SMPDB

Showing 301 - 375 of 1576 proteins

Protein ID	Protein Description	Pathway Class	Pathways
P02730 View in UniProt	Band 3 anion transport protein Gene Name: SLC4A1 Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.	Metabolic	Kidney Function - Collecting Duct
P11362 View in UniProt HMDBP01450 View in HMDB	Basic fibroblast growth factor receptor 1 Gene Name: FGFR1 Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL. A shorter form of the receptor could be a receptor for FGF1 (aFGF)	Metabolic	Bile Acid Indirect Signalling Pathway
Q07817 View in UniProt	Bcl-2-like protein 1 Gene Name: BCL2L1 Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.	Metabolic	Asciminib Inhibition of BCR-ABL Bafetinib Inhibition of BCR-ABL Action Pathway BCR-ABL Action in CML Pathogenesis Bosutinib Inhibition of BCR-ABL Action Pathway Dasatinib Inhibition of BCR-ABL Dasatinib Inhibition of BCR-ABL Action Pathway Imatinib Inhibition of BCR-ABL Nilotinib Inhibition of BCR-ABL Action Pathway Ponatinib Inhibition of BCR-ABL New Ras Signaling Pathway Ruxolitinib Mechanism of Action Action Pathway Tyrosine-Kinase Inhibition of BCR-ABL Pathway ( show more show less )
Q92934 View in UniProt	Bcl2-associated agonist of cell death Gene Name: BAD Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways	Metabolic	Asciminib Inhibition of BCR-ABL Bafetinib Inhibition of BCR-ABL Action Pathway BCR-ABL Action in CML Pathogenesis Bosutinib Inhibition of BCR-ABL Action Pathway Dasatinib Inhibition of BCR-ABL Dasatinib Inhibition of BCR-ABL Action Pathway Imatinib Inhibition of BCR-ABL Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Nilotinib Inhibition of BCR-ABL Action Pathway Ponatinib Inhibition of BCR-ABL New Ras Signaling Pathway Ruxolitinib Mechanism of Action Action Pathway Tyrosine-Kinase Inhibition of BCR-ABL Pathway ( show more show less )
A8E194 View in UniProt	Bcr-abl1 fusion protein Gene Name: BCR-ABL1 Bcr-abl1 fusion protein is a cytoplasm-targeted constitutively active tyrosine kinase that causes uninhibited cell proliferation. This fusion protein is the result of Abelson Murine Leukemia viral oncogene homolog 1 (ABL1) translocating within the Breakpoint Cluster Region (BCR) gene on chromosome 22 and is necessary for Chronic Myeloid Leukemia (CML) pathogenesis.	Metabolic	Asciminib Inhibition of BCR-ABL Bafetinib Inhibition of BCR-ABL Action Pathway BCR-ABL Action in CML Pathogenesis Bosutinib Inhibition of BCR-ABL Action Pathway Dasatinib Inhibition of BCR-ABL Dasatinib Inhibition of BCR-ABL Action Pathway Imatinib Inhibition of BCR-ABL Nilotinib Inhibition of BCR-ABL Action Pathway Ponatinib Inhibition of BCR-ABL New Ruxolitinib Mechanism of Action Action Pathway Tyrosine-Kinase Inhibition of BCR-ABL Pathway ( show more show less )
Q14457 View in UniProt	Beclin-1 Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.	Metabolic	Inositol Metabolism Joubert Syndrome Joubert Syndrome Phosphatidylinositol Phosphate Metabolism
Q9HAY6 View in UniProt HMDBP01568 View in HMDB	Beta,beta-carotene 15,15'-monooxygenase Gene Name: BCMO1 Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.	Metabolic	Retinol Metabolism Vitamin A Deficiency Vitamin A Deficiency
P08588 View in UniProt HMDBP01632 View in HMDB	Beta-1 adrenergic receptor Gene Name: ADRB1 Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity	Metabolic	Acebutolol Action Pathway Acebutolol Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Amine Oxidase Norepinephrine Amiodarone Action Pathway Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway Amlodipine Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Atomoxetine Action Pathway (New) Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Bupranolol Action Pathway Bupranolol Action Pathway Caffeine Cardiac Contraction Action Pathway Carteolol Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Clomipramine Action Pathway (New) Desipramine Action Pathway (New) Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway Diltiazem Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Dopamine Action Pathway Dopamine Action Pathway Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Felodipine Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Ibutilide Action Pathway Imipramine Action Pathway (New) Isocarboxazid Amine Oxidase Norepinephrine Antidepressant Action Pathway Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isradipine Action Pathway Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Levobunolol Action Pathway Levobunolol Action Pathway Levomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Maprotiline Action Pathway Methamphetamine Dopamine Reuptake Inhibitor Action Pathway Methamphetamine Norepinephrine Reuptake Inhibitor Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Metoprolol Action Pathway (New) Mexiletine Action Pathway Milnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway Minaprine Amine oxidase Norepinephrine Antidepressant Action Pathway Moclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nebivolol Action Pathway Nebivolol Action Pathway (New) Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Nortriptyline Action Pathway Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Penbutolol Action Pathway Penbutolol Action Pathway (New) Phenelzine Amine Oxidase Norepinephrine Antidepressant Action Pathway Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Procainamide (Antiarrhythmic) Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Quinidine Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Tocainide Action Pathway Tranylcypromine Amine Oxidase Norepinephrine Antidepressant Action Pathway Trimipramine Action Pathway Verapamil Action Pathway ( show more show less )
O96024 View in UniProt HMDBP01102 View in HMDB	Beta-1,3-galactosyltransferase 4 Gene Name: B3GALT4 Involved in GM1/GD1B/GA1 ganglioside biosynthesis.	Metabolic	G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
Q00973 View in UniProt HMDBP00873 View in HMDB	Beta-1,4 N-acetylgalactosaminyltransferase 1 Gene Name: B4GALNT1 Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.	Metabolic	G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
P15291 View in UniProt HMDBP00377 View in HMDB	Beta-1,4-galactosyltransferase 1 Gene Name: B4GALT1 The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.	Metabolic	Congenital Disorder of Glycosylation CDG-IId Galactose Metabolism Galactosemia Galactosemia GLUT-1 Deficiency Syndrome Lactose Synthesis ( show more show less )
Q9UBX8 View in UniProt HMDBP07258 View in HMDB	Beta-1,4-galactosyltransferase 6 Gene Name: B4GALT6 Required for the biosynthesis of glycosphingolipids.	Metabolic	Fabry Disease Fabry Disease Gaucher Disease Gaucher Disease Globoid Cell Leukodystrophy Globoid Cell Leukodystrophy Krabbe Disease Metachromatic Leukodystrophy (MLD) Metachromatic Leukodystrophy (MLD) Sphingolipid Metabolism ( show more show less )
Q13884 View in UniProt HMDBP01766 View in HMDB	Beta-1-syntrophin Gene Name: SNTB1 Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex	Metabolic	Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dofetilide Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Ethotoin Action Pathway Felodipine Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Fosphenytoin (Antiarrhythmic) Metabolism Pathway Fosphenytoin Action Pathway (New) Ibutilide Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Lamotrigine Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Pancreas Function - Alpha Cell Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propranolol Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Zonisamide Action Pathway ( show more show less )
Q13425 View in UniProt HMDBP08002 View in HMDB	Beta-2-syntrophin Gene Name: SNTB2 Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN	Metabolic	Acebutolol Action Pathway Ajmaline Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amiodarone Action Pathway (New) Amlodipine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dofetilide Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Ethotoin Action Pathway Felodipine Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Fosphenytoin (Antiarrhythmic) Metabolism Pathway Fosphenytoin Action Pathway (New) Ibutilide Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Lamotrigine Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Mexiletine Action Pathway (New) Moricizine Action Pathway Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Pancreas Function - Alpha Cell Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Propafenone Action Pathway Propranolol Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Ranolazine Action Pathway Sotalol Action Pathway Striated Muscle Contraction Timolol Action Pathway Tocainide Action Pathway Tocainide Sodium Channel Antiepileptic Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Zonisamide Action Pathway ( show more show less )
Q96KN2 View in UniProt HMDBP00473 View in HMDB	Beta-Ala-His dipeptidase Gene Name: CNDP1 Preferential hydrolysis of the beta-Ala-\|-His dipeptide (carnosine), and also anserine, Xaa-\|-His dipeptides and other dipeptides including homocarnosine	Metabolic	beta-Alanine Metabolism beta-Aminoisobutyric Aciduria Carnosinuria, Carnosinemia Carnosinuria, Carnosinemia GABA-Transaminase Deficiency GABA-Transaminase Deficiency: beta-alanine Histidine Metabolism Histidinemia Histidinemia Metabolism and Physiological Effects of Beta-Alanine ( show more show less )
P01203 View in UniProt	Beta-endorphin	Metabolic	3-Methylthiofentanyl Action Pathway Alfentanil Action Pathway Alvimopan Action Pathway Alvimopan Opioid Antagonist Action Pathway Anileridine Action Pathway Benzocaine Action Pathway Bupivacaine Action Pathway Buprenorphine Action Pathway Butorphanol Opioid Antagonist Action Pathway Carfentanil Action Pathway Chloroprocaine Action Pathway Citalopram Action Pathway Cocaine Action Pathway Codeine Action Pathway Desipramine Action Pathway Dezocine Action Pathway Dibucaine Action Pathway Dihydromorphine Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Diphenoxylate Opioid Agonist Action Pathway Diprenorphine Action Pathway Eluxadoline Action Pathway Escitalopram Action Pathway Ethylmorphine Action Pathway Fentanyl Action Pathway Fluoxetine Action Pathway Hydrocodone Action Pathway Hydromorphone Action Pathway Imipramine Ketobemidone Action Pathway Levallorphan Action Pathway Levallorphan Action Pathway (New) Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Loperamide Action Pathway Mepivacaine Action Pathway Methadone Action Pathway Methadyl Acetate Action Pathway Methylnaltrexone Opioid Antagonist Action Pathway Morphine Action Pathway Nalbuphine Action Pathway Nalbuphine Opioid Antagonist Action Pathway Naldemedine Opioid Antagonist Action Pathway Nalmefene Opioid Antagonist Action Pathway Naloxegol Action Pathway Naloxone Action Pathway Naloxone Opioid Antagonist Action Pathway Naltrexone Action Pathway Naltrexone Opioid Antagonist Action Pathway Neuron Function Nicotine Action Pathway Oxybuprocaine Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Pentazocine Action Pathway Pentazocine Opioid Antagonist Action Pathway Prilocaine Action Pathway Procaine Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Remifentanil Action Pathway Ropivacaine Action Pathway Samidorphan Action Pathway Sufentanil Action Pathway Tramadol Action Action Pathway Trimebutine M3 Receptor Intestine Relaxation Action Pathway Trimebutine Opioid Action Pathway ( show more show less )
