SMPDB

Showing 226 - 300 of 1576 proteins

Protein ID	Protein Description	Pathway Class	Pathways
Q06203 View in UniProt HMDBP00331 View in HMDB	Amidophosphoribosyltransferase Gene Name: PPAT	Metabolic	2-Hydroxyglutric Aciduria (D and L Form) 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Azathioprine Action Pathway (New) Glutamate Metabolism Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Homocarnosinosis Homocarnosinosis Hyperinsulinism-Hyperammonemia Syndrome Hyperinsulinism-Hyperammonemia Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mercaptopurine Action Pathway (New) Mercaptopurine Metabolism Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Mycophenolic Acid Action Pathway Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Succinic Semialdehyde Dehydrogenase Deficiency Thioguanine Action Pathway (old) Tioguanine Action Pathway Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P19801 View in UniProt HMDBP00390 View in HMDB	Amiloride-sensitive amine oxidase [copper-containing] Gene Name: ABP1 Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.	Metabolic	Alkaptonuria Disulfiram Action Pathway Dopamine beta-Hydroxylase Deficiency Dopamine beta-Hydroxylase Deficiency Hawkinsinuria Hawkinsinuria Histidine Metabolism Histidinemia Histidinemia Monoamine Oxidase-A Deficiency (MAO-A) Monoamine Oxidase-A Deficiency (MAO-A) Tyrosine Metabolism Tyrosinemia Type I Tyrosinemia Type I Tyrosinemia, Transient, of the Newborn Tyrosinemia, Transient, of the Newborn ( show more show less )
P37088 View in UniProt HMDBP02267 View in HMDB	Amiloride-sensitive sodium channel subunit alpha Gene Name: SCNN1A Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	Metabolic	Amiloride Action Pathway Amiloride Action Pathway (New) Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Finerenone Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function - Collecting Duct Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Spironolactone Action Pathway (New) Torsemide Action Pathway Triamterene Action Pathway Triamterene Action Pathway (New) Trichlormethiazide Action Pathway ( show more show less )
P51168 View in UniProt HMDBP09092 View in HMDB	Amiloride-sensitive sodium channel subunit beta Gene Name: SCNN1B Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	Metabolic	Amiloride Action Pathway Amiloride Action Pathway (New) Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Finerenone Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function - Collecting Duct Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Spironolactone Action Pathway (New) Torsemide Action Pathway Triamterene Action Pathway Triamterene Action Pathway (New) Trichlormethiazide Action Pathway ( show more show less )
P51172 View in UniProt HMDBP09093 View in HMDB	Amiloride-sensitive sodium channel subunit delta Gene Name: SCNN1D Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	Metabolic	Amiloride Action Pathway Amiloride Action Pathway (New) Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Finerenone Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function - Collecting Duct Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Spironolactone Action Pathway (New) Torsemide Action Pathway Triamterene Action Pathway Triamterene Action Pathway (New) Trichlormethiazide Action Pathway ( show more show less )
P51170 View in UniProt HMDBP02930 View in HMDB	Amiloride-sensitive sodium channel subunit gamma Gene Name: SCNN1G Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	Metabolic	Amiloride Action Pathway Amiloride Action Pathway (New) Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Finerenone Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function - Collecting Duct Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Spironolactone Action Pathway (New) Torsemide Action Pathway Triamterene Action Pathway Triamterene Action Pathway (New) Trichlormethiazide Action Pathway ( show more show less )
P21397 View in UniProt HMDBP00169 View in HMDB	Amine oxidase [flavin-containing] A Gene Name: MAOA Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.	Metabolic	3-Phosphoglycerate Dehydrogenase Deficiency 3-Phosphoglycerate Dehydrogenase Deficiency Alkaptonuria Amine Oxidase Norepinephrine Amine Oxidase Serotonin Amphetamine Neurological Action Pathway Citalopram Action Pathway Citalopram Metabolism Pathway Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Disulfiram Action Pathway Dopamine beta-Hydroxylase Deficiency Dopamine beta-Hydroxylase Deficiency Glycine and Serine Metabolism Hawkinsinuria Hawkinsinuria Histidine Metabolism Histidinemia Histidinemia Hyperglycinemia, Non-Ketotic Isocarboxazid Amine Oxidase Norepinephrine Antidepressant Action Pathway Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway Levodopa Metabolism Pathway Methamphetamine Dopamine Reuptake Inhibitor Action Pathway Methamphetamine Norepinephrine Reuptake Inhibitor Action Pathway Methamphetamine Serotonin Reuptake Inhibitor Action Pathway Minaprine Amine oxidase Norepinephrine Antidepressant Action Pathway Minaprine Serotonin receptor Antidepressant Action Pathway Moclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway Monoamine Oxidase-A Deficiency (MAO-A) Monoamine Oxidase-A Deficiency (MAO-A) Non-Ketotic Hyperglycinemia Non-Ketotic Hyperglycinemia Phenelzine Amine Oxidase Norepinephrine Antidepressant Action Pathway Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway Phentermine Action Pathway Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway Phenylketonuria Safinamide Action Pathway Sarcosinemia Sarcosinemia Tranylcypromine Amine Oxidase Norepinephrine Antidepressant Action Pathway Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway Tyrosine Metabolism Tyrosinemia Type I Tyrosinemia Type I Tyrosinemia, Transient, of the Newborn Tyrosinemia, Transient, of the Newborn ( show more show less )
P27338 View in UniProt HMDBP00161 View in HMDB	Amine oxidase [flavin-containing] B Gene Name: MAOB Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.	Metabolic	Citalopram Action Pathway Citalopram Metabolism Pathway Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway Pargyline Action Pathway Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway Rasagiline Action Pathway Safinamide Action Pathway Selegiline Action Pathway ( show more show less )
P48728 View in UniProt HMDBP00688 View in HMDB	Aminomethyltransferase, mitochondrial Gene Name: AMT The glycine cleavage system catalyzes the degradation of glycine.	Metabolic	3-Phosphoglycerate Dehydrogenase Deficiency 3-Phosphoglycerate Dehydrogenase Deficiency Ammonia Recycling Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Glycine and Serine Metabolism Hyperglycinemia, Non-Ketotic Non-Ketotic Hyperglycinemia Non-Ketotic Hyperglycinemia Sarcosinemia Sarcosinemia ( show more show less )
P15144 View in UniProt HMDBP00448 View in HMDB	Aminopeptidase N Gene Name: ANPEP Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.	Metabolic	5-Oxoprolinase Deficiency 5-Oxoprolinase Deficiency 5-Oxoprolinuria 5-Oxoprolinuria gamma-Glutamyltransferase Deficiency gamma-Glutamyltransferase Deficiency gamma-Glutamyltranspeptidase Deficiency gamma-Glutamyltranspeptidase Deficiency Glutathione Metabolism Glutathione Synthetase Deficiency Glutathione Synthetase Deficiency ( show more show less )
