SMPDB

Showing 151 - 225 of 1576 proteins

Protein ID	Protein Description	Pathway Class	Pathways
DB00054 View in DrugBank	Abciximab Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor and other adhesive molecules.	Metabolic	Abciximab Action Pathway Abciximab Action Pathway (old) Abciximab Drug Metabolism
Q9BWD1 View in UniProt HMDBP00013 View in HMDB	Acetyl-CoA acetyltransferase, cytosolic Gene Name: ACAT2	Metabolic	Alendronate Action Pathway Atorvastatin Action Pathway Cerivastatin Action Pathway CHILD Syndrome CHILD Syndrome Cholesteryl Ester Storage Disease Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Desmosterolosis Desmosterolosis Fluvastatin Action Pathway Hyper-IgD Syndrome Hyper-IgD Syndrome Hypercholesterolemia Hypercholesterolemia Ibandronate Action Pathway Lovastatin Action Pathway Lysosomal Acid Lipase Deficiency (Wolman Disease) Lysosomal Acid Lipase Deficiency (Wolman Disease) Mevalonic Aciduria Mevalonic Aciduria Pamidronate Action Pathway Pravastatin Action Pathway Risedronate Action Pathway Rosuvastatin Action Pathway Simvastatin Action Pathway Smith-Lemli-Opitz Syndrome (SLOS) Smith-Lemli-Opitz Syndrome (SLOS) Steroid Biosynthesis Wolman Disease Zoledronate Action Pathway ( show more show less )
P24752 View in UniProt HMDBP00038 View in HMDB	Acetyl-CoA acetyltransferase, mitochondrial Gene Name: ACAT1 Plays a major role in ketone body metabolism.	Metabolic	2-Aminoadipic 2-Oxoadipic Aciduria 2-Aminoadipic 2-Oxoadipic Aciduria 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Aciduria 3-Hydroxyisobutyric Aciduria 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type IV 3-Methylglutaconic Aciduria Type IV Alendronate Action Pathway (New Revised) Alendronate Action Pathway (New) Atorvastatin Action Pathway (New) beta-Ketothiolase Deficiency beta-Ketothiolase Deficiency Butyrate Metabolism Carnitine Palmitoyl Transferase Deficiency I Carnitine Palmitoyl Transferase Deficiency I Carnitine Palmitoyl Transferase Deficiency II Carnitine Palmitoyl Transferase Deficiency II Clodronic Acid Action Pathway Ethylmalonic Encephalopathy Ethylmalonic Encephalopathy Etidronic Acid Action Pathway Fatty Acid Metabolism Fluvastatin Action Pathway (New) Glutaric Aciduria Type I Glutaric Aciduria Type I Glutaric Aciduria Type I (Fatty Acid Metabolism) Glutaric Aciduria Type I (Lysine Degradation) Hyperlysinemia I, Familial Hyperlysinemia I, Familial Hyperlysinemia II or Saccharopinuria Ibandronate Action Pathway Isobutyryl-CoA Dehydrogenase Deficiency Isobutyryl-CoA Dehydrogenase Deficiency Isovaleric Acidemia Isovaleric Acidemia Isovaleric Aciduria Isovaleric Aciduria Ketone Body Metabolism Leigh Syndrome Leigh Syndrome Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) (Fatty Acid Metabolism) Lovastatin Action Pathway (New) Lysine Degradation Malonic Aciduria Malonic Aciduria Malonyl-CoA Decarboxylase Deficiency Malonyl-CoA Decarboxylase Deficiency Maple Syrup Urine Disease Maple Syrup Urine Disease Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonic Aciduria Methylmalonic Aciduria Methylmalonic Aciduria Due to Cobalamin-Related Disorders Methylmalonic Aciduria Due to Cobalamin-Related Disorders Mevalonate Pathway Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Pamidronate Action Pathway (new) Pitavastatin Action Pathway Pravastatin Action Pathway (New) Primary Hyperoxaluria II, PH2 Primary Hyperoxaluria II, PH2 Propanoate Metabolism Propionic Acidemia Propionic Acidemia Pyridoxine Dependency with Seizures Pyridoxine Dependency with Seizures Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Pyruvate Metabolism Risedronate Action Pathway (new) Rosuvastatin Saccharopinuria/Hyperlysinemia II Saccharopinuria/Hyperlysinemia II Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (HADH) Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (HADH) Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Simvastatin Action Pathway (New) Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Tiludronic Acid Action Pathway Trifunctional Protein Deficiency Trifunctional Protein Deficiency Valine, Leucine, and Isoleucine Degradation Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Zoledronate Action Pathway ( show more show less )
Q13085 View in UniProt HMDBP00047 View in HMDB	Acetyl-CoA carboxylase 1 Gene Name: ACACA Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Metabolic	Bezafibrate Action Pathway (New) Citrate Immunometabolism Pathway Fatty Acid Biosynthesis Fenofibrate Action Pathway Gemfibrozil Action Pathway Leigh Syndrome Leigh Syndrome LPS and Citrate Signaling and Inflammation Malonic Aciduria Malonic Aciduria Malonyl-CoA Decarboxylase Deficiency Malonyl-CoA Decarboxylase Deficiency Methylmalonic Aciduria Due to Cobalamin-Related Disorders Methylmalonic Aciduria Due to Cobalamin-Related Disorders Primary Hyperoxaluria II, PH2 Primary Hyperoxaluria II, PH2 Propanoate Metabolism Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Pyruvate Metabolism ( show more show less )
Q9NUB1 View in UniProt HMDBP00042 View in HMDB	Acetyl-coenzyme A synthetase 2-like, mitochondrial Gene Name: ACSS1 Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).	Metabolic	Disulfiram Action Pathway Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway Ethanol Degradation Malonic Aciduria Malonic Aciduria Malonyl-CoA Decarboxylase Deficiency Malonyl-CoA Decarboxylase Deficiency Methylmalonic Aciduria Due to Cobalamin-Related Disorders Methylmalonic Aciduria Due to Cobalamin-Related Disorders Propanoate Metabolism ( show more show less )
Q9NR19 View in UniProt HMDBP00037 View in HMDB	Acetyl-coenzyme A synthetase, cytoplasmic Gene Name: ACSS2 Activates acetate so that it can be used for lipid synthesis or for energy generation.	Metabolic	Disulfiram Action Pathway Ethanol Degradation Leigh Syndrome Leigh Syndrome Primary Hyperoxaluria II, PH2 Primary Hyperoxaluria II, PH2 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Pyruvate Metabolism ( show more show less )
P22303 View in UniProt HMDBP00524 View in HMDB	Acetylcholinesterase Gene Name: ACHE Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.	Metabolic	Amifampridine Action Pathway Donepezil Action Pathway Ambenonium Action Pathway (new) Atropine M1/3/5 Muscarinic Poisoning Action Pathway Carbaryl Action Pathway Dalfampridine Action Pathway Demecarium Action Pathway (new) Distigmine Action Pathway Echothiophate Action Pathway Edrophonium Action Pathway (new) Galantamine Action Pathway (new, revision) Isoflurophate Action Pathway (new) Magnesium Sulfate Action Pathway Malathion Action Pathway Methylphosphinic Acid Action Pathway Metrifonate Action Pathway Minaprine Acetylcholinesterase Antidepressant Action Pathway Neostigmine Action Pathway (new) NGX267 Action Pathway Phenserine Action Pathway Phospholipid Biosynthesis Physostigmine Action Pathway Physostigmine Action Pathway (new) Procyclidine M1 Antispasmodic Action Pathway Pyridostigmine Action Pathway Rivastigmine Action Pathway (new) Tacrine Action Pathway (new) Trihexyphenidyl Action Pathway ( show more show less )
P46597 View in UniProt HMDBP00101 View in HMDB	Acetylserotonin O-methyltransferase Gene Name: ASMT Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.	Metabolic	Tryptophan Metabolism