P16278 View in UniProt HMDBP10706 View in HMDB	Beta-galactosidase Gene Name: GLB1 Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.	Metabolic	Fabry Disease Fabry Disease G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Galactose Metabolism Galactosemia Galactosemia Gaucher Disease Gaucher Disease Globoid Cell Leukodystrophy Globoid Cell Leukodystrophy Krabbe Disease Metachromatic Leukodystrophy (MLD) Metachromatic Leukodystrophy (MLD) Sphingolipid Metabolism ( show more show less )
P08236 View in UniProt HMDBP00839 View in HMDB	Beta-glucuronidase Gene Name: GUSB Plays an important role in the degradation of dermatan and keratan sulfates.	Metabolic	Acute Intermittent Porphyria Acute Intermittent Porphyria Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Glycogen Synthetase Deficiency Glycogen Synthetase Deficiency Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type VI. Hers Disease Glycogenosis, Type VI. Hers Disease Hereditary Coproporphyria (HCP) Hereditary Coproporphyria (HCP) Mucopolysaccharidosis VII. Sly Syndrome Mucopolysaccharidosis VII. Sly Syndrome Porphyria Variegata (PV) Porphyria Variegata (PV) Porphyrin Metabolism Starch and Sucrose Metabolism Sucrase-Isomaltase Deficiency Sucrase-Isomaltase Deficiency ( show more show less )
P06865 View in UniProt HMDBP00872 View in HMDB	Beta-hexosaminidase subunit alpha Gene Name: HEXA Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.	Metabolic	Amino Sugar Metabolism G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Salla Disease/Infantile Sialic Acid Storage Disease Salla Disease/Infantile Sialic Acid Storage Disease Sialuria or French Type Sialuria Sialuria or French Type Sialuria Tay-Sachs Disease Tay-Sachs Disease ( show more show less )
P07686 View in UniProt HMDBP00871 View in HMDB	Beta-hexosaminidase subunit beta Gene Name: HEXB Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.	Metabolic	G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
Q86Z14 View in UniProt	Beta-klotho Gene Name: KLB Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).	Metabolic	Bile Acid Indirect Signalling Pathway
P01138 View in UniProt	Beta-nerve growth factor Gene Name: NGF Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).	Metabolic	BTG Family Proteins and Cell Cycle Regulation
Q9UBR1 View in UniProt HMDBP00544 View in HMDB	Beta-ureidopropionase Gene Name: UPB1 Converts N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide.	Metabolic	beta-Alanine Metabolism beta-Aminoisobutyric Aciduria beta-Ureidopropionase Deficiency beta-Ureidopropionase Deficiency Carnosinuria, Carnosinemia Carnosinuria, Carnosinemia Dihydropyrimidinase Deficiency Dihydropyrimidinase Deficiency Fluorouracil Metabolism GABA-Transaminase Deficiency GABA-Transaminase Deficiency: beta-alanine MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Pyrimidine Metabolism UMP Synthase Deficiency (Orotic Aciduria) UMP Synthase Deficiency (Orotic Aciduria) ( show more show less )
Q93088 View in UniProt HMDBP00559 View in HMDB	Betaine--homocysteine S-methyltransferase 1 Gene Name: BHMT Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.	Metabolic	3-Phosphoglycerate Dehydrogenase Deficiency 3-Phosphoglycerate Dehydrogenase Deficiency Betaine Metabolism Cystathionine beta-Synthase Deficiency Cystathionine beta-Synthase Deficiency Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Glycine and Serine Metabolism Glycine N-Methyltransferase Deficiency Glycine N-Methyltransferase Deficiency Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Hyperglycinemia, Non-Ketotic Hypermethioninemia Hypermethioninemia Metabolism and Physiological Effects of Dimethylglycine Methionine Adenosyltransferase Deficiency Methionine Adenosyltransferase Deficiency Methionine Metabolism Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Non-Ketotic Hyperglycinemia Non-Ketotic Hyperglycinemia S-Adenosylhomocysteine (SAH) Hydrolase Deficiency S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Sarcosine Oncometabolite Pathway Sarcosinemia Sarcosinemia ( show more show less )
DB00112 View in DrugBank	Bevacizumab A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.	Metabolic	Bevacizumab Action Pathway Bevacizumab Drug Metabolism Bevacizumab VEGF Inhibitor Action Pathway
O43252 View in UniProt HMDBP00345 View in HMDB	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Gene Name: PAPSS1 Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.	Metabolic	Selenoamino Acid Metabolism
O95340 View in UniProt HMDBP00353 View in HMDB	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Gene Name: PAPSS2 Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).	Metabolic	Sulfate/Sulfite Metabolism Sulfite Oxidase Deficiency Sulfite Oxidase Deficiency
Q13057 View in UniProt HMDBP01886 View in HMDB	Bifunctional coenzyme A synthase Gene Name: COASY Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.	Metabolic	Pantothenate and CoA Biosynthesis
P34913 View in UniProt HMDBP01790 View in HMDB	Bifunctional epoxide hydrolase 2 Gene Name: EPHX2 Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.	Metabolic	Acetaminophen Action Pathway Acetylsalicylic Acid Action Pathway Antipyrine Action Pathway Antrafenine Action Pathway Arachidonic Acid Metabolism Bifunctional epoxide hydrolase 2 Drug Metabolism Bromfenac Action Pathway Carprofen Action Pathway Celecoxib metabolism Pathway Diclofenac Action Pathway Diflunisal Action Pathway Etodolac Action Pathway Etoricoxib Action Pathway Fenoprofen Action Pathway Flurbiprofen Action Pathway Ibuprofen Action Pathway Indomethacin Action Pathway Ketoprofen Action Pathway Ketorolac Action Pathway Leukotriene C4 Synthesis Deficiency Lornoxicam Action Pathway Lumiracoxib Action Pathway Magnesium Salicylate Action Pathway Mefenamic Acid Action Pathway Meloxicam Action Pathway Nabumetone Action Pathway Naproxen Action Pathway Nepafenac Action Pathway Oxaprozin Action Pathway Phenylbutazone Action Pathway Piroxicam Action Pathway Rofecoxib Action Pathway Salicylate-Sodium Action Pathway Salicylic Acid Action Pathway Salsalate Action Pathway Sulindac Action Pathway Suprofen Action Pathway Tenoxicam Action Pathway Tiaprofenic Acid Action Pathway Tolmetin Action Pathway Trisalicylate-Choline Action Pathway Valdecoxib Action Pathway ( show more show less )
P07814 View in UniProt HMDBP00567 View in HMDB	Bifunctional glutamate/proline--tRNA ligase Gene Name: EPRS Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.	Metabolic	Arginine and Proline Metabolism Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperprolinemia Type I Hyperprolinemia Type I Hyperprolinemia Type II Hyperprolinemia Type II L-Arginine:Glycine Amidinotransferase Deficiency L-Arginine:Glycine Amidinotransferase Deficiency Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Aminotransferase Deficiency (OAT Deficiency) Prolidase Deficiency (PD) Prolinemia Type II Prolinemia Type II Protein Synthesis: Glutamic Acid Protein Synthesis: Proline ( show more show less )
P13995 View in UniProt HMDBP00920 View in HMDB	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Gene Name: MTHFD2	Metabolic	Folate Malabsorption, Hereditary Folate Malabsorption, Hereditary Folate Metabolism Methotrexate Action Pathway Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Pafolacianine Action Pathway Pemetrexed Action Pathway Pralatrexate Action Pathway Raltitrexed Action Pathway ( show more show less )
P31939 View in UniProt HMDBP00882 View in HMDB	Bifunctional purine biosynthesis protein PURH Gene Name: ATIC Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Methotrexate Action Pathway (new) Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Mycophenolic Acid Action Pathway Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
Q9Y223 View in UniProt HMDBP00332 View in HMDB	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Gene Name: GNE Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.	Metabolic	Amino Sugar Metabolism Salla Disease/Infantile Sialic Acid Storage Disease Salla Disease/Infantile Sialic Acid Storage Disease Sialuria or French Type Sialuria Sialuria or French Type Sialuria Tay-Sachs Disease Tay-Sachs Disease ( show more show less )
Q96RI1 View in UniProt HMDBP02506 View in HMDB	Bile acid receptor Gene Name: NR1H4 Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus	Metabolic	Bile Acid Direct Signalling Pathway (1) Bile Acid Indirect Signalling Pathway
Q14032 View in UniProt HMDBP00549 View in HMDB	Bile acid-CoA:amino acid N-acyltransferase Gene Name: BAAT Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.	Metabolic
Q9Y2P5 View in UniProt HMDBP03055 View in HMDB	Bile acyl-CoA synthetase Gene Name: SLC27A5 Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.	Metabolic
Q06520 View in UniProt HMDBP00347 View in HMDB	Bile salt sulfotransferase Gene Name: SULT2A1 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.	Metabolic	Acetaminophen Metabolism Pathway Dextromethorphan metabolism
P53004 View in UniProt HMDBP00700 View in HMDB	Biliverdin reductase A Gene Name: BLVRA Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.	Metabolic	Acute Intermittent Porphyria Acute Intermittent Porphyria Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Hereditary Coproporphyria (HCP) Hereditary Coproporphyria (HCP) Porphyria Variegata (PV) Porphyria Variegata (PV) Porphyrin Metabolism ( show more show less )
P50747 View in UniProt HMDBP00509 View in HMDB	Biotin--protein ligase Gene Name: HLCS Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.	Metabolic	Biotin Metabolism Biotinidase Deficiency Biotinidase Deficiency Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Multiple Carboxylase Deficiency, Neonatal or Early Onset Form
P43251 View in UniProt HMDBP00546 View in HMDB	Biotinidase Gene Name: BTD Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.	Metabolic	Biotin Metabolism Biotinidase Deficiency Biotinidase Deficiency Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Multiple Carboxylase Deficiency, Neonatal or Early Onset Form