P23109 View in UniProt HMDBP00657 View in HMDB	AMP deaminase 1 Gene Name: AMPD1 AMP deaminase plays a critical role in energy metabolism.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P12821 View in UniProt HMDBP01710 View in HMDB	Angiotensin-converting enzyme Gene Name: ACE Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety	Metabolic	ACE Angiotensin Metabolism Azilsartan medoxomil Action Pathway Benazepril ACE inhibitor Action Pathway Benazepril Action Pathway Benazepril Metabolism Pathway Candesartan Action Pathway Candesartan Action Pathway (New) Candesartan cilexetil Action Pathway Captopril Action Pathway Cilazapril ACE inhibitor Action Pathway Cilazapril Action Pathway Cilazapril Metabolism Pathway Enalapril ACE Inhibitor Action Pathway Enalapril Action Pathway Enalapril Metabolism Pathway Eprosartan Action Pathway Fimasartan Action Pathway Forasartan Action Pathway Forasartan Angiotensin Blocker Action Pathway Fosinopril ACE Inhibitor Action Pathway Fosinopril Action Pathway Fosinopril Metabolism Pathway Irbesartan Action Pathway Irbesartan Angiotensin blocker Action Pathway Lisinopril ACE Inhibitor Lisinopril Action Pathway Losartan Action Pathway Losartan Angiotensin blocker Action Pathway Moexipril ACE Inhibitor Action Pathway Moexipril Action Pathway Moexipril Metabolism Pathway Olmesartan Action Pathway Olmesartan ARB Action Pathway Perindopril ACE Inhibitor Action Pathway Perindopril Action Pathway Quinapril ACE Inhibitor Action Pathway Quinapril Action Pathway Quinapril Metabolism Pathway Ramipril ACE Inhibitor Action Pathway Ramipril Action Pathway Ramipril Metabolism Pathway Rescinnamine Action Pathway Saprisartan Action Pathway Spirapril Action Pathway Spirapril Metabolism Pathway Tasosartan Action Pathway Telmisartan Action Pathway Telmisartan Action Pathway (New) Temocapril Action Pathway Temocapril Metabolism Pathway Trandolapril ACE Inhibitor Action Pathway Trandolapril Action Pathway Trandolapril Metabolism Pathway Valsartan Action Pathway Valsartan Action Pathway (New) Zofenopril Action Pathway ( show more show less )
P01019 View in UniProt HMDBP02609 View in HMDB	Angiotensinogen Gene Name: AGT Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets	Metabolic	ACE Angiotensin Metabolism Azilsartan medoxomil Action Pathway Benazepril ACE inhibitor Action Pathway Benazepril Action Pathway Candesartan Action Pathway Candesartan Action Pathway (New) Candesartan cilexetil Action Pathway Captopril Action Pathway Cilazapril ACE inhibitor Action Pathway Cilazapril Action Pathway Enalapril ACE Inhibitor Action Pathway Enalapril Action Pathway Eprosartan Action Pathway Fimasartan Action Pathway Forasartan Action Pathway Forasartan Angiotensin Blocker Action Pathway Fosinopril ACE Inhibitor Action Pathway Fosinopril Action Pathway Irbesartan Action Pathway Irbesartan Angiotensin blocker Action Pathway Lisinopril ACE Inhibitor Lisinopril Action Pathway Losartan Action Pathway Losartan Angiotensin blocker Action Pathway Moexipril ACE Inhibitor Action Pathway Moexipril Action Pathway Olmesartan Action Pathway Olmesartan ARB Action Pathway Perindopril ACE Inhibitor Action Pathway Perindopril Action Pathway Quinapril ACE Inhibitor Action Pathway Quinapril Action Pathway Ramipril ACE Inhibitor Action Pathway Ramipril Action Pathway Rescinnamine Action Pathway Saprisartan Action Pathway Spirapril Action Pathway Tasosartan Action Pathway Telmisartan Action Pathway Telmisartan Action Pathway (New) Temocapril Action Pathway Trandolapril ACE Inhibitor Action Pathway Trandolapril Action Pathway Valsartan Action Pathway Valsartan Action Pathway (New) Zofenopril Action Pathway ( show more show less )
DB00029 View in DrugBank	Anistreplase	Metabolic	Anistreplase Action Pathway Anistreplase Action Pathway (new) Anistreplase Drug Metabolism
P01008 View in UniProt HMDBP01724 View in HMDB	Antithrombin-III Gene Name: SERPINC1 Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin	Metabolic	Ardeparin Action Pathway Ardeparin Action Pathway (new) Axitinib Action Pathway Bemiparin Action Pathway Brolucizumab Action Pathway Cabozantinib Action Pathway Certoparin Action Pathway Dalteparin Action Pathway Enoxaparin Action Pathway Enoxaparin Prothrombin Anticoagulation Action Pathway Enoxaparin. Faricimab Action Pathway Fondaparinux Action Pathway Fondaparinux. Heparin Heparin Action Pathway Heparin. Lenvatinib Action Pathway Midostaurin Action Pathway Nadroparin Action Pathway Nintedanib Action Pathway Parnaparin Action Pathway Pazopanib Action Pathway Pegaptanib Action Pathway Ramucirumab Action Pathway Regorafenib Action Pathway Reviparin Action Pathway Ripretinib Action Pathway Sulodexide Action Pathway Sunitinib Action Pathway Tinzaparin Action Pathway Tivozanib Action Pathway ( show more show less )
Q07812 View in UniProt	Apoptosis regulator BAX Gene Name: BAX Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.	Metabolic	p53 Signaling Pathway Vinblastine Action Pathway (New) Vincristine Action Pathway (New) Vindesine Action Pathway (New) Vinorelbine Action Pathway (New)
P10415 View in UniProt	Apoptosis regulator Bcl-2 Gene Name: BCL2 Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).	Metabolic	p53 Signaling Pathway Vinblastine Action Pathway (New) Vincristine Action Pathway (New) Vindesine Action Pathway (New) Vinorelbine Action Pathway (New)
Q9BRQ8 View in UniProt HMDBP08261 View in HMDB	Apoptosis-inducing factor 2 Gene Name: AIFM2 Oxidoreductase, which may play a role in mediating a TP53/p53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest	Metabolic	NAD+ Signalling Pathway (Cancer)
O14727 View in UniProt	Apoptotic protease-activating factor 1 Gene Name: APAF1 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.	Metabolic	D4-GDI Signaling Pathway p53 Signaling Pathway Vinblastine Action Pathway (New) Vincristine Action Pathway (New) Vindesine Action Pathway (New) Vinorelbine Action Pathway (New) ( show more show less )
O14727 View in UniProt HMDBP02284 View in HMDB	Apoptotic protease-activating factor 1 Gene Name: APAF1 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis	Metabolic	Ras Signaling Pathway
DB06692 View in DrugBank	Aprotinin	Metabolic	Aprotinin Action Pathway Aprotinin Drug Metabolism Aprotinin Kallikrein Antifibrinolytic Action Pathway Aprotinin Plasminogen Antifibrinolytic Action Pathway
P29972 View in UniProt HMDBP10782 View in HMDB	Aquaporin-1 Gene Name: AQP1 Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	Metabolic	Amiloride Action Pathway Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function - Descending Limb of the Loop of Henle Kidney Function- Proximal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway ( show more show less )
P41181 View in UniProt HMDBP02881 View in HMDB	Aquaporin-2 Gene Name: AQP2 Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	Metabolic	Amiloride Action Pathway Bendroflumethiazide Action Pathway Bendroflumethiazide Action Pathway (New) Benzthiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Chlorthalidone Diuretic Action Pathway Cyclothiazide Action Pathway Cyclothiazide Diuretic Action Pathway Cystinuria Desmopressin Action Pathway Eplerenone Action Pathway Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Finerenone Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydrochlorothiazide Diuretic Action Pathway Hydroflumethiazide Action Pathway Hydroflumethiazide Diuretic Action Pathway Iminoglycinuria Indapamide Action Pathway Indapamide Diuretic Action Pathway Kidney Function - Collecting Duct Kidney Function - Distal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Methyclothiazide Diuretic Action Pathway Metolazone Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Polythiazide Diuretic Action Pathway Quinethazone Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Spironolactone Action Pathway (New) Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway Trichlormethiazide Action Pathway (New) ( show more show less )
Q92482 View in UniProt HMDBP02583 View in HMDB	Aquaporin-3 Gene Name: AQP3 Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism	Metabolic	Amiloride Action Pathway Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Desmopressin Action Pathway Eplerenone Action Pathway Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Finerenone Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function - Collecting Duct Kidney Function - Distal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Spironolactone Action Pathway (New) Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway ( show more show less )