Q99798 View in UniProt HMDBP00725 View in HMDB	Aconitate hydratase, mitochondrial Gene Name: ACO2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).	Metabolic	2-Ketoglutarate Dehydrogenase Complex Deficiency 2-Ketoglutarate Dehydrogenase Complex Deficiency Aerobic Glycolysis (Warburg Effect) Citrate Immunometabolism Pathway Citric Acid Cycle Congenital Lactic Acidosis Congenital Lactic Acidosis Fumarase Deficiency Fumarase Deficiency Glutaminolysis and Cancer Itaconate Immunometabolism Pathway Mitochondrial Complex II Deficiency Mitochondrial Complex II Deficiency Pyruvate Dehydrogenase Deficiency (E2) Pyruvate Dehydrogenase Deficiency (E2) Pyruvate Dehydrogenase Deficiency (E3) Pyruvate Dehydrogenase Deficiency (E3) Succinate Immunometabolism Pathway The Oncogenic Action of 2-Hydroxyglutarate The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria The Oncogenic Action of Fumarate The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria The Oncogenic Action of Succinate Tricarboxylic acid cycle ( show more show less )
P60709 View in UniProt	Actin, cytoplasmic 1 Gene Name: ACTB Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Metabolic	Drotaverine Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Methyldopa Action Pathway Methylergometrine Mechanism of Action Action Pathway Oxytocin Action Pathway Phenylephrine Action Pathway Prazosin Action Pathway Rac 1 Cell Motility Signaling Pathway Timolol Action Pathway (New) ( show more show less )
Q9C0C7 View in UniProt	Activating molecule in BECN1-regulated autophagy protein 1 Gene Name: AMBRA1	Metabolic	Inositol Metabolism Joubert Syndrome Joubert Syndrome Phosphatidylinositol Phosphate Metabolism
Q9H6R3 View in UniProt HMDBP11602 View in HMDB	Acyl-CoA synthetase short-chain family member 3, mitochondrial Gene Name: ACSS3 Activates acetate so that it can be used for lipid synthesis or for energy generation (By similarity).	Metabolic	Malonic Aciduria Malonic Aciduria Malonyl-CoA Decarboxylase Deficiency Malonyl-CoA Decarboxylase Deficiency Methylmalonic Aciduria Due to Cobalamin-Related Disorders Methylmalonic Aciduria Due to Cobalamin-Related Disorders Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Propanoate Metabolism Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (HADH) Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (HADH) ( show more show less )
Q58HT5 View in UniProt HMDBP07278 View in HMDB	Acyl-CoA wax alcohol acyltransferase 1 Gene Name: AWAT1 Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).	Metabolic	Retinol Metabolism Vitamin A Deficiency Vitamin A Deficiency
Q08AH1 View in UniProt HMDBP04188 View in HMDB	Acyl-coenzyme A synthetase ACSM1, mitochondrial Gene Name: ACSM1 Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro). Functions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase (By similarity).	Metabolic	Butyrate Metabolism Metabolism and Physiological Effects of Phenylacetylglutamine Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Phenylacetate Metabolism Phenylketonuria Valproic Acid Metabolism Pathway ( show more show less )
Q68CK6 View in UniProt HMDBP08700 View in HMDB	Acyl-coenzyme A synthetase ACSM2B, mitochondrial Gene Name: ACSM2B Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).	Metabolic	Phenylacetate Metabolism
Q8WYK0 View in UniProt HMDBP00024 View in HMDB	Acyl-coenzyme A thioesterase 12 Gene Name: ACOT12 Hydrolyzes acetyl-CoA to acetate and CoA.	Metabolic	Leigh Syndrome Leigh Syndrome Primary Hyperoxaluria II, PH2 Primary Hyperoxaluria II, PH2 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Pyruvate Metabolism ( show more show less )
O75608 View in UniProt HMDBP00056 View in HMDB	Acyl-protein thioesterase 1 Gene Name: LYPLA1 Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.	Metabolic	Phospholipid Biosynthesis
P07311 View in UniProt HMDBP00553 View in HMDB	Acylphosphatase-1 Gene Name: ACYP1 Its physiological role is not yet clear.	Metabolic	Leigh Syndrome Leigh Syndrome Primary Hyperoxaluria II, PH2 Primary Hyperoxaluria II, PH2 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Pyruvate Metabolism ( show more show less )
P46108 View in UniProt	Adapter molecule crk Gene Name: CRK The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.	Metabolic	Asciminib Inhibition of BCR-ABL Bafetinib Inhibition of BCR-ABL Action Pathway BCR-ABL Action in CML Pathogenesis Bosutinib Inhibition of BCR-ABL Action Pathway CXCR4 Signaling Pathway Dasatinib Inhibition of BCR-ABL Dasatinib Inhibition of BCR-ABL Action Pathway Imatinib Inhibition of BCR-ABL Nilotinib Inhibition of BCR-ABL Action Pathway Ponatinib Inhibition of BCR-ABL New Ruxolitinib Mechanism of Action Action Pathway Tyrosine-Kinase Inhibition of BCR-ABL Pathway ( show more show less )
P07741 View in UniProt HMDBP00438 View in HMDB	Adenine phosphoribosyltransferase Gene Name: APRT Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Mycophenolic Acid Action Pathway Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P00813 View in UniProt HMDBP00664 View in HMDB	Adenosine deaminase Gene Name: ADA Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Allopurinol Action Pathway (New) Azathioprine Action Pathway Dipyridamole Action Pathway Dipyridamole Phosphodiesterase Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Metabolism and Physiological Effects of Uric acid Metabolism and Physiological Effects of Xanthine Metabolism and Physiological Effects of Xanthosine Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Nelarabine Action Pathway Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P55263 View in UniProt HMDBP00640 View in HMDB	Adenosine kinase Gene Name: ADK ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.	Metabolic	Azathioprine Action Pathway Mercaptopurine Action Pathway Mercaptopurine Metabolism Pathway Thioguanine Action Pathway (old)
P29274 View in UniProt HMDBP01652 View in HMDB	Adenosine receptor A2a Gene Name: ADORA2A Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	Metabolic	Caffeine Adrenergic A1 vasoconstriction Action Pathway Caffeine Nervous Action Pathway Dipyridamole Action Pathway Dipyridamole Phosphodiesterase Action Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Triflusal Action Pathway ( show more show less )
P29275 View in UniProt HMDBP01656 View in HMDB	Adenosine receptor A2b Gene Name: ADORA2B Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	Metabolic	Dipyridamole Action Pathway Dipyridamole Phosphodiesterase Action Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Triflusal Action Pathway
P23526 View in UniProt HMDBP00662 View in HMDB	Adenosylhomocysteinase Gene Name: AHCY Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.	Metabolic	Betaine Metabolism Cystathionine beta-Synthase Deficiency Cystathionine beta-Synthase Deficiency Glycine N-Methyltransferase Deficiency Glycine N-Methyltransferase Deficiency Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Hypermethioninemia Hypermethioninemia Methionine Adenosyltransferase Deficiency Methionine Adenosyltransferase Deficiency Methionine Metabolism Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) S-Adenosylhomocysteine (SAH) Hydrolase Deficiency S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Selenoamino Acid Metabolism ( show more show less )