P50583 View in UniProt HMDBP00621 View in HMDB	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Gene Name: NUDT2 Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P07738 View in UniProt HMDBP00266 View in HMDB	Bisphosphoglycerate mutase Gene Name: BPGM Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.	Metabolic	Fanconi-Bickel Syndrome Fanconi-Bickel Syndrome Fructose-1,6-diphosphatase Deficiency Fructose-1,6-diphosphatase Deficiency Gluconeogenesis Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Glycogenosis, Type IA. Von Gierke Disease Glycogenosis, Type IA. Von Gierke Disease Glycogenosis, Type IB Glycogenosis, Type IB Glycogenosis, Type IC Glycogenosis, Type IC Glycogenosis, Type VII. Tarui Disease Glycogenosis, Type VII. Tarui Disease Glycolysis Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Triosephosphate Isomerase Deficiency Triosephosphate Isomerase Deficiency ( show more show less )
DB00006 View in DrugBank	Bivalirudin	Metabolic	Bivalirudin.
P54687 View in UniProt HMDBP00301 View in HMDB	Branched-chain-amino-acid aminotransferase, cytosolic Gene Name: BCAT1 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.	Metabolic	2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 3-Hydroxyisobutyric Aciduria 3-Hydroxyisobutyric Aciduria 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type I 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type III 3-Methylglutaconic Aciduria Type IV 3-Methylglutaconic Aciduria Type IV beta-Ketothiolase Deficiency beta-Ketothiolase Deficiency Isobutyryl-CoA Dehydrogenase Deficiency Isobutyryl-CoA Dehydrogenase Deficiency Isovaleric Acidemia Isovaleric Acidemia Isovaleric Aciduria Isovaleric Aciduria Maple Syrup Urine Disease Maple Syrup Urine Disease Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonate Semialdehyde Dehydrogenase Deficiency Methylmalonic Aciduria Methylmalonic Aciduria Propionic Acidemia Propionic Acidemia Valine, Leucine, and Isoleucine Degradation ( show more show less )
P56945 View in UniProt	Breast cancer anti-estrogen resistance protein 1 Gene Name: BCAR1 Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.	Metabolic	CXCR4 Signaling Pathway
P11586 View in UniProt HMDBP00923 View in HMDB	C-1-tetrahydrofolate synthase, cytoplasmic Gene Name: MTHFD1	Metabolic	Folate Malabsorption, Hereditary Folate Malabsorption, Hereditary Folate Metabolism Methotrexate Action Pathway Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
Q99417 View in UniProt	C-Myc-binding protein Gene Name: MYCBP May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.	Metabolic	Glutaminolysis and Cancer
P61073 View in UniProt HMDBP07643 View in HMDB	C-X-C chemokine receptor type 4 Gene Name: CXCR4 Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus	Metabolic	CXCR4 Signaling Pathway
P27708 View in UniProt HMDBP03298 View in HMDB	CAD protein Gene Name: CAD This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).	Metabolic	2-Hydroxyglutric Aciduria (D and L Form) 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency Apoptotic DNA Fragmentation and Tissue Homeostasis Aspartate Metabolism beta-Ureidopropionase Deficiency beta-Ureidopropionase Deficiency Canavan Disease Canavan Disease Dihydropyrimidinase Deficiency Dihydropyrimidinase Deficiency Glutamate Metabolism Homocarnosinosis Homocarnosinosis Hyperinsulinism-Hyperammonemia Syndrome Hyperinsulinism-Hyperammonemia Syndrome Hypoacetylaspartia Hypoacetylaspartia Metabolism and Physiological Effects of Orotic acid Metabolism and Physiological Effects of Uridine MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Pyrimidine Metabolism Succinic Semialdehyde Dehydrogenase Deficiency UMP Synthase Deficiency (Orotic Aciduria) UMP Synthase Deficiency (Orotic Aciduria) ( show more show less )
Q96D31 View in UniProt	Calcium release-activated calcium channel protein 1 Gene Name: ORAI1 Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.	Metabolic	BCR Signaling Pathway Growth Hormone Signaling Pathway
Q8NE86 View in UniProt	Calcium uniporter protein, mitochondrial Gene Name: MCU Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity).	Metabolic	Amiodarone Action Pathway
O75746 View in UniProt HMDBP03143 View in HMDB	Calcium-binding mitochondrial carrier protein Aralar1 Gene Name: SLC25A12 Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.	Metabolic	Argininemia Argininemia Argininosuccinic Aciduria Argininosuccinic Aciduria Carbamoyl Phosphate Synthetase Deficiency Carbamoyl Phosphate Synthetase Deficiency Citrullinemia Type I Citrullinemia Type I Malate-Aspartate Shuttle Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine Metabolsim and Physiological Effects of Argininic acid Ornithine Transcarbamylase Deficiency (OTC Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Urea Cycle ( show more show less )
Q8N5S9 View in UniProt HMDBP01316 View in HMDB	Calcium/calmodulin-dependent protein kinase kinase 1 Gene Name: CAMKK1 Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death	Metabolic	NF-kB Signaling Pathway Pancreas Function - Beta Cell
Q96RR4 View in UniProt HMDBP01346 View in HMDB	Calcium/calmodulin-dependent protein kinase kinase 2 Gene Name: CAMKK2 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Seems to be involved in hippocampal activation of CREB1	Metabolic	NF-kB Signaling Pathway
Q9UQM7 View in UniProt	Calcium/calmodulin-dependent protein kinase type II subunit alpha Gene Name: CAMK2A CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).	Metabolic	GnRH Signaling Pathway
P0DP23 View in UniProt HMDBP01777 View in HMDB	Calmodulin-1 Gene Name: CALM1 Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).	Metabolic	Amifampridine Action Pathway Aceprometazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Aceprometazine H1-Antihistamine Blood Vessel Constriction Action Pathway Acrivastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Acrivastine H1-Antihistamine Blood Vessel Constriction Action Pathway Alcaftadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Alcaftadine H1-Antihistamine Blood Vessel Constriction Action Pathway Alimemazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Alimemazine H1-Antihistamine Blood Vessel Constriction Action Pathway Alverine Serotonin Antagonist Action Pathway Ambenonium Action Pathway (new) Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Antazoline H1 Antihistamine Smooth Muscle Relaxation Action Pathway Antazoline H1-Antihistamine Blood Vessel Constriction Action Pathway Arformoterol Action Pathway Aripiprazole lauroxil H1 Antihistamine Smooth Muscle Relaxation Action Pathway Aripiprazole lauroxil H1-Antihistamine Blood Vessel Constriction Action Pathway Astemizole H1 Antihistamine Smooth Muscle Relaxation Action Pathway Astemizole H1-Antihistamine Blood Vessel Constriction Action Pathway Atropine M1/3/5 Muscarinic Poisoning Action Pathway Azatadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Azatadine H1-Antihistamine Blood Vessel Constriction Action Pathway Azelastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Azelastine H1-Antihistamine Blood Vessel Constriction Action Pathway Benzquinamide H1 Antihistamine Smooth Muscle Relaxation Action Pathway Benzquinamide H1-Antihistamine Blood Vessel Constriction Action Pathway Bepotastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Bepotastine H1-Antihistamine Blood Vessel Constriction Action Pathway Bethanechol Action Pathway Bilastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Bilastine H1-Antihistamine Blood Vessel Constriction Action Pathway Bromodiphenhydramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Bromodiphenhydramine H1-Antihistamine Blood Vessel Constriction Action Pathway Brompheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Brompheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Buclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Buclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Butriptyline H1 Antihistamine Smooth Muscle Relaxation Action Pathway Butriptyline H1-Antihistamine Blood Vessel Constriction Action Pathway Caffeine Adrenergic A1 vasoconstriction Action Pathway Caffeine Vasodilation Action Pathway Carbaryl Action Pathway Carbinoxamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Carbinoxamine H1-Antihistamine Blood Vessel Constriction Action Pathway Cariprazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cariprazine H1-Antihistamine Blood Vessel Constriction Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cetirizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cetirizine H1-Antihistamine Blood Vessel Constriction Action Pathway Cevimeline M3 Salivary Gland Smooth Muscle Contraction Action Pathway Chlorcyclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorcyclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Chloropyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chloropyramine H1-Antihistamine Blood Vessel Constriction Action Pathway Chlorpheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorpheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Chlorpromazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorpromazine H1-Antihistamine Blood Vessel Constriction Action Pathway Chlorprothixene H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorprothixene H1-Antihistamine Blood Vessel Constriction Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Cinnarizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cinnarizine H1-Antihistamine Blood Vessel Constriction Action Pathway Clemastine H1-Antihistamine Blood Vessel Constriction Action Pathway Clemastine H1-Antihistamine Smooth Muscle Relaxation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Clofedanol H1 Antihistamine Smooth Muscle Relaxation Action Pathway Clofedanol H1-Antihistamine Blood Vessel Constriction Action Pathway Clozapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Clozapine H1-Antihistamine Blood Vessel Constriction Action Pathway Cyclandelate Action Pathway Cyclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cyclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Cyproheptadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cyproheptadine H1-Antihistamine Blood Vessel Constriction Action Pathway Dalfampridine Action Pathway Darifenacin Action Pathway Deptropine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Deptropine H1-Antihistamine Blood Vessel Constriction Action Pathway Desloratadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Desloratadine H1-Antihistamine Blood Vessel Constriction Action Pathway Dexbrompheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dexbrompheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Dexchlorpheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dexchlorpheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Dexchlorpheniramine maleate H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dexchlorpheniramine maleate H1-Antihistamine Blood Vessel Constriction Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dimenhydrinate H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dimenhydrinate H1-Antihistamine Blood Vessel Constriction