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Mitochondrial
2-
oxoglutarate/malate
carrier protein
Glutathione
synthetase
Gamma-
glutamyltransferase
6
Aminopeptidase
N
Caspase-7
Gamma-
glutamyltransferase
6
Aminopeptidase
N
Caspase-7
Glutamate--
cysteine ligase
catalytic
subunit
Glutamate--
cysteine ligase
regulatory
subunit
5-oxoprolinase
Gamma-
glutamylcyclotransferase
Gamma-
glutamylcyclotransferase
Glutathione
reductase,
mitochondrial
Glutathione
peroxidase 1
Glutathione
S-transferase
omega-2
L-Glutamic acid
L-Cysteine
Dissipation
Glutathione
Dissipation
Glutathione
ATP
Accumulation
γ-Glutamylcysteine
Glycine
ADP
P
i
S-(methyl)glutathione
H
2
O
Methyl-S-Cysteinylglycine
H
2
O
Methyl-S-cystein
Glycine
L-amino acid
(5-L-Glutamyl)-L-amino acid
Cysteinylglycine
H
2
O
ATP
L-Glutamic acid
ADP
P
i
ATP
Accumulation
Pyroglutamic acid
H
2
O
ADP
P
i
L-Cysteine
L-amino acid
Oxidized glutathione
NADPH
NADP
H
2
O
2
H
2
O
Bromomethane
Hydrogen bromide
Zinc (II) ion
Zinc
Zinc (II) ion
Zinc
FAD
Glutamate
Metabolism
Cysteine
Metabolism
Taurine and
Hypotaurine
Metabolism
Gamma Glutamyl cycle
Cytosol
Extracellular Space
Mitochondrion
SLC25A11
GSS
GGT6
ANPEP
CASP7
GGT6
ANPEP
CASP7
GCLC
GCLM
OPLAH
GGCT
GGCT
GSR
GPX1
GSTO2
L-Glutamic acid
L-Cysteine
Dissipation
Glutathione
Dissipation
Glutathione
Adenosine
triphosphate
Accumulation
γ-
Glutamylcysteine
Glycine
Adenosine
diphosphate
Phosphoric acid
S-
(methyl)glutathione
Water
Methyl-S-
Cysteinylglycine
Water
Methyl-S-
cystein
Glycine
L-amino acid
(5-L-
Glutamyl)-L-
amino acid
Cysteinylglycine
Water
Adenosine
triphosphate
L-Glutamic acid
Adenosine
diphosphate
Phosphoric acid
Adenosine
triphosphate
Accumulation
Pyroglutamic
acid
Water
Adenosine
diphosphate
Phosphoric acid
L-Cysteine
L-amino acid
Oxidized
glutathione
NADPH
NADP
Hydrogen
peroxide
Water
Bromomethane
Hydrogen
bromide
Glutamate
Metabolism
Cysteine
Metabolism
Taurine and
Hypotaurine
Metabolism