Q08828 View in UniProt HMDBP00711 View in HMDB	Adenylate cyclase type 1 Gene Name: ADCY1 This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.	Metabolic	Progesterone Action Pathway Alprazolam Action Pathway Amobarbital Action Pathway Brexanolone Action Pathway Bromazepam Action Pathway Butabarbital Action Pathway Butalbital Action Pathway Butobarbital Action Pathway Chlordiazepoxide Action Pathway Clobazam Action Pathway Clonazepam Action Pathway Clorazepic Acid Action Pathway Clotiazepam Action Pathway Desflurane GABA(A) Anesthetic Action Pathway Diazepam Action Pathway Dienogest Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Drospirenone Action Pathway Eletriptan Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Estazolam Action Pathway Eszopiclone Action Pathway Ethanol GABA Agonist Action Pathway Ethosuximide Action Pathway Etizolam Action Pathway Etomidate Action Pathway Etonogestrel Action Pathway Flumazenil Action Pathway Flunitrazepam Action Pathway Flurazepam Action Pathway Fospropofol Action Pathway Frovatriptan Mechanism of Action Action Pathway GABA Gamma-Aminobutyric Acid Biosynthesis Ganaxolone Action Pathway Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Glutethimide Action Pathway GnRH Signaling Pathway Gs Serotonergic Smooth Muscle Contraction Halothane GABA(A) Anesthetic Action Pathway Isoflurane GABA(A) Anesthetic Action Pathway Ketazolam Action Pathway Levonorgestrel Action Pathway Lorazepam Action Pathway Lormetazepam Action Pathway Lysophosphatidic Acid LPA1 Signalling Lysophosphatidic Acid LPA2 Signalling Lysophosphatidic Acid LPA3 Signalling Lysophosphatidic Acid LPA4 Signalling Lysophosphatidic Acid LPA5 Signalling Lysophosphatidic Acid LPA6 Signalling Megestrol acetate Action Pathway Meprobamate Action Pathway Methsuximide Action Pathway Methylphenobarbital Action Pathway Metoclopramide Serotonergic Smooth Muscle Contraction Midazolam Action Pathway Naratriptan Mechanism of Action Action Pathway Nitrazepam Action Pathway Norelgestromin Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Oxazepam Action Pathway Paramethadione Action Pathway Pentobarbital Action Pathway Phenobarbital Action Pathway Prazepam Action Pathway Primidone Action Pathway Prucalopride Action Pathway Quazepam Action Pathway Quinidine barbiturate Action Pathway Remimazolam Action Pathway Rizatriptan Mechanism of Action Action Pathway Secobarbital Action Pathway Segesterone acetate Action Pathway Sevoflurane GABA(A) Anesthetic Action Pathway Stiripentol GABA(A) Antiepileptic Action Pathway Sumatriptan Mechanism of Action Action Pathway Talbutal Action Pathway Temazepam Action Pathway Thiocolchicoside Action Pathway (New) Thiopental Action Pathway Triazolam Action Pathway Trimethadione Action Pathway Zaleplon Action Pathway Zolmitriptan Mechanism of Action Action Pathway Zolpidem Action Pathway (New) Zopiclone Action Pathway ( show more show less )
Q96PN6 View in UniProt HMDBP04127 View in HMDB	Adenylate cyclase type 10 Gene Name: ADCY10 Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.	Metabolic	Amifampridine Action Pathway Activation of cAMP-dependent protein kinase, PKA Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Alprostadil Action Pathway Alverine Serotonin Antagonist Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Azathioprine Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Bimatoprost Action Pathway Caffeine Adrenergic A1 vasoconstriction Action Pathway Cangrelor Action Pathway Carboprost tromethamine Action Pathway Castor Oil Action Pathway Cimetidine H2 Anti-Histamine Action Pathway Clopidogrel Action Pathway (new) Cocaine Dopamine-reuptake Inhibitor Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dinoprost tromethamine Action Pathway Dinoprostone Action Pathway Dipyridamole Action Pathway Dipyridamole Phosphodiesterase Action Pathway Domperidone Mechanism of Action Action Pathway Epoprostenol Action Pathway Famotidine H2 Anti-Histamine Action Pathway Flavoxate Action Pathway Gout or Kelley-Seegmiller Syndrome Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Iloprost Action Pathway Incretins - Insulin release Pathway Ion Channels and Their Functional Role in Vascular Endothelium Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lesch-Nyhan Syndrome (LNS) Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Mercaptopurine Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Metiamide H2 Anti-Histamine Action Pathway Misoprostol Action Pathway Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Pancreas Function - Beta Cell Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Prasugrel Action Pathway Propiverine Action Pathway Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Ranitidine H2 Anti-Histamine Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Selexipag Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Tafluprost Action Pathway Thioguanine Action Pathway (old) Ticagrelor Action Pathway Ticlopidine Action Pathway (new) Travoprost Action Pathway Treprostinil Action Pathway Triflusal Action Pathway Triflusal Action Pathway (new) Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type II ( show more show less )
Q08462 View in UniProt HMDBP00921 View in HMDB	Adenylate cyclase type 2 Gene Name: ADCY2 This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.	Metabolic	3-Methylthiofentanyl Opioid Agonist Action Pathway Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Alfentanil Opioid Agonist Action Pathway Alvimopan Opioid Antagonist Action Pathway Anileridineb Opioid Agonist Action Pathway Apomorphine Mechanism of Action Action Pathway Benzhydrocodone Opioid Agonist Action Pathway Bezitramide Opioid Agonist Action Pathway Bupropion Action Pathway Butorphanol Opioid Antagonist Action Pathway Carfentanil Opioid Agonist Action Pathway Codeine Opioid Action Pathway Corticotropin Activation of Cortisol Production Desomorphine Opioid Agonist Action Pathway Dextromoramide Opioid Agonist Action Pathway Dextropropoxyphene Opioid Agonist Action Pathway Dezocine Kappa Opioid Antagonism Action Pathway Dezocine Mu Opioid Agonism Action Pathway Diamorphine Action Pathway Difelikefalin Opioid Agonist Action Pathway Dihydrocodeine Opioid Agonist Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Dihydroetorphine Opioid Agonist Action Pathway Dihydromorphine Opioid Agonist Action Pathway Diphenoxylate Opioid Agonist Action Pathway Diprenorphine Action Pathway Dopamine Activation of Neurological Reward System Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Eletriptan Mechanism of Action Action Pathway Eluxadoline Action Pathway Epicriptine Mechanism of Action Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Ethylmorphine Opioid Action Pathway Etorphine Opioid Agonist Action Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Fenoldopam Mechanism of Action Action Pathway Fentanyl Opioid Agonist Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gs Serotonergic Smooth Muscle Contraction Hydrocodone Opioid Agonist Action Pathway Hydromorphone Opioid Agonist Action Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Intracellular