O14520 View in UniProt	Aquaporin-7 Gene Name: AQP7 Forms a channel for water and glycerol.	Metabolic	Arsenate Detoxification
O94778 View in UniProt	Aquaporin-8 Gene Name: AQP8 Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.	Metabolic	Ammonia Recycling
O43315 View in UniProt	Aquaporin-9 Gene Name: AQP9 Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.	Metabolic	Arsenate Detoxification Glycerol Kinase Deficiency
O75342 View in UniProt HMDBP03129 View in HMDB	Arachidonate 12-lipoxygenase, 12R-type Gene Name: ALOX12B Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	Metabolic	Acetaminophen Action Pathway Acetylsalicylic Acid Action Pathway Antipyrine Action Pathway Antrafenine Action Pathway Arachidonic Acid Metabolism Bromfenac Action Pathway Carprofen Action Pathway Celecoxib metabolism Pathway Diclofenac Action Pathway Diflunisal Action Pathway Etodolac Action Pathway Etoricoxib Action Pathway Fenoprofen Action Pathway Flurbiprofen Action Pathway Ibuprofen Action Pathway Indomethacin Action Pathway Ketoprofen Action Pathway Ketorolac Action Pathway Leukotriene C4 Synthesis Deficiency Lornoxicam Action Pathway Lumiracoxib Action Pathway Magnesium Salicylate Action Pathway Mefenamic Acid Action Pathway Meloxicam Action Pathway Nabumetone Action Pathway Naproxen Action Pathway Nepafenac Action Pathway Oxaprozin Action Pathway Phenylbutazone Action Pathway Piroxicam Action Pathway Rofecoxib Action Pathway Salicylate-Sodium Action Pathway Salicylic Acid Action Pathway Salsalate Action Pathway Sulindac Action Pathway Suprofen Action Pathway Tenoxicam Action Pathway Tiaprofenic Acid Action Pathway Tolmetin Action Pathway Trisalicylate-Choline Action Pathway Valdecoxib Action Pathway ( show more show less )
P18054 View in UniProt HMDBP00974 View in HMDB	Arachidonate 12-lipoxygenase, 12S-type Gene Name: ALOX12 Oxygenase and 14,15-leukotriene A4 synthase activity.	Metabolic	Acetaminophen Action Pathway Acetylsalicylic Acid Action Pathway Antipyrine Action Pathway Antrafenine Action Pathway Arachidonic Acid Metabolism Bromfenac Action Pathway Carprofen Action Pathway Celecoxib metabolism Pathway Diclofenac Action Pathway Diflunisal Action Pathway Etodolac Action Pathway Etoricoxib Action Pathway Fenoprofen Action Pathway Flurbiprofen Action Pathway Ibuprofen Action Pathway Indomethacin Action Pathway Ketoprofen Action Pathway Ketorolac Action Pathway Leukotriene C4 Synthesis Deficiency Lornoxicam Action Pathway Lumiracoxib Action Pathway Magnesium Salicylate Action Pathway Mefenamic Acid Action Pathway Meloxicam Action Pathway Nabumetone Action Pathway Naproxen Action Pathway Nepafenac Action Pathway Oxaprozin Action Pathway Phenylbutazone Action Pathway Piroxicam Action Pathway Rofecoxib Action Pathway Salicylate-Sodium Action Pathway Salicylic Acid Action Pathway Salsalate Action Pathway Sulindac Action Pathway Suprofen Action Pathway Tenoxicam Action Pathway Tiaprofenic Acid Action Pathway Tolmetin Action Pathway Trisalicylate-Choline Action Pathway Valdecoxib Action Pathway ( show more show less )
P16050 View in UniProt HMDBP00977 View in HMDB	Arachidonate 15-lipoxygenase Gene Name: ALOX15 Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid.	Metabolic	Acetaminophen Action Pathway Acetylsalicylic Acid Action Pathway Antipyrine Action Pathway Antrafenine Action Pathway Arachidonic Acid Metabolism Bromfenac Action Pathway Carprofen Action Pathway Celecoxib metabolism Pathway Diclofenac Action Pathway Diflunisal Action Pathway Etodolac Action Pathway Etoricoxib Action Pathway Fenoprofen Action Pathway Flurbiprofen Action Pathway Ibuprofen Action Pathway Indomethacin Action Pathway Ketoprofen Action Pathway Ketorolac Action Pathway Leukotriene C4 Synthesis Deficiency Lornoxicam Action Pathway Lumiracoxib Action Pathway Magnesium Salicylate Action Pathway Mefenamic Acid Action Pathway Meloxicam Action Pathway Nabumetone Action Pathway Naproxen Action Pathway Nepafenac Action Pathway Oxaprozin Action Pathway Phenylbutazone Action Pathway Piroxicam Action Pathway Rofecoxib Action Pathway Salicylate-Sodium Action Pathway Salicylic Acid Action Pathway Salsalate Action Pathway Sulindac Action Pathway Suprofen Action Pathway Tenoxicam Action Pathway Tiaprofenic Acid Action Pathway Tolmetin Action Pathway Trisalicylate-Choline Action Pathway Valdecoxib Action Pathway ( show more show less )
O15296 View in UniProt HMDBP00973 View in HMDB	Arachidonate 15-lipoxygenase B Gene Name: ALOX15B Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.	Metabolic	Acetaminophen Action Pathway Acetylsalicylic Acid Action Pathway Antipyrine Action Pathway Antrafenine Action Pathway Arachidonic Acid Metabolism Bromfenac Action Pathway Carprofen Action Pathway Celecoxib metabolism Pathway Diclofenac Action Pathway Diflunisal Action Pathway Etodolac Action Pathway Etoricoxib Action Pathway Fenoprofen Action Pathway Flurbiprofen Action Pathway Ibuprofen Action Pathway Indomethacin Action Pathway Ketoprofen Action Pathway Ketorolac Action Pathway Leukotriene C4 Synthesis Deficiency Lornoxicam Action Pathway Lumiracoxib Action Pathway Magnesium Salicylate Action Pathway Mefenamic Acid Action Pathway Meloxicam Action Pathway Nabumetone Action Pathway Naproxen Action Pathway Nepafenac Action Pathway Oxaprozin Action Pathway Phenylbutazone Action Pathway Piroxicam Action Pathway Rofecoxib Action Pathway Salicylate-Sodium Action Pathway Salicylic Acid Action Pathway Salsalate Action Pathway Sulindac Action Pathway Suprofen Action Pathway Tenoxicam Action Pathway Tiaprofenic Acid Action Pathway Tolmetin Action Pathway Trisalicylate-Choline Action Pathway Valdecoxib Action Pathway ( show more show less )
P09917 View in UniProt HMDBP00972 View in HMDB	Arachidonate 5-lipoxygenase Gene Name: ALOX5 Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.	Metabolic	Acetaminophen Action Pathway Acetylsalicylic Acid Action Pathway Antipyrine Action Pathway Antrafenine Action Pathway Arachidonic Acid Metabolism Balsalazide Action Pathway Bromfenac Action Pathway Carprofen Action Pathway Celecoxib metabolism Pathway Diclofenac Action Pathway Diflunisal Action Pathway Etodolac Action Pathway Etoricoxib Action Pathway Fenoprofen Action Pathway Flurbiprofen Action Pathway Ibuprofen Action Pathway Indomethacin Action Pathway Ketoprofen Action Pathway Ketorolac Action Pathway Leukotriene C4 Synthesis Deficiency Lornoxicam Action Pathway Lumiracoxib Action Pathway Magnesium Salicylate Action Pathway Mefenamic Acid Action Pathway Meloxicam Action Pathway Mesalazine Action Pathway Nabumetone Action Pathway Naproxen Action Pathway Nepafenac Action Pathway Olsalazine Action Pathway Oxaprozin Action Pathway Phenylbutazone Action Pathway Piroxicam Action Pathway Rofecoxib Action Pathway Salicylate-Sodium Action Pathway Salicylic Acid Action Pathway Salsalate Action Pathway Sulfasalazine Action Pathway Sulindac Action Pathway Suprofen Action Pathway Tenoxicam Action Pathway Tiaprofenic Acid Action Pathway Tolmetin Action Pathway Trisalicylate-Choline Action Pathway Valdecoxib Action Pathway ( show more show less )
P53365 View in UniProt HMDBP08309 View in HMDB	Arfaptin-2 Gene Name: ARFIP2 Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling	Metabolic	Rac 1 Cell Motility Signaling Pathway
P05089 View in UniProt HMDBP00298 View in HMDB	Arginase-1 Gene Name: ARG1	Metabolic	Anti-inflammatory pathway Arginine and Proline Metabolism Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Argininemia Argininemia Argininosuccinic Aciduria Argininosuccinic Aciduria Carbamoyl Phosphate Synthetase Deficiency Carbamoyl Phosphate Synthetase Deficiency Citrullinemia Type I Citrullinemia Type I Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperprolinemia Type I Hyperprolinemia Type I Hyperprolinemia Type II Hyperprolinemia Type II L-Arginine:Glycine Amidinotransferase Deficiency L-Arginine:Glycine Amidinotransferase Deficiency Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Prolidase Deficiency (PD) Prolinemia Type II Prolinemia Type II T Cell Exhaustion Urea Cycle ( show more show less )