Action Pathway Dimetindene H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dimetindene H1-Antihistamine Blood Vessel Constriction Action Pathway Dimetotiazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dimetotiazine H1-Antihistamine Blood Vessel Constriction Action Pathway Diphenhydramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Diphenhydramine H1-Antihistamine Blood Vessel Constriction Action Pathway Diphenylpyraline H1 Antihistamine Smooth Muscle Relaxation Action Pathway Diphenylpyraline H1-Antihistamine Blood Vessel Constriction Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Distigmine Action Pathway Domperidone Mechanism of Action Action Pathway Doxepin H1 Antihistamine Smooth Muscle Relaxation Action Pathway Doxepin H1-Antihistamine Blood Vessel Constriction Action Pathway Doxylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Doxylamine H1-Antihistamine Blood Vessel Constriction Action Pathway Drotaverine Action Pathway Droxidopa A1-Adrenergic Vasoconstriction Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Ebastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Ebastine H1-Antihistamine Blood Vessel Constriction Action Pathway Edrophonium Action Pathway (new) Eletriptan Mechanism of Action Action Pathway Emedastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Emedastine H1-Antihistamine Blood Vessel Constriction Action Pathway Ephedrine A1-Adrenergic Vasoconstriction Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epinastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Epinastine H1-Antihistamine Blood Vessel Constriction Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergotamine Mechanism of Action Action Pathway Esmirtazapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Esmirtazapine H1-Antihistamine Blood Vessel Constriction Action Pathway Etafedrine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Fesoterodine Action Pathway Fexofenadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Fexofenadine H1-Antihistamine Blood Vessel Constriction Action Pathway Flavoxate Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gq Adrenergic Smooth Muscle Contraction Gq Histaminic Smooth Muscle Contraction Gq Muscarinic Smooth Muscle Contraction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction GSK-1004723 H1 Antihistamine Smooth Muscle Relaxation Action Pathway GSK-1004723 H1-Antihistamine Blood Vessel Constriction Action Pathway Histamine Muscle Contraction Pathway Hydroxyzine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Hydroxyzine H1-Antihistamine Blood Vessel Constriction Action Pathway Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Indacaterol Action Pathway Intestinal Serotonin pathway Ipratropium M3 Bronchodilation Action Pathway Isoetharine Action Pathway Isosorbide Dinitrate Action Pathway Isosorbide Mononitrate Action Pathway Isothipendyl H1 Antihistamine Smooth Muscle Relaxation Action Pathway Isothipendyl H1-Antihistamine Blood Vessel Constriction Action Pathway Isradipine Action Pathway (New) Ketotifen H1 Antihistamine Smooth Muscle Relaxation Action Pathway Ketotifen H1-Antihistamine Blood Vessel Constriction Action Pathway Lacidipine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levocabastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Levocabastine H1-Antihistamine Blood Vessel Constriction Action Pathway Levocetirizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Levocetirizine H1-Antihistamine Blood Vessel Constriction Action Pathway Levosalbutamol Action Pathway Loratadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Loratadine H1-Antihistamine Blood Vessel Constriction Action Pathway Magnesium Sulfate Action Pathway Malathion Action Pathway Manidipine Action Pathway Meclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Meclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Mepyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mepyramine H1-Antihistamine Blood Vessel Constriction Action Pathway Mequitazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mequitazine H1-Antihistamine Blood Vessel Constriction Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methacholine M3 Bronchoconstriction Action Pathway Methapyrilene H1 Antihistamine Smooth Muscle Relaxation Action Pathway Methapyrilene H1-Antihistamine Blood Vessel Constriction Action Pathway Methdilazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Methdilazine H1-Antihistamine Blood Vessel Constriction Action Pathway Methyldopa Action Pathway Methylergometrine Mechanism of Action Action Pathway Methylphosphinic Acid Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Mianserin H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mianserin H1-Antihistamine Blood Vessel Constriction Action Pathway Mirabegron Action Pathway Mirtazapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mirtazapine H1-Antihistamine Blood Vessel Constriction Action Pathway Mizolastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mizolastine H1-Antihistamine Blood Vessel Constriction Action Pathway Muscular Gi Protein Cascade Muscular Gq Protien Cascade Muscular Gs Protein Cascade nAchR Smooth Muscle Contraction Nadolol B2-Adrenergic Vasoconstriction Action Pathway Naratriptan Mechanism of Action Action Pathway Neostigmine Action Pathway (new) Nicardipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway (New) Nitrendipine Action Pathway (New) Nitric Oxide Signaling Pathway Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Nylidrin Action Pathway Olanzapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Olanzapine H1-Antihistamine Blood Vessel Constriction Action Pathway Olodaterol Action Pathway Olopatadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Olopatadine H1-Antihistamine Blood Vessel Constriction Action Pathway Orciprenaline Action Pathway Orphenadrine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Orphenadrine H1-Antihistamine Blood Vessel Constriction Action Pathway Oxatomide H1 Antihistamine Smooth Muscle Relaxation Action Pathway Oxatomide H1-Antihistamine Blood Vessel Constriction Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Oxybutynin Action Pathway Oxyphenonium Action Pathway Oxytocin Action Pathway Phenindamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Phenindamine H1-Antihistamine Blood Vessel Constriction Action Pathway Pheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Pheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Phenylephrine Action Pathway Pilocarpine Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pilocarpine M3 Iris Sphincter Muscle Constriction Action Pathway Pinaverium Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Prazosin Action Pathway Procaterol Action Pathway Procyclidine M1 Antispasmodic Action Pathway Promazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Promazine H1-Antihistamine Blood Vessel Constriction Action Pathway Promethazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Promethazine H1-Antihistamine Blood Vessel Constriction Action Pathway Propantheline Action Pathway Propiomazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Propiomazine H1-Antihistamine Blood Vessel Constriction Action Pathway Propiverine Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Pseudoephedrine Action Pathway Pyridostigmine Action Pathway Quetiapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Quetiapine H1-Antihistamine Blood Vessel Constriction Action Pathway Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rizatriptan Mechanism of Action Action Pathway Rupatadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Rupatadine H1-Antihistamine Blood Vessel Constriction Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Solifenacin M3 Bladder Muscle Relaxation Action Pathway Sumatriptan Mechanism of Action Action Pathway Tamsulosin Action Pathway Terbutaline Action Pathway Terfenadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Terfenadine H1-Antihistamine Blood Vessel Constriction Action Pathway Thonzylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Thonzylamine H1-Antihistamine Blood Vessel Constriction Action Pathway Timolol Action Pathway (New) Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tolterodine Action Pathway Trazodone H1 Antihistamine Smooth Muscle Relaxation Action Pathway Trazodone H1-Antihistamine Blood Vessel Constriction Action Pathway Trimebutine M3 Receptor Intestine Relaxation Action Pathway Tripelennamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Tripelennamine H1-Antihistamine Blood Vessel Constriction Action Pathway Triprolidine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Triprolidine H1-Antihistamine Blood Vessel Constriction Action Pathway Trospium Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Ziprasidone H1 Antihistamine Smooth Muscle Relaxation Action Pathway Ziprasidone H1-Antihistamine Blood Vessel Constriction Action Pathway Zolmitriptan Mechanism of Action Action Pathway Zuclopenthixol H1 Antihistamine Smooth Muscle Relaxation Action Pathway Zuclopenthixol H1-Antihistamine Blood Vessel Constriction Action Pathway ( show more show less )
P0DP23 View in UniProt	Calmodulin-1 Gene Name: CALM1 Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).	Metabolic	BCR Signaling Pathway T Cell Receptor Signaling Pathway
P0DP24 View in UniProt	Calmodulin-2 Gene Name: CALM2 Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).	Metabolic	BCR Signaling Pathway T Cell Receptor Signaling Pathway
P0DP25 View in UniProt	Calmodulin-3 Gene Name: CALM3 Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.	Metabolic	BCR Signaling Pathway T Cell Receptor Signaling Pathway
Q8TD86 View in UniProt	Calmodulin-like protein 6 Gene Name: CALML6	Metabolic	GnRH Signaling Pathway
Q9Y233 View in UniProt HMDBP00604 View in HMDB	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Gene Name: PDE10A Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Triflusal Action Pathway (new) Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