Signalling Through Histamine H2 Receptor and Histamine Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Ketobemidone Opioid Agonist Action Pathway Levacetylmethadol Opioid Agonist Action Pathway Levallorphan Action Pathway (New) Levodopa Pahway Levorphanol Opioid Agonist Action Pathway Lofentanil Opioid Agonist Action Pathway Loperamide Action Pathway Meperidine opioid agonist Action Pathway Methadone Opioid Agonist Action Pathway Methadyl acetate Opioid Agonist Action Pathway Methylnaltrexone Opioid Antagonist Action Pathway Metoclopramide Serotonergic Smooth Muscle Contraction Molybdenum Cofactor Deficiency Morphine Opioid Agonist Action Pathway Morphine Opioid Agonist Brain Action Pathway Myoadenylate Deaminase Deficiency Nalbuphine Opioid Antagonist Action Pathway Naldemedine Opioid Antagonist Action Pathway Nalmefene Opioid Antagonist Action Pathway Naloxegol Action Pathway Naloxone Opioid Antagonist Action Pathway Naltrexone Opioid Antagonist Action Pathway Naratriptan Mechanism of Action Action Pathway Neuronal Dopamine Gs Cascade Normethadone Action Pathway Oliceridine Opioid Agonist Action Pathway Oxycodone Opioid Agonist Action Pathway Oxymorphone Opioid Agonist Action Pathway Pentazocine Opioid Antagonist Action Pathway Pergolide Mechanism of Action Action Pathway Piritramide Opioid Agonist Action Pathway Pramipexole Mechanism of Action Action Pathway Prucalopride Action Pathway Rasagiline Action Pathway Remifentanil Opioid Analgesic Action Pathway Remifentanil Opioid Anasthetic Action Pathway Rizatriptan Mechanism of Action Action Pathway Safinamide Action Pathway Samidorphan Action Pathway Selegiline Action Pathway Solriamfetol Action Pathway Sufentanil Opioid Agonist Action Pathway Sumatriptan Mechanism of Action Action Pathway Tapentadol Opioid Agonist Action Pathway Tramadol Opioid Agonist Action Pathway Trimebutine M3 Receptor Intestine Relaxation Action Pathway Trimebutine Opioid Action Pathway Vasopressin Regulation of Water Homeostasis Xanthinuria Type I Xanthinuria Type II Zolmitriptan Mechanism of Action Action Pathway ( show more show less )
P54819 View in UniProt HMDBP04072 View in HMDB	Adenylate kinase 2, mitochondrial Gene Name: AK2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.	Metabolic	Adefovir Dipivoxil Action Pathway (New) Adefovir Dipivoxil Metabolism Pathway Tenofovir Alafenamide Action Pathway Tenofovir Disoproxil Action Pathway Tenofovir Metabolism Pathway
P00568 View in UniProt HMDBP00562 View in HMDB	Adenylate kinase isoenzyme 1 Gene Name: AK1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.	Metabolic	Adefovir Dipivoxil Metabolism Pathway Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Didanosine Anti-viral Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Tenofovir Action Pathway (New) Tenofovir Alafenamide Action Pathway Tenofovir Disoproxil Action Pathway Tenofovir Metabolism Pathway Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P30566 View in UniProt HMDBP00585 View in HMDB	Adenylosuccinate lyase Gene Name: ADSL	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Aspartate Metabolism Azathioprine Action Pathway Canavan Disease Canavan Disease Didanosine Anti-viral Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Hypoacetylaspartia Hypoacetylaspartia Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Mycophenolic Acid Action Pathway Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
Q8N142 View in UniProt HMDBP00884 View in HMDB	Adenylosuccinate synthetase isozyme 1 Gene Name: ADSSL1 Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).	Metabolic	Aspartate Metabolism Canavan Disease Canavan Disease Didanosine Anti-viral Action Pathway Hypoacetylaspartia Hypoacetylaspartia ( show more show less )
P30520 View in UniProt HMDBP00880 View in HMDB	Adenylosuccinate synthetase isozyme 2 Gene Name: ADSS Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Didanosine Anti-viral Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
Q01518 View in UniProt	Adenylyl cyclase-associated protein 1 Gene Name: CAP1 Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.	Metabolic	Rac 1 Cell Motility Signaling Pathway
P28907 View in UniProt HMDBP00918 View in HMDB	ADP-ribosyl cyclase 1 Gene Name: CD38 Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.	Metabolic	NAD+ Signalling Pathway (Cancer)
Q10588 View in UniProt HMDBP00915 View in HMDB	ADP-ribosyl cyclase 2 Gene Name: BST1 Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.	Metabolic	Nicotinate and Nicotinamide Metabolism
Q9UKK9 View in UniProt HMDBP00627 View in HMDB	ADP-sugar pyrophosphatase Gene Name: NUDT5 Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Mycophenolic Acid Action Pathway Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P12235 View in UniProt HMDBP03916 View in HMDB	ADP/ATP translocase 1 Gene Name: SLC25A4 Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Mitochondrial Electron Transport Chain Tamoxifen Anti-Cancer Action Pathway Tiludronic Acid Action Pathway
Q01718 View in UniProt	Adrenocorticotropic hormone receptor	Metabolic	Corticotropin Activation of Cortisol Production
P24298 View in UniProt HMDBP00850 View in HMDB	Alanine aminotransferase 1 Gene Name: GPT Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).	Metabolic	2-Hydroxyglutric Aciduria (D and L Form) 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency Alanine Metabolism Argininemia Argininemia Argininosuccinic Aciduria Argininosuccinic Aciduria beta-Alanine Metabolism beta-Aminoisobutyric Aciduria Carbamoyl Phosphate Synthetase Deficiency Carbamoyl Phosphate Synthetase Deficiency Carnosinuria, Carnosinemia Carnosinuria, Carnosinemia Citrullinemia Type I Citrullinemia Type I GABA-Transaminase Deficiency GABA-Transaminase Deficiency: beta-alanine Glucose-Alanine Cycle Glutamate Metabolism Homocarnosinosis Homocarnosinosis Hyperinsulinism-Hyperammonemia Syndrome Hyperinsulinism-Hyperammonemia Syndrome Lactic Acidemia Lactic Acidemia Ornithine Transcarbamylase Deficiency (OTC Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Primary Hyperoxaluria Type I Primary Hyperoxaluria Type I Pyruvate Carboxylase Deficiency Pyruvate Carboxylase Deficiency Succinic Semialdehyde Dehydrogenase Deficiency Urea Cycle ( show more show less )
Q8TD30 View in UniProt HMDBP03670 View in HMDB	Alanine aminotransferase 2 Gene Name: GPT2 Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.	Metabolic	Glucose-Alanine Cycle
P49588 View in UniProt HMDBP00625 View in HMDB	Alanine--tRNA ligase, cytoplasmic Gene Name: AARS Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	Metabolic	Alanine Metabolism Lactic Acidemia Lactic Acidemia Primary Hyperoxaluria Type I Primary Hyperoxaluria Type I Protein Synthesis: Alanine Pyruvate Carboxylase Deficiency Pyruvate Carboxylase Deficiency ( show more show less )
Q5JTZ9 View in UniProt HMDBP10671 View in HMDB	Alanine--tRNA ligase, mitochondrial Gene Name: AARS2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	Metabolic	Alanine Metabolism Lactic Acidemia Lactic Acidemia Primary Hyperoxaluria Type I Primary Hyperoxaluria Type I Pyruvate Carboxylase Deficiency Pyruvate Carboxylase Deficiency ( show more show less )
