
View in UniProt
HMDBP01408
View in HMDB
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5-formyltetrahydrofolate cyclo-ligase
Gene Name: MTHFS
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
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Metabolic
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P08908
View in UniProt
HMDBP02566
View in HMDB
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5-hydroxytryptamine receptor 1A
Gene Name: HTR1A
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity
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Metabolic
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P28335
View in UniProt
HMDBP02700
View in HMDB
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5-hydroxytryptamine receptor 2C
Gene Name: HTR2C
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
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Metabolic
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Q13639
View in UniProt
HMDBP02219
View in HMDB
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5-hydroxytryptamine receptor 4
Gene Name: HTR4
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase
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Metabolic
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P50406
View in UniProt
HMDBP02713
View in HMDB
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5-hydroxytryptamine receptor 6
Gene Name: HTR6
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs
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Metabolic
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P34969
View in UniProt
HMDBP02268
View in HMDB
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5-hydroxytryptamine receptor 7
Gene Name: HTR7
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase
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Metabolic
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O14841
View in UniProt
HMDBP00855
View in HMDB
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5-oxoprolinase
Gene Name: OPLAH
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
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Metabolic
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P16118
View in UniProt
HMDBP00799
View in HMDB
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Gene Name: PFKFB1
Synthesis and degradation of fructose 2,6-bisphosphate.
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Metabolic
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P17858
View in UniProt
HMDBP00758
View in HMDB
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6-phosphofructokinase, liver type
Gene Name: PFKL
Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
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Metabolic
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P08237
View in UniProt
HMDBP00762
View in HMDB
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6-phosphofructokinase, muscle type
Gene Name: PFKM
Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
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Metabolic
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P52209
View in UniProt
HMDBP01039
View in HMDB
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6-phosphogluconate dehydrogenase, decarboxylating
Gene Name: PGD
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).
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Metabolic
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O95336
View in UniProt
HMDBP00327
View in HMDB
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6-phosphogluconolactonase
Gene Name: PGLS
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
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Metabolic
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Q03393
View in UniProt
HMDBP00435
View in HMDB
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6-pyruvoyl tetrahydrobiopterin synthase
Gene Name: PTS
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
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Metabolic
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P05388
View in UniProt
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60S acidic ribosomal protein P0
Gene Name: RPLP0
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
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Metabolic
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P05386
View in UniProt
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60S acidic ribosomal protein P1
Gene Name: RPLP1
Plays an important role in the elongation step of protein synthesis.
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Metabolic
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P05387
View in UniProt
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60S acidic ribosomal protein P2
Gene Name: RPLP2
Plays an important role in the elongation step of protein synthesis.
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Metabolic
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P27635
View in UniProt
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60S ribosomal protein L10
Gene Name: RPL10
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Metabolic
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P62906
View in UniProt
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60S ribosomal protein L10a
Gene Name: RPL10A
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Metabolic
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P62913
View in UniProt
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60S ribosomal protein L11
Gene Name: RPL11
Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).
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Metabolic
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P30050
View in UniProt
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60S ribosomal protein L12
Gene Name: RPL12
Binds directly to 26S ribosomal RNA.
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Metabolic
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P26373
View in UniProt
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60S ribosomal protein L13
Gene Name: RPL13
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Metabolic
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P40429
View in UniProt
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60S ribosomal protein L13a
Gene Name: RPL13A
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
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Metabolic
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P50914
View in UniProt
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60S ribosomal protein L14
Gene Name: RPL14
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Metabolic
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P61313
View in UniProt
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60S ribosomal protein L15
Gene Name: RPL15
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Metabolic
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P18621
View in UniProt
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60S ribosomal protein L17
Gene Name: RPL17
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Metabolic
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Q07020
View in UniProt
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60S ribosomal protein L18
Gene Name: RPL18
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Metabolic
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Q02543
View in UniProt
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60S ribosomal protein L18a
Gene Name: RPL18A
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Metabolic
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P84098
View in UniProt
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60S ribosomal protein L19
Gene Name: RPL19
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Metabolic
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P46778
View in UniProt
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60S ribosomal protein L21
Gene Name: RPL21
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Metabolic
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P35268
View in UniProt
HMDBP10729
View in HMDB
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60S ribosomal protein L22
Gene Name: RPL22
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Metabolic
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P62829
View in UniProt
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60S ribosomal protein L23
Gene Name: RPL23
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Metabolic
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P62750
View in UniProt
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60S ribosomal protein L23a
Gene Name: RPL23A
This protein binds to a specific region on the 26S rRNA.
