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Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Leukotriene-
B(4) omega-
hydroxylase 1
Leukotriene A-4
hydrolase
Leukotriene C4
synthase
Gamma-
glutamyltranspeptidase
1
Glutathione
peroxidase 1
Prostacyclin
synthase
Prostaglandin-
H2 D-isomerase
Aldo-keto
reductase
family 1 member
C3
Thromboxane-A
synthase
Prostaglandin E
synthase
Prostamide/prostaglandin
F synthase
Carbonyl
reductase
[NADPH] 1
Arachidonate
15-lipoxygenase
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2B6
Epoxide
hydratase 2
Cytochrome P450
2B6
Epoxide
hydratase 2
Arachidonate
5-lipoxygenase
Arachidonate
5-lipoxygenase
Glutathione
peroxidase 1
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Cytochrome P450
2B6
Epoxide
hydratase 2
Cytochrome P450
2B6
Epoxide
hydratase 2
Arachidonate
15-lipoxygenase
B
Cytochrome P450
2E1
Arachidonate
12-
lipoxygenase,
12R-type
Cytochrome P450
2J2
Cytochrome P450
2U1
Cytochrome P450
4A11
Cytochrome P450
2U1
Arachidonate
12-
lipoxygenase,
12S-type
Cytosolic
phospholipase
A2 beta
Cytochrome P450
4F8
Leukotriene-
B(4) omega-
hydroxylase 2
Ketoprofen
Heme
Heme
20-Hydroxy-leukotriene B4
20-Carboxy-leukotriene B4
Leukotriene B4
NADPH
O
2
NADP
H
2
O
Leukotriene A4
H
2
O
12-Keto-leukotriene B4
Glutathione
Leukotriene C4
H
2
O
Leukotriene D4
L-Glutamic acid
5,6-Epoxytetraene
15(S)-HPETE
Glutathione
15(S)-HETE
Oxidized glutathione
H
2
O
δ-12-Prostaglandin J2
15-Deoxy-d-12,14-PGJ2
6-Keto-prostaglandin F1a
6-Ketoprostaglandin E1
5-HETE
5-KETE
Prostaglandin J2
Prostaglandin I2
Prostaglandin D2
Prostaglandin H2
NADPH
11-Epi-PGF2a
NADP
Thromboxane A2
Prostaglandin E2
Prostaglandin F2a
NADPH
NADP
Prostaglandin A2
Prostaglandin-c2
Thromboxane B2
Prostaglandin B2
11-Dehydro-thromboxane B2
Arachidonic acid
O
2
O
2
11H-14,15-EETA
H
2
O
O
2
11,14,15-THETA
H
2
O
O
2
15H-11,12-EETA
H
2
O