P07327 View in UniProt HMDBP00784 View in HMDB	Alcohol dehydrogenase 1A Gene Name: ADH1A	Metabolic	Alkaptonuria Celecoxib metabolism Pathway Celecoxib metabolism Pathway Disulfiram Action Pathway Dopamine beta-Hydroxylase Deficiency Dopamine beta-Hydroxylase Deficiency Felbamate Metabolism Pathway Hawkinsinuria Hawkinsinuria Monoamine Oxidase-A Deficiency (MAO-A) Monoamine Oxidase-A Deficiency (MAO-A) Retinol Metabolism Tyrosine Metabolism Tyrosinemia Type I Tyrosinemia Type I Tyrosinemia, Transient, of the Newborn Tyrosinemia, Transient, of the Newborn Vitamin A Deficiency Vitamin A Deficiency ( show more show less )
P00325 View in UniProt HMDBP00782 View in HMDB	Alcohol dehydrogenase 1B Gene Name: ADH1B	Metabolic	Celecoxib metabolism Pathway Celecoxib metabolism Pathway Disulfiram Action Pathway Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway Ethanol Degradation
P14550 View in UniProt HMDBP00507 View in HMDB	Alcohol dehydrogenase [NADP(+)] Gene Name: AKR1A1 Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).	Metabolic	Doxorubicin Metabolism Pathway Levodopa Metabolism Pathway
P30837 View in UniProt HMDBP00297 View in HMDB	Aldehyde dehydrogenase X, mitochondrial Gene Name: ALDH1B1 ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.	Metabolic	Disulfiram Action Pathway Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway Ethanol Degradation
P30838 View in UniProt HMDBP00292 View in HMDB	Aldehyde dehydrogenase, dimeric NADP-preferring Gene Name: ALDH3A1 ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.	Metabolic	Alkaptonuria Amine Oxidase Norepinephrine Cyclophosphamide Action Pathway Cyclophosphamide Action Pathway (New) Cyclophosphamide Metabolism Pathway D-Glyceric Acidura D-Glyceric Aciduria Disulfiram Action Pathway Dopamine beta-Hydroxylase Deficiency Dopamine beta-Hydroxylase Deficiency Familial Lipoprotein Lipase Deficiency Familial Lipoprotein Lipase Deficiency Felbamate Metabolism Pathway Glycerol Kinase Deficiency Glycerol Kinase Deficiency Glycerolipid Metabolism Hawkinsinuria Hawkinsinuria Histidine Metabolism Histidinemia Histidinemia Ifosfamide Action Pathway Ifosfamide Alkylating Agent Action Pathway Ifosfamide Metabolism Pathway Isocarboxazid Amine Oxidase Norepinephrine Antidepressant Action Pathway Levodopa Metabolism Pathway Minaprine Amine oxidase Norepinephrine Antidepressant Action Pathway Moclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway Monoamine Oxidase-A Deficiency (MAO-A) Monoamine Oxidase-A Deficiency (MAO-A) Pargyline Action Pathway Phenelzine Amine Oxidase Norepinephrine Antidepressant Action Pathway Phentermine Action Pathway Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway Phenylketonuria Tranylcypromine Amine Oxidase Norepinephrine Antidepressant Action Pathway Tyrosine Metabolism Tyrosinemia Type I Tyrosinemia Type I Tyrosinemia, Transient, of the Newborn Tyrosinemia, Transient, of the Newborn ( show more show less )
P05091 View in UniProt HMDBP00295 View in HMDB	Aldehyde dehydrogenase, mitochondrial Gene Name: ALDH2	Metabolic	2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Aciduria 3-Hydroxyisobutyric Aciduria 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type IV 3-Methylglutaconic Aciduria Type IV 3-Phosphoglycerate Dehydrogenase Deficiency 3-Phosphoglycerate Dehydrogenase Deficiency beta-Alanine Metabolism beta-Aminoisobutyric Aciduria beta-Ketothiolase Deficiency beta-Ketothiolase Deficiency Carnosinuria, Carnosinemia Carnosinuria, Carnosinemia Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Disulfiram Action Pathway Ethanol Degradation GABA-Transaminase Deficiency GABA-Transaminase Deficiency: beta-alanine Glycine and Serine Metabolism Histidine Metabolism Histidinemia Histidinemia Hyperglycinemia, Non-Ketotic Isobutyryl-CoA Dehydrogenase Deficiency Isobutyryl-CoA Dehydrogenase Deficiency Isovaleric Acidemia Isovaleric Acidemia Isovaleric Aciduria Isovaleric Aciduria Leigh Syndrome Leigh Syndrome Maple Syrup Urine Disease Maple Syrup Urine Disease Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonic Aciduria Methylmalonic Aciduria Nevirapine Metabolism Pathway Nitric Oxide Signaling Pathway Nitroglycerin Action Pathway Non-Ketotic Hyperglycinemia Non-Ketotic Hyperglycinemia Oxidation of Branched-Chain Fatty Acids Primary Hyperoxaluria II, PH2 Primary Hyperoxaluria II, PH2 Propionic Acidemia Propionic Acidemia Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Pyruvate Metabolism Sarcosinemia Sarcosinemia Tryptophan Metabolism Valine, Leucine, and Isoleucine Degradation ( show more show less )
Q06278 View in UniProt HMDBP00126 View in HMDB	Aldehyde oxidase Gene Name: AOX1	Metabolic	2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Aciduria 3-Hydroxyisobutyric Aciduria 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type IV 3-Methylglutaconic Aciduria Type IV Azathioprine Action Pathway beta-Ketothiolase Deficiency beta-Ketothiolase Deficiency Citalopram Action Pathway Citalopram Metabolism Pathway Hypophosphatasia Hypophosphatasia Isobutyryl-CoA Dehydrogenase Deficiency Isobutyryl-CoA Dehydrogenase Deficiency Isovaleric Acidemia Isovaleric Acidemia Isovaleric Aciduria Isovaleric Aciduria Maple Syrup Urine Disease Maple Syrup Urine Disease Mercaptopurine Action Pathway Mercaptopurine Metabolism Pathway Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonic Aciduria Methylmalonic Aciduria Nicotinate and Nicotinamide Metabolism Nicotine Action Pathway Nicotine Metabolism Pathway Nicotine Metabolism Pathway Propionic Acidemia Propionic Acidemia Thioguanine Action Pathway (old) Tryptophan Metabolism Valine, Leucine, and Isoleucine Degradation Vitamin B6 Metabolism ( show more show less )
P42330 View in UniProt HMDBP00360 View in HMDB	Aldo-keto reductase family 1 member C3 Gene Name: AKR1C3 Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.	Metabolic	Acetaminophen Action Pathway Acetylsalicylic Acid Action Pathway Alclometasone Action Pathway Amcinonide Action Pathway Antipyrine Action Pathway Antrafenine Action Pathway Arachidonic Acid Metabolism Beclomethasone dipropionate Action Pathway Betamethasone Action Pathway Betamethasone phosphate Action Pathway Bromfenac Action Pathway Budesonide Action Pathway Carprofen Action Pathway Celecoxib metabolism Pathway Ciclesonide Action Pathway Clobetasol propionate Action Pathway Clobetasone Action Pathway Clocortolone Action Pathway Cortisone Acetate Action Pathway Deflazacort Action Pathway Desonide Action Pathway Desoximetasone Action Pathway Dexamethasone Action Pathway Diclofenac Action Pathway Diflorasone Action Pathway Diflunisal Action Pathway Difluprednate Action Pathway Doxorubicin Metabolism Pathway Dutasteride Action Pathway Etodolac Action Pathway Etoricoxib Action Pathway Fenoprofen Action Pathway Finasteride Action Pathway Flumethasone Action Pathway Flunisolide Action Pathway Fluocinolone acetonide Action Pathway Fluocinonide Action Pathway Fluorometholone Action Pathway Flurandrenolide Action Pathway Flurbiprofen Action Pathway Fluticasone Action Pathway Fluticasone furoate Action Pathway Fluticasone propionate Action Pathway Hydrocortamate Action Pathway Hydrocortisone Action Pathway Ibuprofen