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Metabolic
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P83731
View in UniProt
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60S ribosomal protein L24
Gene Name: RPL24
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Metabolic
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P61254
View in UniProt
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60S ribosomal protein L26
Gene Name: RPL26
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Metabolic
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P61353
View in UniProt
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60S ribosomal protein L27
Gene Name: RPL27
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Metabolic
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P46776
View in UniProt
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60S ribosomal protein L27a
Gene Name: RPL27A
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Metabolic
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P46779
View in UniProt
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60S ribosomal protein L28
Gene Name: RPL28
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Metabolic
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P47914
View in UniProt
HMDBP10728
View in HMDB
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60S ribosomal protein L29
Gene Name: RPL29
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Metabolic
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P39023
View in UniProt
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60S ribosomal protein L3
Gene Name: RPL3
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
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Metabolic
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P62888
View in UniProt
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60S ribosomal protein L30
Gene Name: RPL30
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Metabolic
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P62899
View in UniProt
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60S ribosomal protein L31
Gene Name: RPL31
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Metabolic
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P62910
View in UniProt
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60S ribosomal protein L32
Gene Name: RPL32
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Metabolic
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P49207
View in UniProt
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60S ribosomal protein L34
Gene Name: RPL34
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Metabolic
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P42766
View in UniProt
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60S ribosomal protein L35
Gene Name: RPL35
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Metabolic
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P18077
View in UniProt
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60S ribosomal protein L35a
Gene Name: RPL35A
Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.
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Metabolic
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Q9Y3U8
View in UniProt
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60S ribosomal protein L36
Gene Name: RPL36
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Metabolic
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P83881
View in UniProt
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60S ribosomal protein L36a
Gene Name: RPL36A
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Metabolic
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P61927
View in UniProt
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60S ribosomal protein L37
Gene Name: RPL37
Binds to the 23S rRNA.
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Metabolic
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P61513
View in UniProt
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60S ribosomal protein L37a
Gene Name: RPL37A
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Metabolic
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P63173
View in UniProt
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60S ribosomal protein L38
Gene Name: RPL38
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Metabolic
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P62891
View in UniProt
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60S ribosomal protein L39
Gene Name: RPL39
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Metabolic
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P36578
View in UniProt
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60S ribosomal protein L4
Gene Name: RPL4
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Metabolic
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P62945
View in UniProt
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60S ribosomal protein L41
Gene Name: RPL41
Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.
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Metabolic
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P46777
View in UniProt
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60S ribosomal protein L5
Gene Name: RPL5
Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.
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Metabolic
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Q02878
View in UniProt
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60S ribosomal protein L6
Gene Name: RPL6
Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
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Metabolic
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P18124
View in UniProt
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60S ribosomal protein L7
Gene Name: RPL7
Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
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Metabolic
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P62424
View in UniProt
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60S ribosomal protein L7a
Gene Name: RPL7A
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Metabolic
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P62917
View in UniProt
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60S ribosomal protein L8
Gene Name: RPL8
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Metabolic
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P32969
View in UniProt
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60S ribosomal protein L9
Gene Name: RPL9
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Metabolic
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Q9UNU6
View in UniProt
HMDBP06125
View in HMDB
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7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Gene Name: CYP8B1
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
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Metabolic
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Q9UBM7
View in UniProt
HMDBP00548
View in HMDB
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7-dehydrocholesterol reductase
Gene Name: DHCR7
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
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Metabolic
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Q9NRR6
View in UniProt
HMDBP01572
View in HMDB
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72 kDa inositol polyphosphate 5-phosphatase
Gene Name: INPP5E
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
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Metabolic
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P08253
View in UniProt
HMDBP02804
View in HMDB
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72 kDa type IV collagenase
Gene Name: MMP2
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels
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Metabolic
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P11021
View in UniProt
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78 kDa glucose-regulated protein
Gene Name: HSPA5
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Metabolic
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Q15118
View in UniProt
HMDBP01172
View in HMDB
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[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
Gene Name: PDK1
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism
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Metabolic
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