P17612 View in UniProt HMDBP01352 View in HMDB	cAMP-dependent protein kinase catalytic subunit alpha Gene Name: PRKACA Phosphorylates a large number of substrates in the cytoplasm and the nucleus	Metabolic	Amifampridine Action Pathway Progesterone Action Pathway Acebutolol Action Pathway Acebutolol Action Pathway Activation of cAMP-dependent protein kinase, PKA Ajmaline Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Apomorphine Mechanism of Action Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Arformoterol Action Pathway Asenapine Dopamine Antagonist Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Atropine M2 Cardiac Muscle Contraction Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Bupranolol Action Pathway Bupranolol Action Pathway Bupropion Action Pathway Caffeine Cardiac Contraction Action Pathway Carteolol Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Castor Oil Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cilostazol Action Pathway (new) Cimetidine H2 Anti-Histamine Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cyclandelate Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dienogest Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dinoprost tromethamine Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Domperidone Mechanism of Action Action Pathway Dopamine Action Pathway Dopamine Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Drospirenone Action Pathway Drotaverine Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Etafedrine Action Pathway Etonogestrel Action Pathway Famotidine H2 Anti-Histamine Action Pathway Felodipine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Flavoxate Action Pathway Flecainide Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation GnRH Signaling Pathway Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Ibutilide Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Isoetharine Action Pathway Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isradipine Action Pathway Isradipine Action Pathway (New) Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Lacidipine Action Pathway Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levobunolol Action Pathway Levobunolol Action Pathway Levodopa Pahway Levonorgestrel Action Pathway Levosalbutamol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Manidipine Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Megestrol acetate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Methysergide Mechanism of Action Action Pathway Metiamide H2 Anti-Histamine Action Pathway Metipranolol Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Metoprolol Action Pathway Metoprolol Action Pathway (New) Mexiletine Action Pathway Mexiletine Action Pathway (New) Mirabegron Action Pathway Misoprostol Action Pathway Moricizine Action Pathway Muscular Gi Protein Cascade Muscular Gs Protein Cascade Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nadolol B2-Adrenergic Vasoconstriction Action Pathway Nebivolol Action Pathway Nebivolol Action Pathway (New) Neuronal Dopamine Gs Cascade Nicardipine Action Pathway Nifedipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway Nisoldipine Action Pathway (New) Nitrendipine Action Pathway Nitrendipine Action Pathway (New) Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norelgestromin Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Nylidrin Action Pathway Olodaterol Action Pathway Orciprenaline Action Pathway Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Penbutolol Action Pathway Penbutolol Action Pathway (New) Pergolide Mechanism of Action Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pinaverium Action Pathway Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Pramipexole Mechanism of Action Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Procaterol Action Pathway Propafenone Action Pathway Propiverine Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranitidine H2 Anti-Histamine Action Pathway Ranolazine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Segesterone acetate Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solriamfetol Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Tafluprost Action Pathway Terbutaline Action Pathway Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Tocainide Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Travoprost Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway ( show more show less )
P22694 View in UniProt	cAMP-dependent protein kinase catalytic subunit beta Gene Name: PRKACB Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).	Metabolic	Nitric Oxide Signaling Pathway
P22694 View in UniProt HMDBP01415 View in HMDB	cAMP-dependent protein kinase catalytic subunit beta Gene Name: PRKACB Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux	Metabolic	Amifampridine Action Pathway Progesterone Action Pathway Activation of cAMP-dependent protein kinase, PKA Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Apomorphine Mechanism of Action Action Pathway Arformoterol Action Pathway Asenapine Dopamine Antagonist Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Bupropion Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Castor Oil Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cimetidine H2 Anti-Histamine Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Corticotropin Activation of Cortisol Production Cyclandelate Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dienogest Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dinoprost tromethamine Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Domperidone Mechanism of Action Action Pathway Dopamine Activation of Neurological Reward System Drospirenone Action Pathway Drotaverine Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Eletriptan Mechanism of Action Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Etafedrine Action Pathway Etonogestrel Action Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Famotidine H2 Anti-Histamine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Flavoxate Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Intracellular Signalling Through Histamine H2 Receptor and Histamine Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Isoetharine Action Pathway Isradipine Action Pathway (New) Lacidipine Action Pathway Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levodopa Pahway Levonorgestrel Action Pathway Levosalbutamol Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Manidipine Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Megestrol acetate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Metiamide H2 Anti-Histamine Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Mirabegron Action Pathway Misoprostol Action Pathway Muscular Gi Protein Cascade Muscular Gs Protein Cascade Nadolol B2-Adrenergic Vasoconstriction Action Pathway Naratriptan Mechanism of Action Action Pathway Neuronal Dopamine Gs Cascade Nicardipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway (New) Nitrendipine Action Pathway (New) Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norelgestromin Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Nylidrin Action Pathway Olodaterol Action Pathway Orciprenaline Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Pergolide Mechanism of Action Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pinaverium Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Pramipexole Mechanism of Action Action Pathway Procaterol Action Pathway Propiverine Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranitidine H2 Anti-Histamine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rizatriptan Mechanism of Action Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Segesterone acetate Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solriamfetol Action Pathway Sumatriptan Mechanism of Action Action Pathway Tafluprost Action Pathway Terbutaline Action Pathway Timolol Action Pathway (New) Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Travoprost Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Vasopressin Regulation of Water Homeostasis Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Zolmitriptan Mechanism of Action Action Pathway ( show more show less )
P22612 View in UniProt HMDBP01207 View in HMDB	cAMP-dependent protein kinase catalytic subunit gamma Gene Name: PRKACG Phosphorylates a large number of substrates in the cytoplasm and the nucleus	Metabolic	Amifampridine Action Pathway Progesterone Action Pathway Activation of cAMP-dependent protein kinase, PKA Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Apomorphine Mechanism of Action Action Pathway Arformoterol Action Pathway Asenapine Dopamine Antagonist Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Bupropion Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Castor Oil Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cimetidine H2 Anti-Histamine Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cyclandelate Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dienogest Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dinoprost tromethamine Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Domperidone Mechanism of Action Action Pathway Drospirenone Action Pathway Drotaverine Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Eletriptan Mechanism of Action Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Etafedrine Action Pathway Etonogestrel Action Pathway Famotidine H2 Anti-Histamine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Flavoxate Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Isoetharine Action Pathway Isradipine Action Pathway (New) Lacidipine Action Pathway Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levodopa Pahway Levonorgestrel Action Pathway Levosalbutamol Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Manidipine Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Megestrol acetate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Metiamide H2 Anti-Histamine Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Mirabegron Action Pathway Misoprostol Action Pathway Muscular Gi Protein Cascade Muscular Gs Protein Cascade Nadolol B2-Adrenergic Vasoconstriction Action Pathway Naratriptan Mechanism of Action Action Pathway Neuronal Dopamine Gs Cascade Nicardipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway (New) Nitrendipine Action Pathway (New) Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norelgestromin Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Nylidrin Action Pathway Olodaterol Action Pathway Orciprenaline Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Pergolide Mechanism of Action Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pinaverium Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Pramipexole Mechanism of Action Action Pathway Procaterol Action Pathway Propiverine Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranitidine H2 Anti-Histamine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rizatriptan Mechanism of Action Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Segesterone acetate Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solriamfetol Action Pathway Sumatriptan Mechanism of Action Action Pathway Tafluprost Action Pathway Terbutaline Action Pathway Timolol Action Pathway (New) Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Travoprost Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Zolmitriptan Mechanism of Action Action Pathway ( show more show less )