P54136 View in UniProt HMDBP00591 View in HMDB	Arginine--tRNA ligase, cytoplasmic Gene Name: RARS Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.	Metabolic	Protein Synthesis: Arginine
P04424 View in UniProt HMDBP00697 View in HMDB	Argininosuccinate lyase Gene Name: ASL	Metabolic	Arginine and Proline Metabolism Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Argininemia Argininemia Argininosuccinic Aciduria Argininosuccinic Aciduria Aspartate Metabolism Canavan Disease Canavan Disease Carbamoyl Phosphate Synthetase Deficiency Carbamoyl Phosphate Synthetase Deficiency Citrullinemia Type I Citrullinemia Type I Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperprolinemia Type I Hyperprolinemia Type I Hyperprolinemia Type II Hyperprolinemia Type II Hypoacetylaspartia Hypoacetylaspartia L-Arginine:Glycine Amidinotransferase Deficiency L-Arginine:Glycine Amidinotransferase Deficiency Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine Metabolsim and Physiological Effects of Argininic acid Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Prolidase Deficiency (PD) Prolinemia Type II Prolinemia Type II T Cell Exhaustion Urea Cycle ( show more show less )
P00966 View in UniProt HMDBP00656 View in HMDB	Argininosuccinate synthase Gene Name: ASS1	Metabolic	Arginine and Proline Metabolism Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Argininemia Argininemia Argininosuccinic Aciduria Argininosuccinic Aciduria Aspartate Metabolism Canavan Disease Canavan Disease Carbamoyl Phosphate Synthetase Deficiency Carbamoyl Phosphate Synthetase Deficiency Citrullinemia Type I Citrullinemia Type I Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperprolinemia Type I Hyperprolinemia Type I Hyperprolinemia Type II Hyperprolinemia Type II Hypoacetylaspartia Hypoacetylaspartia L-Arginine:Glycine Amidinotransferase Deficiency L-Arginine:Glycine Amidinotransferase Deficiency Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine Metabolsim and Physiological Effects of Argininic acid Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Prolidase Deficiency (PD) Prolinemia Type II Prolinemia Type II T Cell Exhaustion Urea Cycle ( show more show less )
P20711 View in UniProt HMDBP00278 View in HMDB	Aromatic-L-amino-acid decarboxylase Gene Name: DDC Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.	Metabolic	Dolasetron Serotonin antagonist Action Pathway Dosulepin Serotonin antagonist Action Pathway Acepromazine - Serotonin Antagonist Action Pathway Acepromazine Dopamine Antagonist Action Pathway Agomelatine Serotonin Antagonist Action Pathway Alkaptonuria Amine Oxidase Norepinephrine Amine Oxidase Serotonin Amisulpride Serotonin Antagonist Action Pathway Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway Amitriptyline Serotonin Antagonist Action Pathway Amoxapine SSRI Action Pathway Amphetamine Neurological Action Pathway Apomorphine Mechanism of Action Action Pathway Aripiprazole Dopamine agonist Action Pathway Aripiprazole Serotonin Agonist Action Pathway Aromatic L-Aminoacid Decarboxylase Deficiency Aromatic L-Aminoacid Decarboxylase Deficiency Asenapine Dopamine Antagonist Action Pathway Asenapine Serotonin antagonist Action Pathway Atomoxetine Action Pathway (New) Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Brexpiprazole Dopamine Agonist Action Pathway Brexpiprazole Serotonin Action Action Pathway Bromocriptine Mechanism of Action Action Pathway Bromopride Dopamine Antagonist Action Pathway Bupropion Action Pathway Cabergoline Mechanism of Action Action Pathway Cariprazine Mechanism of Action Action Pathway Catecholamine Biosynthesis Chlorpromazine - Dopamine Antagonist Action Pathway Chlorpromazine - Serotonin Antagonist Action Pathway Chlorprothixene Dopamine Antagonist Action Pathway Chlorprothixene Serotonin Antagonist Action Pathway Citalopram Mechanism of Action Action Pathway New Clomipramine Action Pathway (New) Clozapine Dopamine Antagonist Action Pathway Clozapine Serotonin Antagonist Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cocaine Norepinephrine Reuptake Inhibitor Action Pathway Cyclobenzaprine Serotonin antagonist Action Pathway Cyproheptadine Serotonin Antagonist Action Pathway Desipramine Action Pathway (New) Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway Desvenlafaxine SNRI - Serotonin reuptake Inhibition Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Disulfiram Action Pathway Domperidone Mechanism of Action Action Pathway Dopamine beta-Hydroxylase Deficiency Dopamine beta-Hydroxylase Deficiency Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) Droperidol Mechanism of Action Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Duloxetine SNRI - Serotonin reuptake Inhibition Action Pathway Epicriptine Mechanism of Action Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Escitalopram Mechanism of Action Action Pathway New Flibanserin Serotonin Action Action Pathway Fluoxetine - Serotonin reuptake Inhibition Action Pathway Flupentixol Dopamine Antagonist Action Pathway Flupentixol Serotonin Antagonist Action Pathway Fluphenazine Mechanism of Action Action Pathway Fluspirilene Mechanism of Action Action Pathway Fluvoxamine Mechanism of Action Action Pathway New Granisetron Serotonin antagonist Action Pathway Haloperidol Dopamine Antagonist Action Pathway Hawkinsinuria Hawkinsinuria Iloperidone Serotonin antagonist Action Pathway Imipramine Action Pathway (New) Isocarboxazid Amine Oxidase Norepinephrine Antidepressant Action Pathway Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway Levodopa Metabolism Pathway Levodopa Pahway Levomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Levomilnacipran SNRI - Serotonin Reuptake Inhibition Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Lisuride Dopamine Agonist Action Pathway Lorpiprazole Serotonin antagonist Action Pathway Loxapine Dopamine Antagonist Action Pathway Lumateperone Dopamine Action Action Pathway Lumateperone Serotonin Antagonist Action Pathway Lumateperone SSRI Action Action Pathway Lurasidone Dopamine Antagonist Action Pathway Lurasidone Serotonin Antagonist Action Pathway Maprotiline Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Mesoridazine Dopamine Antagonist Action Pathway Mesoridazine Serotonin Antagonist Action Pathway Metabolism and Physiological Effects of Phenylacetic Acid Methamphetamine Dopamine Reuptake Inhibitor Action Pathway Methamphetamine Norepinephrine Reuptake Inhibitor Action Pathway Methamphetamine Serotonin Reuptake Inhibitor Action Pathway Methotrimeprazine Dopamine Antagonist Action Pathway Methyldopa Action Pathway Methyldopa Metabolism Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Methysergide Mechanism of Action Action Pathway Metoclopramide - Dopamine Antagonist Action Pathway Milnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Milnacipran SNRI - Serotonin reuptake Inhibition Action Pathway Minaprine Amine oxidase Norepinephrine Antidepressant Action Pathway Minaprine Serotonin Antagonist Action Pathway Minaprine Serotonin receptor Antidepressant Action Pathway Mirtazapine Serotonin Antagonist Action Pathway Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway Moclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway Modafinil Action Pathway Monoamine Oxidase-A Deficiency (MAO-A) Monoamine Oxidase-A Deficiency (MAO-A) Neuronal Dopamine Gs Cascade Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norepinephrine Neurological Nortriptyline Action Pathway Olanzapine Dopamine Antagonist Action Pathway Olanzapine Serotonin Antagonist Action Pathway Ondansetron Serotonin antagonist Action Pathway