Action Pathway Indomethacin Action Pathway Ketoprofen Action Pathway Ketorolac Action Pathway Leukotriene C4 Synthesis Deficiency Lornoxicam Action Pathway Loteprednol etabonate Action Pathway Lumiracoxib Action Pathway Magnesium Salicylate Action Pathway Medrysone Action Pathway Mefenamic Acid Action Pathway Meloxicam Action Pathway Methyl Prednisolone Action Pathway Nabumetone Action Pathway Naproxen Action Pathway Nepafenac Action Pathway Oxaprozin Action Pathway Oxcarbazepine Action Pathway (New) Phenylbutazone Action Pathway Piroxicam Action Pathway Prednicarbate Action Pathway Prednisolone acetate MOA Action Pathway Prednisolone Action Action Pathway New Prednisolone Phosphate Action Pathway Prednisone Anti-inflammatory Action Pathway Rimexolone Action Pathway Rofecoxib Action Pathway Salicylate-Sodium Action Pathway Salicylic Acid Action Pathway Salsalate Action Pathway Sulindac Action Pathway Suprofen Action Pathway Tenoxicam Action Pathway Tiaprofenic Acid Action Pathway Tolmetin Action Pathway Triamcinolone Action Pathway Trisalicylate-Choline Action Pathway Ulobetasol Action Pathway Valdecoxib Action Pathway ( show more show less )
P17516 View in UniProt HMDBP00074 View in HMDB	Aldo-keto reductase family 1 member C4 Gene Name: AKR1C4 Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.	Metabolic	11-beta-Hydroxylase Deficiency (CYP11B1) 11-beta-Hydroxylase Deficiency (CYP11B1) 17-alpha-Hydroxylase Deficiency (CYP17) 21-Hydroxylase Deficiency (CYP21) 3-beta-Hydroxysteroid Dehydrogenase Deficiency 3-beta-Hydroxysteroid Dehydrogenase Deficiency Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Androstenedione Metabolism Apparent Mineralocorticoid Excess Syndrome Brexanolone Action Pathway Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Corticosterone Methyl Oxidase I Deficiency (CMO I) Corticosterone Methyl Oxidase I Deficiency (CMO I) Corticosterone Methyl Oxidase II Deficiency (CMO II) Corticosterone Methyl Oxidase II Deficiency (CMO II) Metabolism and Physiological Effects of Androsterone sulfate Steroidogenesis ( show more show less )
Q96C23 View in UniProt HMDBP07277 View in HMDB	Aldose 1-epimerase Gene Name: GALM Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).	Metabolic	Fanconi-Bickel Syndrome Fanconi-Bickel Syndrome Fructose-1,6-diphosphatase Deficiency Fructose-1,6-diphosphatase Deficiency Gluconeogenesis Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Glycogenosis, Type IA. Von Gierke Disease Glycogenosis, Type IA. Von Gierke Disease Glycogenosis, Type IB Glycogenosis, Type IB Glycogenosis, Type IC Glycogenosis, Type IC Glycogenosis, Type VII. Tarui Disease Glycogenosis, Type VII. Tarui Disease Glycolysis Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Triosephosphate Isomerase Deficiency Triosephosphate Isomerase Deficiency ( show more show less )
P15121 View in UniProt HMDBP00088 View in HMDB	Aldose reductase Gene Name: AKR1B1 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.	Metabolic	D-Glyceric Acidura D-Glyceric Aciduria DOPA-Responsive Dystonia DOPA-Responsive Dystonia Familial Lipoprotein Lipase Deficiency Familial Lipoprotein Lipase Deficiency Fructose and Mannose Degradation Fructose Intolerance, Hereditary Fructose Intolerance, Hereditary Fructosuria Fructosuria Galactose Metabolism Galactosemia Galactosemia Glycerol Kinase Deficiency Glycerol Kinase Deficiency Glycerolipid Metabolism Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Hyperphenylalaninemia Due to DHPR-Deficiency Hyperphenylalaninemia Due to DHPR-Deficiency Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Leigh Syndrome Leigh Syndrome Metabolism and Physiological Effects of 3-Deoxyglucosone Primary Hyperoxaluria II, PH2 Primary Hyperoxaluria II, PH2 Pterine Biosynthesis Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Pyruvate Metabolism Segawa Syndrome Segawa Syndrome Sepiapterin Reductase Deficiency Sepiapterin Reductase Deficiency ( show more show less )
Q8TDN7 View in UniProt HMDBP10638 View in HMDB	Alkaline ceramidase 1 Gene Name: ACER1 Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity).	Metabolic	Fabry Disease Fabry Disease Gaucher Disease Gaucher Disease Globoid Cell Leukodystrophy Globoid Cell Leukodystrophy Krabbe Disease Metachromatic Leukodystrophy (MLD) Metachromatic Leukodystrophy (MLD) Sphingolipid Metabolism ( show more show less )
Q9NUN7 View in UniProt HMDBP07413 View in HMDB	Alkaline ceramidase 3 Gene Name: ACER3 Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.	Metabolic	Fabry Disease Fabry Disease Gaucher Disease Gaucher Disease Globoid Cell Leukodystrophy Globoid Cell Leukodystrophy Krabbe Disease Metachromatic Leukodystrophy (MLD) Metachromatic Leukodystrophy (MLD) Sphingolipid Metabolism ( show more show less )
P05186 View in UniProt HMDBP00096 View in HMDB	Alkaline phosphatase, tissue-nonspecific isozyme Gene Name: ALPL This isozyme may play a role in skeletal mineralization.	Metabolic	Betamethasone phosphate Action Pathway Fosphenytoin Action Pathway (New) Hypophosphatasia Hypophosphatasia Metabolism and Physiological Effects of 3-Deoxyglucosone Prednisolone Phosphate Action Pathway Ribose-5-phosphate Isomerase Deficiency Vitamin B6 Metabolism ( show more show less )
O00116 View in UniProt HMDBP01542 View in HMDB	Alkyldihydroxyacetonephosphate synthase, peroxisomal Gene Name: AGPS 1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion	Metabolic	Plasmalogen Synthesis
Q6NUM9 View in UniProt HMDBP08290 View in HMDB	All-trans-retinol 13,14-reductase Gene Name: RETSAT Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).	Metabolic	Retinol Metabolism Vitamin A Deficiency Vitamin A Deficiency
Q13424 View in UniProt HMDBP08001 View in HMDB	Alpha-1-syntrophin Gene Name: SNTA1 Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- biphosphate	Metabolic	Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dofetilide Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Ethotoin Action Pathway Felodipine Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Fosphenytoin (Antiarrhythmic) Metabolism Pathway Fosphenytoin Action Pathway (New) Ibutilide Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Lamotrigine Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Pancreas Function - Alpha Cell Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propranolol Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Zonisamide Action Pathway ( show more show less )