P10644 View in UniProt HMDBP02560 View in HMDB	cAMP-dependent protein kinase type I-alpha regulatory subunit Gene Name: PRKAR1A	Metabolic	Amifampridine Action Pathway Progesterone Action Pathway Acebutolol Action Pathway Acebutolol Action Pathway Activation of cAMP-dependent protein kinase, PKA Ajmaline Action Pathway Alprenolol Action Pathway Alprenolol Action Pathway Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Apomorphine Mechanism of Action Action Pathway Arbutamine Action Pathway Arbutamine Action Pathway Arformoterol Action Pathway Asenapine Dopamine Antagonist Action Pathway Atenolol Action Pathway Atenolol Action Pathway (New) Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Betaxolol Action Pathway Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Bevantolol Action Pathway Bevantolol Beta Blocker Cardiac Action Pathway Bisoprolol Action Pathway Bisoprolol Action Pathway (New) Bopindolol Action Pathway Bopindolol Action Pathway (New) Bupranolol Action Pathway Bupranolol Action Pathway Bupropion Action Pathway Caffeine Cardiac Contraction Action Pathway Carteolol Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Carvedilol Action Pathway Carvedilol Action Pathway Castor Oil Action Pathway Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cimetidine H2 Anti-Histamine Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cyclandelate Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dienogest Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Diltiazem Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dinoprost tromethamine Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Disopyramide Action Pathway Disopyramide Cardiac Action Pathway Dobutamine Action Pathway Dobutamine Action Pathway (New) Domperidone Mechanism of Action Action Pathway Dopamine Action Pathway Dopamine Action Pathway Dronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway Drospirenone Action Pathway Drotaverine Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Eletriptan Mechanism of Action Action Pathway Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway Ephedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Esmolol Action Pathway Esmolol Action Pathway (New) Etafedrine Action Pathway Etonogestrel Action Pathway Famotidine H2 Anti-Histamine Action Pathway Felodipine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Flavoxate Action Pathway Flecainide Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Ibutilide Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Isoetharine Action Pathway Isoprenaline Action Pathway Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway Isradipine Action Pathway Isradipine Action Pathway (New) Labetalol Action Pathway Labetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Lacidipine Action Pathway Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levobunolol Action Pathway Levobunolol Action Pathway Levodopa Pahway Levonorgestrel Action Pathway Levosalbutamol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Manidipine Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Megestrol acetate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Metiamide H2 Anti-Histamine Action Pathway Metipranolol Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Metoprolol Action Pathway Metoprolol Action Pathway (New) Mexiletine Action Pathway Mexiletine Action Pathway (New) Mirabegron Action Pathway Misoprostol Action Pathway Moricizine Action Pathway Muscular Gi Protein Cascade Muscular Gs Protein Cascade Nadolol Action Pathway Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Nadolol B2-Adrenergic Vasoconstriction Action Pathway Naratriptan Mechanism of Action Action Pathway Nebivolol Action Pathway Nebivolol Action Pathway (New) Neuronal Dopamine Gs Cascade Nicardipine Action Pathway Nifedipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway Nisoldipine Action Pathway (New) Nitrendipine Action Pathway Nitrendipine Action Pathway (New) Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norelgestromin Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Nylidrin Action Pathway Olodaterol Action Pathway Orciprenaline Action Pathway Oxprenolol Action Pathway Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Penbutolol Action Pathway Penbutolol Action Pathway (New) Pergolide Mechanism of Action Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pinaverium Action Pathway Pindolol Action Pathway Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Practolol Action Pathway Practolol Action Pathway (New) Pramipexole Mechanism of Action Action Pathway Procainamide (Antiarrhythmic) Action Pathway Procainamide Action Pathway (New) Procaterol Action Pathway Propafenone Action Pathway Propiverine Action Pathway Propranolol Action Pathway Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Quinidine Action Pathway Quinidine Action Pathway (New) Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranitidine H2 Anti-Histamine Action Pathway Ranolazine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rizatriptan Mechanism of Action Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Segesterone acetate Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solriamfetol Action Pathway Sotalol Action Pathway Sotalol Action Pathway (New) Striated Muscle Contraction Sumatriptan Mechanism of Action Action Pathway Tafluprost Action Pathway Terbutaline Action Pathway Timolol Action Pathway Timolol Action Pathway (New) Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Tocainide Action Pathway Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Travoprost Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Verapamil Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Zolmitriptan Mechanism of Action Action Pathway ( show more show less )
P31321 View in UniProt HMDBP08137 View in HMDB	cAMP-dependent protein kinase type I-beta regulatory subunit Gene Name: PRKAR1B	Metabolic	Amifampridine Action Pathway Progesterone Action Pathway Activation of cAMP-dependent protein kinase, PKA Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Apomorphine Mechanism of Action Action Pathway Arformoterol Action Pathway Asenapine Dopamine Antagonist Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Bupropion Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Castor Oil Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cimetidine H2 Anti-Histamine Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cyclandelate Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dienogest Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dinoprost tromethamine Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Domperidone Mechanism of Action Action Pathway Drospirenone Action Pathway Drotaverine Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Eletriptan Mechanism of Action Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Etafedrine Action Pathway Etonogestrel Action Pathway Famotidine H2 Anti-Histamine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Flavoxate Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Isoetharine Action Pathway Isradipine Action Pathway (New) Lacidipine Action Pathway Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levodopa Pahway Levonorgestrel Action Pathway Levosalbutamol Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Manidipine Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Megestrol acetate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Metiamide H2 Anti-Histamine Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Mirabegron Action Pathway Misoprostol Action Pathway Muscular Gi Protein Cascade Muscular Gs Protein Cascade Nadolol B2-Adrenergic Vasoconstriction Action Pathway Naratriptan Mechanism of Action Action Pathway Neuronal Dopamine Gs Cascade Nicardipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway (New) Nitrendipine Action Pathway (New) Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norelgestromin Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Nylidrin Action Pathway Olodaterol Action Pathway Orciprenaline Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Pergolide Mechanism of Action Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pinaverium Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Pramipexole Mechanism of Action Action Pathway Procaterol Action Pathway Propiverine Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranitidine H2 Anti-Histamine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rizatriptan Mechanism of Action Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Segesterone acetate Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solriamfetol Action Pathway Sumatriptan Mechanism of Action Action Pathway Tafluprost Action Pathway Terbutaline Action Pathway Timolol Action Pathway (New) Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Travoprost Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Zolmitriptan Mechanism of Action Action Pathway ( show more show less )
P13861 View in UniProt HMDBP08138 View in HMDB	cAMP-dependent protein kinase type II-alpha regulatory subunit Gene Name: PRKAR2A Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase	Metabolic	Amifampridine Action Pathway Progesterone Action Pathway Activation of cAMP-dependent protein kinase, PKA Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Apomorphine Mechanism of Action Action Pathway Arformoterol Action Pathway Asenapine Dopamine Antagonist Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Bupropion Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Castor Oil Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cimetidine H2 Anti-Histamine Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cyclandelate Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dienogest Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dinoprost tromethamine Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Domperidone Mechanism of Action Action Pathway Drospirenone Action Pathway Drotaverine Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Eletriptan Mechanism of Action Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Etafedrine Action Pathway Etonogestrel Action Pathway Famotidine H2 Anti-Histamine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Flavoxate Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Isoetharine Action Pathway Isradipine Action Pathway (New) Lacidipine Action Pathway Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levodopa Pahway Levonorgestrel Action Pathway Levosalbutamol Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Manidipine Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Megestrol acetate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Metiamide H2 Anti-Histamine Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Mirabegron Action Pathway Misoprostol Action Pathway Muscular Gi Protein Cascade Muscular Gs Protein Cascade Nadolol B2-Adrenergic Vasoconstriction Action Pathway Naratriptan Mechanism of Action Action Pathway Neuronal Dopamine Gs Cascade Nicardipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway (New) Nitrendipine Action Pathway (New) Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norelgestromin Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Nylidrin Action Pathway Olodaterol Action Pathway Orciprenaline Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Pergolide Mechanism of Action Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pinaverium Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Pramipexole Mechanism of Action Action Pathway Procaterol Action Pathway Propiverine Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranitidine H2 Anti-Histamine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rizatriptan Mechanism of Action Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Segesterone acetate Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solriamfetol Action Pathway Sumatriptan Mechanism of Action Action Pathway Tafluprost Action Pathway Terbutaline Action Pathway Timolol Action Pathway (New) Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Travoprost Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Zolmitriptan Mechanism of Action Action Pathway ( show more show less )