Paliperidone Dopamine Antagonist Action Pathway Paliperidone Serotonin Antagonist Action Pathway Palonosetron Serotonin antagonist Action Pathway Pargyline Action Pathway Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway Paroxetine Mechanism of Action Action Pathway New Pergolide Mechanism of Action Action Pathway Perphenazine Mechanism of Action Action Pathway Phenelzine Amine Oxidase Norepinephrine Antidepressant Action Pathway Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway Phentermine Action Pathway Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway Phenylketonuria Pimozide Mechanism of Action Action Pathway Pipotiazine Dopamine Antagonist Action Pathway Pipotiazine Serotonin antagonist Action Pathway Pramipexole Mechanism of Action Action Pathway Prochlorperazine - Dopamine Antagonist Action Pathway Prochlorperazine Mechanism of Action Action Pathway Promazine Mechanism of Action Action Pathway Quetiapine Dopamine Antagonist Action Pathway Quetiapine Serotonin Antagonist Action Pathway Quinagolide Mechanism of Action Action Pathway Rasagiline Action Pathway Remoxipride Mechanism of Action Action Pathway Risperidone Dopamine Antagonist Action Pathway Risperidone Serotonin Antagonist Action Pathway Ropinirole Mechanism of Action Action Pathway Rotigotine Dopamine Agonist Action Pathway Safinamide Action Pathway Segawa Syndrome Selegiline Action Pathway Sepiapterin Reductase Deficiency Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sertraline Mechanism of Action Action Pathway New Sibutramine Dopamine Reuptake Inhibitor Action Pathway Solriamfetol Action Pathway Sulpiride Mechanism of Action Action Pathway Thiethylperazine Dopamine Antagonist Action Pathway Thiethylperazine Serotonin Antagonist Action Pathway Thioridazine Dopamine Antagonist Action Pathway Thioridazine Serotonin Antagonist Action Pathway Thiothixene Dopamine Antagonist Action Pathway Tiapride Dopamine Antagonist Action Pathway Tiapride Serotonin Antagonist Action Pathway Tranylcypromine Amine Oxidase Norepinephrine Antidepressant Action Pathway Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway Trifluoperazine Dopamine Antagonist Action Pathway Triflupromazine - Dopamine Antagonist Action Pathway Triflupromazine Mechanism of Action Action Pathway Triflupromazine Serotonin Antagonist Action Pathway Trimipramine Action Pathway Tropisetron Serotonin antagonist Action Pathway Tryptophan Metabolism Tyrosine Hydroxylase Deficiency Tyrosine Hydroxylase Deficiency Tyrosine Metabolism Tyrosinemia Type I Tyrosinemia Type I Tyrosinemia, Transient, of the Newborn Tyrosinemia, Transient, of the Newborn Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Vilazodone mechanism of Action Action Pathway Vortioxetine Serotonin Action Action Pathway Ziprasidone Dopamine Antagonist Action Pathway Ziprasidone Serotonin Action Action Pathway Zuclopenthixol Dopamine Antagonist Action Pathway ( show more show less )
Q9HBK9 View in UniProt HMDBP00408 View in HMDB	Arsenite methyltransferase Gene Name: AS3MT Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).	Metabolic	Arsenate Detoxification
P35869 View in UniProt HMDBP01861 View in HMDB	Aryl hydrocarbon receptor Gene Name: AHR Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues	Metabolic	Ahr Signal Transduction Pathway
P35869 View in UniProt	Aryl hydrocarbon receptor Gene Name: AHR Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.	Metabolic	Ahr Signal Transduction Pathway Anti-inflammatory pathway Bacterial Sepsis Metabolism and Physiological Effects of 2-Aminobenzoic acid Metabolism and Physiological Effects of Kynurenine Viral Sepsis ( show more show less )
P35869 View in UniProt	Aryl hydrocarbon receptor Gene Name: AHR Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.	Metabolic	Ahr Signal Transduction Pathway
P27540 View in UniProt	Aryl hydrocarbon receptor nuclear translocator Gene Name: ARNT Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.	Metabolic	Ahr Signal Transduction Pathway
P27540 View in UniProt	Aryl hydrocarbon receptor nuclear translocator Gene Name: ARNT Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.	Metabolic	Ahr Signal Transduction Pathway
A4Z6T9 View in UniProt HMDBP09128 View in HMDB	Arylamine N-acetyltransferase 2 Gene Name: NAT2	Metabolic	Caffeine Metabolism
P15289 View in UniProt HMDBP00320 View in HMDB	Arylsulfatase A Gene Name: ARSA Hydrolyzes cerebroside sulfate.	Metabolic	Fabry Disease Fabry Disease Gaucher Disease Gaucher Disease Globoid Cell Leukodystrophy Globoid Cell Leukodystrophy Krabbe Disease Metachromatic Leukodystrophy (MLD) Metachromatic Leukodystrophy (MLD) Sphingolipid Metabolism ( show more show less )
P08243 View in UniProt HMDBP00583 View in HMDB	Asparagine synthetase [glutamine-hydrolyzing] Gene Name: ASNS	Metabolic	Ammonia Recycling Aspartate Metabolism Canavan Disease Canavan Disease Hypoacetylaspartia Hypoacetylaspartia ( show more show less )
O43776 View in UniProt HMDBP00611 View in HMDB	Asparagine--tRNA ligase, cytoplasmic Gene Name: NARS	Metabolic	Aspartate Metabolism Canavan Disease Canavan Disease Hypoacetylaspartia Hypoacetylaspartia Protein Synthesis: Asparagine ( show more show less )
P17174 View in UniProt HMDBP00283 View in HMDB	Aspartate aminotransferase, cytoplasmic Gene Name: GOT1 Plays a key role in amino acid metabolism (By similarity).	Metabolic	Alkaptonuria Arginine and Proline Metabolism Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) beta-Mercaptolactate-Cysteine Disulfiduria beta-Mercaptolactate-Cysteine Disulfiduria Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Cysteine Metabolism Cystinosis, Ocular Nonnephropathic Cystinosis, Ocular Nonnephropathic Disulfiram Action Pathway Dopamine beta-Hydroxylase Deficiency Dopamine beta-Hydroxylase Deficiency Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Hawkinsinuria Hawkinsinuria Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperprolinemia Type I Hyperprolinemia Type I Hyperprolinemia Type II Hyperprolinemia Type II L-Arginine:Glycine Amidinotransferase Deficiency L-Arginine:Glycine Amidinotransferase Deficiency Monoamine Oxidase-A Deficiency (MAO-A) Monoamine Oxidase-A Deficiency (MAO-A) Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Aminotransferase Deficiency (OAT Deficiency) Phenylalanine and Tyrosine Metabolism Phenylketonuria Prolidase Deficiency (PD) Prolinemia Type II Prolinemia Type II Tyrosine Metabolism Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Tyrosinemia Type 3 (TYRO3) Tyrosinemia Type 3 (TYRO3) Tyrosinemia Type I Tyrosinemia Type I Tyrosinemia, Transient, of the Newborn Tyrosinemia, Transient, of the Newborn ( show more show less )
P00505 View in UniProt HMDBP00284 View in HMDB	Aspartate aminotransferase, mitochondrial Gene Name: GOT2 Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.	Metabolic	2-Hydroxyglutric Aciduria (D and L Form) 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency Argininemia Argininemia Argininosuccinic Aciduria Argininosuccinic Aciduria Carbamoyl Phosphate Synthetase Deficiency Carbamoyl Phosphate Synthetase Deficiency Citrullinemia Type I Citrullinemia Type I Glutamate Metabolism Glutaminolysis and Cancer Homocarnosinosis Homocarnosinosis Hyperinsulinism-Hyperammonemia Syndrome Hyperinsulinism-Hyperammonemia Syndrome Malate-Aspartate Shuttle Metabolism and Physiological Effects of Oxalic acid Ornithine Transcarbamylase Deficiency (OTC Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Succinic Semialdehyde Dehydrogenase Deficiency Urea Cycle ( show more show less )
P14868 View in UniProt HMDBP00608 View in HMDB	Aspartate--tRNA ligase, cytoplasmic Gene Name: DARS Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.	Metabolic	Aspartate Metabolism Canavan Disease Canavan Disease Hypoacetylaspartia Hypoacetylaspartia Protein Synthesis: Aspartic Acid ( show more show less )