P35348 View in UniProt HMDBP07433 View in HMDB	Alpha-1A adrenergic receptor Gene Name: ADRA1A This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins	Metabolic	3-Methylthiofentanyl Action Pathway Alfentanil Action Pathway Alvimopan Action Pathway Amine Oxidase Norepinephrine Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway Anileridine Action Pathway Atomoxetine Action Pathway (New) Benzocaine Action Pathway Bupivacaine Action Pathway Buprenorphine Action Pathway Bupropion Action Pathway Caffeine Nervous Action Pathway Carfentanil Action Pathway Carvedilol Action Pathway Chloroprocaine Action Pathway Citalopram Action Pathway Clomipramine Action Pathway (New) Cocaine Action Pathway Cocaine Norepinephrine Reuptake Inhibitor Action Pathway Codeine Action Pathway Desipramine Action Pathway Desipramine Action Pathway (New) Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway Dezocine Action Pathway Dibucaine Action Pathway Dihydromorphine Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) Droxidopa A1-Adrenergic Vasoconstriction Action Pathway Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Ephedrine A1-Adrenergic Vasoconstriction Action Pathway Escitalopram Action Pathway Ethylmorphine Action Pathway Fentanyl Action Pathway Fluoxetine Action Pathway Hydrocodone Action Pathway Hydromorphone Action Pathway Imipramine Imipramine Action Pathway (New) Isocarboxazid Amine Oxidase Norepinephrine Antidepressant Action Pathway Ketobemidone Action Pathway Labetalol Action Pathway Levallorphan Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Levorphanol Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Maprotiline Action Pathway Mepivacaine Action Pathway Methadone Action Pathway Methadyl Acetate Action Pathway Methamphetamine Dopamine Reuptake Inhibitor Action Pathway Methamphetamine Norepinephrine Reuptake Inhibitor Action Pathway Methyldopa Action Pathway Milnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Minaprine Amine oxidase Norepinephrine Antidepressant Action Pathway Moclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway Morphine Action Pathway Nalbuphine Action Pathway Naloxone Action Pathway Naltrexone Action Pathway Neuron Function Nicotine Action Pathway Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway Norepinephrine Neurological Nortriptyline Action Pathway Oxybuprocaine Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Pentazocine Action Pathway Phenelzine Amine Oxidase Norepinephrine Antidepressant Action Pathway Phentermine Action Pathway Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway Phenylephrine Action Pathway Prazosin Action Pathway Prilocaine Action Pathway Procaine Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Pseudoephedrine Action Pathway Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway Remifentanil Action Pathway Ropivacaine Action Pathway Solriamfetol Action Pathway Sufentanil Action Pathway Tamsulosin Action Pathway Tramadol Action Action Pathway Tranylcypromine Amine Oxidase Norepinephrine Antidepressant Action Pathway Trimipramine Action Pathway ( show more show less )
O15466 View in UniProt	Alpha-2,8-sialyltransferase 8E Gene Name: ST8SIA5 May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.	Metabolic	G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
O43707 View in UniProt	Alpha-actinin-4 Gene Name: ACTN4 F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).	Metabolic	GnRH Signaling Pathway
P49419 View in UniProt HMDBP00293 View in HMDB	Alpha-aminoadipic semialdehyde dehydrogenase Gene Name: ALDH7A1 Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.	Metabolic	2-Aminoadipic 2-Oxoadipic Aciduria 2-Aminoadipic 2-Oxoadipic Aciduria Betaine Metabolism Glutaric Aciduria Type I Glutaric Aciduria Type I (Lysine Degradation) Hyperlysinemia I, Familial Hyperlysinemia I, Familial Hyperlysinemia II or Saccharopinuria Lysine Degradation Metabolism and Physiological Effects of Dimethylglycine Pyridoxine Dependency with Seizures Pyridoxine Dependency with Seizures Saccharopinuria/Hyperlysinemia II Saccharopinuria/Hyperlysinemia II Sarcosine Oncometabolite Pathway ( show more show less )
Q9UDR5 View in UniProt HMDBP00852 View in HMDB	Alpha-aminoadipic semialdehyde synthase, mitochondrial Gene Name: AASS Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.	Metabolic	2-Aminoadipic 2-Oxoadipic Aciduria 2-Aminoadipic 2-Oxoadipic Aciduria Glutaric Aciduria Type I Glutaric Aciduria Type I (Lysine Degradation) Hyperlysinemia I, Familial Hyperlysinemia I, Familial Hyperlysinemia II or Saccharopinuria Lysine Degradation Pyridoxine Dependency with Seizures Pyridoxine Dependency with Seizures Saccharopinuria/Hyperlysinemia II Saccharopinuria/Hyperlysinemia II ( show more show less )
P04745 View in UniProt HMDBP02083 View in HMDB	Alpha-amylase 1 Gene Name: AMY1A	Metabolic	Glycogen Synthetase Deficiency Glycogen Synthetase Deficiency Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type VI. Hers Disease Glycogenosis, Type VI. Hers Disease Mucopolysaccharidosis VII. Sly Syndrome Mucopolysaccharidosis VII. Sly Syndrome Starch and Sucrose Metabolism Sucrase-Isomaltase Deficiency Sucrase-Isomaltase Deficiency ( show more show less )
P06733 View in UniProt HMDBP01087 View in HMDB	Alpha-enolase Gene Name: ENO1 Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.	Metabolic	Aerobic Glycolysis (Warburg Effect) Fanconi-Bickel Syndrome Fanconi-Bickel Syndrome Fructose-1,6-diphosphatase Deficiency Fructose-1,6-diphosphatase Deficiency Gluconeogenesis Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Glycogenosis, Type IA. Von Gierke Disease Glycogenosis, Type IA. Von Gierke Disease Glycogenosis, Type IB Glycogenosis, Type IB Glycogenosis, Type IC Glycogenosis, Type IC Glycogenosis, Type VII. Tarui Disease Glycogenosis, Type VII. Tarui Disease Glycolysis Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Triosephosphate Isomerase Deficiency Triosephosphate Isomerase Deficiency ( show more show less )
P06280 View in UniProt HMDBP00723 View in HMDB	Alpha-galactosidase A Gene Name: GLA	Metabolic	Fabry Disease Fabry Disease Galactose Metabolism Galactosemia Galactosemia Gaucher Disease Gaucher Disease Globoid Cell Leukodystrophy Globoid Cell Leukodystrophy Krabbe Disease Metachromatic Leukodystrophy (MLD) Metachromatic Leukodystrophy (MLD) Sphingolipid Metabolism ( show more show less )
P00709 View in UniProt HMDBP00372 View in HMDB	Alpha-lactalbumin Gene Name: LALBA Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.	Metabolic	alpha-Lactalbumin Drug Metabolism Congenital Disorder of Glycosylation CDG-IId GLUT-1 Deficiency Syndrome Lactose Synthesis
Q9UHK6 View in UniProt HMDBP02680 View in HMDB	Alpha-methylacyl-CoA racemase Gene Name: AMACR Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.	Metabolic
Q9H4F1 View in UniProt HMDBP09352 View in HMDB	Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase Gene Name: ST6GALNAC4 Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).	Metabolic	G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
Q969X2 View in UniProt HMDBP03365 View in HMDB	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Gene Name: ST6GALNAC6 Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)), a representative tumor-associated antigen in cancers of the pancreas and colon, in colon tissues	Metabolic	G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
Q92185 View in UniProt HMDBP00271 View in HMDB	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Gene Name: ST8SIA1 Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.	Metabolic	G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
P16234 View in UniProt HMDBP01355 View in HMDB	Alpha-type platelet-derived growth factor receptor Gene Name: PDGFRA Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity	Metabolic	Rac 1 Cell Motility Signaling Pathway
DB00009 View in DrugBank	Alteplase	Metabolic	Alteplase Action Pathway Alteplase Action Pathway Alteplase Drug Metabolism