P31323 View in UniProt HMDBP08139 View in HMDB	cAMP-dependent protein kinase type II-beta regulatory subunit Gene Name: PRKAR2B Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase	Metabolic	Amifampridine Action Pathway Progesterone Action Pathway Activation of cAMP-dependent protein kinase, PKA Alverine Serotonin Antagonist Action Pathway Amiodarone Action Pathway Amlodipine Smooth Muscle Relaxation Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Apomorphine Mechanism of Action Action Pathway Arformoterol Action Pathway Asenapine Dopamine Antagonist Action Pathway Benzatropine Dopamine Reuptake Inhibitor Action Pathway Benzphetamine Dopamine Reuptake Inhibitor Action Pathway Bupropion Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Castor Oil Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cimetidine H2 Anti-Histamine Action Pathway Cinnarizine Calcium Channel Vasodilation Action Pathway Clenbuterol Action Pathway Clevidipine Action Pathway Cocaine Dopamine-reuptake Inhibitor Action Pathway Cyclandelate Action Pathway Dalfampridine Action Pathway Desmopressin Action Pathway Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway Dienogest Action Pathway Dihydroergocryptine Mechanism of Action Action Pathway Dihydroergotamine Mechanism of Action Action Pathway Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway Diltiazem Calcium Channel Vasodilation Action Pathway Dinoprost tromethamine Action Pathway Dipivefrin A2-Adrenergic Vasocontriction Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Domperidone Mechanism of Action Action Pathway Drospirenone Action Pathway Drotaverine Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway Eletriptan Mechanism of Action Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epicriptine Mechanism of Action Action Pathway Epinephrine B2-Adrenergic Bronchodilation Action Pathway Ergoloid mesylate Mechanism of Action Action Pathway Ergotamine Mechanism of Action Action Pathway Etafedrine Action Pathway Etonogestrel Action Pathway Famotidine H2 Anti-Histamine Action Pathway Felodipine Action Pathway (New) Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Flavoxate Action Pathway Flunarizine Calcium Channel Artery Dilation Action Pathway Formoterol Action Pathway Frovatriptan Mechanism of Action Action Pathway Gi Adrenergic Smooth Muscle Contraction Gi Serotonergic Smooth Muscle Relaxation Gi Serotonergic Vasoconstriction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Gs Serotonergic Smooth Muscle Contraction Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Isoetharine Action Pathway Isradipine Action Pathway (New) Lacidipine Action Pathway Latanoprost Action Pathway Latanoprostene bunod Action Pathway Lavoltidine H2 Anti-histamine Action Pathway Lercanidipine Action Pathway Levamlodipine Action Pathway Levodopa Pahway Levonorgestrel Action Pathway Levosalbutamol Action Pathway Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway Magnesium Sulfate Action Pathway Manidipine Action Pathway Mazindol Dopamine Reuptake Inhibitor Action Pathway Megestrol acetate Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methylphenidate Dopamine Reuptake Inhibitor Action Pathway Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway Metiamide H2 Anti-Histamine Action Pathway Metipranolol Action Pathway (New) Metoclopramide Serotonergic Smooth Muscle Contraction Mirabegron Action Pathway Misoprostol Action Pathway Muscular Gi Protein Cascade Muscular Gs Protein Cascade Nadolol B2-Adrenergic Vasoconstriction Action Pathway Naratriptan Mechanism of Action Action Pathway Neuronal Dopamine Gs Cascade Nicardipine Action Pathway Nifedipine Action Pathway (New) Nilvadipine Action Pathway Nimodipine Action Pathway (New) Nisoldipine Action Pathway (New) Nitrendipine Action Pathway (New) Nizatidine H2 Anti-Histamine Action Pathway Nomifensine Dopamine Reuptake Inhibitor Action Pathway Norelgestromin Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Norethisterone Action Pathway Norgestrel Action Pathway Nylidrin Action Pathway Olodaterol Action Pathway Orciprenaline Action Pathway Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Pergolide Mechanism of Action Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pinaverium Action Pathway Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Pramipexole Mechanism of Action Action Pathway Procaterol Action Pathway Propiverine Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Prucalopride Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ranitidine H2 Anti-Histamine Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rizatriptan Mechanism of Action Action Pathway Roxatidine Acetate H2 Anti-Histamine Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Segesterone acetate Action Pathway Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway Sibutramine Dopamine Reuptake Inhibitor Action Pathway Sitagliptin Action Pathway Solriamfetol Action Pathway Sumatriptan Mechanism of Action Action Pathway Tafluprost Action Pathway Terbutaline Action Pathway Timolol Action Pathway (New) Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tizanidine Travoprost Action Pathway Vanoxerine Dopamine Reuptake Inhibitor Action Pathway Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway Verapamil Calcium Channel Vasodilation Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Zolmitriptan Mechanism of Action Action Pathway ( show more show less )
Q08499 View in UniProt HMDBP00636 View in HMDB	cAMP-specific 3',5'-cyclic phosphodiesterase 4D Gene Name: PDE4D Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.	Metabolic	Adenine Phosphoribosyltransferase Deficiency (APRT) Adenine Phosphoribosyltransferase Deficiency (APRT) Adenosine Deaminase Deficiency Adenosine Deaminase Deficiency Adenylosuccinate Lyase Deficiency Adenylosuccinate Lyase Deficiency AICA-Ribosiduria Azathioprine Action Pathway Cilostazol Action Pathway Cilostazol Action Pathway (new) Dipyridamole (Antiplatelet) Action Pathway Dipyridamole Action Pathway Dipyridamole Phosphodiesterase Action Pathway Gout or Kelley-Seegmiller Syndrome Gout or Kelley-Seegmiller Syndrome Lesch-Nyhan Syndrome (LNS) Mercaptopurine Action Pathway Mitochondrial DNA Depletion Syndrome-3 Mitochondrial DNA Depletion Syndrome-3 Molybdenum Cofactor Deficiency Molybdenum Cofactor Deficiency Myoadenylate Deaminase Deficiency Myoadenylate Deaminase Deficiency Purine Metabolism Purine Nucleoside Phosphorylase Deficiency Purine Nucleoside Phosphorylase Deficiency Thioguanine Action Pathway (old) Triflusal Action Pathway Xanthine Dehydrogenase Deficiency (Xanthinuria) Xanthinuria Type I Xanthinuria Type I Xanthinuria Type II Xanthinuria Type II ( show more show less )
Q92887 View in UniProt HMDBP01658 View in HMDB	Canalicular multispecific organic anion transporter 1 Gene Name: ABCC2 Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter	Metabolic	Docetaxel Action Pathway Doxorubicin Metabolism Pathway Irinotecan Action Pathway Irinotecan Metabolism Pathway Lamivudine Metabolism Pathway Mycophenolic Acid Metabolism Pathway (old) Paclitaxel Action Pathway (old) Tramadol Metabolism Pathway Tramadol Metabolism Pathway (New) Vinblastine Action Pathway Vincristine Action Pathway Vindesine Action Pathway Vinorelbine Action Pathway ( show more show less )
O15438 View in UniProt HMDBP02040 View in HMDB	Canalicular multispecific organic anion transporter 2 Gene Name: ABCC3 May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes	Metabolic	Etoposide Action Pathway Etoposide Anti-Cancer Action Pathway Etoposide Metabolism Pathway Fluconazole Metabolism Idarubicin Action Pathway Itraconazole Metabolism Lamivudine Metabolism Pathway Loperamide Metabolism Mitoxantrone Action Pathway Topotecan Action Pathway Valrubicin Action Pathway Vinblastine Action Pathway Vincristine Action Pathway Vindesine Action Pathway Vinorelbine Action Pathway ( show more show less )
Q9BSD7 View in UniProt HMDBP10641 View in HMDB	Cancer-related nucleoside-triphosphatase Gene Name: NTPCR Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.	Metabolic	Thiamine Metabolism
P31327 View in UniProt HMDBP00359 View in HMDB	Carbamoyl-phosphate synthase [ammonia], mitochondrial Gene Name: CPS1 Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.	Metabolic	2-Hydroxyglutric Aciduria (D and L Form) 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency Ammonia Recycling Arginine and Proline Metabolism Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Argininemia Argininemia Argininosuccinic Aciduria Argininosuccinic Aciduria Carbamoyl Phosphate Synthetase Deficiency Carbamoyl Phosphate Synthetase Deficiency Citrullinemia Type I Citrullinemia Type I Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Glutamate Metabolism Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Homocarnosinosis Homocarnosinosis Hyperinsulinism-Hyperammonemia Syndrome Hyperinsulinism-Hyperammonemia Syndrome Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia with Gyrate Atrophy (HOGA) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-syndrome) Hyperprolinemia Type I Hyperprolinemia Type I Hyperprolinemia Type II Hyperprolinemia Type II L-Arginine:Glycine Amidinotransferase Deficiency L-Arginine:Glycine Amidinotransferase Deficiency Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Aminotransferase Deficiency (OAT Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Ornithine Transcarbamylase Deficiency (OTC Deficiency) Prolidase Deficiency (PD) Prolinemia Type II Prolinemia Type II Succinic Semialdehyde Dehydrogenase Deficiency Urea Cycle ( show more show less )
Q9NPF2 View in UniProt HMDBP00286 View in HMDB	Carbohydrate sulfotransferase 11 Gene Name: CHST11 Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.	Metabolic	Sulfate/Sulfite Metabolism Sulfite Oxidase Deficiency Sulfite Oxidase Deficiency