P45381 View in UniProt HMDBP00555 View in HMDB	Aspartoacylase Gene Name: ASPA Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.	Metabolic	Aspartate Metabolism Canavan Disease Canavan Disease Hypoacetylaspartia Hypoacetylaspartia
Q06055 View in UniProt	ATP synthase lipid-binding protein, mitochondrial Gene Name: ATP5G2	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
P00846 View in UniProt	ATP synthase subunit a Gene Name: MT-ATP6	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
P25705 View in UniProt HMDBP01448 View in HMDB	ATP synthase subunit alpha, mitochondrial Gene Name: ATP5A1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
P24539 View in UniProt HMDBP01419 View in HMDB	ATP synthase subunit b, mitochondrial Gene Name: ATP5F1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
P06576 View in UniProt HMDBP01465 View in HMDB	ATP synthase subunit beta, mitochondrial Gene Name: ATP5B Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
P30049 View in UniProt	ATP synthase subunit delta, mitochondrial Gene Name: ATP5D	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
P56381 View in UniProt HMDBP01206 View in HMDB	ATP synthase subunit epsilon, mitochondrial Gene Name: ATP5E Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
P36542 View in UniProt HMDBP01343 View in HMDB	ATP synthase subunit gamma, mitochondrial Gene Name: ATP5C1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits	Metabolic	Clodronic Acid Action Pathway Etidronic Acid Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Mitochondrial Electron Transport Chain Tiludronic Acid Action Pathway
Q09428 View in UniProt HMDBP10762 View in HMDB	ATP-binding cassette sub-family C member 8 Gene Name: ABCC8 Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release	Metabolic	Amifampridine Action Pathway Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Bendroflumethiazide Action Pathway (New) Benzthiazide Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Chlorothiazide Action Pathway Chlorpropamide Action Pathway Chlorthalidone Diuretic Action Pathway Cyclothiazide Diuretic Action Pathway Dalfampridine Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dofetilide Action Pathway Domperidone Mechanism of Action Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Flavoxate Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Glibenclamide Action Pathway Gliclazide Action Pathway Gliclazide Action Pathway (New) Glimepiride Action Pathway Glipizide Action Pathway Gliquidone Action Pathway Glyburide Action Pathway Hydrochlorothiazide Diuretic Action Pathway Hydroflumethiazide Diuretic Action Pathway Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Ibutilide Action Pathway Indapamide Diuretic Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Magnesium Sulfate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methyclothiazide Diuretic Action Pathway Metipranolol Action Pathway Metolazone Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nateglinide Action Pathway Nateglinide Action Pathway (New) Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Pancreas Function - Alpha Cell Pancreas Function - Beta Cell Pancreas Function - Delta Cell Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pindolol Action Pathway Polythiazide Diuretic Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propiverine Action Pathway Propranolol Action Pathway Quinethazone Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Repaglinide Action Pathway Repaglinide Action Pathway (New) Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Sitagliptin Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Tolazamide Action Pathway Tolbutamide Action Pathway Trichlormethiazide Action Pathway (New) Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway ( show more show less )
O60706 View in UniProt	ATP-binding cassette sub-family C member 9	Metabolic	Amifampridine Action Pathway Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Bendroflumethiazide Action Pathway (New) Benzthiazide Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Chlorothiazide Action Pathway Chlorthalidone Diuretic Action Pathway Cyclothiazide Diuretic Action Pathway Dalfampridine Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dofetilide Action Pathway Domperidone Mechanism of Action Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Flavoxate Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Hydrochlorothiazide Diuretic Action Pathway Hydroflumethiazide Diuretic Action Pathway Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Ibutilide Action Pathway Indapamide Diuretic Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Magnesium Sulfate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methyclothiazide Diuretic Action Pathway Metipranolol Action Pathway Metolazone Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pindolol Action Pathway Polythiazide Diuretic Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propiverine Action Pathway Propranolol Action Pathway Quinethazone Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Trichlormethiazide Action Pathway (New) Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway ( show more show less )
P33897 View in UniProt	ATP-binding cassette sub-family D member 1	Metabolic	Adrenoleukodystrophy, X-Linked Adrenoleukodystrophy, X-Linked Beta Oxidation of Very Long Chain Fatty Acids Carnitine-Acylcarnitine Translocase Deficiency Carnitine-Acylcarnitine Translocase Deficiency Oxidation of Branched-Chain Fatty Acids Phytanic Acid Peroxisomal Oxidation Refsum Disease Refsum Disease ( show more show less )
Q9UBJ2 View in UniProt	ATP-binding cassette sub-family D member 2	Metabolic	Adrenoleukodystrophy, X-Linked Adrenoleukodystrophy, X-Linked Beta Oxidation of Very Long Chain Fatty Acids Carnitine-Acylcarnitine Translocase Deficiency Carnitine-Acylcarnitine Translocase Deficiency Oxidation of Branched-Chain Fatty Acids Phytanic Acid Peroxisomal Oxidation Refsum Disease Refsum Disease ( show more show less )
Q9UNQ0 View in UniProt HMDBP02257 View in HMDB	ATP-binding cassette sub-family G member 2 Gene Name: ABCG2 Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123	Metabolic	Acetaminophen Metabolism Pathway Docetaxel Action Pathway Doxorubicin Metabolism Pathway Erlotinib Action Pathway Gout or Kelley-Seegmiller Syndrome Irinotecan Action Pathway Irinotecan Metabolism Pathway Lamivudine Metabolism Pathway Metabolism and Physiological Effects of Uric acid Mycophenolic Acid Metabolism Pathway (old) Paclitaxel Action Pathway (old) Purine Nucleoside Phosphorylase Deficiency ( show more show less )
P53396 View in UniProt HMDBP00010 View in HMDB	ATP-citrate synthase Gene Name: ACLY ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.	Metabolic	Citrate Immunometabolism Pathway Glutaminolysis and Cancer LPS and Citrate Signaling and Inflammation Transfer of Acetyl Groups into Mitochondria
Q14654 View in UniProt HMDBP02918 View in HMDB	ATP-sensitive inward rectifier potassium channel 11 Gene Name: KCNJ11 This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	Metabolic	Amifampridine Action Pathway Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Bendroflumethiazide Action Pathway (New) Benzthiazide Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Chlorothiazide Action Pathway Chlorthalidone Diuretic Action Pathway Cyclothiazide Diuretic Action Pathway Dalfampridine Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dofetilide Action Pathway Domperidone Mechanism of Action Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Flavoxate Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Hydrochlorothiazide Diuretic Action Pathway Hydroflumethiazide Diuretic Action Pathway Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Ibutilide Action Pathway Indapamide Diuretic Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Magnesium Sulfate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methyclothiazide Diuretic Action Pathway Metipranolol Action Pathway Metolazone Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pindolol Action Pathway Polythiazide Diuretic Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propiverine Action Pathway Propranolol Action Pathway Quinethazone Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Trichlormethiazide Action Pathway (New) Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway ( show more show less )