Showing 151 - 225 of 1576 proteins

Browsing Proteins

Protein ID

Protein Description

Pathway Class

Pathways

DB00054

Abciximab

Q9BWD1

HMDBP00013

Acetyl-CoA acetyltransferase, cytosolic

P24752

HMDBP00038

Acetyl-CoA acetyltransferase, mitochondrial

Q13085

HMDBP00047

Acetyl-CoA carboxylase 1

Q9NUB1

HMDBP00042

Acetyl-coenzyme A synthetase 2-like, mitochondrial

Q9NR19

HMDBP00037

Acetyl-coenzyme A synthetase, cytoplasmic

P22303

HMDBP00524

Acetylcholinesterase

P46597

HMDBP00101

Acetylserotonin O-methyltransferase

Q99798

HMDBP00725

Aconitate hydratase, mitochondrial

P60709

Actin, cytoplasmic 1

Q9C0C7

Activating molecule in BECN1-regulated autophagy protein 1

Q9H6R3

HMDBP11602

Acyl-CoA synthetase short-chain family member 3, mitochondrial

Q58HT5

HMDBP07278

Acyl-CoA wax alcohol acyltransferase 1

Q08AH1

HMDBP04188

Acyl-coenzyme A synthetase ACSM1, mitochondrial

Q68CK6

HMDBP08700

Acyl-coenzyme A synthetase ACSM2B, mitochondrial

Q8WYK0

HMDBP00024

Acyl-coenzyme A thioesterase 12

O75608

HMDBP00056

Acyl-protein thioesterase 1

P07311

HMDBP00553

Acylphosphatase-1

P46108

Adapter molecule crk

P07741

HMDBP00438

Adenine phosphoribosyltransferase

P00813

HMDBP00664

Adenosine deaminase

P55263

HMDBP00640

Adenosine kinase

P29274

HMDBP01652

Adenosine receptor A2a

P29275

HMDBP01656

Adenosine receptor A2b

P23526

HMDBP00662

Adenosylhomocysteinase

Q08828

HMDBP00711

Adenylate cyclase type 1

Q96PN6