Showing 301 - 375 of 1576 proteins

Browsing Proteins

Protein ID

Protein Description

Pathway Class

Pathways

P02730

Band 3 anion transport protein

P11362

HMDBP01450

Basic fibroblast growth factor receptor 1

Q07817

Bcl-2-like protein 1

Q92934

Bcl2-associated agonist of cell death

A8E194

Bcr-abl1 fusion protein

Q14457

Beclin-1

Q9HAY6

HMDBP01568

Beta,beta-carotene 15,15'-monooxygenase

P08588

HMDBP01632

Beta-1 adrenergic receptor

O96024

HMDBP01102

Beta-1,3-galactosyltransferase 4

Q00973

HMDBP00873

Beta-1,4 N-acetylgalactosaminyltransferase 1

P15291

HMDBP00377

Beta-1,4-galactosyltransferase 1

Q9UBX8

HMDBP07258

Beta-1,4-galactosyltransferase 6

Q13884

HMDBP01766

Beta-1-syntrophin

Q13425

HMDBP08002

Beta-2-syntrophin

Q96KN2

HMDBP00473

Beta-Ala-His dipeptidase

P01203

Beta-endorphin

P16278

HMDBP10706

Beta-galactosidase

P08236

HMDBP00839

Beta-glucuronidase

P06865

HMDBP00872

Beta-hexosaminidase subunit alpha

P07686

HMDBP00871

Beta-hexosaminidase subunit beta

Q86Z14

Beta-klotho

P01138

Beta-nerve growth factor

Q9UBR1

HMDBP00544

Beta-ureidopropionase

Q93088

HMDBP00559

Betaine--homocysteine S-methyltransferase 1

DB00112

Bevacizumab

O43252

HMDBP00345

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

O95340

HMDBP00353

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Q13057

HMDBP01886

Bifunctional coenzyme A synthase