Q15842 View in UniProt HMDBP08745 View in HMDB	ATP-sensitive inward rectifier potassium channel 8 Gene Name: KCNJ8 This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium	Metabolic	Amifampridine Action Pathway Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Bendroflumethiazide Action Pathway (New) Benzthiazide Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Chlorothiazide Action Pathway Chlorthalidone Diuretic Action Pathway Cyclothiazide Diuretic Action Pathway Dalfampridine Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dofetilide Action Pathway Domperidone Mechanism of Action Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Flavoxate Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Hydrochlorothiazide Diuretic Action Pathway Hydroflumethiazide Diuretic Action Pathway Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Ibutilide Action Pathway Indapamide Diuretic Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Magnesium Sulfate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methyclothiazide Diuretic Action Pathway Metipranolol Action Pathway Metolazone Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pindolol Action Pathway Polythiazide Diuretic Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propiverine Action Pathway Propranolol Action Pathway Quinethazone Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Trichlormethiazide Action Pathway (New) Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway ( show more show less )
Q8NBU5 View in UniProt HMDBP11625 View in HMDB	ATPase family AAA domain-containing protein 1 Gene Name: ATAD1 ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
B7ZKV8 View in UniProt	ATPase, (Na+)/K+ transporting, beta 4 polypeptide	Metabolic	3-Methylthiofentanyl Action Pathway Acebutolol Action Pathway Alfentanil Action Pathway Alprenolol Action Pathway Alvimopan Action Pathway Amiloride Action Pathway Amiloride Action Pathway (New) Amiodarone Action Pathway Amlodipine Action Pathway Anileridine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Atropine M2 Cardiac Muscle Contraction Action Pathway Bendroflumethiazide Action Pathway Bendroflumethiazide Action Pathway (New) Benzocaine Action Pathway Benzthiazide Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Blue Diaper Syndrome Bopindolol Action Pathway Bumetanide Action Pathway Bumetanide Diruretic Action Pathway Bupivacaine Action Pathway Bupranolol Action Pathway Buprenorphine Action Pathway Carfentanil Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Chloroprocaine Action Pathway Chlorothiazide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Chlorthalidone Diuretic Action Pathway Citalopram Action Pathway Cocaine Action Pathway Codeine Action Pathway Cyclothiazide Action Pathway Cyclothiazide Diuretic Action Pathway Cystinuria Desipramine Action Pathway Dezocine Action Pathway Dibucaine Action Pathway Digoxin Cardiac Action Pathway Dihydromorphine Action Pathway Diltiazem Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Epinephrine Action Pathway Eplerenone Action Pathway Eplerenone Action Pathway (Old) Escitalopram Action Pathway Esmolol Action Pathway Esomeprazole Action Pathway Ethacrynic Acid Action Pathway Ethacrynic Acid Diuretic Action Pathway Ethylmorphine Action Pathway Felodipine Action Pathway Fentanyl Action Pathway Finerenone Action Pathway Flecainide Action Pathway Fluoxetine Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Furosemide Action Pathway Furosemide Diuretic Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydrochlorothiazide Diuretic Action Pathway Hydrocodone Action Pathway Hydroflumethiazide Action Pathway Hydroflumethiazide Diuretic Action Pathway Hydromorphone Action Pathway Ibutilide Action Pathway Iminoglycinuria Imipramine Indapamide Action Pathway Indapamide Diuretic Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Ketobemidone Action Pathway Kidney Function - Ascending Limb of The Loop of Henle Kidney Function - Collecting Duct Kidney Function - Distal Convoluted Tubule Labetalol Action Pathway Lactose Degradation Lactose Intolerance Lactose Intolerance Lansoprazole Action Pathway Levallorphan Action Pathway Levobunolol Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Long-Chain Acylcarnitine-induced lipotoxicity: targets for treatment Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Mepivacaine Action Pathway Methadone Action Pathway Methadyl Acetate Action Pathway Methyclothiazide Action Pathway Methyclothiazide Diuretic Action Pathway Metipranolol Action Pathway Metolazone Action Pathway Metolazone Action Pathway (old) Metoprolol Action Pathway Mexiletine Action Pathway Morphine Action Pathway Nadolol Action Pathway Nalbuphine Action Pathway Naloxone Action Pathway Naltrexone Action Pathway Nebivolol Action Pathway Neuron Function Nicotine Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Omeprazole Action Pathway Oxprenolol Action Pathway Oxybuprocaine Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Pantoprazole Action Pathway Penbutolol Action Pathway Pentazocine Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Polythiazide Action Pathway Polythiazide Diuretic Action Pathway Practolol Action Pathway Prilocaine Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procaine Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Propranolol Action Pathway Quinethazone Action Pathway Quinethazone Action Pathway (old) Quinidine Action Pathway Rabeprazole Antacid Action Pathway Remifentanil Action Pathway Ropivacaine Action Pathway Sotalol Action Pathway Spironolactone Action Pathway Spironolactone Action Pathway (New) Striated Muscle Contraction Sufentanil Action Pathway Timolol Action Pathway Tocainide Action Pathway Torasemide Action Pathway (New) Torsemide Action Pathway Tramadol Action Action Pathway Trehalose Degradation Triamterene Action Pathway Triamterene Action Pathway (New) Trichlormethiazide Action Pathway Trichlormethiazide Action Pathway (New) Verapamil Action Pathway ( show more show less )
P16066 View in UniProt HMDBP01069 View in HMDB	Atrial natriuretic peptide receptor 1 Gene Name: NPR1 Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.	Metabolic	Circadian Rhythms NAD+ Signalling and Aging
P82251 View in UniProt HMDBP01816 View in HMDB	B(0,+)-type amino acid transporter 1 Gene Name: SLC7A9 Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule	Metabolic	Amiloride Action Pathway Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Iminoglycinuria Indapamide Action Pathway Kidney Function- Proximal Convoluted Tubule Levodopa Metabolism Pathway Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Metabolism and Physiological Effects of 2-Aminobenzoic acid Metabolism and Physiological Effects of Kynurenine Metabolism and Physiological Effects of Quinolinic Acid Methyclothiazide Action Pathway Metolazone Action Pathway (old) Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway ( show more show less )
P11912 View in UniProt	B-cell antigen receptor complex-associated protein alpha chain Gene Name: CD79A Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.	Metabolic	BCR Signaling Pathway
P40259 View in UniProt	B-cell antigen receptor complex-associated protein beta chain Gene Name: CD79B Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.	Metabolic	BCR Signaling Pathway
Q8WV28 View in UniProt	B-cell linker protein Gene Name: BLNK Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.	Metabolic	BCR Signaling Pathway

