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Aspartate
aminotransferase,
cytoplasmic
L-amino-acid
oxidase
Tyrosine
aminotransferase
Phenylalanine-
4-hydroxylase
Aspartate
aminotransferase,
cytoplasmic
Tyrosine
aminotransferase
L-amino-acid
oxidase
Tyrosine--tRNA
ligase,
cytoplasmic
Phenylalanine--
tRNA ligase
4-
hydroxyphenylpyruvate
dioxygenase
Homogentisate
1,2-dioxygenase
Maleylacetoacetate
isomerase
Fumarylacetoacetase
L-Tyrosine
Fumaric acid
Acetoacetic acid
L-Phenylalanine
Oxoglutaric acid
Phenylpyruvic
acid
L-Glutamic acid
H
2
O
O
2
NH
3
H
2
O
2
Oxoglutaric acid
L-Glutamic acid
L-erythro-
tetrahydrobiopterin
O
2
4a-
Hydroxytetrahydrobiopterin
Oxoglutaric acid
4-
Hydroxyphenylpyruvic
acid
L-Glutamic acid
Oxoglutaric acid
L-Glutamic acid
H
2
O
O
2
NH
3
H
2
O
2
ATP
AMP
PP
i
ATP
AMP
PP
i
O
2
Homogentisic acid
CO
2
O
2
Maleylacetoacetic
acid
4-
Fumarylacetoacetic
acid
H
2
O
Fe2+
Fe3+
Calcium
Magnesium
tRNA(Tyr)
L-Tyrosyl-
tRNA(Tyr)
tRNA(Phe)
L-
Phenylalanyl-
tRNA(Phe)
Catecholamine
Biosynthesis
Tyrosine
Metabolism
Citric Acid
Cycle
Pyridoxal
5'-phosphate
FAD
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
FAD
Iron
Cytosol
Extracellular Space
Liver Hepatic Cell
Lysosome
GOT1
IL4I1
TAT
PAH
GOT1
TAT
IL4I1
YARS
FARSA
FARSB
HPD
HGD
GSTZ1
FAH
L-Tyrosine
Fumaric acid
Acetoacetic acid
L-Phenylalanine
Oxoglutaric acid
Phenylpyruvic
acid
L-Glutamic acid
Water
Oxygen
Ammonia
Hydrogen peroxide
Oxoglutaric acid
L-Glutamic acid
L-erythro-
tetrahydrobiopterin
Oxygen
4a-
Hydroxytetrahydrobiopterin
Oxoglutaric acid
4-
Hydroxyphenylpyruvic
acid
L-Glutamic acid
Oxoglutaric acid
L-Glutamic acid
Water
Oxygen
Ammonia
Hydrogen peroxide
Adenosine
triphosphate
Adenosine
monophosphate
Pyrophosphate
Adenosine
triphosphate
Adenosine
monophosphate
Pyrophosphate
Oxygen
Homogentisic acid
Carbon dioxide
Oxygen
Maleylacetoacetic
acid
4-
Fumarylacetoacetic
acid
Water
tRNA(Tyr)
L-Tyrosyl-
tRNA(Tyr)
tRNA(Phe)
L-
Phenylalanyl-
tRNA(Phe)
Catecholamine
Biosynthesis
Tyrosine
Metabolism
Citric Acid Cycle