Showing 226 - 300 of 1576 proteins

Browsing Proteins

Protein ID

Protein Description

Pathway Class

Pathways

Q06203

HMDBP00331

Amidophosphoribosyltransferase

P19801

HMDBP00390

Amiloride-sensitive amine oxidase [copper-containing]

P37088

HMDBP02267

Amiloride-sensitive sodium channel subunit alpha

P51168

HMDBP09092

Amiloride-sensitive sodium channel subunit beta

P51172

HMDBP09093

Amiloride-sensitive sodium channel subunit delta

P51170

HMDBP02930

Amiloride-sensitive sodium channel subunit gamma

P21397

HMDBP00169

Amine oxidase [flavin-containing] A

P27338

HMDBP00161

Amine oxidase [flavin-containing] B

P48728

HMDBP00688

Aminomethyltransferase, mitochondrial

P15144

HMDBP00448

Aminopeptidase N

P23109

HMDBP00657

AMP deaminase 1

P12821

HMDBP01710

Angiotensin-converting enzyme

P01019

HMDBP02609

Angiotensinogen

DB00029

Anistreplase

P01008

HMDBP01724

Antithrombin-III

Q07812

Apoptosis regulator BAX

P10415

Apoptosis regulator Bcl-2

Q9BRQ8

HMDBP08261

Apoptosis-inducing factor 2

O14727

Apoptotic protease-activating factor 1

O14727

HMDBP02284

Apoptotic protease-activating factor 1

DB06692

Aprotinin

P29972

HMDBP10782

Aquaporin-1

P41181

HMDBP02881

Aquaporin-2

Q92482

HMDBP02583

Aquaporin-3

O14520

Aquaporin-7

O94778

Aquaporin-8

O43315

Aquaporin-9

O75342

HMDBP03129